Acute interstitial nephritis related to SGLT-2 inhibitor

Sodium–glucose cotransporter-2 (SGLT-2) inhibitors are effective antihyperglycemic agents with proven cardiovascular and renal benefits.1 2 The risk for acute kidney injury (AKI) in patients on SGLT-2 inhibitors is considered to be relatively low. However, there have been postmarketing reports of episodes of AKI, some requiring hospitalisation and even dialysis in patients receiving SGLT-2 inhibitors.3 This phenomenon may be related to volume contraction and haemodynamic changes, particularly in patients with other risk factors (such as patients on renin–angiotensin–aldosterone system blocking agents or non-steroidal anti-inflammatory drugs, patients with chronic kidney disease).4 Here, we present a case of acute interstitial nephritis (AIN) and acute tubular necrosis likely related to a SGLT-2 inhibitor. A 67-year-old woman was admitted with weakness, dizziness and abdominal pain. Her medical history was remarkable for hypertension, diabetes mellitus, ischaemic heart disease and peripheral vascular disease. Her medications included bisoprolol, losartan,...
Source: Postgraduate Medical Journal - Category: General Medicine Authors: Tags: Adverse drug reactions Source Type: research