Berbamine ameliorates DSS-induced colitis by inhibiting peptidyl-arginine deiminase 4-dependent neutrophil extracellular traps formation
Eur J Pharmacol. 2024 May 4:176634. doi: 10.1016/j.ejphar.2024.176634. Online ahead of print.ABSTRACTUlcerative colitis (UC) is a chronic inflammatory bowel disease with immune dysregulation affecting colon inflammatory response. Recent studies have highlighted that neutrophil extracellular traps (NETs) play an important role in the pathogenesis of UC. Berbamine (BBM), one of the bioactive ingredients extracted from Chinese herbal medicine Berberis vulgaris L, has attracted intensive attentions due to its significant anti-inflammatory activity and a marketing drug for treating leukemia in China. However, the exact role and...
Source: European Journal of Pharmacology - May 6, 2024 Category: Drugs & Pharmacology Authors: Wenwen Tang Jiaze Ma Kaidi Chen Kuiling Wang Zepeng Chen Chen Chen Yuji Wang Yi Shu Wei Zhang Xiaomin Yuan Guoping Shi Tuo Chen Peimin Wang Yugen Chen Source Type: research
Ruthenium Red Alleviates Post-Resuscitation Myocardial Dysfunction by Upregulating Mitophagy through Inhibition of USP33 in a Cardiac Arrest Rat Model
This study investigated the effects of RR on PRMD and analyzed its underlying mechanisms. Ventricular fibrillation was induced in rats, which were then subjected to cardiopulmonary resuscitation to establish an experimental CA model. At the onset of return of spontaneous circulation, RR (2.5 mg/kg) was administered intraperitoneally. Our study showed that RR improved myocardial function and reduced the production of oxidative stress markers such as malondialdehyde (MDA), glutathione peroxidase (GSSG), and reactive oxygen species (ROS) production. RR also helped maintain mitochondrial structure and increased ATP and GTP lev...
Source: European Journal of Pharmacology - May 4, 2024 Category: Drugs & Pharmacology Authors: Fan Zhang Zhou Ye Yingqi Ran Cong Liu Mingtao Zhang Xiangchang Xu Fengqing Song Lan Yao Source Type: research
Ruthenium Red Alleviates Post-Resuscitation Myocardial Dysfunction by Upregulating Mitophagy through Inhibition of USP33 in a Cardiac Arrest Rat Model
This study investigated the effects of RR on PRMD and analyzed its underlying mechanisms. Ventricular fibrillation was induced in rats, which were then subjected to cardiopulmonary resuscitation to establish an experimental CA model. At the onset of return of spontaneous circulation, RR (2.5 mg/kg) was administered intraperitoneally. Our study showed that RR improved myocardial function and reduced the production of oxidative stress markers such as malondialdehyde (MDA), glutathione peroxidase (GSSG), and reactive oxygen species (ROS) production. RR also helped maintain mitochondrial structure and increased ATP and GTP lev...
Source: European Journal of Pharmacology - May 4, 2024 Category: Drugs & Pharmacology Authors: Fan Zhang Zhou Ye Yingqi Ran Cong Liu Mingtao Zhang Xiangchang Xu Fengqing Song Lan Yao Source Type: research
Ruthenium Red Alleviates Post-Resuscitation Myocardial Dysfunction by Upregulating Mitophagy through Inhibition of USP33 in a Cardiac Arrest Rat Model
This study investigated the effects of RR on PRMD and analyzed its underlying mechanisms. Ventricular fibrillation was induced in rats, which were then subjected to cardiopulmonary resuscitation to establish an experimental CA model. At the onset of return of spontaneous circulation, RR (2.5 mg/kg) was administered intraperitoneally. Our study showed that RR improved myocardial function and reduced the production of oxidative stress markers such as malondialdehyde (MDA), glutathione peroxidase (GSSG), and reactive oxygen species (ROS) production. RR also helped maintain mitochondrial structure and increased ATP and GTP lev...
Source: European Journal of Pharmacology - May 4, 2024 Category: Drugs & Pharmacology Authors: Fan Zhang Zhou Ye Yingqi Ran Cong Liu Mingtao Zhang Xiangchang Xu Fengqing Song Lan Yao Source Type: research
Combination of dasatinib and quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice
CONCLUSIONS: First, our data show that the aged male mice are more vulnerable to HS-induced cognitive deficits than those of the young adult male mice. Second, we demonstrate that combination of D and Q therapy attenuates cognitive deficits in heat stressed aged or young adult male mice via broad normalization of the brain-gut-endotoxin axis function.PMID:38692425 | DOI:10.1016/j.ejphar.2024.176631 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Xiaojing Lin Kangli Zhang Chenyi Li Kewei Liu Yanping Sun Wei Wu Kai Liu Xeuqing Yi Xiaowen Wang Zixuan Qu Xiaohong Liu Yao Xing M J Walker Qinglei Gong Ruoxu Liu Xiaoming Xu Cheng-Hsien Lin Gang Sun Source Type: research
Repurposing the multiple sclerosis drug Siponimod for osteoporosis treatment
Eur J Pharmacol. 2024 Apr 29:176630. doi: 10.1016/j.ejphar.2024.176630. Online ahead of print.ABSTRACTOsteoporosis is the most common bone disorder, in which an imbalance between osteoclastic bone resorption and osteoblastic bone formation disrupts bone homeostasis. Osteoporosis management using anti-osteoclastic agents is a promising strategy; however, this remains an unmet need. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) are essential for maintaining bone homeostasis. Here, we identified that Siponimod, a Food and Drug Administration-approved S1PR antagonist for the treatment of multiple sclerosis, shows pro...
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sitao Hu Yangyang Hu Zenglin Tan Chengyu Zhou Cheng Zhang Sheng Yin Xiaojun Chen Kai Chen Lu Wang Lei Chen Source Type: research
Combination of dasatinib and quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice
CONCLUSIONS: First, our data show that the aged male mice are more vulnerable to HS-induced cognitive deficits than those of the young adult male mice. Second, we demonstrate that combination of D and Q therapy attenuates cognitive deficits in heat stressed aged or young adult male mice via broad normalization of the brain-gut-endotoxin axis function.PMID:38692425 | DOI:10.1016/j.ejphar.2024.176631 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Xiaojing Lin Kangli Zhang Chenyi Li Kewei Liu Yanping Sun Wei Wu Kai Liu Xeuqing Yi Xiaowen Wang Zixuan Qu Xiaohong Liu Yao Xing M J Walker Qinglei Gong Ruoxu Liu Xiaoming Xu Cheng-Hsien Lin Gang Sun Source Type: research
Repurposing the multiple sclerosis drug Siponimod for osteoporosis treatment
Eur J Pharmacol. 2024 Apr 29:176630. doi: 10.1016/j.ejphar.2024.176630. Online ahead of print.ABSTRACTOsteoporosis is the most common bone disorder, in which an imbalance between osteoclastic bone resorption and osteoblastic bone formation disrupts bone homeostasis. Osteoporosis management using anti-osteoclastic agents is a promising strategy; however, this remains an unmet need. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) are essential for maintaining bone homeostasis. Here, we identified that Siponimod, a Food and Drug Administration-approved S1PR antagonist for the treatment of multiple sclerosis, shows pro...
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sitao Hu Yangyang Hu Zenglin Tan Chengyu Zhou Cheng Zhang Sheng Yin Xiaojun Chen Kai Chen Lu Wang Lei Chen Source Type: research
Combination of dasatinib and quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice
CONCLUSIONS: First, our data show that the aged male mice are more vulnerable to HS-induced cognitive deficits than those of the young adult male mice. Second, we demonstrate that combination of D and Q therapy attenuates cognitive deficits in heat stressed aged or young adult male mice via broad normalization of the brain-gut-endotoxin axis function.PMID:38692425 | DOI:10.1016/j.ejphar.2024.176631 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Xiaojing Lin Kangli Zhang Chenyi Li Kewei Liu Yanping Sun Wei Wu Kai Liu Xeuqing Yi Xiaowen Wang Zixuan Qu Xiaohong Liu Yao Xing M J Walker Qinglei Gong Ruoxu Liu Xiaoming Xu Cheng-Hsien Lin Gang Sun Source Type: research
Repurposing the multiple sclerosis drug Siponimod for osteoporosis treatment
Eur J Pharmacol. 2024 Apr 29:176630. doi: 10.1016/j.ejphar.2024.176630. Online ahead of print.ABSTRACTOsteoporosis is the most common bone disorder, in which an imbalance between osteoclastic bone resorption and osteoblastic bone formation disrupts bone homeostasis. Osteoporosis management using anti-osteoclastic agents is a promising strategy; however, this remains an unmet need. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) are essential for maintaining bone homeostasis. Here, we identified that Siponimod, a Food and Drug Administration-approved S1PR antagonist for the treatment of multiple sclerosis, shows pro...
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sitao Hu Yangyang Hu Zenglin Tan Chengyu Zhou Cheng Zhang Sheng Yin Xiaojun Chen Kai Chen Lu Wang Lei Chen Source Type: research
Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1
This study provides a theoretical basis for the application of ORI based on the mechanism of ferroptosis, and provides potential natural drug candidates for cancer prevention and treatment.PMID:38685305 | DOI:10.1016/j.ejphar.2024.176620 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Shiying Ye Xiangyan Hu Shaowei Sun Bo Su Jiye Cai Jinhuan Jiang Source Type: research
MiR-29a efficiently suppresses the generation of reactive oxygen species and α-synuclein in a cellular model of Parkinson's disease by potentially targeting GSK-3β
This study explored the protective role of miR-29a in a cellular model of PD using SH-SY5Y cell lines through iTRAQ-based quantitative proteomic and biochemistry analysis. The findings showed that using a miR-29a mimic in SH-SY5Y cells treated with 1-methyl-4-phenylpyridinium (MPP+) significantly decreased cell death and increased mitochondrial membrane potential. It also reduced mitochondrial reactive oxygen species (ROS) and the production of α-synuclein. Subsequent heatmap analysis using iTRAQ-based quantitative proteomics revealed remarkably contrasting protein expression profiles for 882 genes when comparing the grou...
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Ya-Ling Yang Tsu-Kung Lin Ying-Hsien Huang Source Type: research
Peptide PDRPS6 Attenuates Myocardial Ischemia Injury by Improving Mitochondrial Function
This study aimed to investigate the function and mechanism of action of PDRPS6 in I/R injury. In vivo, PDRPS6 ameliorated myocardial tissue injury and cardiomyocyte apoptosis and decreased cardiac function induced by I/R injury in rats. PDRPS6 supplementation significantly reduced apoptosis in vitro. Mechanistically, PDRPS6 improved mitochondrial function by decreasing reactive oxygen species (ROS) levels, maintaining mitochondrial membrane potential (MMP), and inhibiting mitochondrial fission. Pull-down assay analyses revealed that phosphoglycerate mutase 5 (PGAM5) may be the target of PDRPS6, which can lead to the dephos...
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Mengwen Feng Li Zhang Anwen Yin Han Zhang Xueping Wu Lingmei Qian Source Type: research
Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1
This study provides a theoretical basis for the application of ORI based on the mechanism of ferroptosis, and provides potential natural drug candidates for cancer prevention and treatment.PMID:38685305 | DOI:10.1016/j.ejphar.2024.176620 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Shiying Ye Xiangyan Hu Shaowei Sun Bo Su Jiye Cai Jinhuan Jiang Source Type: research
MiR-29a efficiently suppresses the generation of reactive oxygen species and α-synuclein in a cellular model of Parkinson's disease by potentially targeting GSK-3β
This study explored the protective role of miR-29a in a cellular model of PD using SH-SY5Y cell lines through iTRAQ-based quantitative proteomic and biochemistry analysis. The findings showed that using a miR-29a mimic in SH-SY5Y cells treated with 1-methyl-4-phenylpyridinium (MPP+) significantly decreased cell death and increased mitochondrial membrane potential. It also reduced mitochondrial reactive oxygen species (ROS) and the production of α-synuclein. Subsequent heatmap analysis using iTRAQ-based quantitative proteomics revealed remarkably contrasting protein expression profiles for 882 genes when comparing the grou...
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Ya-Ling Yang Tsu-Kung Lin Ying-Hsien Huang Source Type: research
