Combination of dasatinib and quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice

CONCLUSIONS: First, our data show that the aged male mice are more vulnerable to HS-induced cognitive deficits than those of the young adult male mice. Second, we demonstrate that combination of D and Q therapy attenuates cognitive deficits in heat stressed aged or young adult male mice via broad normalization of the brain-gut-endotoxin axis function.PMID:38692425 | DOI:10.1016/j.ejphar.2024.176631

Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Xiaojing Lin Kangli Zhang Chenyi Li Kewei Liu Yanping Sun Wei Wu Kai Liu Xeuqing Yi Xiaowen Wang Zixuan Qu Xiaohong Liu Yao Xing M J Walker Qinglei Gong Ruoxu Liu Xiaoming Xu Cheng-Hsien Lin Gang Sun Source Type: research