Efficacy, safety, and patient satisfaction of norditropin and sogroya in patients with growth hormone deficiency: a systematic review and meta-analysis of randomized controlled trials
ConclusionNorditropin and Sogroya showed comparable efficacy and safety profiles, except for the prevalence of rash in the Norditropin group, and Sogroya has higher satisfaction among adults. More high-quality studies with more patients are required to confirm these results. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
Effectiveness of prognostic nutritional index in predicting overall survival and evaluating immunotherapy response in anaplastic thyroid carcinoma
ConclusionPNI is an independent predictor of overall survival and holds the potential to serve as a valuable indicator for assessing and predicting immunotherapy efficacy in ATC patients. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
Therapeutic patient education and treatment intensification of diabetes and hypertension in subjects with newly diagnosed type 2 diabetes mellitus: a longitudinal study
ConclusionsTPE, delivered as both individual and group sessions, represents an effective tool to reduce the need to intensify treatment of both diabetes and hypertension. Therefore, it can ensure better control of diabetes and hypertension with fewer medications. This could reduce adverse effects and costs and improve quality of life and medication taking in patients with type 2 diabetes. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
1,25(OH)2D3 inhibits pancreatic stellate cells activation and promotes insulin secretion in T2DM
ConclusionOur findings identify that PSCs activation contributes to islet fibrosis and β-cell dysfunction. 1,25(OH)2D3 exerts beneficial effects on T2DM potentially by inhibiting PSCs activation and inflammatory response, highlighting promising control strategies of T2DM by vitamin D.Graphical AbstractFig. 7 Molecular mechanism of 1,25(OH)2D3 in β cell damage following PSCs activation in T2DM mice. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
Thyroid dysfunction in nonvalvular atrial fibrillation and clinical outcomes
ConclusionLow T3 syndrome are linked to an increased risk of heart failure and all-cause death in individuals with NVAF. And Patients with NVAF and low TT3 levels have a higher risk of thromboembolism. (Source: Endocrine)
Source: Endocrine - April 22, 2024 Category: Endocrinology Source Type: research
No requirement of perioperative glucocorticoid replacement in patients with endogenous Cushing ’s syndrome – a pilot study
ConclusionPerioperative glucocorticoid replacement may be unnecessary in patients with central or adrenal CS undergoing curative surgery as first-line treatment. (Source: Endocrine)
Source: Endocrine - April 22, 2024 Category: Endocrinology Source Type: research
Semaglutide attenuates pathological electrophysiological remodeling in diabetic cardiomyopathy via restoring Cx43 expression
ConclusionsOur research results showed that semaglutide protected against oxidative stress and apoptosis in diabetic heart, thereby improving cardiac function and electrophysiological remodelling in DCM mice, which may attribute to activation of Sirt1/AMPK pathway and restore of Cx43 expression. (Source: Endocrine)
Source: Endocrine - April 22, 2024 Category: Endocrinology Source Type: research
Relationship between indices of insulin resistance and incident type 2 diabetes mellitus in Chinese adults
ConclusionTG/HDL-c, TyG, and TyG –BMI index were all significantly positively associated with higher risk for future T2DM. Baseline TyG–BMI level had high predictive value for the identification of T2DM. (Source: Endocrine)
Source: Endocrine - April 20, 2024 Category: Endocrinology Source Type: research
Ameliorative effect of ferulic acid on thyroid dysfunction against propyl-thiouracil induced hypothyroid rats
ConclusionIn conclusion, FA treatment showed a protective effect against hypothyroidism by stimulating the thyroid hormones through the activation of thyroid peroxidase enzyme and improving thyroid function. In addition, FA diminished the increase in lipids, liver and kidney markers, oxidative stress and inflammation.Graphical Abstract (Source: Endocrine)
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
One sip of water with LT-4 supplementation —a key to euthyroidism in Hashimoto’s thyroiditis
ConclusionsThe reduction of water ingestion to a maximum of two sips, which is<50 mL, combined with LT-4 supplementation helps to achieve euthyroidism in HT. In addition, it reduces the L-T4 medication dosage needed to lower TSH serum levels and decreases TPO antibodies in HT. (Source: Endocrine)
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction
AbstractNeuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent. Reproductive events, such as pregnancy, bring about significant changes in metabolism, and meta...
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
One sip of water with LT-4 supplementation —a key to euthyroidism in Hashimoto’s thyroiditis
ConclusionsThe reduction of water ingestion to a maximum of two sips, which is<50 mL, combined with LT-4 supplementation helps to achieve euthyroidism in HT. In addition, it reduces the L-T4 medication dosage needed to lower TSH serum levels and decreases TPO antibodies in HT. (Source: Endocrine)
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction
AbstractNeuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent. Reproductive events, such as pregnancy, bring about significant changes in metabolism, and meta...
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research
New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases
ConclusionsAssessing the status of the vitamin D/PTH axis and using vitamin D and PTH as therapeutic agents is mandatory in several endocrine-related bone metabolic conditions. (Source: Endocrine)
Source: Endocrine - April 17, 2024 Category: Endocrinology Source Type: research
The health-related quality of life of patients with type 1 and type 2 diabetes mellitus: a meta-analysis
ConclusionOur results are sample-specific and cannot be generalized to all patients with DM. Therefore, more research is warranted on this topic. (Source: Endocrine)
Source: Endocrine - April 17, 2024 Category: Endocrinology Source Type: research
