Peritoneal dialysis in an end-stage renal disease patient with massive ascites and primary liver cancer
We present a case of a 68-year-old male patient with ESRD who experienced various decompensated complications of liver cirrhosis, particularly massive ascites and hepatic space-occupying lesions. Peritoneal dialysis (PD) catheter insertion and continuous ambulatory peritoneal dialysis (CAPD) treatment were successfully performed. During meticulous follow-up, the patient survived for one year but ultimately succumbed to complications related to liver cancer. PD can serve as an efficacious therapeutic approach for such late-stage patients afflicted together with severe cirrhosis, massive ascites and primary liver cancer.PMID...
Source: Renal Failure - May 3, 2024 Category: Urology & Nephrology Authors: Lulu Sun Chunmei Liang Yuqin Wang Hui Li Lijun Yao Huajun Jiang Source Type: research
Lipid nephrotoxicity mediated by HIF-1 α activation accelerates tubular injury in diabetic nephropathy
This study is intended to explore the effect of hypoxia-inducible factor-1α (HIF-1α) activation on lipid accumulation in the diabetic kidney. A type 1 diabetic rat model was established by STZ intraperitoneal injection. Cobalt chloride (CoCl2) and YC-1 were used as the HIF-1α activator and antagonist, respectively. CoCl2 treatment significantly increased HIF-1α expression, accelerated lipid deposition, and accelerated tubular injury in diabetic kidneys. In vitro, CoCl2 effectively stabilized HIF-1α and increased its transportation from the cytoplasm to the nucleus, which was accompanied by significantly increased lipi...
Source: Renal Failure - May 2, 2024 Category: Urology & Nephrology Authors: Zebo Hu Qianwen Zhu Ying Wang Xue Deng Hui Yang Mingjun Zhou Jiyuan Zhang Hao Wang Haosen Wang Lin Wang Cui Zhang Shu Li Source Type: research
Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study
Ren Fail. 2024 Dec;46(1):2344655. doi: 10.1080/0886022X.2024.2344655. Epub 2024 Apr 29.ABSTRACTThe association between blood flow rate (BFR) and clinical outcomes in patients undergoing maintenance hemodialysis (MHD) is inconclusive. This retrospective study included 175 patients undergoing MHD treatment between July 2015 and March 2022, divided into two groups based on time-averaged effective blood flow rate (eBFR) median value. We investigated arteriovenous fistula (AVF) outcomes and the association of eBFR with all-cause mortality and new major adverse cardiovascular events (MACE). Mean ± SD and median time-averaged eB...
Source: Renal Failure - April 30, 2024 Category: Urology & Nephrology Authors: Zhoucang Zhang Jiarui Li Jiaxiang Ding Shenglei Zhang Mei Wang Jinsheng Xu Source Type: research
Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity
This study investigated the mechanism by which gallic acid (GA) protects mice kidneys against renal damage induced by Nickel oxide nanoparticles (NiO-NPs). Forty male Swiss albino mice were randomly assigned into four groups, each consisting of ten mice (n = 10/group): Group I the control group, received no treatment; Group II, the GA group, was administrated GA at a dosage of 110 mg/kg/day body weight; Group III, the NiO-NPs group, received injection of NiO-NPs at a concentration of 20 mg/kg body weight for 10 consecutive days; Group IV, the GA + NiO-NPs group, underwent treatment with both GA and NiO-NPs. The results sho...
Source: Renal Failure - April 30, 2024 Category: Urology & Nephrology Authors: Areej I Alhazmi Mohamed F El-Refaei Eman A A Abdallah Source Type: research
Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study
Ren Fail. 2024 Dec;46(1):2344655. doi: 10.1080/0886022X.2024.2344655. Epub 2024 Apr 29.ABSTRACTThe association between blood flow rate (BFR) and clinical outcomes in patients undergoing maintenance hemodialysis (MHD) is inconclusive. This retrospective study included 175 patients undergoing MHD treatment between July 2015 and March 2022, divided into two groups based on time-averaged effective blood flow rate (eBFR) median value. We investigated arteriovenous fistula (AVF) outcomes and the association of eBFR with all-cause mortality and new major adverse cardiovascular events (MACE). Mean ± SD and median time-averaged eB...
Source: Renal Failure - April 30, 2024 Category: Urology & Nephrology Authors: Zhoucang Zhang Jiarui Li Jiaxiang Ding Shenglei Zhang Mei Wang Jinsheng Xu Source Type: research
Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity
This study investigated the mechanism by which gallic acid (GA) protects mice kidneys against renal damage induced by Nickel oxide nanoparticles (NiO-NPs). Forty male Swiss albino mice were randomly assigned into four groups, each consisting of ten mice (n = 10/group): Group I the control group, received no treatment; Group II, the GA group, was administrated GA at a dosage of 110 mg/kg/day body weight; Group III, the NiO-NPs group, received injection of NiO-NPs at a concentration of 20 mg/kg body weight for 10 consecutive days; Group IV, the GA + NiO-NPs group, underwent treatment with both GA and NiO-NPs. The results sho...
Source: Renal Failure - April 30, 2024 Category: Urology & Nephrology Authors: Areej I Alhazmi Mohamed F El-Refaei Eman A A Abdallah Source Type: research
Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study
Ren Fail. 2024 Dec;46(1):2344655. doi: 10.1080/0886022X.2024.2344655. Epub 2024 Apr 29.ABSTRACTThe association between blood flow rate (BFR) and clinical outcomes in patients undergoing maintenance hemodialysis (MHD) is inconclusive. This retrospective study included 175 patients undergoing MHD treatment between July 2015 and March 2022, divided into two groups based on time-averaged effective blood flow rate (eBFR) median value. We investigated arteriovenous fistula (AVF) outcomes and the association of eBFR with all-cause mortality and new major adverse cardiovascular events (MACE). Mean ± SD and median time-averaged eB...
Source: Renal Failure - April 30, 2024 Category: Urology & Nephrology Authors: Zhoucang Zhang Jiarui Li Jiaxiang Ding Shenglei Zhang Mei Wang Jinsheng Xu Source Type: research
Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity
This study investigated the mechanism by which gallic acid (GA) protects mice kidneys against renal damage induced by Nickel oxide nanoparticles (NiO-NPs). Forty male Swiss albino mice were randomly assigned into four groups, each consisting of ten mice (n = 10/group): Group I the control group, received no treatment; Group II, the GA group, was administrated GA at a dosage of 110 mg/kg/day body weight; Group III, the NiO-NPs group, received injection of NiO-NPs at a concentration of 20 mg/kg body weight for 10 consecutive days; Group IV, the GA + NiO-NPs group, underwent treatment with both GA and NiO-NPs. The results sho...
Source: Renal Failure - April 30, 2024 Category: Urology & Nephrology Authors: Areej I Alhazmi Mohamed F El-Refaei Eman A A Abdallah Source Type: research
Budapest nephrology school - 30 years of history - from modest start to an international success: systematic summary of the 27th BNS held between 28 < sup > th < /sup > August and 2 < sup > nd < /sup > of September 2023
Ren Fail. 2024 Dec;46(1):2282709. doi: 10.1080/0886022X.2023.2282709. Epub 2024 Apr 29.ABSTRACTBudapest Nephrology School (BNS) could have celebrated its 30th event if it had not been interrupted by COVID pandemic for a few years. Yet, the organization of 27th BNS in August 2023 resumed its successful and traditional activities at Semmelweis University, in the beautiful central European city of Budapest. In over two decades, BNS has faithfully adapted to the changes and developments of medical science and clinical nephrology, the fact which has kept it unique and attractive for nephrologists from across the globe. With suc...
Source: Renal Failure - April 29, 2024 Category: Urology & Nephrology Authors: Orsolya Cseprek ál Laszlo Rosivall Source Type: research
DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/ β-catenin pathway-dependent manner
CONCLUSION: Upregulation of DKK3 caused by m6A modification activated the Wnt/β-catenin pathway to increase MFF transcriptional expression, leading to mitochondrial dysfunction and oxidative stress, thereby promoting RF progression.PMID:38682264 | DOI:10.1080/0886022X.2024.2343817 (Source: Renal Failure)
Source: Renal Failure - April 29, 2024 Category: Urology & Nephrology Authors: Jianling Song Yanxia Chen Yan Chen Minzi Qiu Wenliu Xiang Ben Ke Xiangdong Fang Source Type: research
Budapest nephrology school - 30 years of history - from modest start to an international success: systematic summary of the 27th BNS held between 28 < sup > th < /sup > August and 2 < sup > nd < /sup > of September 2023
Ren Fail. 2024 Dec;46(1):2282709. doi: 10.1080/0886022X.2023.2282709. Epub 2024 Apr 29.ABSTRACTBudapest Nephrology School (BNS) could have celebrated its 30th event if it had not been interrupted by COVID pandemic for a few years. Yet, the organization of 27th BNS in August 2023 resumed its successful and traditional activities at Semmelweis University, in the beautiful central European city of Budapest. In over two decades, BNS has faithfully adapted to the changes and developments of medical science and clinical nephrology, the fact which has kept it unique and attractive for nephrologists from across the globe. With suc...
Source: Renal Failure - April 29, 2024 Category: Urology & Nephrology Authors: Orsolya Cseprek ál Laszlo Rosivall Source Type: research
DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/ β-catenin pathway-dependent manner
CONCLUSION: Upregulation of DKK3 caused by m6A modification activated the Wnt/β-catenin pathway to increase MFF transcriptional expression, leading to mitochondrial dysfunction and oxidative stress, thereby promoting RF progression.PMID:38682264 | DOI:10.1080/0886022X.2024.2343817 (Source: Renal Failure)
Source: Renal Failure - April 29, 2024 Category: Urology & Nephrology Authors: Jianling Song Yanxia Chen Yan Chen Minzi Qiu Wenliu Xiang Ben Ke Xiangdong Fang Source Type: research
Assessing the role of Chemokine (C-C motif) ligand 14 in AKI: a European consensus meeting
CONCLUSION: Real world urinary CCL14 use appears to provide improved care options to patients at risk for persistent severe AKI. Experts believe there is a role for CCL14 in AKI management and it may potentially reduce AKI-disease burden. There is, however, an urgent need for evidence on treatment decisions and adjustments based on CCL14 results.PMID:38666354 | DOI:10.1080/0886022X.2024.2345747 (Source: Renal Failure)
Source: Renal Failure - April 26, 2024 Category: Urology & Nephrology Authors: Jay L Koyner Christian Arndt Jaume Baldira Martinez de Irujo S ílvia Coelho Manuel Garcia-Montesinos de la Pe ña Luca di Girolamo Michael Joannidis Pablo Jorge-Monjas Christian Koch Steven Lobaz Alain Meyer Marlies Ostermann Nicoletta Pertica John R Pro Source Type: research
