Control Compounds for Preclinical Drug-Induced Liver Injury Assessment: Consensus-driven systematic review by the ProEuroDILI Network
Idiosyncratic drug-induced liver injury (DILI) is a complex and unpredictable event caused by drugs, herbal or dietary supplements. Early identification of human hepatotoxicity at preclinical stages remains a major challenge, in which the selection of validated in vitro systems and test drugs has a significant impact. This systematic review analyzed the compounds used in hepatotoxicity assays and established a list of DILI positive and negative control drugs for validation of in vitro models of DILI, supported by literature and clinical evidence and endorsed by an expert committee from COST Action ProEuroDILI Network (CA17...
Source: Journal of Hepatology - May 2, 2024 Category: Gastroenterology Authors: Antonio Segovia-Zafra, Marina Villanueva-Paz, Ana Sofia Serras, Gonzalo Matilla-Cabello, Ana Bodoque-Garc ía, Daniel Di Zeo-Sánchez, Hao Niu, Ismael Álvarez-Álvarez, Laura Sanz-Villanueva, Sergej Godec, Irina Milisav, Pierre Bagnaninchi, Raúl J. Andr Source Type: research
Hepatic phenotypes of EFL1-related Shwachman-Diamond syndrome in a biopsy-validated study
Shwachman Diamond Syndrome (SDS), an inherited bone marrow failure syndrome, is characterized by exocrine pancreatic deficiency, predisposition to myeloid malignancies, and skeletal dysplasia. Other symptoms also include hepatic and renal involvement. Hepatomegaly and aminotransaminase elevation can be observed at an early age in SDS patients, typically with an overall good prognosis. A follow-up with mild cholestasis may reflect primary alterations in liver metabolism in SDS. During the long follow-up, no major liver abnormalities appeared [1]. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 2, 2024 Category: Gastroenterology Authors: Bing Zhu, Yibing Guo, Sa Lv, Xiuxin Ling, Shaoli You Source Type: research
Osteoporosis in hepatitis B patients receiving tenofovir disoproxil fumarate: does fibroblast growth factor 23 play a role?
No financial support was received for this study. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 2, 2024 Category: Gastroenterology Authors: Eva van Oorschot, Ozgur M. Koc, Ger H. Koek Source Type: research
Sex and ethnic disparities in hepatitis B evaluation and treatment across the world
We examined rates of evaluation and treatment in patients from the REAL-B consortium. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Sahith Kudaravalli, Daniel Q. Huang, Ming-Lun Yeh, Lindsey Trinh, P.C. Tsai, Yao-Chun Hsu, Leslie Y. Kam, Vy H. Nguyen, Eiichi Ogawa, Dong Hyun Lee, Takanori Ito, Tsunamasa Watanabe, Masaru Enomoto, Carmen Monica Preda, Michael K.L. Ko, Rex Wan-Hin Hui, M Tags: Research Article Source Type: research
ormothermic Perfusion of a Human Tumoral Liver for 17 Days with concomitant extracorporeal blood purification therapy: case description
Normothermic machine perfusion (NMP) is currently under extensive investigation in its ability to reduce graft injury and increase organ utilization . Moreover, NMP has the invaluable potential to be transformative as a platform for prolonged isolated organ studies and manipulation including physiology in deep analyses, therapeutics and gene products delivery [1] . In this view, achieving stable long-term ex vivo homeostasis, particularly in the metabolic complex liver settings, represents a fundamental prerequisite. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Umberto Cillo, Federico Nalesso, Alessandra Bertacco, Stefano Indraccolo, Enrico Gringeri Source Type: research
Individuals with cardiometabolic risk factors are at higher risk for early-onset NAFLD
Study concept and design: Tianshu Zeng, Wenkong, and Linfeng He; Statistical analysis and interpretation: Linfeng He; Data acquisition and validation: Wenbin Zheng and Yunfei Liao; All authors wrote and approved final manuscripts. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Linfeng He, Wenbin Zheng, Liao Yunfei, Wen Kong, Tianshu Zeng Source Type: research
Looking for a deeper characterization of new decompensation patterns
The authors received no financial support for the writing of this letter and have no conflict of interest to report. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Marta Tonon, Anna Barone, Paolo Angeli Source Type: research
A Closer Look at the Innovative PAGED-B Score
I wish to express my thoughts regarding the recent publication titled “PAGE-B incorporating moderate HBV DNA levels predicts risk of HCC among patients entering into HBeAg-positive chronic hepatitis B” 1. Chun et al. developed a new hepatocellular carcinoma (HCC) risk prediction score (PAGED-B score) in non-cirrhotic treatment-naïve adult patients who started ant iviral therapy upon entering into hepatitis B e antigen (HBeAg)-positive chronic hepatitis B from chronic infection which was found to have a high accuracy of predicting the 5-year risk of HCC. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 30, 2024 Category: Gastroenterology Authors: Hanyun Tu Source Type: research
Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
Intrahepatic cholangiocarcinoma (iCCA) is a fatal malignancy of the biliary system. The lack of a detailed understanding of oncogenic signaling or global gene expression alterations has impeded clinical iCCA diagnosis and therapy. The role of protein lactylation, a newly unraveled post-translational modification that orchestrates gene expression, remains largely elusive in the pathogenesis of iCCA. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Long Yang, Kunwei Niu, Jianlin Wang, Weiwei Shen, Rui Jiang, Lu Liu, Wenjie Song, Xudan Wang, Xuan Zhang, Ruohan Zhang, Dan Wei, Ming Fan, Lintao Jia, Kaishan Tao Source Type: research
Trends in Current Use of Machine Perfusion for Donation after Cardiac Death Donors in the United States
The recent meta-analysis of machine-perfusion techniques for liver transplant by Parente et al.1 provides a much-awaited comprehensive assessment of the current literature on machine perfusion compared to static cold storage. With the promise of optimizing marginal and extended criteria grafts, and minimizing their risk of ischemic reperfusion injury, the transplant community has seen a progressive adoption of various perfusion strategies in the last several years. However, the landscape remains in flux regarding its optimal role and indications. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Lauren E. Matevish, Parsia A. Vagefi, Madhukar S. Patel Tags: Letter to the Editor Source Type: research
Exploring Hepatocellular Carcinoma Risks in Sub-Saharan African and Afro-Surinamese Individuals with Chronic Hepatitis B living in Europe
We read with great interest the article by Lesley A. Patmore et al., published in the Journal of Hepatology, titled “Hepatocellular carcinoma risk in sub-Saharan African and Afro-Surinamese individuals with chronic hepatitis B living in Europe [1].” The study highlights that, among chronic hepatitis B (CHB) patients of Sub-Saharan African and Afro-Surinamese descent residing in Europe, the cumulative incidenc e rates of hepatocellular carcinoma (HCC) over 5 and 10 years are 1% and 2.4%, respectively. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Mo-Yao Tan, Jun-Hua Su Tags: Letter to the Editor Source Type: research
Response to: The Synergism of Public Health Policies and Social Work May Reduce Mortality from Cancer, Liver Disease and Cardiovascular Disease
We appreciate the interest that emerged from our recent publication [1], ‘Association between public health policies on alcohol and worldwide cancer, liver disease, and cardiovascular disease outcomes’ [2]. In our research, we evidenced a strong relationship between alcohol-related public health policies (PHP) establishment and the decrease of alcohol-related health consequences over time among 169 countries, including liver disease and other significant causes of burden of disease worldwide. These associations were stronger over time, and consistent with the framework SAFER proposed by the World Health Organization (W...
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Luis Antonio D íaz, Eduardo Fuentes-López, Juan Pablo Arab Tags: Letter to the Editor Source Type: research
Genomic testing for inborn errors of immunity in seronegative autoimmune hepatitis of childhood
Pandurangi et al. describe association of pathogenic variants in tumour necrosis factor alpha-induced protein 3 (TNFAIP3) which encodes the NF-kB regulatory protein A20, with seronegative and type II autoimmune hepatitis (AIH) of childhood.1 We would like to support their experience by reporting our own young paediatric patient harbouring a variant in TNFAIP3 who presented with indetermined acute liver failure (ALF), subsequently leading to progressive liver injury, histologically in keeping with seronegative AIH. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Robert Hegarty, Nedim Hadzic Tags: Letter to the Editor Source Type: research
Recurrent splanchnic and extrasplanchnic thrombotic events in patients with non-cirrhotic portal vein thrombosis associated with local factors
Lay summaryThis retrospective large serie of recent noncirrhotic portal vein thrombosis associated with local factors highlights that prothrombotic factors with high-risk of thrombosis identified in one-third of cases were highly associated with a risk of new thrombotic events. Recanalization and permanent anticoagulation prevented the risk of rethrombosis. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 25, 2024 Category: Gastroenterology Authors: Isabelle Ollivier-Hourmand, Louise Lebedel, Berta Bartroli Alabau, Odile Goria, Christophe Bureau, J érome Dumortier, Alexandra Heurgué, Christine Silvain, Victor De-Ledinghen, Pierre-Emmanuel Rautou, Audrey Payancé, Teresa García Ballester, Edilmar A Tags: Research Article Source Type: research
Every sheriff needs a deputy: targeting non-parenchymal cells to treat hepatic fibrosis
The landscape of anti-fibrotic drug development for liver disease is littered with failed clinical trials. In 2020, the CCR2 and CCR5 receptor antagonist, Cenicriviroc, failed to achieve its primary endpoint of fibrosis improvement of ≥1 stage without worsening of steatohepatitis at 12 months despite promising preclinical and phase 2 data[1]. This failure was particularly disappointing as it was one of the most promising immune-targeted therapeutics to reach phase 3 testing. In 2023, the FXR agonist, obeticholic acid, met the p rimary endpoint that Cenicriviroc could not, but the FDA voted against its approval for treatm...
Source: Journal of Hepatology - April 25, 2024 Category: Gastroenterology Authors: Brett McGettigan, Vijay Shah Tags: Editorial Source Type: research
