Genomic testing for inborn errors of immunity in seronegative autoimmune hepatitis of childhood

Pandurangi et al. describe association of pathogenic variants in tumour necrosis factor alpha-induced protein 3 (TNFAIP3) which encodes the NF-kB regulatory protein A20, with seronegative and type II autoimmune hepatitis (AIH) of childhood.1 We would like to support their experience by reporting our own young paediatric patient harbouring a variant in TNFAIP3 who presented with indetermined acute liver failure (ALF), subsequently leading to progressive liver injury, histologically in keeping with seronegative AIH.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research