Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD

Intrahepatic cholangiocarcinoma (iCCA) is a fatal malignancy of the biliary system. The lack of a detailed understanding of oncogenic signaling or global gene expression alterations has impeded clinical iCCA diagnosis and therapy. The role of protein lactylation, a newly unraveled post-translational modification that orchestrates gene expression, remains largely elusive in the pathogenesis of iCCA.

Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Long Yang, Kunwei Niu, Jianlin Wang, Weiwei Shen, Rui Jiang, Lu Liu, Wenjie Song, Xudan Wang, Xuan Zhang, Ruohan Zhang, Dan Wei, Ming Fan, Lintao Jia, Kaishan Tao Source Type: research