Unearthing naturally-occurring cyclic antibacterial peptides and their structural optimization strategies
We present here a detail review on the novel naturally-occurring CABPs discovered in the past decade and some of them are under clinical trials, exhibiting anticipated application potential. According to their chemical structures, they were broadly classified into five groups, including (i) lactam/lactone-based CABPs, (ii) cyclic lipopeptides, (iii) glycopeptides, (iv) cyclic sulfur-rich peptides and (v) multiple-modified CABPs. Their chemical structures, antibacterial spectrums and proposed mechanisms are discussed. Moreover, engineered analogs of these novel CABPs are also summarized to preliminarily analyze their struct...
Source: Biotechnology Advances - May 4, 2024 Category: Biotechnology Authors: Ping Zeng Honglan Wang Pengfei Zhang Sharon Shui Yee Leung Source Type: research
Surfactant-mediated bio-manufacture: A unique strategy for promoting microbial biochemicals production
Biotechnol Adv. 2024 May 3;73:108373. doi: 10.1016/j.biotechadv.2024.108373. Online ahead of print.ABSTRACTBiochemicals are widely used in the medicine and food industries and are more efficient and safer than synthetic chemicals. The amphipathic surfactants can interact with the microorganisms and embed the extracellular metabolites, which induce microbial metabolites secretion and biosynthesis, performing an attractive prospect of promoting the biochemical production. However, the commonness and differences of surfactant-mediated bio-manufacture in various fields are largely unexplored. Accordingly, this review comprehen...
Source: Biotechnology Advances - May 4, 2024 Category: Biotechnology Authors: Yunxin Yi Xiaofan Jin Moutong Chen Teodora Emilia Coldea Haifeng Zhao Source Type: research
Unearthing naturally-occurring cyclic antibacterial peptides and their structural optimization strategies
We present here a detail review on the novel naturally-occurring CABPs discovered in the past decade and some of them are under clinical trials, exhibiting anticipated application potential. According to their chemical structures, they were broadly classified into five groups, including (i) lactam/lactone-based CABPs, (ii) cyclic lipopeptides, (iii) glycopeptides, (iv) cyclic sulfur-rich peptides and (v) multiple-modified CABPs. Their chemical structures, antibacterial spectrums and proposed mechanisms are discussed. Moreover, engineered analogs of these novel CABPs are also summarized to preliminarily analyze their struct...
Source: Biotechnology Advances - May 4, 2024 Category: Biotechnology Authors: Ping Zeng Honglan Wang Pengfei Zhang Sharon Shui Yee Leung Source Type: research
Surfactant-mediated bio-manufacture: A unique strategy for promoting microbial biochemicals production
Biotechnol Adv. 2024 May 3;73:108373. doi: 10.1016/j.biotechadv.2024.108373. Online ahead of print.ABSTRACTBiochemicals are widely used in the medicine and food industries and are more efficient and safer than synthetic chemicals. The amphipathic surfactants can interact with the microorganisms and embed the extracellular metabolites, which induce microbial metabolites secretion and biosynthesis, performing an attractive prospect of promoting the biochemical production. However, the commonness and differences of surfactant-mediated bio-manufacture in various fields are largely unexplored. Accordingly, this review comprehen...
Source: Biotechnology Advances - May 4, 2024 Category: Biotechnology Authors: Yunxin Yi Xiaofan Jin Moutong Chen Teodora Emilia Coldea Haifeng Zhao Source Type: research
Aptamer-modified paper-based analytical devices for the detection of food hazards: Emerging applications and future perspective
Biotechnol Adv. 2024 Apr 30;73:108368. doi: 10.1016/j.biotechadv.2024.108368. Online ahead of print.ABSTRACTFood analysis plays a critical role in assessing human health risks and monitoring food quality and safety. Currently, there is a pressing need for a reliable, portable, and quick recognition element for point-of-care testing (POCT) to better serve the demands of on-site food analysis. Aptamer-modified paper-based analytical devices (Apt-PADs) have excellent characteristics of high portability, high sensitivity, high specificity, and on-site detection, which have been widely used and concerned in the field of food sa...
Source: Biotechnology Advances - May 1, 2024 Category: Biotechnology Authors: Mingwei Qin Imran Mahmood Khan Ning Ding Shuo Qi Xiaoze Dong Yin Zhang Zhouping Wang Source Type: research
Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms
Biotechnol Adv. 2024 Apr 29;73:108370. doi: 10.1016/j.biotechadv.2024.108370. Online ahead of print.ABSTRACTRecombinant adeno-associated viruses (rAAVs) stand at the forefront of gene therapy applications, holding immense significance for their safe and efficient gene delivery capabilities. The constantly increasing and unmet demand for rAAVs underscores the need for a more comprehensive understanding of AAV biology and its impact on rAAV production. In this literature review, we delved into AAV biology and rAAV manufacturing bioprocesses, unravelling the functions and essentiality of proteins involved in rAAV production. ...
Source: Biotechnology Advances - May 1, 2024 Category: Biotechnology Authors: David Catal án-Tatjer Konstantina Tzimou Lars K Nielsen Jes ús Lavado-García Source Type: research
Aptamer-modified paper-based analytical devices for the detection of food hazards: Emerging applications and future perspective
Biotechnol Adv. 2024 Apr 29:108368. doi: 10.1016/j.biotechadv.2024.108368. Online ahead of print.ABSTRACTFood analysis plays a critical role in assessing human health risks and monitoring food quality and safety. Currently, there is a pressing need for a reliable, portable, and quick recognition element for point-of-care testing (POCT) to better serve the demands of on-site food analysis. Aptamer-modified paper-based analytical devices (Apt-PADs) have excellent characteristics of high portability, high sensitivity, high specificity, and on-site detection, which have been widely used and concerned in the field of food safet...
Source: Biotechnology Advances - May 1, 2024 Category: Biotechnology Authors: Mingwei Qin Imran Mahmood Khan Ning Ding Shuo Qi Xiaoze Dong Yin Zhang Zhouping Wang Source Type: research
Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms
Biotechnol Adv. 2024 Apr 29;73:108370. doi: 10.1016/j.biotechadv.2024.108370. Online ahead of print.ABSTRACTRecombinant adeno-associated viruses (rAAVs) stand at the forefront of gene therapy applications, holding immense significance for their safe and efficient gene delivery capabilities. The constantly increasing and unmet demand for rAAVs underscores the need for a more comprehensive understanding of AAV biology and its impact on rAAV production. In this literature review, we delved into AAV biology and rAAV manufacturing bioprocesses, unravelling the functions and essentiality of proteins involved in rAAV production. ...
Source: Biotechnology Advances - May 1, 2024 Category: Biotechnology Authors: David Catal án-Tatjer Konstantina Tzimou Lars K Nielsen Jes ús Lavado-García Source Type: research
Aptamer-modified paper-based analytical devices for the detection of food hazards: Emerging applications and future perspective
Biotechnol Adv. 2024 Apr 29:108368. doi: 10.1016/j.biotechadv.2024.108368. Online ahead of print.ABSTRACTFood analysis plays a critical role in assessing human health risks and monitoring food quality and safety. Currently, there is a pressing need for a reliable, portable, and quick recognition element for point-of-care testing (POCT) to better serve the demands of on-site food analysis. Aptamer-modified paper-based analytical devices (Apt-PADs) have excellent characteristics of high portability, high sensitivity, high specificity, and on-site detection, which have been widely used and concerned in the field of food safet...
Source: Biotechnology Advances - May 1, 2024 Category: Biotechnology Authors: Mingwei Qin Imran Mahmood Khan Ning Ding Shuo Qi Xiaoze Dong Yin Zhang Zhouping Wang Source Type: research
Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms
Biotechnol Adv. 2024 Apr 29;73:108370. doi: 10.1016/j.biotechadv.2024.108370. Online ahead of print.ABSTRACTRecombinant adeno-associated viruses (rAAVs) stand at the forefront of gene therapy applications, holding immense significance for their safe and efficient gene delivery capabilities. The constantly increasing and unmet demand for rAAVs underscores the need for a more comprehensive understanding of AAV biology and its impact on rAAV production. In this literature review, we delved into AAV biology and rAAV manufacturing bioprocesses, unravelling the functions and essentiality of proteins involved in rAAV production. ...
Source: Biotechnology Advances - May 1, 2024 Category: Biotechnology Authors: David Catal án-Tatjer Konstantina Tzimou Lars K Nielsen Jes ús Lavado-García Source Type: research
Relevance of extracellular electron uptake mechanisms for electromethanogenesis applications
Biotechnol Adv. 2024 Apr 27:108369. doi: 10.1016/j.biotechadv.2024.108369. Online ahead of print.ABSTRACTElectromethanogenesis has emerged as a biological branch of Power-to-X technologies that implements methanogenic microorganisms, as an alternative to chemical Power-to-X, to convert electrical power from renewable sources, and CO2 into methane. Unlike biomethanation processes where CO2 is converted via exogenously added hydrogen, electromethanogenesis occurs in a bioelectrochemical set-up that combines electrodes and microorganisms. Thereby, mixed, or pure methanogenic cultures catalyze the reduction of CO2 to methane v...
Source: Biotechnology Advances - April 30, 2024 Category: Biotechnology Authors: Paola Andrea Palacios Jo Philips Anders Bentien Michael Vedel Wegener Kofoed Source Type: research
Relevance of extracellular electron uptake mechanisms for electromethanogenesis applications
Biotechnol Adv. 2024 Apr 27:108369. doi: 10.1016/j.biotechadv.2024.108369. Online ahead of print.ABSTRACTElectromethanogenesis has emerged as a biological branch of Power-to-X technologies that implements methanogenic microorganisms, as an alternative to chemical Power-to-X, to convert electrical power from renewable sources, and CO2 into methane. Unlike biomethanation processes where CO2 is converted via exogenously added hydrogen, electromethanogenesis occurs in a bioelectrochemical set-up that combines electrodes and microorganisms. Thereby, mixed, or pure methanogenic cultures catalyze the reduction of CO2 to methane v...
Source: Biotechnology Advances - April 30, 2024 Category: Biotechnology Authors: Paola Andrea Palacios Jo Philips Anders Bentien Michael Vedel Wegener Kofoed Source Type: research
Relevance of extracellular electron uptake mechanisms for electromethanogenesis applications
Biotechnol Adv. 2024 Apr 27:108369. doi: 10.1016/j.biotechadv.2024.108369. Online ahead of print.ABSTRACTElectromethanogenesis has emerged as a biological branch of Power-to-X technologies that implements methanogenic microorganisms, as an alternative to chemical Power-to-X, to convert electrical power from renewable sources, and CO2 into methane. Unlike biomethanation processes where CO2 is converted via exogenously added hydrogen, electromethanogenesis occurs in a bioelectrochemical set-up that combines electrodes and microorganisms. Thereby, mixed, or pure methanogenic cultures catalyze the reduction of CO2 to methane v...
Source: Biotechnology Advances - April 30, 2024 Category: Biotechnology Authors: Paola Andrea Palacios Jo Philips Anders Bentien Michael Vedel Wegener Kofoed Source Type: research
Sustainable media feedstocks for cellular agriculture
Biotechnol Adv. 2024 Apr 26:108367. doi: 10.1016/j.biotechadv.2024.108367. Online ahead of print.ABSTRACTThe global food system is shifting towards cellular agriculture, a second domestication marked by cultivating microorganisms and tissues for sustainable food production. This involves tissue engineering, precision fermentation, and microbial biomass fermentation to establish food value chains independent of traditional agriculture. However, these techniques rely on growth media sourced from agricultural, chemical (fossil fuels), and mining supply chains, raising concerns about land use competition, emissions, and resour...
Source: Biotechnology Advances - April 28, 2024 Category: Biotechnology Authors: Lutz Grossmann Source Type: research
Sustainable media feedstocks for cellular agriculture
Biotechnol Adv. 2024 Apr 26:108367. doi: 10.1016/j.biotechadv.2024.108367. Online ahead of print.ABSTRACTThe global food system is shifting towards cellular agriculture, a second domestication marked by cultivating microorganisms and tissues for sustainable food production. This involves tissue engineering, precision fermentation, and microbial biomass fermentation to establish food value chains independent of traditional agriculture. However, these techniques rely on growth media sourced from agricultural, chemical (fossil fuels), and mining supply chains, raising concerns about land use competition, emissions, and resour...
Source: Biotechnology Advances - April 28, 2024 Category: Biotechnology Authors: Lutz Grossmann Source Type: research
