Clinical Profile and Treatment of Multiple Myeloma at a Tertiary Hospital in Kenya: A Five-Year Retrospective Review
CONCLUSIONS: MM in KNH is a disease of the middle aged, affecting men and women almost equally and presenting mainly with bone pain and anaemia. Although there seems to be a general improvement in diagnosis and care, access to novel and less toxic agents for treatment is still wanting.PMID:38375211 | PMC:PMC10876299 | DOI:10.1155/2024/3208717 (Source: Advances in Hematology)
Source: Advances in Hematology - February 20, 2024 Category: Hematology Authors: Wanjiku Gichuru Nicholas A O Abinya Andrew Odhiambo Fredrick C F Otieno Simon Harrison Matilda Ong'ondi Source Type: research
Immune profiles to predict bortezomib-based treatment response for multiple myeloma patients
CONCLUSIONS: Overall, these results suggest that the analysis of lymphocyte subsets along with plasma cell immunophenotyping could be a potential index for determining the prognosis of MM patients.PMID:38377849 | DOI:10.1016/j.intimp.2024.111640 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 20, 2024 Category: Allergy & Immunology Authors: Zhaoyun Liu Hongli Shen Mei Han Xianghong Zhao Hui Liu Kai Ding Jia Song Rong Fu Source Type: research
Light-chain proximal tubulopathy: a retrospective study from a single Chinese nephrology referral center
Conclusions: This is the first case series report of LCPT in four different pathological types in northern China. Clone-targeted chemotherapy may help preserve the kidney function in these patients.PMID:38374684 | PMC:PMC10880565 | DOI:10.1080/0886022X.2023.2283587 (Source: Renal Failure)
Source: Renal Failure - February 20, 2024 Category: Urology & Nephrology Authors: Xin Wang Xiao-Juan Yu Su-Xia Wang Fu-de Zhou Ming-Hui Zhao Source Type: research
Clinical Profile and Treatment of Multiple Myeloma at a Tertiary Hospital in Kenya: A Five-Year Retrospective Review
CONCLUSIONS: MM in KNH is a disease of the middle aged, affecting men and women almost equally and presenting mainly with bone pain and anaemia. Although there seems to be a general improvement in diagnosis and care, access to novel and less toxic agents for treatment is still wanting.PMID:38375211 | PMC:PMC10876299 | DOI:10.1155/2024/3208717 (Source: Advances in Hematology)
Source: Advances in Hematology - February 20, 2024 Category: Hematology Authors: Wanjiku Gichuru Nicholas A O Abinya Andrew Odhiambo Fredrick C F Otieno Simon Harrison Matilda Ong'ondi Source Type: research
Bortezomib modulated the autophagy-lysosomal pathway in a TFEB-dependent manner in multiple myeloma
CONCLUSION: Bortezomib effectively inhibits MM cell proliferation and induces autophagy, partly through TFEB-mediated mechanisms, with potential involvement of the MAPK pathway.PMID:38368721 | DOI:10.1016/j.leukres.2024.107455 (Source: Cell Research)
Source: Cell Research - February 18, 2024 Category: Cytology Authors: Rongjuan Zhang Xinhong Yang Xiaomin Shi Enhong Xing Lihong Wang Changlai Hao Zhihua Zhang Source Type: research
A Novel Necroptosis-Related Signature Can Predict Prognosis and Chemotherapy Sensitivity in Multiple Myeloma
CONCLUSION: A systematic analysis of NRGs can help identify potential necroptosis-related mechanisms and provide novel biomarkers for MM prognosis prediction, tumor microenvironment evaluation, and personalized treatment planning.PMID:38361483 | DOI:10.1177/15330338241232554 (Source: Cell Research)
Source: Cell Research - February 16, 2024 Category: Cytology Authors: Jun-Yao Jiang Fang-Yi Yao Jing Liu Xin-Lu Wang Bo Huang Fang-Min Zhong Xiao-Zhong Wang Source Type: research
A Novel Necroptosis-Related Signature Can Predict Prognosis and Chemotherapy Sensitivity in Multiple Myeloma
CONCLUSION: A systematic analysis of NRGs can help identify potential necroptosis-related mechanisms and provide novel biomarkers for MM prognosis prediction, tumor microenvironment evaluation, and personalized treatment planning.PMID:38361483 | DOI:10.1177/15330338241232554 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - February 16, 2024 Category: Cancer & Oncology Authors: Jun-Yao Jiang Fang-Yi Yao Jing Liu Xin-Lu Wang Bo Huang Fang-Min Zhong Xiao-Zhong Wang Source Type: research
A Novel Necroptosis-Related Signature Can Predict Prognosis and Chemotherapy Sensitivity in Multiple Myeloma
CONCLUSION: A systematic analysis of NRGs can help identify potential necroptosis-related mechanisms and provide novel biomarkers for MM prognosis prediction, tumor microenvironment evaluation, and personalized treatment planning.PMID:38361483 | DOI:10.1177/15330338241232554 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - February 16, 2024 Category: Cancer & Oncology Authors: Jun-Yao Jiang Fang-Yi Yao Jing Liu Xin-Lu Wang Bo Huang Fang-Min Zhong Xiao-Zhong Wang Source Type: research
