Long-term outcomes by bone marrow B-cell depletion from the R2W trial of bortezomib with cyclophosphamide and rituximab in Waldenstrőm macroglobulinaemia
Leukemia, Published online: 26 February 2024; doi:10.1038/s41375-024-02162-5Long-term outcomes by bone marrow B-cell depletion from the R2W trial of bortezomib with cyclophosphamide and rituximab in Waldenstrőm macroglobulinaemia (Source: Leukemia)
Source: Leukemia - February 26, 2024 Category: Hematology Authors: Ruth de Tute Nicholas Counsell Laura Clifton-Hadley Shirley D ’Sa Guy Pratt Gavin Campbell Lauren Campbell Ross Sadler William Townsend Bilyana Popova Paul Smith Oliver Schofield Roger Owen Rebecca Auer Source Type: research
A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
Haematologica. 2024 Feb 22. doi: 10.3324/haematol.2023.284443. Online ahead of print.ABSTRACTMultiple myeloma (MM) remains incurable due to disease relapse and drug resistance. Notch signals from the tumor microenvironment (TME) confer chemoresistance, but the cellular and molecular mechanisms are not entirely understood. Using clinical and transcriptomic datasets, we found that NOTCH3 is upregulated in CD138+ cells from newly diagnosed MM (NDMM) patients compared to healthy individuals and increased in progression/relapsed MM (PRMM) patients. Further, NDMM patients with high NOTCH3 expression exhibited worse responses to ...
Source: Haematologica - February 22, 2024 Category: Hematology Authors: Hayley M Sabol Cody Ashby Manish Adhikari Aric Anloague Japneet Kaur Sharmin Khan Samrat Roy Choudhury Carolina Schinke Michela Palmieri C Lowry Barnes Elena Ambrogini Intawat Nookaew Jesus Delgado-Calle Source Type: research
A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
Haematologica. 2024 Feb 22. doi: 10.3324/haematol.2023.284443. Online ahead of print.ABSTRACTMultiple myeloma (MM) remains incurable due to disease relapse and drug resistance. Notch signals from the tumor microenvironment (TME) confer chemoresistance, but the cellular and molecular mechanisms are not entirely understood. Using clinical and transcriptomic datasets, we found that NOTCH3 is upregulated in CD138+ cells from newly diagnosed MM (NDMM) patients compared to healthy individuals and increased in progression/relapsed MM (PRMM) patients. Further, NDMM patients with high NOTCH3 expression exhibited worse responses to ...
Source: Haematologica - February 22, 2024 Category: Hematology Authors: Hayley M Sabol Cody Ashby Manish Adhikari Aric Anloague Japneet Kaur Sharmin Khan Samrat Roy Choudhury Carolina Schinke Michela Palmieri C Lowry Barnes Elena Ambrogini Intawat Nookaew Jesus Delgado-Calle Source Type: research
Risk Factors and the Effect of Antiviral Prophylaxis for Herpes Zoster in Multiple Myeloma Patients
CONCLUSION: The risk of herpes zoster in multiple myeloma patients was increased. Antiviral prophylaxis can reduce the risk of herpes zoster in patients on bortezomib-based therapy.PMID:38387917 | DOI:10.19746/j.cnki.issn.1009-2137.2024.01.027 (Source: Herpes)
Source: Herpes - February 22, 2024 Category: Infectious Diseases Authors: Li-Xia Wang Yan-Ping Ji Fang Lei Xian-Qiu Yu Xiao-Ming Fei Source Type: research
A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
Haematologica. 2024 Feb 22. doi: 10.3324/haematol.2023.284443. Online ahead of print.ABSTRACTMultiple myeloma (MM) remains incurable due to disease relapse and drug resistance. Notch signals from the tumor microenvironment (TME) confer chemoresistance, but the cellular and molecular mechanisms are not entirely understood. Using clinical and transcriptomic datasets, we found that NOTCH3 is upregulated in CD138+ cells from newly diagnosed MM (NDMM) patients compared to healthy individuals and increased in progression/relapsed MM (PRMM) patients. Further, NDMM patients with high NOTCH3 expression exhibited worse responses to ...
Source: Haematologica - February 22, 2024 Category: Hematology Authors: Hayley M Sabol Cody Ashby Manish Adhikari Aric Anloague Japneet Kaur Sharmin Khan Samrat Roy Choudhury Carolina Schinke Michela Palmieri C Lowry Barnes Elena Ambrogini Intawat Nookaew Jesus Delgado-Calle Source Type: research
A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
Haematologica. 2024 Feb 22. doi: 10.3324/haematol.2023.284443. Online ahead of print.ABSTRACTMultiple myeloma (MM) remains incurable due to disease relapse and drug resistance. Notch signals from the tumor microenvironment (TME) confer chemoresistance, but the cellular and molecular mechanisms are not entirely understood. Using clinical and transcriptomic datasets, we found that NOTCH3 is upregulated in CD138+ cells from newly diagnosed MM (NDMM) patients compared to healthy individuals and increased in progression/relapsed MM (PRMM) patients. Further, NDMM patients with high NOTCH3 expression exhibited worse responses to ...
Source: Haematologica - February 22, 2024 Category: Hematology Authors: Hayley M Sabol Cody Ashby Manish Adhikari Aric Anloague Japneet Kaur Sharmin Khan Samrat Roy Choudhury Carolina Schinke Michela Palmieri C Lowry Barnes Elena Ambrogini Intawat Nookaew Jesus Delgado-Calle Source Type: research
A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
Haematologica. 2024 Feb 22. doi: 10.3324/haematol.2023.284443. Online ahead of print.ABSTRACTMultiple myeloma (MM) remains incurable due to disease relapse and drug resistance. Notch signals from the tumor microenvironment (TME) confer chemoresistance, but the cellular and molecular mechanisms are not entirely understood. Using clinical and transcriptomic datasets, we found that NOTCH3 is upregulated in CD138+ cells from newly diagnosed MM (NDMM) patients compared to healthy individuals and increased in progression/relapsed MM (PRMM) patients. Further, NDMM patients with high NOTCH3 expression exhibited worse responses to ...
Source: Haematologica - February 22, 2024 Category: Hematology Authors: Hayley M Sabol Cody Ashby Manish Adhikari Aric Anloague Japneet Kaur Sharmin Khan Samrat Roy Choudhury Carolina Schinke Michela Palmieri C Lowry Barnes Elena Ambrogini Intawat Nookaew Jesus Delgado-Calle Source Type: research
A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
Haematologica. 2024 Feb 22. doi: 10.3324/haematol.2023.284443. Online ahead of print.ABSTRACTMultiple myeloma (MM) remains incurable due to disease relapse and drug resistance. Notch signals from the tumor microenvironment (TME) confer chemoresistance, but the cellular and molecular mechanisms are not entirely understood. Using clinical and transcriptomic datasets, we found that NOTCH3 is upregulated in CD138+ cells from newly diagnosed MM (NDMM) patients compared to healthy individuals and increased in progression/relapsed MM (PRMM) patients. Further, NDMM patients with high NOTCH3 expression exhibited worse responses to ...
Source: Haematologica - February 22, 2024 Category: Hematology Authors: Hayley M Sabol Cody Ashby Manish Adhikari Aric Anloague Japneet Kaur Sharmin Khan Samrat Roy Choudhury Carolina Schinke Michela Palmieri C Lowry Barnes Elena Ambrogini Intawat Nookaew Jesus Delgado-Calle Source Type: research
A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
Haematologica. 2024 Feb 22. doi: 10.3324/haematol.2023.284443. Online ahead of print.ABSTRACTMultiple myeloma (MM) remains incurable due to disease relapse and drug resistance. Notch signals from the tumor microenvironment (TME) confer chemoresistance, but the cellular and molecular mechanisms are not entirely understood. Using clinical and transcriptomic datasets, we found that NOTCH3 is upregulated in CD138+ cells from newly diagnosed MM (NDMM) patients compared to healthy individuals and increased in progression/relapsed MM (PRMM) patients. Further, NDMM patients with high NOTCH3 expression exhibited worse responses to ...
Source: Haematologica - February 22, 2024 Category: Hematology Authors: Hayley M Sabol Cody Ashby Manish Adhikari Aric Anloague Japneet Kaur Sharmin Khan Samrat Roy Choudhury Carolina Schinke Michela Palmieri C Lowry Barnes Elena Ambrogini Intawat Nookaew Jesus Delgado-Calle Source Type: research
Prognostic factors in 448 newly diagnosed multiple myeloma receiving bortezomib-based induction: impact of ASCT, transplant refusal and high-risk MM
Bone Marrow Transplantation, Published online: 21 February 2024; doi:10.1038/s41409-024-02227-0Prognostic factors in 448 newly diagnosed multiple myeloma receiving bortezomib-based induction: impact of ASCT, transplant refusal and high-risk MM (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - February 21, 2024 Category: Hematology Authors: Hoi Ki Karen Tang Chi Yeung Fung Yu Yan Hwang Harold Lee Grace Lau Sze Fai Yip Bonnie Kho Chi Kuen Lau Kwan Hung Leung Elaine Au Eric Tse Joycelyn Sim Yok Lam Kwong Chor Sang Chim Source Type: research
Clinical Profile and Treatment of Multiple Myeloma at a Tertiary Hospital in Kenya: A Five-Year Retrospective Review
CONCLUSIONS: MM in KNH is a disease of the middle aged, affecting men and women almost equally and presenting mainly with bone pain and anaemia. Although there seems to be a general improvement in diagnosis and care, access to novel and less toxic agents for treatment is still wanting.PMID:38375211 | PMC:PMC10876299 | DOI:10.1155/2024/3208717 (Source: Advances in Hematology)
Source: Advances in Hematology - February 20, 2024 Category: Hematology Authors: Wanjiku Gichuru Nicholas A O Abinya Andrew Odhiambo Fredrick C F Otieno Simon Harrison Matilda Ong'ondi Source Type: research
Light-chain proximal tubulopathy: a retrospective study from a single Chinese nephrology referral center
Conclusions: This is the first case series report of LCPT in four different pathological types in northern China. Clone-targeted chemotherapy may help preserve the kidney function in these patients.PMID:38374684 | DOI:10.1080/0886022X.2023.2283587 (Source: Renal Failure)
Source: Renal Failure - February 20, 2024 Category: Urology & Nephrology Authors: Xin Wang Xiao-Juan Yu Su-Xia Wang Fu-de Zhou Ming-Hui Zhao Source Type: research
Clinical Profile and Treatment of Multiple Myeloma at a Tertiary Hospital in Kenya: A Five-Year Retrospective Review
CONCLUSIONS: MM in KNH is a disease of the middle aged, affecting men and women almost equally and presenting mainly with bone pain and anaemia. Although there seems to be a general improvement in diagnosis and care, access to novel and less toxic agents for treatment is still wanting.PMID:38375211 | PMC:PMC10876299 | DOI:10.1155/2024/3208717 (Source: Adv Data)
Source: Adv Data - February 20, 2024 Category: Epidemiology Authors: Wanjiku Gichuru Nicholas A O Abinya Andrew Odhiambo Fredrick C F Otieno Simon Harrison Matilda Ong'ondi Source Type: research
