Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system
We report a rapid and economical human microphysiological system ("RCC-on-a-chip") to investigate therapies targeting RCC spheroids in a 3D collagen ECM. We first demonstrate that culture of RCC cell lines A498 and RCC4 in a 3D collagen ECM more faithfully reproduces the gene expression program of primary RCC tumors compared to 2D culture. We next used bortezomib as a cytotoxin to develop automated quantification of dose-dependent tumor spheroid killing. We observed that viable RCC spheroids exhibited collective migration within the ECM and demonstrated that our 3D system can be used to identify compounds that inhibit sphe...
Source: Neoplasia - November 9, 2023 Category: Cancer & Oncology Authors: Chris P Miller Megan Fung Carla A Jaeger-Ruckstuhl Yuexin Xu Edus H Warren Shreeram Akilesh Scott S Tykodi Source Type: research
Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system
We report a rapid and economical human microphysiological system ("RCC-on-a-chip") to investigate therapies targeting RCC spheroids in a 3D collagen ECM. We first demonstrate that culture of RCC cell lines A498 and RCC4 in a 3D collagen ECM more faithfully reproduces the gene expression program of primary RCC tumors compared to 2D culture. We next used bortezomib as a cytotoxin to develop automated quantification of dose-dependent tumor spheroid killing. We observed that viable RCC spheroids exhibited collective migration within the ECM and demonstrated that our 3D system can be used to identify compounds that inhibit sphe...
Source: Neoplasia - November 9, 2023 Category: Cancer & Oncology Authors: Chris P Miller Megan Fung Carla A Jaeger-Ruckstuhl Yuexin Xu Edus H Warren Shreeram Akilesh Scott S Tykodi Source Type: research
Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system
We report a rapid and economical human microphysiological system ("RCC-on-a-chip") to investigate therapies targeting RCC spheroids in a 3D collagen ECM. We first demonstrate that culture of RCC cell lines A498 and RCC4 in a 3D collagen ECM more faithfully reproduces the gene expression program of primary RCC tumors compared to 2D culture. We next used bortezomib as a cytotoxin to develop automated quantification of dose-dependent tumor spheroid killing. We observed that viable RCC spheroids exhibited collective migration within the ECM and demonstrated that our 3D system can be used to identify compounds that inhibit sphe...
Source: Neoplasia - November 9, 2023 Category: Cancer & Oncology Authors: Chris P Miller Megan Fung Carla A Jaeger-Ruckstuhl Yuexin Xu Edus H Warren Shreeram Akilesh Scott S Tykodi Source Type: research
Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system
We report a rapid and economical human microphysiological system ("RCC-on-a-chip") to investigate therapies targeting RCC spheroids in a 3D collagen ECM. We first demonstrate that culture of RCC cell lines A498 and RCC4 in a 3D collagen ECM more faithfully reproduces the gene expression program of primary RCC tumors compared to 2D culture. We next used bortezomib as a cytotoxin to develop automated quantification of dose-dependent tumor spheroid killing. We observed that viable RCC spheroids exhibited collective migration within the ECM and demonstrated that our 3D system can be used to identify compounds that inhibit sphe...
Source: Neoplasia - November 9, 2023 Category: Cancer & Oncology Authors: Chris P Miller Megan Fung Carla A Jaeger-Ruckstuhl Yuexin Xu Edus H Warren Shreeram Akilesh Scott S Tykodi Source Type: research
Cancers, Vol. 15, Pages 5338: Evolution of Pharmacological Treatments and Associated Costs for Multiple Myeloma in the Public Healthcare System of Catalonia: A Retrospective Observational Study
Conclusions: The study reveals a progressive increase in the number of MM patients treated and rising pharmaceutical costs. Lenalidomide and daratumumab incurred the highest costs. The findings highlight MM treatment’s economic impact and the need to monitor prescription patterns and expenditures to optimize healthcare resources and decision making. Understanding these trends can guide resource allocation effectively. (Source: Cancers)
Source: Cancers - November 9, 2023 Category: Cancer & Oncology Authors: Gemma Garrido-Alejos Guillem Saborit-Canals Laura Guarga Thais de Pando Miriam Umbria Albert Oriol Anna Feliu Caridad Pontes Antonio Vallano Tags: Article Source Type: research
