Genes, Vol. 15, Pages 387: In Vitro Low-Bortezomib Doses Induce Apoptosis and Independently Decrease the Activities of Glutathione S-Transferase and Glutathione Peroxidase in Multiple Myeloma, Taking into Account the GSTT1 and GSTM1 Gene Variants
Conclusions: Bortezomib affects the activities of GST and GPx. GST activity was associated with GSTT1 and GSTM1 variants but only at some bortezomib doses. (Source: Genes)
Source: Genes - March 21, 2024 Category: Genetics & Stem Cells Authors: Szymon Zmorzynski Sylwia Popek-Marciniec Beata Biernacka Aneta Szudy-Szczyrek Sylwia Chocholska Wojciech Styk Joanna Czerwik-Marcinkowska Grazyna Swiderska-Kolacz Tags: Article Source Type: research
Adjusted Indirect Treatment Comparison of Progression-Free Survival with D-Rd and VRd Based on MAIA and SWOG S0777 Individual Patient-Level Data
CONCLUSION: This anchored ITC demonstrated a greater PFS benefit for D-Rd versus VRd in TIE patients with NDMM. In the absence of head-to-head trials comparing D-Rd and VRd, the present trial may help inform treatment selection in this patient population.PMID:38494542 | DOI:10.1007/s12325-024-02807-y (Source: Adv Data)
Source: Adv Data - March 18, 2024 Category: Epidemiology Authors: Brian G M Durie Shaji K Kumar Eric M Ammann Alex Z Fu Shuchita Kaila Annette Lam Saad Z Usmani Thierry Facon Source Type: research
Adjusted Indirect Treatment Comparison of Progression-Free Survival with D-Rd and VRd Based on MAIA and SWOG S0777 Individual Patient-Level Data
CONCLUSION: This anchored ITC demonstrated a greater PFS benefit for D-Rd versus VRd in TIE patients with NDMM. In the absence of head-to-head trials comparing D-Rd and VRd, the present trial may help inform treatment selection in this patient population.PMID:38494542 | DOI:10.1007/s12325-024-02807-y (Source: Adv Data)
Source: Adv Data - March 18, 2024 Category: Epidemiology Authors: Brian G M Durie Shaji K Kumar Eric M Ammann Alex Z Fu Shuchita Kaila Annette Lam Saad Z Usmani Thierry Facon Source Type: research
Adjusted Indirect Treatment Comparison of Progression-Free Survival with D-Rd and VRd Based on MAIA and SWOG S0777 Individual Patient-Level Data
ConclusionThis anchored ITC demonstrated a greater PFS benefit for D-Rd versus VRd in TIE patients with NDMM. In the absence of head-to-head trials comparing D-Rd and VRd, the present trial may help inform treatment selection in this patient population. (Source: Advances in Therapy)
Source: Advances in Therapy - March 18, 2024 Category: Drugs & Pharmacology Source Type: research
