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Effect of Radiotherapy on Sino-nasal Function in Nasopharynx Cancer Patients
Conclusion: In this study, we concluded that NPC patients who received radiotherapy suffered a worsening of sino-nasal functional changes, including the olfaction threshold, olfaction identification, and nasal symptoms. However, the sino-nasal structural changes on nasal cross-sectional area, nasal flow, and nasal resistance after radiation remain questionable.PMID:37994527 | DOI:10.1177/01455613231204210 (Source: Cancer Control)
Source: Cancer Control - November 23, 2023 Category: Cancer & Oncology Authors: Fergus Kai-Chuen Wong Edwin Chun-Yin Wong Alvin Po-Ngai Chu Peter Ka-Chung Kwan Fu-Man Tong Source Type: research

Effect of Radiotherapy on Sino-nasal Function in Nasopharynx Cancer Patients
Conclusion: In this study, we concluded that NPC patients who received radiotherapy suffered a worsening of sino-nasal functional changes, including the olfaction threshold, olfaction identification, and nasal symptoms. However, the sino-nasal structural changes on nasal cross-sectional area, nasal flow, and nasal resistance after radiation remain questionable.PMID:37994527 | DOI:10.1177/01455613231204210 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - November 23, 2023 Category: ENT & OMF Authors: Fergus Kai-Chuen Wong Edwin Chun-Yin Wong Alvin Po-Ngai Chu Peter Ka-Chung Kwan Fu-Man Tong Source Type: research

Feeling full? Researchers pinpoint neurons that prevent eating too much, too fast
As millions in the United States settle down to Thanksgiving dinner this week, few will be pondering a major question in neuroscience: Why, when so much of life across the animal kingdom revolves around finding and consuming food, do we ever stop eating? Scientists have identified brain regions and even specific cells involved in terminating meals. But exactly how this process is coordinated remains murky. Now, using brain recordings from mice tucking into food, researchers have for the first time identified how specific neurons in a region called the caudal nucleus of the solitary tract (cNTS) switch on du...
Source: Science of Aging Knowledge Environment - November 22, 2023 Category: Geriatrics Source Type: research

Antimicrobial resistance patterns and empiric antibiotic selections for patients admitted from post-acute care facilities
CONCLUSION: Clinically significant differences in antimicrobial susceptibility were found among patients admitted from PACFs compared to our health system's general antibiogram. The increased resistance rates identified in this study support the need for hospitals to evaluate this at-risk patient population, which may drive changes to empiric antibiotic prescribing practices.PMID:37979151 | DOI:10.1093/ajhp/zxad290 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 18, 2023 Category: Drugs & Pharmacology Authors: Sandhya Vijapurapu Christina Maguire Amanda Binkley Shawn Binkley Raymond Lamore Source Type: research

Non-Radiographic Axial Spondyloarthritis
SAN DIEGO—Alexis Ogdie-Beatty, MD, MSCE, associate professor of medicine, associate professor of epidemiology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, gave a presentation on non-radiographic axial spondyloarthritis (nr-axSpA) in the Review Course prior to ACR Convergence 2023. (Source: The Rheumatologist)
Source: The Rheumatologist - November 16, 2023 Category: Rheumatology Authors: Jason Liebowitz, MD Tags: ACR Convergence Axial Spondyloarthritis Conditions Meeting Reports ACR Convergence 2023 AS Resource Center Source Type: research

Proprioceptive and olfactory deficits in individuals with Parkinson disease and mild cognitive impairment
ConclusionsProprioceptive and olfactory sensitivities were reduced in individuals with PD and MCI, and these deficits were related to disease severity. These findings support previous findings indicating that perceptual loss may be a potential biomarker for diagnosing and monitoring disease progression in individuals with neurodegenerative diseases. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - November 14, 2023 Category: Neurology Source Type: research

Heart failure with preserved ejection fraction risk is associated with prevalence and severity of obstructive sleep apnea
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - November 14, 2023 Category: Sleep Medicine Authors: John E. Connolly Michael V. Genuardi Jorge I. Mora Stuart B. Prenner 1Department of Internal Medicine, Johns Hopkins Hospital, Baltimore, MD 2Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 3Division of Sl Source Type: research

Significant Underreporting of Preoperative Hyposmia in Patients Undergoing Endoscopic Skull Base Surgery: Discrepancies Between Subjective and Objective Measurements
Conclusions Our analysis demonstrates higher than anticipated underreporting of preoperative hyposmia in patients undergoing ESBS as well as discrepancies between subjective and objective olfactory functions in the FESS population. The results highlight several gaps in knowledge regarding perioperative olfactory function that would be best examined with more thorough pre- and postoperative objective olfactory testing. This analysis demonstrates significant prognostic uncertainty for patients and providers and creates significant medicolegal uncertainty regarding the appropriate attribution of postoperative olfactory loss...
Source: Journal of Neurological Surgery Part B: Skull Base - November 8, 2023 Category: Neurosurgery Authors: Jackson, Lindsey F. Mulligan, Jennifer K. Justice, Jeb M. Roper, Steven N. Blatt, Jason E. Lobo, Brian C. Tags: Original Article Source Type: research

Why don ’t fish have tonsils? They have a good alternative, study suggests
When microbes try to invade our body through the nose or mouth, they have to get past the tonsils, lumps of tissue garrisoned by immune cells that help fight off the intruders. But many animals don’t have obvious tonsils, an apparent gap in their defenses. In Science Advances today, however, researchers report uncovering a comparable organ in fish that may take on a similar immune role. “It’s a very well-done study that convincingly shows there is a tonsil-like structure” in the fish, says immunologist and cell biologist Anna Huttenlocher of the University of Wisconsin-Madison, who wasn’t connecte...
Source: Science of Aging Knowledge Environment - November 1, 2023 Category: Geriatrics Source Type: research

UPSIT subitems may predict motor progression in Parkinson ’s disease
ConclusionPreserved identification of neutral/pleasant odors may help to predict PD motor progression, and detection of ≥1.5 UPSIT motor progression risk odors could improve the predictive power. In PD patients with a similar level of motor disability during initial screening, preserved pleasant/neutral odor identification may imply relatively better cortical odor discriminative function, which may suggest the body-first (caudo-rostral) subtype with faster disease progression. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - October 23, 2023 Category: Neurology Source Type: research

Increasing antiretroviral therapy adherence and retention in care among adults living with HIV in Philadelphia: a study protocol for a stepped-wedge cluster-randomised type 2 hybrid effectiveness-implementation trial of managed problem-solving plus (MAPS+) delivered by community health workers
Introduction To end the HIV epidemic in Philadelphia, implementation of evidence-based practices (EBP) to increase viral suppression and retention in HIV care is critical. Managed problem solving (MAPS), an EBP for antiretroviral therapy adherence, follows a problem-solving approach to empower people living with HIV (PWH) to manage their health. To overcome barriers to care experienced by PWH in Philadelphia, the EBP was adapted to include a focus on care retention and delivery by community health workers (CHWs). The adapted intervention is MAPS+. To maximise the clinical impact and reach of the intervention, evaluation of...
Source: BMJ Open - October 21, 2023 Category: General Medicine Authors: Van Pelt, A. E., Bilker, W. B., Nkwihorez, H., Ghadimi, F., Brady, K. A., Cidav, Z., Schriger, S. H., Beidas, R. S., Gross, R., Momplaisir, F. Tags: Open access HIV/AIDS Source Type: research

Research trends and hotspots regarding treatment of obstructive sleep apnea
ConclusionOver the past two decades, research in the field of OSA therapeutics has experienced significant growth in depth and breadth. The author cooperation network has already established a solid foundation, while there is potential for further strengthening the cooperation network between countries and institutions. Currently, positive airway pressure and surgery are the primary treatments for OSA in adults and children. Future research will focus on multidisciplinary combination targeted therapy, which presents a key area of interest and challenge. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - October 18, 2023 Category: Neurology Source Type: research