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Two-pronged immunotherapy approach could treat most blood cancers
The genetically modified immune cells known as CAR-T cells have cured thousands of people with blood cancers, but so far the treatments only work against a few types of the disease. Today in Science Translational Medicine ( STM ), a research team describes a provocative CAR-T strategy to tackle most blood cancers. Working in mice, the scientists sicced the immune cells on a protein common to nearly all cancerous blood cells. Because that protein is also found on normal blood-forming stem cells, the team also replaced those vital cells with ones genetically tweaked to be invisible to the cancer...
Source: Science of Aging Knowledge Environment - August 31, 2023 Category: Geriatrics Source Type: research

Racial Differences in Retinopathy of Prematurity –Reply to Letter to the Editor
. (Source: Ophthalmic Epidemiology)
Source: Ophthalmic Epidemiology - August 28, 2023 Category: Opthalmology Authors: Jingyun WangGui-Shuang YingYinxi YuLauren TomlinsonGil Binenbauma State University of New York College of Optometry, New York, NY, USAb Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USAc Divisio Source Type: research

Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in children: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh School of Dental Medicine, and the Center for Integrative Global Oral Health at the University of Pennsylvania
CONCLUSIONS AND PRACTICAL IMPLICATIONS: Nonopioid medications, specifically nonsteroidal anti-inflammatory drugs like ibuprofen and naproxen alone or in combination with acetaminophen, are recommended for managing acute dental pain after 1 or more tooth extractions (that is, simple and surgical) and the temporary management of toothache in children (conditional recommendation, very low certainty). According to the US Food and Drug Administration, the use of codeine and tramadol in children for managing acute pain is contraindicated.PMID:37634915 | DOI:10.1016/j.adaj.2023.06.014 (Source: Journal of the American Dental Association)
Source: Journal of the American Dental Association - August 27, 2023 Category: Dentistry Authors: Alonso Carrasco-Labra Deborah E Polk Olivia Urquhart Tara Aghaloo J William Claytor Vineet Dhar Raymond A Dionne Lorena Espinoza Sharon M Gordon Elliot V Hersh Alan S Law Brian S-K Li Paul J Schwartz Katie J Suda Michael A Turturro Marjorie L Wright Tim D Source Type: research

Non-Isocentric Geometry for Next-Generation Tomosynthesis With Super-Resolution
In conclusion, the non-isocentric geometry improved image quality in several ways. (Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - August 21, 2023 Category: Biomedical Engineering Source Type: research

Associations Between Valenced News and Affect in Daily Life: Experimental and Ecological Momentary Assessment Approaches
. (Source: Media Psychology)
Source: Media Psychology - August 17, 2023 Category: Psychiatry & Psychology Authors: S.J. ShaikhA.L. McGowanD.M. Lydon-Staleya Annenberg School for Communication, University of Pennsylvania, Philadelphia, Pennsylvania, USAb Amsterdam School of Communication Research, University of Amsterdam, Amsterdam, Netherlandsc Department of Psycholog Source Type: research

A Quick Test to Objectify Smell and Taste Dysfunction at Home: a Proof-of-Concept for the Validation of the Chemosensory Perception Test
This study aims at providing proof-of-concept for the validation of the new Chemosensory Perception Test (CPT) developed to remotely assess orthonasal olfactory, retronasal olfactory and gustatory functions in various populations using common North American household items. In the two experiments, a total of 121 participants irrespective of having olfactory and/or gustatory complaints from various causes (COVID-19, sinunasal, post-viral, idiopathic) were tested first, with one/ many of the following tests: 1) a brief chemosensory questionnaire, 2) an olfactory test - Sniffin'Sticks Test (SST) or University of Pennsylvania ...
Source: Chemical Senses - August 16, 2023 Category: Biochemistry Authors: Cindy Levesque-Boissonneault Nicholas Bussi ère Fr édérique Roy-Côté Frank Cloutier Marie- Ève Caty Johannes Frasnelli Source Type: research

Strategies to reduce morbidity following pleurectomy and decortication for malignant pleural mesothelioma
DiscussionPatients undergoing tracheostomy creation, therapeutic AC at the time of diagnosis, and gastrostomy tube placement had a reduced risk of aspiration PNA, DVT, and catheter sepsis. (Source: Thoracic Cancer)
Source: Thoracic Cancer - August 14, 2023 Category: Cancer & Oncology Authors: Patrick Bou ‐Samra, Austin Chang, Kevin Zhang, Feredun Azari, Gregory Kennedy, Emily Guo, Wei‐Ting Hwang, Sunil Singhal Tags: ORIGINAL ARTICLE Source Type: research

Among U.S. postdoc applicants, researchers of color often fare worst
Credit: Abscent84/istockphoto, adapted by N. Jessup/ Science Many researchers of color are at a disadvantage when applying for postdoctoral positions. That’s one of the main findings of a new study of 22,098 applications for 769 scientific postdoc positions at nine U.S. universities. The results could inform long-standing efforts to diversify science faculty, as postdoc appointments are a key stage in the academic career pipeline—but notoriously difficult to track or study because they are generally managed at the level of individual principal investigators (PIs) rather than departments or in...
Source: Science of Aging Knowledge Environment - August 10, 2023 Category: Geriatrics Source Type: research

Training Health Policy Researchers on Policy Engagement and Research Translation for Greater Impact: Evaluation of the Amplify@LDI Program
DiscussionIn our preliminary evaluation of Amplify@LDI, we find strong evidence of positive impact from participant evaluations, and suggestive evidence that participation in the program is associated with significant increases in the reach of their research. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - August 9, 2023 Category: Internal Medicine Source Type: research

Back to the basics: Abstract painting as an index of creativity
Volume 35, Issue 4, October-December 2023 . (Source: Creativity Research Journal)
Source: Creativity Research Journal - August 8, 2023 Category: Psychiatry & Psychology Authors: Lucas BellaicheAnna P. SmithNathaniel BarrAlexander ChristensenChloe WilliamsAnya RagnhildstveitJonathan SchoolerRoger BeatyAnjan ChatterjeePaul Selia Duke Universityb Sheridan Collegec University of Pennsylvania Perelman School of Medicined Vanderbilt Un Source Type: research

Up all night: the effect of the COVID-19 pandemic on insomnia among college students
. (Source: Journal of American College Health)
Source: Journal of American College Health - August 7, 2023 Category: Universities & Medical Training Authors: Rebecca DoyleRebecca HuxtaOmotoyosi Soniyia Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USAb Public Health and Wellbeing, University of Pennsylvania, Philadelphia, Pennsylvania, USA Source Type: research

Outcomes of Endoscopic Sinus Surgery for Chronic Rhinosinusitis in Adults with Primary Ciliary Dyskinesia
Conclusion The endoscopic sinus surgery treatment of chronic rhinosinusitis in adults with PCD was associated with improvement in quality of life and endoscopic findings. However, no improvement in olfaction was demonstrated. Studies with a larger number of patients and control groups should help confirm these findings. [...] Thieme Revinter Publicações Ltda. Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, BrazilArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: International Archives of Otorhinolaryngology)
Source: International Archives of Otorhinolaryngology - August 4, 2023 Category: ENT & OMF Authors: Plantier, Diogo Barreto Pinna, F ábio de Rezende Olm, Mary Anne Kowal Athan ázio, Rodrigo Pilan, Renata Ribeiro de Mendon ça Voegels, Richard Louis Tags: Original Research Source Type: research

Frances hesselbein: a study in courage and grace
AbstractThe author, an executive coach, and Adjunct Full Professor at the University of Pennsylvania knew and collaborated with Frances Hesselbein for many years. She discusses the qualities that made Frances stand out as a person and as a leader: “Frances stood up for honor, for responsibility, and for choosing the right path. More, Frances called on us to see the truth, maybe especially when it hurt, and to optimistically choose that right path even when the forces that be were insidiously pushing us to choose the easier, quieter, and yes , the cowardly path.” Along with courage, “I believe that what enabled France...
Source: Leader to Leader - July 31, 2023 Category: Health Management Authors: Annie McKee Tags: ORIGINAL ARTICLE Source Type: research