[Vestibular paroxysmia and paroxysmal tinnitus].
g R PMID: 28197658 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - February 13, 2017 Category: Neurology Authors: Urban PP, Brüning R Tags: Nervenarzt Source Type: research

Acoustic Coordinated Reset Neuromodulation: A Systematic Review of a Novel Therapy for Tinnitus
Marie Wegger, Therese Ovesen, Dalia Gustaityte Larsen (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 13, 2017 Category: Neurology Source Type: research

Tinnitus – Klinik und Therapie
Laryngo-Rhino-Otol 2017; 96: 47-59 DOI: 10.1055/s-0042-119419Tinnitus ist ein Phantomgeräusch, das ein Symptom verschiedener Störungen sein kann, z. B. durch Hörverlust, kardiovaskuläre oder neurologische Erkrankungen, Diabetes oder Tumoren. Bei dekompensiertem Tinnitus leiden die Patienten aufgrund ihrer Unfähigkeit, die auditive Aufmerksamkeit vom Tinnitus-Ton abzulenken, an Schlaflosigkeit, Konzentrationsproblemen und anderen psychologischen Störungen. In extremen Fällen kann es zu Symptomen einer manifesten Depression kommen. Der auditorische Charakter des Tinnitus veranlasst d...
Source: Laryngo- Rhino- Otologie - February 12, 2017 Category: ENT & OMF Authors: Mazurek, Birgit Szczepek, Agnieszka J. Br üggemann, Petra Tags: CME-Fortbildung Source Type: research

Long-term ototoxicity in women after cisplatin treatment for ovarian germ cell cancer.
CONCLUSION: Long-term MOGCT survivors treated with CBCT have small but significant reductions in age-adjusted hearing thresholds at 4, 6 and 8kHz versus Controls. Approximately one in four women experienced subjective hearing loss. To avoid overestimation of clinically relevant cisplatin-induced ototoxicity, absolute hearing thresholds should be age-adjusted and compared to an age-matched control group. PMID: 28202195 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 11, 2017 Category: Cancer & Oncology Authors: Skalleberg J, Solheim O, Fosså SD, Småstuen MC, Osnes T, Gundersen PO, Bunne M Tags: Gynecol Oncol Source Type: research

Learning from tinnitus patients' narratives-A case study in the psychodynamic approach.
Authors: Dauman N, Erlandsson SI Abstract Tinnitus is assumed to be the perception of sound that results exclusively from activity within the nervous system without any external stimulation. Approximately 1-2% of the population regard their tinnitus as a serious threat towards their quality of life. The way the patients describe their suffering varies, sometimes also depending on the interest and insight of the clinician to whom they turn to for help. The lack of insightful narratives of someone who is severely annoyed by the presence of a constant tinnitus sound may lead to limited and biased models of tinnitus su...
Source: International Journal of Qualitative Studies on Health and Well-being - February 11, 2017 Category: Global & Universal Tags: Int J Qual Stud Health Well-being Source Type: research

Categorization of tinnitus in view of history and medical discourse.
Authors: PMID: 28169727 [PubMed - in process] (Source: International Journal of Qualitative Studies on Health and Well-being)
Source: International Journal of Qualitative Studies on Health and Well-being - February 11, 2017 Category: Global & Universal Tags: Int J Qual Stud Health Well-being Source Type: research

Pre- and post-operative dizziness, tinnitus, and taste disturbances among cochlear implant recipients.
CONCLUSION: The high prevalence of dizziness, tinnitus and taste disturbances reported by cochlear implant recipients necessitates that assessment of symptoms related to inner ear and chorda tympani damage are included when evaluating operative results. PMID: 28173884 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - February 9, 2017 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Transcranial magnetic stimulation for tinnitus: using the Tinnitus Functional Index to predict benefit in a randomized controlled trial
Identifying characteristics associated with transcranial magnetic stimulation (TMS) benefit would offer insight as to why some individuals experience tinnitus relief following TMS treatment, whereas others do ... (Source: Trials)
Source: Trials - February 9, 2017 Category: Journals (General) Authors: Sarah M. Theodoroff, Susan E. Griest and Robert L. Folmer Source Type: research

Analysis of Audiometric Differences of Patients with and without Tinnitus in a Large Clinical Database
Dominik Gollnast, Konstantin Tziridis, Patrick Krauss, Achim Schilling, Ulrich Hoppe, Holger Schulze (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 8, 2017 Category: Neurology Source Type: research

Abnormal regional activity and functional connectivity in resting-state brain networks associated with etiology confirmed unilateral pulsatile tinnitus in the early stage of disease.
This study was designed to demonstrate the functional network alterations in the patients with pulsatile tinnitus (PT). In this study, we recruited 45 patients with unilateral PT in the early stage of disease (less than 48 months of disease duration) and 45 normal controls. We used regional homogeneity (ReHo) and seed-based FC computational methods to reveal resting-state brain activity features associated with pulsatile tinnitus. Compared with healthy controls, PT patients showed regional abnormalities mainly in the left middle occipital gyrus (MOG), posterior cingulate gyrus (PCC), precuneus and right anterior insula (AI...
Source: Hearing Research - February 6, 2017 Category: Audiology Authors: Lv H, Zhao P, Liu Z, Li R, Zhang L, Wang P, Yan F, Liu L, Wang G, Zeng R, Li T, Dong C, Gong S, Wang Z Tags: Hear Res Source Type: research

Antidiabetic effects of Morus alba fruit polysaccharides on high-fat diet- and streptozotocin-induced type 2 diabetes in rats
Conclusions MFP50 and MFP90 have markedly antihyperglycemic and antihyperlipidemic effects and can clearly relieve diabetes symptoms in the T2DM rat model. The M. alba fruit polysaccharides may potentially be utilized as an effective treatment for T2DM. Further research into the structures of active M. alba fruit polysaccharides and their mechanisms in promoting antidiabetic effects are underway. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 5, 2017 Category: Drugs & Pharmacology Source Type: research

High-Resolution fMRI of Auditory Cortical Map Changes in Unilateral Hearing Loss and Tinnitus.
Abstract Animal models of hearing loss and tinnitus observe pathological neural activity in the tonotopic frequency maps of the primary auditory cortex. Here, we applied ultra high-field fMRI at 7 T to test whether human patients with unilateral hearing loss and tinnitus also show altered functional activity in the primary auditory cortex. The high spatial resolution afforded by 7 T imaging allowed tonotopic mapping of primary auditory cortex on an individual subject basis. Eleven patients with unilateral hearing loss and tinnitus were compared to normal-hearing controls. Patients showed an over-represen...
Source: Brain Topography - February 5, 2017 Category: Neuroscience Authors: Ghazaleh N, Zwaag WV, Clarke S, Ville DV, Maire R, Saenz M Tags: Brain Topogr Source Type: research

A 15-Year-Old Girl With Unexplained Intracranial Hypertension
A white, nonobese, 15-year-old girl presented with 1 month of frontal and occipital throbbing headaches, tinnitus, and “whooshing” in the ears. What is your diagnosis? (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - February 2, 2017 Category: Pediatrics Source Type: research

Is CBT for Tinnitus Overemphasized?
No abstract available (Source: The Hearing Journal)
Source: The Hearing Journal - February 1, 2017 Category: Audiology Tags: Journal Club Source Type: research

A comparative study on the effects of systemic manual acupuncture, periauricular electroacupuncture, and digital electroacupuncture to treat tinnitus: A randomized, paralleled, open-labeled exploratory trial
This study evaluated and compared the... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - January 31, 2017 Category: Complementary Medicine Authors: Bong Hyun Kim, Kyuseok Kim and Hae Jeong Nam Source Type: research

Prevalence of hearing loss and tinnitus in Iraq and Afghanistan veterans: A Chronic Effects of Neurotrauma Consortium study.
Abstract The purpose of this study was to describe the prevalence of hearing loss and tinnitus in a cohort of Iraq and Afghanistan veterans (IAV) with common post-deployment conditions, including traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), and other typical post-concussive conditions such as headaches and vertigo/dizziness. This retrospective observational study used data from the national Veterans Health Administration (VA) data repository from fiscal years 2001-2014. Veteran data was included if there were at least three years of VA care, with one or more years of care in 2007 or after. ...
Source: Hearing Research - January 29, 2017 Category: Audiology Authors: Swan AA, Nelson JT, Swiger B, Jaramillo CA, Eapen BC, Packer M, Pugh MJ Tags: Hear Res Source Type: research

Imaging of carotid artery-cochlear dehiscence. A cause of pulsatile tinnitus
This study was conducted on 8 adult patients. The dehiscences ranged between 0.7 and 1.7mm (average 1.04mm). Two male patients showed bilateral dehiscences together with excessive pneumatization of both petrous apices. Six female patients showed only unilateral dehiscences. In the controls, the internal carotid artery to cochlea (ICA/Ch) distance ranged from 0.59mm to 3.1mm and was 1.618mm in average. The dehiscences were more common in female. However when they occur in males, they tend to be bilateral and seems to be predisposed by excessive pneumatization of both petrous apices. (Source: The Egyptian Journal of Radiolog...
Source: The Egyptian Journal of Radiology and Nuclear Medicine - January 28, 2017 Category: Nuclear Medicine Source Type: research

Repetitive Transcranial Magnetic Stimulation for Tinnitus
This Viewpoint discusses evidence of the efficacy of repetitive transcranial magnetic stimulation for treatment of tinnitus and the need for a randomized clinical trial. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - January 26, 2017 Category: ENT & OMF Source Type: research

Simultaneous idiopathic bilateral sudden hearing loss – characteristics and response to treatment
The objective of this study is identify the characteristics and treatment response of simultaneous bilateral sudden hearing loss. Methods This is a case–control study that practised in tertiary care academic centre. 132 patients with sudden hearing loss (SHL) who were treated with systemic steroid and hyperbaric oxygen together were included. 26 patients had bilateral SHL and 106 patients had unilateral SHL. Patients were evaluated with clinical, audiological and radiological examinations and laboratory tests were done. Findings and response to treatment of the patients were compared. Results and conclusion The mean ...
Source: Brazilian Journal of Otorhinolaryngology - January 24, 2017 Category: ENT & OMF Source Type: research

Neurotological findings after electrical injury at the workplace
ConclusionsFrequency and characterization of symptoms following electrical injury are provided. Dizziness is the most common presenting neurotological feature. Loss of consciousness and/or associated head injury do not affect the clinical presentation in this particular population. Level of Evidence2b. Laryngoscope, 2017 (Source: The Laryngoscope)
Source: The Laryngoscope - January 24, 2017 Category: ENT & OMF Authors: Carolina Wuesthoff, Ophir Ilan, John Alexander Rutka Tags: Otology/Neurotology Source Type: research

Resting-State Brain Abnormalities in Chronic Subjective Tinnitus: A Meta-Analysis
Yu-Chen Chen, Fang Wang, Jie Wang, Fan Bo, Wenqing Xia, Jian-Ping Gu, Xindao Yin (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - January 24, 2017 Category: Neuroscience Source Type: research

Pulsatile Tinnitus: Differential Diagnosis and Radiological Work-Up
AbstractPurpose of ReviewIdentification of the underlying cause of pulsatile tinnitus is important for treatment decision making and for prognosis estimation. For this, an adequate diagnostic imaging strategy is crucial.Recent FindingsBoth CT and MRI can be useful, and in general, these modalities provide complementary diagnostic information. The scanning protocol can be optimized based on the estimated a priori chance for finding specific pathology, or the need to rule out more rare but clinical significant disease. In recent years, dynamic CTA, also referred to as 4D-CTA, has become available as a new technique that enab...
Source: Current Radiology Reports - January 23, 2017 Category: Radiology Source Type: research

Tinnitus distress is linked to enhanced resting ‐state functional connectivity from the limbic system to the auditory cortex
Abstract The phantom sound of tinnitus is believed to be triggered by aberrant neural activity in the central auditory pathway, but since this debilitating condition is often associated with emotional distress and anxiety, these comorbidities likely arise from maladaptive functional connections to limbic structures such as the amygdala and hippocampus. To test this hypothesis, resting‐state functional magnetic resonance imaging (fMRI) was used to identify aberrant effective connectivity of the amygdala and hippocampus in tinnitus patients and to determine the relationship with tinnitus characteristics. Chronic tinnitus p...
Source: Human Brain Mapping - January 22, 2017 Category: Neurology Authors: Yu ‐Chen Chen, Wenqing Xia, Huiyou Chen, Yuan Feng, Jin‐Jing Xu, Jian‐Ping Gu, Richard Salvi, Xindao Yin Tags: Research Article Source Type: research

Pulsatile tinnitus and carotid artery dissection
Carotid artery dissection is an uncommon entity associated with head and neck pain, partial Horner ’s syndrome, amaurosis fugax, and brain ischemia, which may all occur in isolation or in combination. Herein, we report a rare case of cervical artery dissection in which pulsatile tinnitus was the only reported symptom. A 38-years-old man attended our hospital with a 4-days history of left side p ulsatile tinnitus which began after stumbling. He had no other symptom. MRA showed luminal stenosis with pseudo lumen of the internal carotid artery. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - January 22, 2017 Category: ENT & OMF Authors: Yuya Shimizu, Masato Yagi Source Type: research

Noise level measurement and its effects on hospital employees based on complaint reports
Conclusion: noise levels are above the recommended levels in different sectors and professionals manifest discomfort and tinnitus before and after their exposure. (Source: Revista CEFAC)
Source: Revista CEFAC - January 19, 2017 Category: Speech Therapy Source Type: research

Influence of factors and personal habits on the tinnitus perception
Conclusion: more than half of the subjects had bilateral tinnitus and that most situations surveyed do not cause change in the tinnitus perception to the studied people. It is noteworthy, however, that the presence of ambient noise helps to reduce the feeling of tinnitus annoyance, as well as the silence, the period of night and the anxiety contribute to accentuate it. (Source: Revista CEFAC)
Source: Revista CEFAC - January 19, 2017 Category: Speech Therapy Source Type: research

Cognitive Training for Adults With Bothersome Tinnitus
This randomized clinical trial evaluates the effect of a cognitive training program on bothersome tinnitus in adults. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - January 19, 2017 Category: ENT & OMF Source Type: research

Cochlear implantation for single-sided deafness and tinnitus suppression
Conclusion The present data is in agreement with previously published studies that have shown an improvement in tinnitus following cochlear implantation for the large majority of patients with single-sided deafness. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - January 18, 2017 Category: Endocrinology Source Type: research

A Systems Science Approach to Understanding Polytrauma and Blast-Related Injury: Bayesian Network Model of Data From a Survey of the Florida National Guard
AbstractWe sought to further define the epidemiology of the complex, multiple injuries collectively known as polytrauma/blast-related injury (PT/BRI). Using a systems science approach, we performed Bayesian network modeling to find the most accurate representation of the complex system of PT/BRI and identify key variables for understanding the subsequent effects of blast exposure in a sample of Florida National Guard members (1,443 deployed to Operation Enduring Freedom/Operation Iraqi Freedom and 1,655 not deployed) who completed an online survey during the period from 2009 to 2010. We found that postdeployment symptoms r...
Source: American Journal of Epidemiology - January 18, 2017 Category: Epidemiology Source Type: research

Somatosensory Tinnitus: Correlation between Cranio-Cervico-Mandibular Disorder History and Somatic Modulation
In this study, we included 310 tinnitus patients with normal hearing, no psychiatric comorbidities, and a positive history of TMJ and/or NECK dysfunction and/or a positive modulation of tinnitus to evaluate the characteristics of somatic modulation, investigate the relationship between positive history and positive modulation, and identify factors most strongly associated with somatic modulation. Tinnitus modulation was present in 79.67% of the patients. We found a significant association within the same subjects between a positive history and a positive tinnitus modulation for the same region, mainly for TMJ in unilateral...
Source: Audiology and Neurotology - January 18, 2017 Category: Audiology Source Type: research

The hearing benefit of cochlear implantation for individuals with unilateral hearing loss, but no tinnitus.
CONCLUSION: Cochlear implants improve the hearing abilities of individuals with unilateral hearing loss and no tinnitus. The benefit is no different from that seen in patients with unilateral hearing loss and incapacitating tinnitus. OBJECTIVE: To evaluate hearing outcomes after cochlear implantation in individuals with unilateral hearing loss and no tinnitus and compare them to those obtained in a similar group who had incapacitating tinnitus. METHODS: Six cases who did not experience tinnitus before operation and 15 subjects with pre-operative tinnitus were evaluated with a structured interview, a monosyllabic ...
Source: Acta Oto-Laryngologica - January 17, 2017 Category: ENT & OMF Authors: Skarzynski H, Lorens A, Kruszynska M, Obrycka A, Pastuszak D, Skarzynski PH Tags: Acta Otolaryngol Source Type: research

Selective attentional impairment in chronic tinnitus: Evidence from an event-related potentials study.
CONCLUSION: These results point to a general slowing in early stimulus perception in tinnitus subjects. Moreover, a specific difficulty emerged in attentional switching to unexpected events during an orienting response, probably owing to a dysfunction in the ventral attention network. SIGNIFICANCE: Psychophysiological approach reveals selective attentional impairment and could provide useful data for rehabilitative strategies in chronic tinnitus. PMID: 28160746 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - January 15, 2017 Category: Neurology Authors: Mannarelli D, Pauletti C, Mancini P, Fioretti A, Greco A, De Vincentiis M, Fattapposta F Tags: Clin Neurophysiol Source Type: research

Selective attentional impairment in chronic tinnitus: evidence from an event-related potentials study
Tinnitus is an auditory phantom sensation experienced in the absence of a sound source (Eggermont and Roberts, 2004; Eggermont and Roberts, 2012). Tinnitus is a common symptom that is perceived as chronic by 10-15% of adults (Heller, 2003; Henry et al., 2005), 10-20% of whom report that it interferes with their everyday life (Leske, 1981; Quaranta et al., 1996). It is usually described as a ringing noise, though some patients experience a high-pitched whining, hissing or steady tone. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - January 13, 2017 Category: Neuroscience Authors: Daniela Mannarelli, Caterina Pauletti, Patrizia Mancini, Alessandra Fioretti, Antonio Greco, Marco De Vincentiis, Francesco Fattapposta Source Type: research

Venous sinus compromise after pre-sigmoid, transpetrosal approach for skull base tumors: A study on the asymptomatic incidence and report of a rare dural arteriovenous fistula as symptomatic manifestation
Publication date: Available online 12 January 2017 Source:Journal of Clinical Neuroscience Author(s): Walter C. Jean, Daniel R. Felbaum, Andrew B. Stemer, Michael Hoa, H. Jeffrey Kim The sigmoid sinus is routinely exposed and manipulated during pre-sigmoid, transpetrosal approaches to the skull base, but there is scant data available on the incidence of venous sinus compromise after surgery. We encountered a dural arteriovenous fistula as a result of sigmoid sinus occlusion and examined the incidence of venous sinus thrombosis or narrowing after transpetrosal surgeries. We performed a retrospective analysis of a series of...
Source: Journal of Clinical Neuroscience - January 12, 2017 Category: Neuroscience Source Type: research

Non-invasive vagus nerve stimulation reduces sympathetic preponderance in patients with tinnitus.
CONCLUSION: Transcutaneous vagal nerve stimulation (tVNS) might offer a targeted, patient-friendly, and low-cost therapeutic tool for tinnitus patients with sympathovagal imbalance. OBJECTIVES: Conventionally, VNS has been performed to treat severe epilepsy and depression with an electrode implanted to the cervical trunk of vagus nerve. This study investigated the acute effects of tVNS on autonomic nervous system (ANS) imbalance, which often occurs in patients with tinnitus-triggered stress. METHODS: This study retrospectively analysed records of 97 patients who had undergone ANS function testing by heart rate va...
Source: Acta Oto-Laryngologica - January 12, 2017 Category: ENT & OMF Authors: Ylikoski J, Lehtimäki J, Pirvola U, Mäkitie A, Aarnisalo A, Hyvärinen P, Ylikoski M Tags: Acta Otolaryngol Source Type: research

Ruxolitinib for symptom control in patients with chronic lymphocytic leukaemia: a single-group, phase 2 trial
Publication date: Available online 12 January 2017 Source:The Lancet Haematology Author(s): Preetesh Jain, Michael Keating, Sarah Renner, Charles Cleeland, Huang Xuelin, Graciela Nogueras Gonzalez, David Harris, Ping Li, Zhiming Liu, Ivo Veletic, Uri Rozovski, Nitin Jain, Phillip Thompson, Prithviraj Bose, Courtney DiNardo, Alessandra Ferrajoli, Susan O'Brien, Jan Burger, William Wierda, Srdan Verstovsek, Hagop Kantarjian, Zeev Estrov Background Disease-related symptoms impair the quality of life of patients with chronic lymphocytic leukaemia (CLL) who do not require systemic therapy. Available therapies are not specifica...
Source: The Lancet Haematology - January 11, 2017 Category: Hematology Source Type: research

[Idiopathic intracranial hypertension].
f A Abstract This review describes the clinical findings as well as thes diagnostic and therapeutic options for idiopathic intracranial hypertension (pseudotumor cerebri). Furthermore, the pathophysiological concepts are discussed. Idiopathic intracranial hypertension is characterized by signs and symptoms of raised intracranial pressure with no established pathogenesis. Common symptoms include headaches, visual loss and pulsatile tinnitus. Treatment has two major goals: the alleviation of headaches and the preservation of vision. Weight loss and acetazolamide are the cornerstones in the treatment of the disorder....
Source: Der Nervenarzt - January 11, 2017 Category: Neurology Authors: Bäuerle J, Egger K, Harloff A Tags: Nervenarzt Source Type: research

Comparison of Treatment Outcomes Following Either Prefrontal Cortical-only or Dual-site Repetitive Transcranial Magnetic Stimulation in Chronic Tinnitus Patients: A Double-blind Randomized Study
Conclusions: The rTMS protocol effectively suppressed tinnitus in the dual-site rTMS (AC+FC) group but not in the single-site rTMS (DLPFC) group. Although recent evidence has shown that non-auditory cortices in the tinnitus network play an important role in the generation of tinnitus, our findings indicate that rTMS on non-auditory cortical sites alone may not be sufficient for treatment. Thus, dual-site rTMS in the AC and DLPFC may be preferable for controlling this condition. (Source: Otology and Neurotology)
Source: Otology and Neurotology - January 11, 2017 Category: ENT & OMF Tags: Medical Neurotology Source Type: research

A Novel Mutation in SLC26A4 Causes Nonsyndromic Autosomal Recessive Hearing Impairment
Conclusions: Screening for SLC26A4 mutations may identify the genetic causes of hearing loss in patients bearing heterozygous mutations in GJB2. Hypothesis: SLC26A4 coding mutations are genetic causes for nonsyndromic HI in patients bearing heterozygous GJB2 35delG mutations. (Source: Otology and Neurotology)
Source: Otology and Neurotology - January 11, 2017 Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research

Effects of Intratympanic Dexamethasone on High-Dose Radiation Ototoxicity In Vivo
Background: Stereotactic radiosurgery for lateral skull base tumors can cause hearing loss when the cochleae are exposed to high doses of single-fraction radiation. Currently, there are no known nondosimetric preventative treatments for radiation-induced ototoxicity. Hypothesis: Intratympanic (IT) dexamethasone (DXM), a synthetic steroid, protects against radiation-induced auditory hair cell (HC) and hearing losses in rats in vivo. Methods: Seven rats received radiation (12 Gy) to both cochleae. In irradiated rats and six nonirradiated rats, IT DXM was randomized to one ear, while tympanic puncture without DXM was perfor...
Source: Otology and Neurotology - January 11, 2017 Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research

The Weather and Ménière's Disease: A Longitudinal Analysis in the UK
Conclusion: This study provides the strongest evidence to date that changes in atmospheric pressure and humidity are associated with symptom exacerbation in MD. Improving our understanding of the role of weather and other environmental triggers in Ménière's may reduce the uncertainty associated with living with this condition, significantly contributing to improved quality of life. (Source: Otology and Neurotology)
Source: Otology and Neurotology - January 11, 2017 Category: ENT & OMF Tags: Vestibular Disorders Source Type: research

Long-term Symptom-specific Outcomes for Patients With Petrous Apex Cholesterol Granulomas: Surgery Versus Observation
Conclusion: Symptom-specific outcomes were better in patients managed surgically for PACG. Individual symptom resolution rates were highly variable. Some symptoms were refractory regardless of management strategy. Surgical approach and stent usage did not significantly influence symptom outcomes. (Source: Otology and Neurotology)
Source: Otology and Neurotology - January 11, 2017 Category: ENT & OMF Tags: Tumors of the Ear and Cranial Base Source Type: research

Neuropsychiatric Outcomes After Mefloquine Exposure Among U.S. Military Service Members.
Abstract Mefloquine was widely prescribed to U.S. military service members until 2009 when use was limited to personnel with contraindications to doxycycline and no contraindications to mefloquine. The need to estimate the occurrence of neuropsychiatric outcomes (NPOs) in service members prescribed mefloquine warranted a comprehensive evaluation of this issue. Active component service members filling a prescription for mefloquine, doxycycline, or atovaquone/proguanil (A/P) between January 1, 2008 and June 30, 2013, were included in the analysis. The risk of developing incident NPOs and the risk of subsequent NPOs ...
Source: The American Journal of Tropical Medicine and Hygiene - January 10, 2017 Category: Tropical Medicine Authors: Eick-Cost AA, Hu Z, Rohrbeck P, Clark LL Tags: Am J Trop Med Hyg Source Type: research

Clinical Guidelines for Management of Acne Vulgaris
To the Editor Dr Roman and colleagues summarized the guideline from the American Academy of Dermatology on the management of acne vulgaris. I would like to discuss the possibility of using minocycline as a first-line oral antibiotic for moderate and severe acne. The authors recommended doxycycline and minocycline equally. However, they stated that “minocycline may cause tinnitus, dizziness, and pigment deposit in the skin, mucous membranes, and teeth.” Minocycline may also induce a severe adverse reaction, drug reaction with eosinophilia and systemic symptoms (DRESS). In a review, minocycline-induced DRESS repr...
Source: JAMA - January 10, 2017 Category: Journals (General) Source Type: research

Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms.
Abstract Common causes of hearing loss in humans - exposure to loud noise or ototoxic drugs and aging - often damage sensory hair cells, reflected as elevated thresholds on the clinical audiogram. Recent studies in animal models suggest, however, that well before this overt hearing loss can be seen, a more insidious, but likely more common, process is taking place that permanently interrupts synaptic communication between sensory inner hair cells and subsets of cochlear nerve fibers. The silencing of affected neurons alters auditory information processing, whether accompanied by threshold elevations or not, and is...
Source: Hearing Research - January 9, 2017 Category: Audiology Authors: Liberman MC, Kujawa SG Tags: Hear Res Source Type: research

Temperament and character traits in patients with tinnitus: a prospective case series with comparisons
ConclusionsThere may be a connection between tinnitus and personality traits, especially in the case of ‘novelty seeking’, which is relatively constant over a lifetime. The TCI questionnaire may be useful in facilitating the application of personality traits to tailored counselling for tinnitus. (Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - January 8, 2017 Category: ENT & OMF Authors: J.H. Chung, H. Byun, S.H. Lee, C.W. Park, E.Y. Jang Tags: Original Article Source Type: research

Relationship between increased carotid artery stiffness and idiopathic subjective tinnitus
AbstractTinnitus is defined as perception of sound with no external stimulus, and can separate into pulsatile and non-pulsatile types. Arterial stiffness is a parameter that can predict the cardiovascular event and associated with incidence of stroke. It has been shown that increased arterial stiffness may lead to microvascular damage in brain. Our aim was to assess the arterial stiffness of the carotid system in the development and severity of idiopathic subjective tinnitus. Forty subjective tinnitus patients and 40 age- and sex-matched controls were enrolled in the study. The parameters obtained from the participants inc...
Source: European Archives of Oto-Rhino-Laryngology - January 5, 2017 Category: ENT & OMF Source Type: research

Continuous vs. intermittent neurofeedback to regulate auditory cortex activity of tinnitus patients using real-time fMRI - A pilot study
Publication date: Available online 6 January 2017 Source:NeuroImage: Clinical Author(s): Kirsten Emmert, Rotem Kopel, Yury Koush, Raphael Maire, Pascal Senn, Dimitri Van De Ville, Sven Haller The emerging technique of real-time fMRI neurofeedback trains individuals to regulate their own brain activity via feedback from an fMRI measure of neural activity. Optimum feedback presentation has yet to be determined, particularly when working with clinical populations. To this end, we compared continuous against intermittent feedback in subjects with tinnitus. Fourteen participants with tinnitus completed the whole experiment con...
Source: NeuroImage: Clinical - January 5, 2017 Category: Radiology Source Type: research

Tinnitus in Normal-Hearing Participants after Exposure to Intense Low-Frequency Sound and in M énière’s Disease Patients
Margarete Anna Ueberfuhr, Lutz Wiegrebe, Eike Krause, Robert G ürkov, Markus Drexl (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 4, 2017 Category: Neurology Source Type: research

Head-to-head comparison between 18 F-FDOPA PET/CT and MR/CT angiography in clinically recurrent head and neck paragangliomas
Conclusion18F-FDOPA PET/CT is highly sensitive in posttreatment evaluation of patients with HNPGLs, and also offers better interobserver reproducibility than MRA/CTA and whole-body examination. We therefore suggest that18F-FDOPA PET/CT is performed as the first diagnostic imaging modality in symptomatic patients with suspicion of HNPGL relapse after primary treatment when68Ga-labeled somatostatin analogues are not available. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 2, 2017 Category: Nuclear Medicine Source Type: research