Tinnitus: Clinical Insights in Its Pathophysiology-A Perspective
AbstractTinnitus, the perception of sound without a corresponding external sound source, and tinnitus disorder, which is tinnitus with associated suffering, present a multifaceted clinical challenge due to its heterogeneity and its incompletely understood pathophysiology and especially due to the limited therapeutic options. In this narrative review, we give an overview on various clinical aspects of tinnitus including its heterogeneity, contributing factors, comorbidities and therapeutic pathways with a specific emphasis on the implications for its pathophysiology and future research directions. Tinnitus exhibits high per...
Source: JARO - Journal of the Association for Research in Otolaryngology - March 26, 2024 Category: ENT & OMF Source Type: research
Endovascular vs surgical treatment of sigmoid sinus diverticulum causing pulsatile tinnitus: A systematic review
CONCLUSION: EVT in patients with PT and venous diverticulum appears more effective and safer than surgical treatment, but large studies are lacking. Studies directly comparing endovascular and surgical treatment are needed.PMID:38515373 | DOI:10.1177/15910199241231325 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - March 22, 2024 Category: Radiology Authors: Anvitha Sathya Thanh N Nguyen Piers Klein Stephanos Finitsis Bindu N Setty Adam A Dmytriw Kyle M Fargen Ferdinand K Hui Peter Weber Matthew R Amans Mohamad Abdalkader Source Type: research
Refined Sound Therapy in Combination with Cognitive Behavioural Therapy to Treat Tinnitus: A Randomized Controlled Trial
CONCLUSIONS: (1) This new combination is more effective than post-auricular injection of lidocaine and methylprednisolone sodium succinate in treating tinnitus and improving psychological symptoms. The latter had no effect on improving psychological indicators. (2) With this combination, patients with different tinnitus frequencies experienced different improvements in anxiety. (3) Low-frequency tinnitus seems have been more likely to cause sound adaptation. (4) The improvement in tinnitus and anxiety was the same regardless of whether or not there was hearing loss.PMID:38518137 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Di Ji Xueqin Zhou Yao Fan Junjie Yang Baiyang Ren Shuanghong Chen Anchun Deng Source Type: research
Endovascular vs surgical treatment of sigmoid sinus diverticulum causing pulsatile tinnitus: A systematic review
CONCLUSION: EVT in patients with PT and venous diverticulum appears more effective and safer than surgical treatment, but large studies are lacking. Studies directly comparing endovascular and surgical treatment are needed.PMID:38515373 | DOI:10.1177/15910199241231325 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - March 22, 2024 Category: Radiology Authors: Anvitha Sathya Thanh N Nguyen Piers Klein Stephanos Finitsis Bindu N Setty Adam A Dmytriw Kyle M Fargen Ferdinand K Hui Peter Weber Matthew R Amans Mohamad Abdalkader Source Type: research
Tinnitus-related increases in single-unit activity in awake rat auditory cortex correlate with tinnitus behavior
Hear Res. 2024 Mar 16;445:108993. doi: 10.1016/j.heares.2024.108993. Online ahead of print.ABSTRACTTinnitus is known to affect 10-15 % of the population, severely impacting 1-2 % of those afflicted. Canonically, tinnitus is generally a consequence of peripheral auditory damage resulting in maladaptive plastic changes in excitatory/inhibitory homeostasis at multiple levels of the central auditory pathway as well as changes in diverse nonauditory structures. Animal studies of primary auditory cortex (A1) generally find tinnitus-related changes in excitability across A1 layers and differences between inhibitory neuronal subty...
Source: Hearing Research - March 22, 2024 Category: Audiology Authors: Rui Cai Lynne Ling Madan Ghimire Kevin A Brownell Donald M Caspary Source Type: research
Endovascular vs surgical treatment of sigmoid sinus diverticulum causing pulsatile tinnitus: A systematic review
CONCLUSION: EVT in patients with PT and venous diverticulum appears more effective and safer than surgical treatment, but large studies are lacking. Studies directly comparing endovascular and surgical treatment are needed.PMID:38515373 | DOI:10.1177/15910199241231325 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - March 22, 2024 Category: Radiology Authors: Anvitha Sathya Thanh N Nguyen Piers Klein Stephanos Finitsis Bindu N Setty Adam A Dmytriw Kyle M Fargen Ferdinand K Hui Peter Weber Matthew R Amans Mohamad Abdalkader Source Type: research
Refined Sound Therapy in Combination with Cognitive Behavioural Therapy to Treat Tinnitus: A Randomized Controlled Trial
CONCLUSIONS: (1) This new combination is more effective than post-auricular injection of lidocaine and methylprednisolone sodium succinate in treating tinnitus and improving psychological symptoms. The latter had no effect on improving psychological indicators. (2) With this combination, patients with different tinnitus frequencies experienced different improvements in anxiety. (3) Low-frequency tinnitus seems have been more likely to cause sound adaptation. (4) The improvement in tinnitus and anxiety was the same regardless of whether or not there was hearing loss.PMID:38518137 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Di Ji Xueqin Zhou Yao Fan Junjie Yang Baiyang Ren Shuanghong Chen Anchun Deng Source Type: research
Endovascular vs surgical treatment of sigmoid sinus diverticulum causing pulsatile tinnitus: A systematic review
CONCLUSION: EVT in patients with PT and venous diverticulum appears more effective and safer than surgical treatment, but large studies are lacking. Studies directly comparing endovascular and surgical treatment are needed.PMID:38515373 | DOI:10.1177/15910199241231325 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - March 22, 2024 Category: Radiology Authors: Anvitha Sathya Thanh N Nguyen Piers Klein Stephanos Finitsis Bindu N Setty Adam A Dmytriw Kyle M Fargen Ferdinand K Hui Peter Weber Matthew R Amans Mohamad Abdalkader Source Type: research
Refined Sound Therapy in Combination with Cognitive Behavioural Therapy to Treat Tinnitus: A Randomized Controlled Trial
CONCLUSIONS: (1) This new combination is more effective than post-auricular injection of lidocaine and methylprednisolone sodium succinate in treating tinnitus and improving psychological symptoms. The latter had no effect on improving psychological indicators. (2) With this combination, patients with different tinnitus frequencies experienced different improvements in anxiety. (3) Low-frequency tinnitus seems have been more likely to cause sound adaptation. (4) The improvement in tinnitus and anxiety was the same regardless of whether or not there was hearing loss.PMID:38518137 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Di Ji Xueqin Zhou Yao Fan Junjie Yang Baiyang Ren Shuanghong Chen Anchun Deng Source Type: research
Refined Sound Therapy in Combination with Cognitive Behavioural Therapy to Treat Tinnitus: A Randomized Controlled Trial
CONCLUSIONS: (1) This new combination is more effective than post-auricular injection of lidocaine and methylprednisolone sodium succinate in treating tinnitus and improving psychological symptoms. The latter had no effect on improving psychological indicators. (2) With this combination, patients with different tinnitus frequencies experienced different improvements in anxiety. (3) Low-frequency tinnitus seems have been more likely to cause sound adaptation. (4) The improvement in tinnitus and anxiety was the same regardless of whether or not there was hearing loss.PMID:38518137 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Di Ji Xueqin Zhou Yao Fan Junjie Yang Baiyang Ren Shuanghong Chen Anchun Deng Source Type: research
Modulations of resting-static functional connectivity on insular by electroacupuncture in subjective tinnitus
DiscussionElectroacupuncture treatment can effectively reduce or eliminate tinnitus symptoms in ST patients and improve the hearing by decreasing FC between the INS and the frontal and temporal brain regions. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 22, 2024 Category: Neurology Source Type: research
Effects of transcranial direct current stimulation combined with tinnitus retraining therapy on sleep disorders in patients with chronic tinnitus
CONCLUSIONS: TDCS combined with TRT had obvious effects in treating chronic tinnitus, which largely reduced the severity of tinnitus, improved patients' sleep quality and psychological status, and improved the quality of life, indicating a certain worthy of clinical application and promotion.PMID:38497859 | DOI:10.26355/eurrev_202403_35590 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: X-D Jia Y-K Li C-C Xie X-L Ding S-G Ding H-J Liu Source Type: research
Tocilizumab Successfully Treating Refractory Hearing Impairment in a Patient With Cogan Syndrome: A Case Report and Review of the Literature
Ear Nose Throat J. 2024 Mar 17:1455613241237079. doi: 10.1177/01455613241237079. Online ahead of print.ABSTRACTCogan syndrome (CS) is a rare systemic vasculitis characterized primarily by nonsyphilitic interstitial keratitis and vestibular and auditory dysfunction. In this article, we report the case of a 31-year-old male diagnosed with CS for 1 year. He was admitted to the hospital with fever, dizziness, headache, tinnitus, and hearing loss. After being treated with glucocorticoids, cellular immunosuppressants, and infliximab therapy, his symptoms were greatly relieved except for hearing loss. Then, he attempted to use to...
Source: Ear, Nose and Throat Journal - March 18, 2024 Category: ENT & OMF Authors: Yan Chen Jiarui Hu Dongze Wu Tong Wu Jing Zhu Source Type: research
Therapist-guided remote versus in-person cognitive behavioural therapy: a systematic review and meta-analysis of randomized controlled trials
CMAJ. 2024 Mar 17;196(10):E327-E340. doi: 10.1503/cmaj.230274.ABSTRACTBACKGROUND: Cognitive behavioural therapy (CBT) has been shown to be effective for several psychiatric and somatic conditions; however, most randomized controlled trials (RCTs) have administered treatment in person and whether remote delivery is similarly effective remains uncertain. We sought to compare the effectiveness of therapist-guided remote CBT and in-person CBT.METHODS: We systematically searched MEDLINE, Embase, PsycINFO, CINAHL, and the Cochrane Central Register of Controlled Trials from inception to July 4, 2023, for RCTs that enrolled adults...
Source: cmaj - March 18, 2024 Category: General Medicine Authors: Sara Zandieh Seyedeh Maryam Abdollahzadeh Behnam Sadeghirad Li Wang Randi E McCabe Liam Yao Briar E Inness Ananya Pathak Rachel J Couban Holly Crandon Kian Torabiardakani Peter Bieling Jason W Busse Source Type: research
Effects of transcranial direct current stimulation combined with tinnitus retraining therapy on sleep disorders in patients with chronic tinnitus
CONCLUSIONS: TDCS combined with TRT had obvious effects in treating chronic tinnitus, which largely reduced the severity of tinnitus, improved patients' sleep quality and psychological status, and improved the quality of life, indicating a certain worthy of clinical application and promotion.PMID:38497859 | DOI:10.26355/eurrev_202403_35590 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: X-D Jia Y-K Li C-C Xie X-L Ding S-G Ding H-J Liu Source Type: research
