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Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhinolaryngology
Conclusion Scientific proof of the benefit of phytotherapy in otorhinolaryngology remains to be established but, given its widespread use and the reported data, knowledge of this form of treatment needs to be developed. (Source: European Annals of Otorhinolaryngology, Head and Neck Diseases)
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - November 30, 2016 Category: ENT & OMF Source Type: research

Does Tinnitus Lead to Depression?
CONCLUSION: No correlation was seen between THI and tinnitus frequency, but a moderate correlation was seem between BDS score and tinnitus frequency. There were also weak correlations between tinnitus intensity and THI and BDS scores. PMID: 27917796 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - November 30, 2016 Category: Biomedical Science Authors: Temugan E, Yildirım RB, Onat H, Susuz M, Elden C, Unsal S, Gumus NM, Kaya M Tags: Clin Invest Med Source Type: research

Temperament and character traits in patients with tinnitus; a prospective case series with comparisons
ConclusionsThere may be a connection between tinnitus and personality traits, especially in the case of “Novelty Seeking”, which is relatively constant over a lifetime. The TCI questionnaire may be useful in facilitating the application of personality traits to tailored counselling for tinnitus.This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - November 30, 2016 Category: ENT & OMF Authors: Jae Ho Chung, Hayoung Byun, Seung Hwan Lee, Chul Won Park, Eun Young Jang Tags: Original Article Source Type: research

Primary solitary intralabyrinthine schwannoma: A report of 7 cases and a review of the literature.
We describe a series of 7 cases of primary ILS that were managed at two of our institutions. We also discuss the need for a comprehensive otoneurologic evaluation that encompasses the functional derangement and the tumor location as delineated by MRI, and we describe the treatment options. PMID: 27929596 [PubMed - in process] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - November 30, 2016 Category: ENT & OMF Authors: Shupak A, Holdstein Y, Kaminer M, Braverman I Tags: Ear Nose Throat J Source Type: research

[Idiopathic intracranial hypertension as a cause of headache].
Abstract Idiopathic intracranial hypertension (IIH) is characterised by increased intracranial pressure with normal cerebrospinal fluid, and no evidence of space occupying process, meningeal pathology or venous thrombosis. The condition is associated with obesity, especially in women of childbearing age. IIH is a rare but serious cause of headache, and constitutes a differential diagnosis for sudden-onset headache, particularly if the patient has visual disturbances not related to migraine and reports pulsatile tinnitus, cranial nerve palsy or radiculopathy. PMID: 27929555 [PubMed - in process] (Source: Tidss...
Source: Tidsskrift for den Norske Laegeforening - November 30, 2016 Category: Journals (General) Authors: Farmen AH, Ringstad G, Kerty E Tags: Tidsskr Nor Laegeforen Source Type: research

Robustness and dynamicity of functional networks in phantom sound
Publication date: 1 February 2017 Source:NeuroImage, Volume 146 Author(s): Anusha Mohan, Dirk De Ridder, Sven Vanneste Phantom sound perception is the perception of a sound in the absence of a corresponding external sound source. It is a common symptom for which no treatment exists. Gaining a better understanding of its pathophysiology by applying network science might help in identifying targets in the brain for neuromodulatory approaches to treat this elusive symptom. Brain networks are commonly organized as functional modules which have a densely connected core network coupled to a communally-organized peripheral netwo...
Source: NeuroImage - November 29, 2016 Category: Neuroscience Source Type: research

Blast-induced tinnitus and hyperactivity in the auditory cortex of rats
In this study, we induced tinnitus in rats using blast exposure and investigated changes in spontaneous firing and bursting activity in the auditory cortex (AC) at one day, one month, and three months after blast exposure. Our results showed that spontaneous activity in the tinnitus-positive group began changing at one month after blast exposure, and manifested as robust hyperactivity at all frequency regions at three months after exposure. We also observed an increased bursting rate in the low-frequency region at one month after blast exposure and in all frequency regions at three months after exposure. Taken together, sp...
Source: Neuroscience - November 28, 2016 Category: Neuroscience Source Type: research

Audiologic characteristics in a sample of recently-separated military Veterans: The Noise Outcomes in Servicemembers Epidemiology Study (NOISE Study).
Abstract Military Service Members are often exposed to high levels of occupational noise, solvents, and other exposures that can be damaging to the auditory system. Little is known about hearing loss and how it progresses in Veterans following military service. This epidemiology study is designed to evaluate and monitor a cohort of Veterans for 20 years or more to determine how hearing loss changes over time and how those changes are related to noise exposure and other ototoxic exposures encountered during military service. Data reported here are from baseline assessments of the first 100 study participants (84 ma...
Source: Hearing Research - November 28, 2016 Category: Audiology Authors: Gordon JS, Griest SE, Thielman EJ, Carlson KC, Helt WJ, Lewis MS, Blankenship C, Austin D, Theodoroff SM, Henry JA Tags: Hear Res Source Type: research

Pre-market version of a commercially available hearing instrument with a tinnitus sound generator: feasibility of evaluation in a clinical trial
. (Source: International Journal of Audiology)
Source: International Journal of Audiology - November 25, 2016 Category: Audiology Authors: Magdalena Sereda Jeff Davies Deborah A. Hall Source Type: research

Surgical outcomes of middle fossa approach in intracanalicular vestibular schwannoma.
CONCLUSION: Middle fossa approach (MFA) shows a hearing preservation rate of 86% and facial nerve function was preserved with HB grade I or II in 93%. MFA is a good treatment option for intra-canalicular vestibular schwannomas when surgical excision is needed. BACKGROUND: Surgical outcomes of vestibular schwannoma have progressively improved with the advancement of microsurgical instruments. MFA is known to have better chances to preserve hearing, while it has limited access to the posterior fossa, limitation of tumor size, and higher risk of post-operative facial nerve weakness. OBJECTIVES: To investigate surgic...
Source: Acta Oto-Laryngologica - November 24, 2016 Category: ENT & OMF Authors: Kang WS, Kim SA, Yang CJ, Nam SH, Chung JW Tags: Acta Otolaryngol Source Type: research

Tinnitus, Depression, Anxiety, and Suicide: A Retrospective Analysis
The purpose of this project is to investigate whether there is an association between a tinnitus diagnosis and suicide and whether depression and anxiety mediate the association. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - November 23, 2016 Category: Rehabilitation Authors: Erin Martz, Chennettee Jelleberg, Deborah D. Dougherty, Charles Wolters, Aaron Schneiderman Tags: Research poster Source Type: research

Update on Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension (IIH) is a disorder of elevated intracranial pressure of unknown cause occurring predominantly in young women of childbearing age. The typical patient symptom profile is the presence of daily headache, pulse synchronous tinnitus, transient visual obscurations, and papilledema with its associated visual loss. Although surgical procedures are performed for those who fail medical therapy, their relative efficacy remains unclear. The main morbidity of IIH is from visual loss. This visual loss is present in most patients and can usually be reversed if recognized early in the patients ’...
Source: Neurologic Clinics - November 23, 2016 Category: Neurology Authors: Michael Wall Source Type: research

Occult infratemporal fossa neurofibroma presenting with persistent unilateral tinnitus and middle ear effusion: More than meets the eye
Publication date: Available online 23 November 2016 Source:American Journal of Otolaryngology Author(s): Lucas P. Carlstrom, Kathryn M. Van Abel, Matthew L Carlson, Eric J. Moore, Janalee K. Stokken Herein, we present the case of a previously healthy 54year-old female who developed several weeks of unilateral tinnitus and aural fullness. She subsequently underwent unilateral pressure equalization tube placement at an outside institution after exam demonstrated a middle ear effusion, conductive hearing loss and normal nasopharyngoscopy. Ultimately, an MRI revealed an occult mass in the infratemporal fossa (ITF), which was ...
Source: American Journal of Otolaryngology - November 22, 2016 Category: Endocrinology Source Type: research

Cochlear implantation in Meniere ’s disease
Publication date: Available online 13 October 2016 Source:Operative Techniques in Otolaryngology-Head and Neck Surgery Author(s): Jacob B. Hunter, Brendan P. O׳Connell, David S. Haynes Meniere’s disease (MD) is characterized by fluctuating hearing loss, episodic vertigo, tinnitus, and aural fullness. Whether secondary to intervention or to natural disease progression, a considerable subset of patients with MD has nonserviceable hearing in at least one ear. As such, cochlear implantation counseling and decision-making in the setting of MD must take into account the patient׳s surgical history. In patients who have u...
Source: Operative Techniques in Otolaryngology Head and Neck Surgery - November 22, 2016 Category: ENT & OMF Source Type: research

Bedaquiline in the multidrug-resistant tuberculosis treatment: Belarus experience
Conclusion Our interim results on safety and effectiveness of bedaquiline-containing regimens in multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) patients are encouraging. They will add value to understanding role and place of this new anti-TB drug in M/XDR-TB treatment. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 22, 2016 Category: Infectious Diseases Source Type: research

Zinc supplementation for tinnitus.
CONCLUSIONS: We found no evidence that the use of oral zinc supplementation improves symptoms in adults with tinnitus. PMID: 27879981 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 22, 2016 Category: Journals (General) Authors: Person OC, Puga ME, da Silva EM, Torloni MR Tags: Cochrane Database Syst Rev Source Type: research

Botulinum toxin treatment for essential palatal tremors presenting with nasal clicks instead of pulsatile tinnitus: a case report
In this study, we report a rare case of an adult patient with essential palatal tremors (EPT) presenting as nasal clicks, instead of otic clicks or objective pulsatile tinnitus in common EPT. (Source: Head and Face Medicine)
Source: Head and Face Medicine - November 22, 2016 Category: ENT & OMF Authors: Yufeng Ye, Shiyu Liao, Baozhen Luo and Liyan Ni Source Type: research

Evidence that hidden hearing loss underlies amplitude modulation encoding deficits in individuals with and without tinnitus.
Abstract Damage to auditory nerve fibers that expresses with suprathreshold sounds but is hidden from the audiogram has been proposed to underlie deficits in temporal coding ability observed among individuals with otherwise normal hearing, and to be present in individuals experiencing chronic tinnitus with clinically normal audiograms. We tested whether these individuals may have hidden synaptic losses on auditory nerve fibers with low spontaneous rates of firing (low-SR fibers) that are important for coding suprathreshold sounds in noise while high-SR fibers determining threshold responses in quiet remain relativ...
Source: Hearing Research - November 21, 2016 Category: Audiology Authors: Paul BT, Bruce IC, Roberts LE Tags: Hear Res Source Type: research

Electroacoustic evaluation of the olivocochlear efferent pathway in subjects with tinnitus complaint
Conclusion: suppression values of otoacoustic emissions were similar in subjects with and without tinnitus, although the results of the tinnitus group were lower, suggesting worse performance of the Superior Olivary Complex. (Source: Revista CEFAC)
Source: Revista CEFAC - November 21, 2016 Category: Speech Therapy Source Type: research

Differences in VigiBase ® reporting of aminoglycoside and capreomycin‐suspected ototoxicity during tuberculosis treatment
ConclusionSpontaneous reporting of deafness cases within VigiBase® was most disproportionately associated with amikacin use, followed by kanamycin. There were regional variations in the global reporting of ototoxicity. These findings should be verified through a follow up study. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - November 19, 2016 Category: Drugs & Pharmacology Authors: Evans L. Sagwa, Patrick C. Souverein, In ês Ribeiro, Hubert G. M. Leufkens, Aukje K. Mantel‐Teeuwisse Tags: Original Report Source Type: research

Noise-Induced Hearing Loss among Professional Musicians.
CONCLUSIONS: Long-term exposure to loud sounds puts musicians at risk of hearing loss. However, due to their inadequate knowledge, most musicians never use protective devices to prevent damage to their auditory system. PMID: 27853057 [PubMed - as supplied by publisher] (Source: Journal of Occupational Health)
Source: Journal of Occupational Health - November 19, 2016 Category: Occupational Health Tags: J Occup Health Source Type: research

Factor Analysis of Low-Frequency Repetitive Transcranial Magnetic Stimulation to the Temporoparietal Junction for Tinnitus.
Conclusion. Active low-frequency rTMS results in a significant reduction in the loudness of tinnitus. Significant tinnitus suppression was shown in subjects with shorter tinnitus duration, with normal hearing, and without sleep disturbance. PMID: 27847647 [PubMed - in process] (Source: Neural Plasticity)
Source: Neural Plasticity - November 18, 2016 Category: Neurology Authors: Wang H, Li B, Wang M, Li M, Yu D, Shi H, Yin S Tags: Neural Plast Source Type: research

A comprehensive database of published tDCS clinical trials (2005 –2016)
This article does not include any meta-analysis and aims simply at providing a comprehensive overview of the raw data reported in this field to date, as an aid to researchers. (Source: Neurophysiologie Clinique)
Source: Neurophysiologie Clinique - November 17, 2016 Category: Neuroscience Source Type: research

An Integrative Tinnitus Model Based on Sensory Precision.
Abstract Tinnitus is a common disorder that often complicates hearing loss. Its mechanisms are incompletely understood. Current theories proposing pathophysiology from the ear to the cortex cannot individually - or collectively - explain the range of experimental evidence available. We propose a new framework, based on predictive coding, in which spontaneous activity in the subcortical auditory pathway constitutes a 'tinnitus precursor' which is normally ignored as imprecise evidence against the prevailing percept of 'silence'. Extant models feature as contributory mechanisms acting to increase either the intensit...
Source: Trends in Neurosciences - November 17, 2016 Category: Neuroscience Authors: Sedley W, Friston KJ, Gander PE, Kumar S, Griffiths TD Tags: Trends Neurosci Source Type: research

Use of an Intrathecal Catheter for Analgesia, Anesthesia, and Therapy in an Obstetric Patient With Pseudotumor Cerebri Syndrome
(A A Case Rep. 2016;6:160–162) In this case report, a 32-year-old primigravida woman with a history of idiopathic intracranial hypertension (IIH) presented to the labor and delivery suite at 40 weeks gestation in active labor and with pseudotumor cerebri syndrome (PTCS). PTCS, which includes IIH, is a rare disorder mainly of obese women of childbearing age, characterized by increased intracranial pressure in the absence of a space-occupying lesion, ventriculomegaly, or abnormal cerebrospinal fluid (CSF) composition. Symptoms include headache, pulsatile tinnitus, back pain, dizziness, photophobia, neck pain, cognitiv...
Source: Obstetric Anesthesia Digest - November 17, 2016 Category: Anesthesiology Tags: Case Reports Source Type: research

Effect of direct stimulation of the cochleovestibular nerve on tinnitus: a long-term follow-up study
Tinnitus is a common entity that may lead to severe impairment in quality of life. An adequate treatment modality for severe tinnitus is currently lacking. Neurostimulation of the auditory tract may serve as a promising adjunct in tinnitus treatment. The aim is to investigate the effect of direct stimulation on the cochleovestibular nerve for intractable tinnitus. (Source: World Neurosurgery)
Source: World Neurosurgery - November 16, 2016 Category: Neurosurgery Authors: Minke J.C. van den Berge, J. Marc C. van Dijk, Rolien H. Free, Janke Stienstra, Pim van Dijk, Bernard F.A.M. van der Laan Tags: Original article Source Type: research

Tinnitus and leisure noise
. (Source: International Journal of Audiology)
Source: International Journal of Audiology - November 16, 2016 Category: Audiology Authors: Warwick Williams Lyndal Carter Source Type: research

Tibialis anterior muscle biopsy - a patient reported outcome study
Conclusions This small patient reported outcome study suggests that percutaneous tibialis anterior muscle biopsy is safe and well tolerated. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Lilleker, J., Woodall, A., Roberts, M., Chinoy, H. Tags: Drugs: CNS (not psychiatric), Neuromuscular disease, Pain (neurology), Radiology, Surgical diagnostic tests, Ear, nose and throat/otolaryngology, Trauma, Injury ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

The Manifestation of Vortical and Secondary Flow in the Cerebral Venous Outflow Tract: An In Vivo MR Velocimetry Study
Aberrations in flow in the cerebral venous outflow tract (CVOT) have been implicated as the cause of several pathologic conditions including idiopathic intracranial hypertension (IIH), multiple sclerosis (MS), and pulsatile tinnitus (PT). The advent of 4D Flow magnetic resonance imaging (4D-Flow MRI) has recently allowed researchers to evaluate blood flow patterns in the arterial structures with great success. We utilized similar imaging techniques and found several distinct flow characteristics in the CVOT of subjects with and without lumenal irregularities. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - November 14, 2016 Category: Biomedical Science Authors: Sarah Kefayati, Matthew Amans, Farshid Faraji, Megan Ballweber, Evan Kao, Sinyeob Ahn, Karl Meisel, Van Halbach, David Saloner Tags: SI: Biofluid Mechanics Source Type: research

Sound generator associated with the counseling in the treatment of tinnitus: evaluation of the effectiveness
Conclusion The use of the SG was similarly effective in the treatment of the tinnitus in individuals with and without hearing loss, causing an improvement of the nuisance and handicap. (Source: Brazilian Journal of Otorhinolaryngology)
Source: Brazilian Journal of Otorhinolaryngology - November 11, 2016 Category: ENT & OMF Source Type: research

Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs
This article is protected by copyright. All rights reserved. (Source: European Journal of Neuroscience)
Source: European Journal of Neuroscience - November 11, 2016 Category: Neuroscience Authors: Joel I. Berger, Ben Coomber, Mark N. Wallace, Alan R. Palmer Tags: Research Report Source Type: research

Histopathology of Meniere ’s Disease
This study aims to perform an up-to-date review on Meniere’s Disease, focusing on histopathology, pathophysiology, genetics, and causative mechanisms. (Source: Operative Techniques in Otolaryngology Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology Head and Neck Surgery - November 11, 2016 Category: ENT & OMF Source Type: research

Investigating the Effects of a Personalized, Spectrally Altered Music-Based Sound Therapy on Treating Tinnitus: A Blinded, Randomized Controlled Trial
Conclusion: The personalized music therapy was effective in reducing subjective tinnitus and represents a meaningful advancement in tinnitus intervention.Audiol Neurotol 2016;21:296-304 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - November 11, 2016 Category: Audiology Source Type: research

Morphine-induced hearing loss.
CONCLUSION: A 52-year-old man developed tinnitus and hearing loss after receiving high doses of oral morphine sulfate. His hearing loss did not fully resolve after the discontinuation of morphine, and he required the use of hearing aids. PMID: 27821396 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 11, 2016 Category: Drugs & Pharmacology Authors: Leache L, Aquerreta I, Moraza L, Ortega A Tags: Am J Health Syst Pharm Source Type: research

Vascular loops in the anterior inferior cerebellar artery, as identified by magnetic resonance imaging, and their relationship with otologic symptoms
Abstract Objective: To use magnetic resonance imaging to identify vascular loops in the anterior inferior cerebellar artery and to evaluate their relationship with otologic symptoms. Materials and Methods: We selected 33 adults with otologic complaints who underwent magnetic resonance imaging at our institution between June and November 2013. Three experienced independent observers evaluated the trajectory of the anterior inferior cerebellar artery in relation to the internal auditory meatus and graded the anterior inferior cerebellar artery vascular loops according to the Chavda classification. Kappa and chi-square tests ...
Source: Radiologia Brasileira - November 11, 2016 Category: Radiology Source Type: research

Reply to: Psychometric properties of the Tinnitus Functional Index (TFI): Assessment in a UK research volunteer population.
PMID: 27842215 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - November 10, 2016 Category: Audiology Authors: Henry JA, Thielman E, Zaugg T Tags: Hear Res Source Type: research

Clinical Implication of the Threshold Equalizing Noise Test in Patients With Sudden Sensorineural Hearing Loss
Conclusion: DRs are associated with worse hearing thresholds at follow-up audiogram and might be associated with unfavorable hearing outcome in patients with SSNHL. (Source: Otology and Neurotology)
Source: Otology and Neurotology - November 10, 2016 Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research

Diagnostic Criteria for Detection of Vestibular Schwannomas in the VA Population
Objective: To investigate the prevalence of vestibular schwannoma (VS) and asymmetric sensorineural hearing loss in the Veterans Administration hospital population and analyze a more efficient method of diagnosing VS in a population with significant noise exposure. Study Design: Retrospective review of South Central (VISN 16) Veterans Administration hospitals. Methods: Record query for ICD-9 codes for asymmetric sensorineural hearing loss or VS between 1999 and 2012. Patient demographics, signs and symptoms at presentation, audiogram and imaging data, and management data were collected and analyzed. Audiograms from tumor...
Source: Otology and Neurotology - November 10, 2016 Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research

Single Institutional Experience With Observing 564 Vestibular Schwannomas: Factors Associated With Tumor Growth
Conclusion: To date, this is the largest series of observed VS reported in the literature. Risk of VS growth is significantly increased among patients who present with larger tumors and who have concomitant disequilibrium. IRB: 151481. Define Professional Practice Gap and Educational Need: No cohort with this sample size has assessed vestibular schwannoma growth rates in conjunction with this number of variables. Learning Objective: To characterize vestibular schwannoma growth rates and predictors of growth. (Source: Otology and Neurotology)
Source: Otology and Neurotology - November 10, 2016 Category: ENT & OMF Tags: Tumors of the Ear and Cranial Base Source Type: research

Intratympanic Sustained-Exposure Dexamethasone Thermosensitive Gel for Symptoms of Ménière's Disease: Randomized Phase 2b Safety and Efficacy Trial
Conclusion: OTO-104 was well-tolerated, did not significantly affect change from baseline in vertigo rate, but did reduce number definitive vertigo days, vertigo severity, and average daily vertigo count compared with placebo during Month 3. Results provide insight into analyzing for a vertigo treatment effect and support advancing OTO-104 into Phase 3 clinical trials for the treatment of Ménière's disease symptoms. (Source: Otology and Neurotology)
Source: Otology and Neurotology - November 10, 2016 Category: ENT & OMF Tags: Medical Neurotology Source Type: research

Radiological and audiometric evaluation of high jugular bulb and dehiscent high jugular bulb.
Authors: Sayit AT, Gunbey HP, Fethallah B, Gunbey E, Karabulut E Abstract OBJECTIVE: To inform on the incidence of high jugular bulb and dehiscent high jugular bulb, and the symptoms related to these vascular anomalies. METHODS: A retrospective analysis was performed of temporal bone computed tomography scans of 3285 patients who attended our clinic with various symptoms. The medical records of patients with high jugular bulb and dehiscent high jugular bulb were analysed, and the clinical findings reviewed. Patients with dehiscent high jugular bulb were evaluated for hearing loss with pure tone audiometry. ...
Source: Journal of Laryngology and Otology - November 10, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Effects of two different local anaesthetic methods vs no anaesthesia on pain scores for intratympanic injections.
This study compared the pain associated with the intratympanic injection combined with various local anaesthetics vs without anaesthesia. METHODS: The study included 40 patients (aged 18-78 years) who received intratympanic steroid injections for sudden idiopathic hearing loss or tinnitus. Each patient underwent all three injection methods at one-week intervals. Patients received one of two local anaesthetics (lidocaine injection or lidocaine spray) or no anaesthesia before intratympanic injection, and used a visual analogue scale to indicate the pain level after 5 and 45 minutes. RESULTS: Five minutes after inject...
Source: Journal of Laryngology and Otology - November 10, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Long-Lasting forward Suppression of Spontaneous Firing in Auditory Neurons: Implication to the Residual Inhibition of Tinnitus
AbstractTinnitus is the perception of a sound that has no external source. Sound stimuli can suppress spontaneous firing in auditory neurons long after stimulus offset. It is unknown how changes in sound stimulus parameters affect this forward suppression. Using in vivo extracellular recording in awake mice, we found that about 40  % of spontaneously active inferior colliculus (IC) neurons exhibited forward suppression of spontaneous activity after sound offset. The duration of this suppression increased with sound duration and lasted about 40 s following a 30-s stimulus offset. Pure tones presented at the neuron...
Source: JARO - Journal of the Association for Research in Otolaryngology - November 9, 2016 Category: ENT & OMF Source Type: research

Cervical spine disorders and its association with tinnitus: The “TRIPLE” hypothesis
Subjective Tinnitus and cervical spine disorders (CSD) are among the most common complaints encountered by physicians. Although the relationship between tinnitus and CSD has attracted great interest during the past several years, the pathogenesis of tinnitus induced by CSD remains unclear. Conceivably, CSD could trigger a somatosensory pathway-induced disinhibition of dorsal cochlear nucleus (DCN) activity in the auditory pathway; furthermore, CSD can cause inner ear blood impairment induced by vertebral arteries hemodynamic alterations and trigeminal irritation. (Source: Medical Hypotheses)
Source: Medical Hypotheses - November 7, 2016 Category: Biomedical Science Authors: Bressi Federica, Manuele Casale, Papalia Rocco, Moffa Antonio, Di Martino Alberto, Miccinilli Sandra, Salvinelli Fabrizio, Denaro Vincenzo, Sterzi Silvia Source Type: research

Translabyrinthine vestibular neurectomy and simultaneous cochlear implant for M énière’s disease
ConclusionsIn our preliminary report, translabyrinthine vestibular nerve section and simultaneous cochlear implant showed encouraging results in order to definitively control both vestibular and cochlear symptoms during the same therapeutic procedure. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - November 3, 2016 Category: Neurosurgery Source Type: research

Lifetime leisure music exposure associated with increased frequency of tinnitus.
The objective measure of speech reception threshold had only a minimal relationship with tinnitus. Self-reported hearing difficulty was more strongly associated with tinnitus, but 76% of people reporting usual or constant tinnitus also reported little or no hearing difficulty. Overall, around 40% of participants of all ages reported never experiencing tinnitus, while 29% reported sometimes, usually or constantly experiencing tinnitus that lasted more than 5 minutes. Together, the results suggest that tinnitus is much more common than hearing loss, but that there is little association between the two, especially among the y...
Source: Hearing Research - November 3, 2016 Category: Audiology Authors: Moore DR, Zobay O, Mackinnon RC, Whitmer WM, Akeroyd MA Tags: Hear Res Source Type: research

Occult Pulsatile Tinnitus in Association with a Prominent Vein of Hypoglossal Canal: Two Case Reports.
We described 2 rare cases of troublesome pulsatile tinnitus associated with prominent vein of hypoglossal canal, which communicates with the jugular bulb and the marginal sinus. Both cases were successfully treated by positioning a stent across the vein of hypoglossal canal and jugular bulb. The 2 present clinical cases represent the first report of such a condition. The therapeutic decision-making is discussed in relation to the persistent pulsatile tinnitus and the etiopathologic hypothesis put forward. PMID: 27349391 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - November 3, 2016 Category: Neurosurgery Authors: Li B, Lv X, Wu Z, Cao X, Wang J, Ge A, Liu X, Li S Tags: Turk Neurosurg Source Type: research

First hearing-disorder drugs stumble
Nature Reviews Drug Discovery 15, 733 (2016). doi:10.1038/nrd.2016.222 Author: Katie Kingwell Clinical trial failures of two drugs for hearing loss and tinnitus underscore pitfalls for a nascent area of drug development, but lessons learned may help in navigating the uncharted path to approval. (Source: Nature Reviews Drug Discovery)
Source: Nature Reviews Drug Discovery - November 2, 2016 Category: Drugs & Pharmacology Authors: Katie Kingwell Tags: News and Analysis Source Type: research