A large hiatal hernia with cameron ulcer presenting as refractory sever iron deficiency anemia: A case report
ConclusionCameron ulcer is a rare cause of iron deficiency anemia from chronic blood loss. It is fatal but easily treatable ulcer at hiatal hernia. It very rare in pediatrics age particularly under five children and high index of suspicion is lifesaving. (Source: Journal of Pediatric Surgery Case Reports)
Source: Journal of Pediatric Surgery Case Reports - July 13, 2018 Category: Surgery Source Type: research

Effective deep brain stimulation of intractable tinnitus: A case study
Publication date: Available online 11 July 2018Source: Brain StimulationAuthor(s): Eva Dijkstra, Martijn Figee, Damiaan Denys, P. Richard Schuurman (Source: Brain Stimulation)
Source: Brain Stimulation - July 12, 2018 Category: Neurology Source Type: research

Tinnitus perception in patients after vagal nerve stimulator implantation for epilepsy
Publication date: Available online 11 July 2018Source: American Journal of OtolaryngologyAuthor(s): Helena Wichova, Sameer A. Alvi, James Lin, Keith Sale, Christopher Larsen, Hinrich StaeckerAbstractPurposeVagal nerve stimulation in conjunction with sound therapy has been proposed as a treatment for subjective tinnitus. The purpose of this study is to retrospectively review the effect of VNS on perception of tinnitus in epilepsy patients. We explore the incidence of tinnitus and its perceived reduction in patients requiring implantation of VNS for medically refractory seizures.Materials and methodsA phone survey was conduc...
Source: American Journal of Otolaryngology - July 12, 2018 Category: Endocrinology Source Type: research

Effective deep brain stimulation of intractable tinnitus: A case study
Tinnitus, the hearing of sound when no external sound is present, may cause severe distress and impair quality of life in 0.5-3% of the adult population [1]. Chronic severe tinnitus is often accompanied by severe insomnia, anxiety and depression, eventually resulting in suicide and requests for euthanasia [2]. For these patients, few treatment options are currently available and 20% remains affected despite treatment [1]. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 12, 2018 Category: Neurology Authors: Eva Dijkstra, Martijn Figee, Damiaan Denys, P. Richard Schuurman Source Type: research

The Role of Migraine in Hearing and Balance Symptoms
Episodic dizziness is a highly prevalent symptom that has historically been a challenge for primary care physicians, neurologists, and otolaryngologists to accurately diagnosis and properly treat. With an array of diagnoses to consider, including benign positional vertigo, vestibular migraine, M énière disease, vertebrobasilar syndrome, and vestibular schwannoma, among others, considerable effort has been placed by otolaryngology and neurology societies to carefully examine the literature and generate clinical criteria and guidelines to aid the clinician and to standardize diagnostic algo rithms and treatment...
Source: JAMA Otolaryngology - Head and Neck Surgery - July 12, 2018 Category: ENT & OMF Source Type: research

Association of Tinnitus and Other Cochlear Disorders With a History of Migraines
This cohort study used claims data from the Taiwan Longitudinal Health Insurance Database 2005 to investigate the risk of tinnitus and other cochlear disorders inr patients with a history of migraines. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - July 12, 2018 Category: ENT & OMF Source Type: research

Idiopathic Sudden Sensorineural Hearing Loss Is Not a Sentinel Event for Acute Myocardial Infarction
Conclusions: ISSNHL is not a predictor of an initial AMI in adult patients from the United States. Considerable inconsistencies in associations between cardiovascular risk factors and ISSNHL exist in the literature. Further work is needed to confirm or refute direct associations between cardiovascular disease risk factors and ISSNHL before definitive mechanistic conclusions can be made. (Source: Otology and Neurotology)
Source: Otology and Neurotology - July 11, 2018 Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research

Use of recombinant tissue plasminogen activator for treatment of recalcitrant anterior uveitis: A case series
Publication date: Available online 6 April 2018Source: Journal of Taibah University Medical SciencesAuthor(s): Sylves Patrick, Chan Hui-Tze, Wan Hitam Wan-Hazabbah, Embong Zunaina, Yaakub Azhany, Ahmad Tajudin Liza-SharminiAbstractManagement of inflammation after surgery for recalcitrant anterior uveitis is challenging. Herein, we report successful treatment using intracameral injection of recombinant tissue plasminogen activator (rtPA) in two patients with recalcitrant anterior uveitis, due to infective uveitis and Vogt–Koyanagi–Harada disease, respectively. A 40-year-old woman presented with bilateral redness...
Source: Journal of Taibah University Medical Sciences - July 11, 2018 Category: Universities & Medical Training Source Type: research

The efficacy and safety of multiple sessions of multisite transcranial random noise stimulation in treating chronic tinnitus
ConclusionsThe results of this study showed a substantial improvement in tinnitus symptoms by using the multiple sessions of transcranial random noise stimulation in the multisite protocol without producing any additional side effects. We suggest further clinical trials with long-term follow-up be investigated.ResumoIntroduçãoTem sido relatado que a estimulação transcraniana por ruído aleatório é um tipo mais eficaz e seguro de técnica de estimulação elétrica no alívio dos sintomas do zumbido. O protocolo multissítio da estimula&cced...
Source: Brazilian Journal of Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Source Type: research

Tinnitus evaluation: relation among pitch matching and loudness, visual analog scale and tinnitus handicap inventory
ConclusionThere was a significant correlation between the values measured by the tinnitus handicap inventory, visual analogical scale (annoyance) and loudness matching in the evaluation of tinnitus. The selection of any one of the three evaluative methods for tinnitus investigation provides different dimensions of the tinnitus and complements the others.ResumoIntroduçãoO zumbido é um sintoma auditivo de natureza subjetivo, normalmente associado a um som, mesmo na ausência de fontes sonoras externas. Apresenta diagnóstico complexo, uma das formas de mensuração é a utili...
Source: Brazilian Journal of Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Source Type: research

Effect of caffeine on vestibular evoked myogenic potential: a systematic review with meta-analysis
ConclusionAnalyzing the articles found, caffeine has no effect on vestibular evoked myogenic potential in normal individuals.ResumoIntroduçãoA cafeína pode ser considerada a droga mais consumida por adultos em nível mundial, podendo ser encontrada em inúmeros alimentos, como no chocolate, café, chá, refrigerante e outros. Em geral, a cafeína em doses moderadas, produz ótimos rendimentos físico e intelectual, aumenta a capacidade de concentração e diminui o tempo de reação aos estímulos sensoriais. Por outro lado, doses ...
Source: Brazilian Journal of Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Source Type: research

Evaluation of selective attention in patients with misophonia
ConclusionThe misophonia participants presented a lower percentage of correct responses in the dichotic sentence identification test with chewing sound; suggesting that individuals with misophonia may have selective attention impairment when they are exposed to sounds that trigger this condition.ResumoIntroduçãoA misofonia é caracterizada pela aversão a certos sons muito seletivos, que evocam uma forte reação emocional. Tem sido demonstrado que a misofonia, bem como o zumbido, estão associados à hiperconectividade entre os sistemas auditivo e límbico. Indiv&iac...
Source: Brazilian Journal of Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Source Type: research

The use of tDCS as a therapeutic option for tinnitus: a systematic review
ConclusionBased on literature studied, there is no therapeutic response of tinnitus to transcranial direct current stimulation.ResumoIntroduçãoDevido à subjetividade do diagnóstico do zumbido e a suas diversas etiologias, o estabelecimento de um tratamento eficaz é complexo. Neste contexto surge a transcranial direct current stimulation, uma opção não invasiva, acessível para grande parte dos pacientes, e que tem apresentado bons resultados no tratamento de outros sintomas como dor crônica.ObjetivoAvaliar a resposta terapêutica do zumbido ao transcr...
Source: Brazilian Journal of Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Source Type: research

Role of preoperative air-bone gap in tinnitus outcome after tympanoplasty for chronic otitis media with tinnitus
Publication date: March–April 2018Source: Brazilian Journal of Otorhinolaryngology, Volume 84, Issue 2Author(s): Hong Chan Kim, Chul Ho Jang, Young Yoon Kim, Jong Yuap Seong, Sung Hoon Kang, Yong Beom ChoAbstractIntroductionPrevious reports indicated that middle ear surgery might partially improve tinnitus after surgery. However, until now, no influencing factor has been determined for tinnitus outcome after middle ear surgery.ObjectiveThe purpose of this study was to investigate the association between preoperative air-bone gap and tinnitus outcome after tympanoplasty type I.MethodsSeventy-five patients with tinnitu...
Source: Brazilian Journal of Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Source Type: research

Tinnitus and sound intolerance: evidence and experience of a Brazilian group
ConclusionA review on tinnitus and auditory sensitivity was presented, allowing the reader a broad view of the approach to these patients, based on scientific evidence and national experience.ResumoIntroduçãoZumbido e intolerância a sons são queixas frequentes e subjetivas que podem ter impacto na qualidade de vida do paciente.ObjetivoApresentar uma revisão dos principais pontos incluindo conceitos, fisiopatologia, diagnóstico e abordagem do paciente com zumbido e sensibilidade a sons.MétodoRevisão da literatura com levantamento bibliográfico na base de dados da...
Source: Brazilian Journal of Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Source Type: research

Degree of tinnitus improvement with stapes surgery – a review
ConclusionWe conclude that stapes surgery is effective for the treatment of tinnitus (average improvement is 85.52%), and hearing loss (average improvement is 93%). When deciding about the surgical indication in patients with otosclerosis, the presence and level tinnitus should be considered as well as the level of hearing.ResumoIntroduçãoA otosclerose é uma osteodistrofia do osso temporal, caracterizada pela reabsorção e neoformação óssea desordenadas em indivíduos geneticamente predispostos. Clinicamente, a otosclerose é caracterizada por perda auditiv...
Source: Brazilian Journal of Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Source Type: research

The Cochleural Alternating Acoustic Beam Therapy (CAABT): A pre-clinical trial
ConclusionThe therapy seemed effective in patients of varying severities, and no side effects were observed in this trial. The CAABT can be an alternative for those who are suitable for sound therapy once a large scale of and better controlled clinical studies have validated the findings of this experiment. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - July 10, 2018 Category: Endocrinology Source Type: research

Diagnostic yield of MRI of the brain and IAC in patients with neurotologic complaints
ConclusionsIn a tertiary neurotology center, the likelihood of finding a retrocochlear tumor on MRI is rare. In the current study, unilateral tinnitus exclusively, “definite MD,” and “probable MD” failed to yield a single example of retrocochlear tumor. Patients with “possible MD” had the highest probability of finding retrocochlear tumors and other relevant pathology. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - July 10, 2018 Category: Endocrinology Source Type: research

Comparison of intratympanic dexamethasone therapy and hyperbaric oxygen therapy for the salvage treatment of refractory high-frequency sudden sensorineural hearing loss
ConclusionITD therapy may have better improvements of tinnitus and hearing gains at 8 KHz than HBO therapy in patients with refractory high-frequency SSNHL. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - July 10, 2018 Category: Endocrinology Source Type: research

Genes important for otoneurological diagnostic purposes - current status and future prospects.
Authors: Pawlak-Osiñska K, Linkowska K, Grzybowski T Abstract SUMMARY: This review focuses on the current knowledge of the genes responsible for non-syndromic hearing loss that can be useful for otoneurological diagnostic purposes. From among a large number of genes that have been associated with non-syndromic hearing impairment, we selected several best-known genes, including the COCH gene, GJB2, GJB6 and SLC26A4, and we describe their role and effects of mutations and prevalence of mutations in various populations. Next, we focus on genes associated with tinnitus. Important areas for further research inclu...
Source: Acta Otorhinolaryngologica Italica - July 10, 2018 Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research

MRI compatible MS2 nanoparticles designed to cross the blood–brain-barrier: providing a path towards tinnitus treatment
Publication date: Available online 14 April 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Aaron K. Apawu, Stephanie M. Curley, Angela R. Dixon, Mirabela Hali, Moaz Sinan, Rod D. Braun, James Castracane, Anthony T. Cacace, Magnus Bergkvist, Avril Genene HoltAbstractFundamental challenges of targeting specific brain regions for treatment using pharmacotherapeutic nanoparticle (NP) carriers include circumventing the blood–brain-barrier (BBB) and tracking delivery. Angiopep-2 (AP2) has been shown to facilitate the transport of large macromolecules and synthetic nanoparticles across the BBB. Thu...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - July 10, 2018 Category: Nanotechnology Source Type: research

Influencing connectivity and cross-frequency coupling by real-time source localized neurofeedback of the posterior cingulate cortex reduces tinnitus related distress
ConclusionThis suggests that neurofeedback could remove the information, processed in beta and gamma, from the carrier wave, alpha, which transports the high frequency information and influences the salience attributed to the tinnitus sound. Based on the observation that much pathology is the result of an abnormal functional connectivity within and between neural networks various pathologies should be considered eligible candidates for the application of source localized EEG based neurofeedback training.Graphical abstract (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 10, 2018 Category: Neuroscience Source Type: research

Incidence of intraoperative hearing loss during middle cranial fossa approach for repair of superior semicircular canal dehiscence
ConclusionThe results of this retrospective review demonstrate a low risk for hearing loss due to SSCD surgery via the middle fossa craniotomy approach. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research

Spontaneous resolution of a non-traumatic vertebro-vertebral arteriovenous fistula in a paediatric patient
We report the case of a 10 year old male who presented with right sided tinnitus and a pulsatile neck mass. MRI of the neck demonstrated a vertebro-vertebral arteriovenous fistula (VAVF), with supply from the right vertebral artery and drainage into a paraspinal venous plexus at C1/2. Endovascular treatment would have necessitated vertebral artery sacrifice with significant risk of complication, therefore a conservative approach was adopted; the patient was lost to follow up but presented 5 years later with complete resolution. We therefore advocate a role for conservative management when treatment would pose undue ris...
Source: Journal of Clinical Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research

A rare case of facial nerve schwannoma masked by a concomitant temporomandibular disorder pain
Publication date: Available online 26 June 2018Source: Interdisciplinary NeurosurgeryAuthor(s): Natália R. Ferreira, Aleli T. Oliveira, Marcos F. DosSantos, Valéria Battistella, Paulo R.V. Bahia, Antônio C.P. Carvalho, André Antonio MonteiroAbstractFacial nerve schwannoma (FNS) is an uncommon benign tumor that arises from the Schwann cells of the facial nerve (FN). Although rare, this is the most frequent type of FN tumor, potentially affecting any segment of the nerve. Nevertheless, a higher incidence of intracranial lesions and a predilection for the geniculate ganglion has been reported. Heari...
Source: Interdisciplinary Neurosurgery - July 10, 2018 Category: Neurosurgery Source Type: research

Endovascular Treatment of Dural Arteriovenous Fistulas Using Transarterial Liquid Embolization in Combination with Transvenous Balloon-Assisted Protection of the Venous Sinus [INTERVENTIONAL]
CONCLUSIONS: Transarterial liquid embolization of dural arteriovenous fistulas in combination with transvenous balloon-assisted protection of the venous sinus is feasible and safe and offers high rates of occlusion and of symptom remission. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - July 9, 2018 Category: Radiology Authors: Vollherbst, D. F., Ulfert, C., Neuberger, U., Herweh, C., Laible, M., Nagel, S., Bendszus, M., Möhlenbruch, M. A. Tags: INTERVENTIONAL Source Type: research

The efficacy and safety of multiple sessions of multisite transcranial random noise stimulation in treating chronic tinnitus
ConclusionsThe results of this study showed a substantial improvement in tinnitus symptoms by using the multiple sessions of transcranial random noise stimulation in the multisite protocol without producing any additional side effects. We suggest further clinical trials with long-term follow-up be investigated.ResumoIntroduçãoTem sido relatado que a estimulação transcraniana por ruído aleatório é um tipo mais eficaz e seguro de técnica de estimulação elétrica no alívio dos sintomas do zumbido. O protocolo multissítio da estimula&cced...
Source: Brazilian Journal of Otorhinolaryngology - July 6, 2018 Category: ENT & OMF Source Type: research

Tinnitus evaluation: relation among pitch matching and loudness, visual analog scale and tinnitus handicap inventory
ConclusionThere was a significant correlation between the values measured by the tinnitus handicap inventory, visual analogical scale (annoyance) and loudness matching in the evaluation of tinnitus. The selection of any one of the three evaluative methods for tinnitus investigation provides different dimensions of the tinnitus and complements the others.ResumoIntroduçãoO zumbido é um sintoma auditivo de natureza subjetivo, normalmente associado a um som, mesmo na ausência de fontes sonoras externas. Apresenta diagnóstico complexo, uma das formas de mensuração é a utili...
Source: Brazilian Journal of Otorhinolaryngology - July 6, 2018 Category: ENT & OMF Source Type: research

Effect of caffeine on vestibular evoked myogenic potential: a systematic review with meta-analysis
ConclusionAnalyzing the articles found, caffeine has no effect on vestibular evoked myogenic potential in normal individuals.ResumoIntroduçãoA cafeína pode ser considerada a droga mais consumida por adultos em nível mundial, podendo ser encontrada em inúmeros alimentos, como no chocolate, café, chá, refrigerante e outros. Em geral, a cafeína em doses moderadas, produz ótimos rendimentos físico e intelectual, aumenta a capacidade de concentração e diminui o tempo de reação aos estímulos sensoriais. Por outro lado, doses ...
Source: Brazilian Journal of Otorhinolaryngology - July 6, 2018 Category: ENT & OMF Source Type: research

Evaluation of selective attention in patients with misophonia
ConclusionThe misophonia participants presented a lower percentage of correct responses in the dichotic sentence identification test with chewing sound; suggesting that individuals with misophonia may have selective attention impairment when they are exposed to sounds that trigger this condition.ResumoIntroduçãoA misofonia é caracterizada pela aversão a certos sons muito seletivos, que evocam uma forte reação emocional. Tem sido demonstrado que a misofonia, bem como o zumbido, estão associados à hiperconectividade entre os sistemas auditivo e límbico. Indiv&iac...
Source: Brazilian Journal of Otorhinolaryngology - July 6, 2018 Category: ENT & OMF Source Type: research

The use of tDCS as a therapeutic option for tinnitus: a systematic review
ConclusionBased on literature studied, there is no therapeutic response of tinnitus to transcranial direct current stimulation.ResumoIntroduçãoDevido à subjetividade do diagnóstico do zumbido e a suas diversas etiologias, o estabelecimento de um tratamento eficaz é complexo. Neste contexto surge a transcranial direct current stimulation, uma opção não invasiva, acessível para grande parte dos pacientes, e que tem apresentado bons resultados no tratamento de outros sintomas como dor crônica.ObjetivoAvaliar a resposta terapêutica do zumbido ao transcr...
Source: Brazilian Journal of Otorhinolaryngology - July 6, 2018 Category: ENT & OMF Source Type: research

Role of preoperative air-bone gap in tinnitus outcome after tympanoplasty for chronic otitis media with tinnitus
Publication date: March–April 2018Source: Brazilian Journal of Otorhinolaryngology, Volume 84, Issue 2Author(s): Hong Chan Kim, Chul Ho Jang, Young Yoon Kim, Jong Yuap Seong, Sung Hoon Kang, Yong Beom ChoAbstractIntroductionPrevious reports indicated that middle ear surgery might partially improve tinnitus after surgery. However, until now, no influencing factor has been determined for tinnitus outcome after middle ear surgery.ObjectiveThe purpose of this study was to investigate the association between preoperative air-bone gap and tinnitus outcome after tympanoplasty type I.MethodsSeventy-five patients with tinnitu...
Source: Brazilian Journal of Otorhinolaryngology - July 6, 2018 Category: ENT & OMF Source Type: research

Tinnitus and sound intolerance: evidence and experience of a Brazilian group
ConclusionA review on tinnitus and auditory sensitivity was presented, allowing the reader a broad view of the approach to these patients, based on scientific evidence and national experience.ResumoIntroduçãoZumbido e intolerância a sons são queixas frequentes e subjetivas que podem ter impacto na qualidade de vida do paciente.ObjetivoApresentar uma revisão dos principais pontos incluindo conceitos, fisiopatologia, diagnóstico e abordagem do paciente com zumbido e sensibilidade a sons.MétodoRevisão da literatura com levantamento bibliográfico na base de dados da...
Source: Brazilian Journal of Otorhinolaryngology - July 6, 2018 Category: ENT & OMF Source Type: research

Degree of tinnitus improvement with stapes surgery – a review
ConclusionWe conclude that stapes surgery is effective for the treatment of tinnitus (average improvement is 85.52%), and hearing loss (average improvement is 93%). When deciding about the surgical indication in patients with otosclerosis, the presence and level tinnitus should be considered as well as the level of hearing.ResumoIntroduçãoA otosclerose é uma osteodistrofia do osso temporal, caracterizada pela reabsorção e neoformação óssea desordenadas em indivíduos geneticamente predispostos. Clinicamente, a otosclerose é caracterizada por perda auditiv...
Source: Brazilian Journal of Otorhinolaryngology - July 6, 2018 Category: ENT & OMF Source Type: research

Use of recombinant tissue plasminogen activator for treatment of recalcitrant anterior uveitis: A case series
Publication date: Available online 6 April 2018Source: Journal of Taibah University Medical SciencesAuthor(s): Sylves Patrick, Chan Hui-Tze, Wan Hitam Wan-Hazabbah, Embong Zunaina, Yaakub Azhany, Ahmad Tajudin Liza-SharminiAbstractManagement of inflammation after surgery for recalcitrant anterior uveitis is challenging. Herein, we report successful treatment using intracameral injection of recombinant tissue plasminogen activator (rtPA) in two patients with recalcitrant anterior uveitis, due to infective uveitis and Vogt–Koyanagi–Harada disease, respectively. A 40-year-old woman presented with bilateral redness...
Source: Journal of Taibah University Medical Sciences - July 5, 2018 Category: Universities & Medical Training Source Type: research

The Cochleural Alternating Acoustic Beam Therapy (CAABT): A pre-clinical trial
ConclusionThe therapy seemed effective in patients of varying severities, and no side effects were observed in this trial. The CAABT can be an alternative for those who are suitable for sound therapy once a large scale of and better controlled clinical studies have validated the findings of this experiment. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - July 5, 2018 Category: Endocrinology Source Type: research

Diagnostic yield of MRI of the brain and IAC in patients with neurotologic complaints
ConclusionsIn a tertiary neurotology center, the likelihood of finding a retrocochlear tumor on MRI is rare. In the current study, unilateral tinnitus exclusively, “definite MD,” and “probable MD” failed to yield a single example of retrocochlear tumor. Patients with “possible MD” had the highest probability of finding retrocochlear tumors and other relevant pathology. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - July 5, 2018 Category: Endocrinology Source Type: research

Comparison of intratympanic dexamethasone therapy and hyperbaric oxygen therapy for the salvage treatment of refractory high-frequency sudden sensorineural hearing loss
ConclusionITD therapy may have better improvements of tinnitus and hearing gains at 8 KHz than HBO therapy in patients with refractory high-frequency SSNHL. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - July 5, 2018 Category: Endocrinology Source Type: research

MRI compatible MS2 nanoparticles designed to cross the blood–brain-barrier: providing a path towards tinnitus treatment
Publication date: Available online 14 April 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Aaron K. Apawu, Stephanie M. Curley, Angela R. Dixon, Mirabela Hali, Moaz Sinan, Rod D. Braun, James Castracane, Anthony T. Cacace, Magnus Bergkvist, Avril Genene HoltAbstractFundamental challenges of targeting specific brain regions for treatment using pharmacotherapeutic nanoparticle (NP) carriers include circumventing the blood–brain-barrier (BBB) and tracking delivery. Angiopep-2 (AP2) has been shown to facilitate the transport of large macromolecules and synthetic nanoparticles across the BBB. Thu...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - July 5, 2018 Category: Nanotechnology Source Type: research

Influencing connectivity and cross-frequency coupling by real-time source localized neurofeedback of the posterior cingulate cortex reduces tinnitus related distress
ConclusionThis suggests that neurofeedback could remove the information, processed in beta and gamma, from the carrier wave, alpha, which transports the high frequency information and influences the salience attributed to the tinnitus sound. Based on the observation that much pathology is the result of an abnormal functional connectivity within and between neural networks various pathologies should be considered eligible candidates for the application of source localized EEG based neurofeedback training.Graphical abstract (Source: Neurobiology of Stress)
Source: Neurobiology of Stress - July 5, 2018 Category: Neuroscience Source Type: research

Spontaneous resolution of a non-traumatic vertebro-vertebral arteriovenous fistula in a paediatric patient
We report the case of a 10 year old male who presented with right sided tinnitus and a pulsatile neck mass. MRI of the neck demonstrated a vertebro-vertebral arteriovenous fistula (VAVF), with supply from the right vertebral artery and drainage into a paraspinal venous plexus at C1/2. Endovascular treatment would have necessitated vertebral artery sacrifice with significant risk of complication, therefore a conservative approach was adopted; the patient was lost to follow up but presented 5 years later with complete resolution. We therefore advocate a role for conservative management when treatment would pose undue ris...
Source: Journal of Clinical Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

Incidence of intraoperative hearing loss during middle cranial fossa approach for repair of superior semicircular canal dehiscence
ConclusionThe results of this retrospective review demonstrate a low risk for hearing loss due to SSCD surgery via the middle fossa craniotomy approach. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

A rare case of facial nerve schwannoma masked by a concomitant temporomandibular disorder pain
Publication date: Available online 26 June 2018Source: Interdisciplinary NeurosurgeryAuthor(s): Natália R. Ferreira, Aleli T. Oliveira, Marcos F. DosSantos, Valéria Battistella, Paulo R.V. Bahia, Antônio C.P. Carvalho, André Antonio MonteiroAbstractFacial nerve schwannoma (FNS) is an uncommon benign tumor that arises from the Schwann cells of the facial nerve (FN). Although rare, this is the most frequent type of FN tumor, potentially affecting any segment of the nerve. Nevertheless, a higher incidence of intracranial lesions and a predilection for the geniculate ganglion has been reported. Heari...
Source: Interdisciplinary Neurosurgery - July 5, 2018 Category: Neurosurgery Source Type: research

Objective assessment of subjective tinnitus through contralateral suppression of otoacoustic emissions by white noise: effects of frequency, gender, tinnitus bilaterality and age.
Authors: Riga M, Komis A, Maragoudakis P, Korres G, Ferekidis E, Danielides V Abstract SUMMARY: Accumulating evidence seems to support an association between tinnitus and medial olivocochlear bundle (MOCB) dysfunction. Most studies use patient/control comparisons to support this correlation. The aim of this study was to investigate the hypothesis in a substantially different way and evaluate the roles of gender, age, frequency and tinnitus bilaterality as possible confounding factors. The population consisted of 78 normal hearing patients with chronic tinnitus, 28 normal hearing controls, 19 presbycousic tinnitus p...
Source: Acta Otorhinolaryngologica Italica - July 5, 2018 Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research

Different infusion durations for preventing platinum-induced hearing loss in children with cancer.
CONCLUSIONS: Since only one eligible RCT evaluating the use of a continuous cisplatin infusion versus a one-hour bolus cisplatin infusion was found, and that had methodological limitations, no definitive conclusions can be made. It should be noted that 'no evidence of effect', as identified in this review, is not the same as 'evidence of no effect'. For other (combinations of) infusion durations and other platinum analogues no eligible studies were identified. More high-quality research is needed. PMID: 29975402 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - July 5, 2018 Category: General Medicine Authors: van As JW, van den Berg H, van Dalen EC Tags: Cochrane Database Syst Rev Source Type: research

Associations of Collective Self-Help Activity, Health Literacy and Quality of Life in Patients with Tinnitus
This study analyzes whether SHG-participation is associated with tinnitus-related Health Literacy (HLit) and Quality of Life (QoL). (Source: Patient Education and Counseling)
Source: Patient Education and Counseling - July 3, 2018 Category: International Medicine & Public Health Authors: Christopher Kofahl Source Type: research

Nociceptive and Cognitive Changes in a Murine Model of Polytrauma
With a global incidence estimated to be about 106 per 100,000 population, TBI is a leading cause of trauma-related disability 15. In the US more than 1.7 million injuries occur per year resulting in 250,000 hospitalizations and 52,000 deaths 9. The majority (75-80%) of all TBI cases are, however, mild and are accompanied by the rapid resolution of the immediate symptoms including disorientation, dizziness, tinnitus, nausea and balance problems 24. The incidence of TBI is higher overall in males than females, and is particularly common in the very young, adolescents and elderly 3. (Source: The Journal of Pain)
Source: The Journal of Pain - July 2, 2018 Category: Materials Science Authors: Peyman Sahbaie, Maral Tajerian, Phillip Yang, Karen Amanda Irvine, Ting-Ting Huang, Jian Luo, Tony Wyss-Coray, J David Clark Tags: Original Reports Source Type: research

Rare Cause of Tinnitus: Spontaneous Temporomandibular Joint Herniation Into the External Auditory Canal
The herniation of temporomandibular joint (TMJ) into external auditory canal (EAC) may occur due to trauma, neoplastic, infectious, and inflammatory processes. On the other hand, spontaneous herniation of TMJ into EAC is an extremely rare conduction and occurs as a consequence of patent retention of foramen of Huschke (FH). Patent FH is usually an asymptomatic situation. In this article, a patient having otologic symptoms as a result of spontaneous herniation of TMJ into EAC was presented in the light of current literature. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - July 1, 2018 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Transverse venous stenting for the treatment of idiopathic intracranial hypertension, or pseudotumor cerebri.
CONCLUSIONS Transverse sinus stenting is a rapidly developing technique that has shown good effectiveness and safety in the literature. Authors of the present study found that stenting a flow-obstructed transverse sinus in patients with IIH was a safe and effective way to treat the condition. PMID: 29961386 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - July 1, 2018 Category: Neurosurgery Authors: Cappuzzo JM, Hess RM, Morrison JF, Davies JM, Snyder KV, Levy EI, Siddiqui AH Tags: Neurosurg Focus Source Type: research

Vogt-Koyanagi-Harada Disease Associated with Hepatitis B Vaccination.
CONCLUSIONS: VKH disease is an inflammatory condition primarily affecting the choroid, retinal pigment epithelium, and outer retina. The underlying etiology is unclear, but it can be associated with a viral prodrome suggesting an infectious trigger in a genetically susceptible individual. Our case suggests that hepatitis B vaccination may trigger a similar inflammatory response. PMID: 29953303 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - June 29, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research