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Update on Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension (IIH) is a disorder of elevated intracranial pressure of unknown cause occurring predominantly in young women of childbearing age. The typical patient symptom profile is the presence of daily headache, pulse synchronous tinnitus, transient visual obscurations, and papilledema with its associated visual loss. Although surgical procedures are performed for those who fail medical therapy, their relative efficacy remains unclear. The main morbidity of IIH is from visual loss. This visual loss is present in most patients and can usually be reversed if recognized early in the patients ’...
Source: Neurologic Clinics - November 23, 2016 Category: Neurology Authors: Michael Wall Source Type: research

Occult infratemporal fossa neurofibroma presenting with persistent unilateral tinnitus and middle ear effusion: More than meets the eye
Publication date: Available online 23 November 2016 Source:American Journal of Otolaryngology Author(s): Lucas P. Carlstrom, Kathryn M. Van Abel, Matthew L Carlson, Eric J. Moore, Janalee K. Stokken Herein, we present the case of a previously healthy 54year-old female who developed several weeks of unilateral tinnitus and aural fullness. She subsequently underwent unilateral pressure equalization tube placement at an outside institution after exam demonstrated a middle ear effusion, conductive hearing loss and normal nasopharyngoscopy. Ultimately, an MRI revealed an occult mass in the infratemporal fossa (ITF), which was ...
Source: American Journal of Otolaryngology - November 22, 2016 Category: Endocrinology Source Type: research

Cochlear implantation in Meniere ’s disease
Publication date: Available online 13 October 2016 Source:Operative Techniques in Otolaryngology-Head and Neck Surgery Author(s): Jacob B. Hunter, Brendan P. O׳Connell, David S. Haynes Meniere’s disease (MD) is characterized by fluctuating hearing loss, episodic vertigo, tinnitus, and aural fullness. Whether secondary to intervention or to natural disease progression, a considerable subset of patients with MD has nonserviceable hearing in at least one ear. As such, cochlear implantation counseling and decision-making in the setting of MD must take into account the patient׳s surgical history. In patients who have u...
Source: Operative Techniques in Otolaryngology Head and Neck Surgery - November 22, 2016 Category: ENT & OMF Source Type: research

Bedaquiline in the multidrug-resistant tuberculosis treatment: Belarus experience
Conclusion Our interim results on safety and effectiveness of bedaquiline-containing regimens in multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) patients are encouraging. They will add value to understanding role and place of this new anti-TB drug in M/XDR-TB treatment. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 22, 2016 Category: Infectious Diseases Source Type: research

Zinc supplementation for tinnitus.
CONCLUSIONS: We found no evidence that the use of oral zinc supplementation improves symptoms in adults with tinnitus. PMID: 27879981 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 22, 2016 Category: Journals (General) Authors: Person OC, Puga ME, da Silva EM, Torloni MR Tags: Cochrane Database Syst Rev Source Type: research

Botulinum toxin treatment for essential palatal tremors presenting with nasal clicks instead of pulsatile tinnitus: a case report
In this study, we report a rare case of an adult patient with essential palatal tremors (EPT) presenting as nasal clicks, instead of otic clicks or objective pulsatile tinnitus in common EPT. (Source: Head and Face Medicine)
Source: Head and Face Medicine - November 22, 2016 Category: ENT & OMF Authors: Yufeng Ye, Shiyu Liao, Baozhen Luo and Liyan Ni Source Type: research

Evidence that hidden hearing loss underlies amplitude modulation encoding deficits in individuals with and without tinnitus.
Abstract Damage to auditory nerve fibers that expresses with suprathreshold sounds but is hidden from the audiogram has been proposed to underlie deficits in temporal coding ability observed among individuals with otherwise normal hearing, and to be present in individuals experiencing chronic tinnitus with clinically normal audiograms. We tested whether these individuals may have hidden synaptic losses on auditory nerve fibers with low spontaneous rates of firing (low-SR fibers) that are important for coding suprathreshold sounds in noise while high-SR fibers determining threshold responses in quiet remain relativ...
Source: Hearing Research - November 21, 2016 Category: Audiology Authors: Paul BT, Bruce IC, Roberts LE Tags: Hear Res Source Type: research

Electroacoustic evaluation of the olivocochlear efferent pathway in subjects with tinnitus complaint
Conclusion: suppression values of otoacoustic emissions were similar in subjects with and without tinnitus, although the results of the tinnitus group were lower, suggesting worse performance of the Superior Olivary Complex. (Source: Revista CEFAC)
Source: Revista CEFAC - November 21, 2016 Category: Speech Therapy Source Type: research

Differences in VigiBase ® reporting of aminoglycoside and capreomycin‐suspected ototoxicity during tuberculosis treatment
ConclusionSpontaneous reporting of deafness cases within VigiBase® was most disproportionately associated with amikacin use, followed by kanamycin. There were regional variations in the global reporting of ototoxicity. These findings should be verified through a follow up study. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - November 19, 2016 Category: Drugs & Pharmacology Authors: Evans L. Sagwa, Patrick C. Souverein, In ês Ribeiro, Hubert G. M. Leufkens, Aukje K. Mantel‐Teeuwisse Tags: Original Report Source Type: research

Noise-Induced Hearing Loss among Professional Musicians.
CONCLUSIONS: Long-term exposure to loud sounds puts musicians at risk of hearing loss. However, due to their inadequate knowledge, most musicians never use protective devices to prevent damage to their auditory system. PMID: 27853057 [PubMed - as supplied by publisher] (Source: Journal of Occupational Health)
Source: Journal of Occupational Health - November 19, 2016 Category: Occupational Health Tags: J Occup Health Source Type: research

Factor Analysis of Low-Frequency Repetitive Transcranial Magnetic Stimulation to the Temporoparietal Junction for Tinnitus.
Conclusion. Active low-frequency rTMS results in a significant reduction in the loudness of tinnitus. Significant tinnitus suppression was shown in subjects with shorter tinnitus duration, with normal hearing, and without sleep disturbance. PMID: 27847647 [PubMed - in process] (Source: Neural Plasticity)
Source: Neural Plasticity - November 18, 2016 Category: Neurology Authors: Wang H, Li B, Wang M, Li M, Yu D, Shi H, Yin S Tags: Neural Plast Source Type: research

A comprehensive database of published tDCS clinical trials (2005 –2016)
This article does not include any meta-analysis and aims simply at providing a comprehensive overview of the raw data reported in this field to date, as an aid to researchers. (Source: Neurophysiologie Clinique)
Source: Neurophysiologie Clinique - November 17, 2016 Category: Neuroscience Source Type: research

An Integrative Tinnitus Model Based on Sensory Precision.
Abstract Tinnitus is a common disorder that often complicates hearing loss. Its mechanisms are incompletely understood. Current theories proposing pathophysiology from the ear to the cortex cannot individually - or collectively - explain the range of experimental evidence available. We propose a new framework, based on predictive coding, in which spontaneous activity in the subcortical auditory pathway constitutes a 'tinnitus precursor' which is normally ignored as imprecise evidence against the prevailing percept of 'silence'. Extant models feature as contributory mechanisms acting to increase either the intensit...
Source: Trends in Neurosciences - November 17, 2016 Category: Neuroscience Authors: Sedley W, Friston KJ, Gander PE, Kumar S, Griffiths TD Tags: Trends Neurosci Source Type: research

Use of an Intrathecal Catheter for Analgesia, Anesthesia, and Therapy in an Obstetric Patient With Pseudotumor Cerebri Syndrome
(A A Case Rep. 2016;6:160–162) In this case report, a 32-year-old primigravida woman with a history of idiopathic intracranial hypertension (IIH) presented to the labor and delivery suite at 40 weeks gestation in active labor and with pseudotumor cerebri syndrome (PTCS). PTCS, which includes IIH, is a rare disorder mainly of obese women of childbearing age, characterized by increased intracranial pressure in the absence of a space-occupying lesion, ventriculomegaly, or abnormal cerebrospinal fluid (CSF) composition. Symptoms include headache, pulsatile tinnitus, back pain, dizziness, photophobia, neck pain, cognitiv...
Source: Obstetric Anesthesia Digest - November 17, 2016 Category: Anesthesiology Tags: Case Reports Source Type: research

Effect of direct stimulation of the cochleovestibular nerve on tinnitus: a long-term follow-up study
Tinnitus is a common entity that may lead to severe impairment in quality of life. An adequate treatment modality for severe tinnitus is currently lacking. Neurostimulation of the auditory tract may serve as a promising adjunct in tinnitus treatment. The aim is to investigate the effect of direct stimulation on the cochleovestibular nerve for intractable tinnitus. (Source: World Neurosurgery)
Source: World Neurosurgery - November 16, 2016 Category: Neurosurgery Authors: Minke J.C. van den Berge, J. Marc C. van Dijk, Rolien H. Free, Janke Stienstra, Pim van Dijk, Bernard F.A.M. van der Laan Tags: Original article Source Type: research

Tinnitus and leisure noise
. (Source: International Journal of Audiology)
Source: International Journal of Audiology - November 16, 2016 Category: Audiology Authors: Warwick Williams Lyndal Carter Source Type: research

Tibialis anterior muscle biopsy - a patient reported outcome study
Conclusions This small patient reported outcome study suggests that percutaneous tibialis anterior muscle biopsy is safe and well tolerated. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Lilleker, J., Woodall, A., Roberts, M., Chinoy, H. Tags: Drugs: CNS (not psychiatric), Neuromuscular disease, Pain (neurology), Radiology, Surgical diagnostic tests, Ear, nose and throat/otolaryngology, Trauma, Injury ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

The Manifestation of Vortical and Secondary Flow in the Cerebral Venous Outflow Tract: An In Vivo MR Velocimetry Study
Aberrations in flow in the cerebral venous outflow tract (CVOT) have been implicated as the cause of several pathologic conditions including idiopathic intracranial hypertension (IIH), multiple sclerosis (MS), and pulsatile tinnitus (PT). The advent of 4D Flow magnetic resonance imaging (4D-Flow MRI) has recently allowed researchers to evaluate blood flow patterns in the arterial structures with great success. We utilized similar imaging techniques and found several distinct flow characteristics in the CVOT of subjects with and without lumenal irregularities. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - November 14, 2016 Category: Biomedical Science Authors: Sarah Kefayati, Matthew Amans, Farshid Faraji, Megan Ballweber, Evan Kao, Sinyeob Ahn, Karl Meisel, Van Halbach, David Saloner Tags: SI: Biofluid Mechanics Source Type: research

Sound generator associated with the counseling in the treatment of tinnitus: evaluation of the effectiveness
Conclusion The use of the SG was similarly effective in the treatment of the tinnitus in individuals with and without hearing loss, causing an improvement of the nuisance and handicap. (Source: Brazilian Journal of Otorhinolaryngology)
Source: Brazilian Journal of Otorhinolaryngology - November 11, 2016 Category: ENT & OMF Source Type: research

Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs
This article is protected by copyright. All rights reserved. (Source: European Journal of Neuroscience)
Source: European Journal of Neuroscience - November 11, 2016 Category: Neuroscience Authors: Joel I. Berger, Ben Coomber, Mark N. Wallace, Alan R. Palmer Tags: Research Report Source Type: research

Histopathology of Meniere ’s Disease
This study aims to perform an up-to-date review on Meniere’s Disease, focusing on histopathology, pathophysiology, genetics, and causative mechanisms. (Source: Operative Techniques in Otolaryngology Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology Head and Neck Surgery - November 11, 2016 Category: ENT & OMF Source Type: research

Investigating the Effects of a Personalized, Spectrally Altered Music-Based Sound Therapy on Treating Tinnitus: A Blinded, Randomized Controlled Trial
Conclusion: The personalized music therapy was effective in reducing subjective tinnitus and represents a meaningful advancement in tinnitus intervention.Audiol Neurotol 2016;21:296-304 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - November 11, 2016 Category: Audiology Source Type: research

Morphine-induced hearing loss.
CONCLUSION: A 52-year-old man developed tinnitus and hearing loss after receiving high doses of oral morphine sulfate. His hearing loss did not fully resolve after the discontinuation of morphine, and he required the use of hearing aids. PMID: 27821396 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 11, 2016 Category: Drugs & Pharmacology Authors: Leache L, Aquerreta I, Moraza L, Ortega A Tags: Am J Health Syst Pharm Source Type: research

Vascular loops in the anterior inferior cerebellar artery, as identified by magnetic resonance imaging, and their relationship with otologic symptoms
Abstract Objective: To use magnetic resonance imaging to identify vascular loops in the anterior inferior cerebellar artery and to evaluate their relationship with otologic symptoms. Materials and Methods: We selected 33 adults with otologic complaints who underwent magnetic resonance imaging at our institution between June and November 2013. Three experienced independent observers evaluated the trajectory of the anterior inferior cerebellar artery in relation to the internal auditory meatus and graded the anterior inferior cerebellar artery vascular loops according to the Chavda classification. Kappa and chi-square tests ...
Source: Radiologia Brasileira - November 11, 2016 Category: Radiology Source Type: research

Reply to: Psychometric properties of the Tinnitus Functional Index (TFI): Assessment in a UK research volunteer population.
PMID: 27842215 [PubMed - as supplied by publisher] (Source: Hearing Research)
Source: Hearing Research - November 10, 2016 Category: Audiology Authors: Henry JA, Thielman E, Zaugg T Tags: Hear Res Source Type: research

Clinical Implication of the Threshold Equalizing Noise Test in Patients With Sudden Sensorineural Hearing Loss
Conclusion: DRs are associated with worse hearing thresholds at follow-up audiogram and might be associated with unfavorable hearing outcome in patients with SSNHL. (Source: Otology and Neurotology)
Source: Otology and Neurotology - November 10, 2016 Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research

Diagnostic Criteria for Detection of Vestibular Schwannomas in the VA Population
Objective: To investigate the prevalence of vestibular schwannoma (VS) and asymmetric sensorineural hearing loss in the Veterans Administration hospital population and analyze a more efficient method of diagnosing VS in a population with significant noise exposure. Study Design: Retrospective review of South Central (VISN 16) Veterans Administration hospitals. Methods: Record query for ICD-9 codes for asymmetric sensorineural hearing loss or VS between 1999 and 2012. Patient demographics, signs and symptoms at presentation, audiogram and imaging data, and management data were collected and analyzed. Audiograms from tumor...
Source: Otology and Neurotology - November 10, 2016 Category: ENT & OMF Tags: Sensorineural Hearing Loss and Tinnitus Source Type: research

Single Institutional Experience With Observing 564 Vestibular Schwannomas: Factors Associated With Tumor Growth
Conclusion: To date, this is the largest series of observed VS reported in the literature. Risk of VS growth is significantly increased among patients who present with larger tumors and who have concomitant disequilibrium. IRB: 151481. Define Professional Practice Gap and Educational Need: No cohort with this sample size has assessed vestibular schwannoma growth rates in conjunction with this number of variables. Learning Objective: To characterize vestibular schwannoma growth rates and predictors of growth. (Source: Otology and Neurotology)
Source: Otology and Neurotology - November 10, 2016 Category: ENT & OMF Tags: Tumors of the Ear and Cranial Base Source Type: research

Intratympanic Sustained-Exposure Dexamethasone Thermosensitive Gel for Symptoms of Ménière's Disease: Randomized Phase 2b Safety and Efficacy Trial
Conclusion: OTO-104 was well-tolerated, did not significantly affect change from baseline in vertigo rate, but did reduce number definitive vertigo days, vertigo severity, and average daily vertigo count compared with placebo during Month 3. Results provide insight into analyzing for a vertigo treatment effect and support advancing OTO-104 into Phase 3 clinical trials for the treatment of Ménière's disease symptoms. (Source: Otology and Neurotology)
Source: Otology and Neurotology - November 10, 2016 Category: ENT & OMF Tags: Medical Neurotology Source Type: research

Radiological and audiometric evaluation of high jugular bulb and dehiscent high jugular bulb.
Authors: Sayit AT, Gunbey HP, Fethallah B, Gunbey E, Karabulut E Abstract OBJECTIVE: To inform on the incidence of high jugular bulb and dehiscent high jugular bulb, and the symptoms related to these vascular anomalies. METHODS: A retrospective analysis was performed of temporal bone computed tomography scans of 3285 patients who attended our clinic with various symptoms. The medical records of patients with high jugular bulb and dehiscent high jugular bulb were analysed, and the clinical findings reviewed. Patients with dehiscent high jugular bulb were evaluated for hearing loss with pure tone audiometry. ...
Source: Journal of Laryngology and Otology - November 10, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Effects of two different local anaesthetic methods vs no anaesthesia on pain scores for intratympanic injections.
This study compared the pain associated with the intratympanic injection combined with various local anaesthetics vs without anaesthesia. METHODS: The study included 40 patients (aged 18-78 years) who received intratympanic steroid injections for sudden idiopathic hearing loss or tinnitus. Each patient underwent all three injection methods at one-week intervals. Patients received one of two local anaesthetics (lidocaine injection or lidocaine spray) or no anaesthesia before intratympanic injection, and used a visual analogue scale to indicate the pain level after 5 and 45 minutes. RESULTS: Five minutes after inject...
Source: Journal of Laryngology and Otology - November 10, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Long-Lasting forward Suppression of Spontaneous Firing in Auditory Neurons: Implication to the Residual Inhibition of Tinnitus
AbstractTinnitus is the perception of a sound that has no external source. Sound stimuli can suppress spontaneous firing in auditory neurons long after stimulus offset. It is unknown how changes in sound stimulus parameters affect this forward suppression. Using in vivo extracellular recording in awake mice, we found that about 40  % of spontaneously active inferior colliculus (IC) neurons exhibited forward suppression of spontaneous activity after sound offset. The duration of this suppression increased with sound duration and lasted about 40 s following a 30-s stimulus offset. Pure tones presented at the neuron...
Source: JARO - Journal of the Association for Research in Otolaryngology - November 9, 2016 Category: ENT & OMF Source Type: research

Cervical spine disorders and its association with tinnitus: The “TRIPLE” hypothesis
Subjective Tinnitus and cervical spine disorders (CSD) are among the most common complaints encountered by physicians. Although the relationship between tinnitus and CSD has attracted great interest during the past several years, the pathogenesis of tinnitus induced by CSD remains unclear. Conceivably, CSD could trigger a somatosensory pathway-induced disinhibition of dorsal cochlear nucleus (DCN) activity in the auditory pathway; furthermore, CSD can cause inner ear blood impairment induced by vertebral arteries hemodynamic alterations and trigeminal irritation. (Source: Medical Hypotheses)
Source: Medical Hypotheses - November 7, 2016 Category: Biomedical Science Authors: Bressi Federica, Manuele Casale, Papalia Rocco, Moffa Antonio, Di Martino Alberto, Miccinilli Sandra, Salvinelli Fabrizio, Denaro Vincenzo, Sterzi Silvia Source Type: research

Translabyrinthine vestibular neurectomy and simultaneous cochlear implant for M énière’s disease
ConclusionsIn our preliminary report, translabyrinthine vestibular nerve section and simultaneous cochlear implant showed encouraging results in order to definitively control both vestibular and cochlear symptoms during the same therapeutic procedure. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - November 3, 2016 Category: Neurosurgery Source Type: research

Lifetime leisure music exposure associated with increased frequency of tinnitus.
The objective measure of speech reception threshold had only a minimal relationship with tinnitus. Self-reported hearing difficulty was more strongly associated with tinnitus, but 76% of people reporting usual or constant tinnitus also reported little or no hearing difficulty. Overall, around 40% of participants of all ages reported never experiencing tinnitus, while 29% reported sometimes, usually or constantly experiencing tinnitus that lasted more than 5 minutes. Together, the results suggest that tinnitus is much more common than hearing loss, but that there is little association between the two, especially among the y...
Source: Hearing Research - November 3, 2016 Category: Audiology Authors: Moore DR, Zobay O, Mackinnon RC, Whitmer WM, Akeroyd MA Tags: Hear Res Source Type: research

Occult Pulsatile Tinnitus in Association with a Prominent Vein of Hypoglossal Canal: Two Case Reports.
We described 2 rare cases of troublesome pulsatile tinnitus associated with prominent vein of hypoglossal canal, which communicates with the jugular bulb and the marginal sinus. Both cases were successfully treated by positioning a stent across the vein of hypoglossal canal and jugular bulb. The 2 present clinical cases represent the first report of such a condition. The therapeutic decision-making is discussed in relation to the persistent pulsatile tinnitus and the etiopathologic hypothesis put forward. PMID: 27349391 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - November 3, 2016 Category: Neurosurgery Authors: Li B, Lv X, Wu Z, Cao X, Wang J, Ge A, Liu X, Li S Tags: Turk Neurosurg Source Type: research

First hearing-disorder drugs stumble
Nature Reviews Drug Discovery 15, 733 (2016). doi:10.1038/nrd.2016.222 Author: Katie Kingwell Clinical trial failures of two drugs for hearing loss and tinnitus underscore pitfalls for a nascent area of drug development, but lessons learned may help in navigating the uncharted path to approval. (Source: Nature Reviews Drug Discovery)
Source: Nature Reviews Drug Discovery - November 2, 2016 Category: Drugs & Pharmacology Authors: Katie Kingwell Tags: News and Analysis Source Type: research

Contralateral hearing loss and facial palsy in an operated case of vestibular schwannoma —Case report
Conclusion Hearing loss and facial palsy on the contralateral side after VS surgery is extremely rare. It is imperative that this rare complication should be considered following VS surgery. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - November 2, 2016 Category: Surgery Source Type: research

Rapid Positive Influence of Cochlear Implantation on the Quality of Life in Adults 70 Years and Older
The deteriorating ability to communicate has a negative impact on quality of life in the aging population. Cochlear implantation is increasingly used to treat hearing impairment and to restore the ability to communicate. Here, in a sample of 79 adults (70 years and older), we explored the effect of cochlear implantation on the health-related quality of life via the Nijmegen Cochlear Implant Questionnaire, auditory performance for speech recognition comparing scores on the Freiburg Monosyllabic Test and Oldenburg Inventory and tinnitus-related distress using the German version of the Tinnitus Questionnaire. We observed that...
Source: Audiology and Neurotology - November 2, 2016 Category: Audiology Source Type: research

Improving the Reliability of Tinnitus Screening in Laboratory Animals
This study introduces stimulus classification as an alternative approach to tinnitus screening. Classification procedures train animals to respond to the common perceptual features that define a group of sounds (e.g., high pitch or narrow bandwidth). Our procedure trains animals to drink when they hear tinnitus and to suppress drinking when they hear other sounds. Animals with tinnitus are revealed by their tendency to drink in the presence of unreinforced probe sounds that share the perceptual features of the tinnit us classification. The advantages of this approach are illustrated by taking laboratory rats through a test...
Source: JARO - Journal of the Association for Research in Otolaryngology - November 1, 2016 Category: ENT & OMF Source Type: research

Tympanic Membrane Perforation Caused by Thunderbolt Strike
In this report, a 43-year-old male patient with unilateral tympanic membrane perforation, tinnitus, and bilateral sensorineural hearing loss caused by thunderbolt strike is presented through a review of the literature. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - November 1, 2016 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Fractionated vs. single-fraction stereotactic radiotherapy in patients with vestibular schwannoma
ConclusionThese data confirm that RS and FSRT are comparable in terms of local control for VS. RS should be reserved for smaller lesions, while FSRT can be offered independently of tumor size. Patient self-reported outcome during follow-up is of high value. The established questionnaire could be validated in the independent cohort. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 31, 2016 Category: Cancer & Oncology Source Type: research

Clinical outcomes of middle fossa craniotomy for superior semicircular canal dehiscence repair.
CONCLUSIONS SSCD remains an underdiagnosed and undertreated condition. Surgical repair of SSCD using a middle fossa craniotomy is associated with a high rate of symptom resolution. Continued investigation using a larger patient cohort and longer-term follow-up could further demonstrate the effectiveness of using middle fossa craniotomy for SSCD repair. PMID: 26871374 [PubMed - in process] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - October 31, 2016 Category: Neurosurgery Authors: Chung LK, Ung N, Spasic M, Nagasawa DT, Pelargos PE, Thill K, Voth B, Hirt D, Gopen Q, Yang I Tags: J Neurosurg Source Type: research

Prevalence of tinnitus and noise-induced hearing loss in dentists.
CONCLUSION: Results from sound level measurements and questionnaire responses indicate that dentists are a population that could be placing their hearing health at risk in a typical daily work environment. PMID: 27991466 [PubMed - in process] (Source: Noise and Health)
Source: Noise and Health - October 31, 2016 Category: Audiology Authors: Myers J, John AB, Kimball S, Fruits T Tags: Noise Health Source Type: research

Evidence of activity-dependent plasticity in the dorsal cochlear nucleus, in  vivo, induced by brief sound exposure.
We examined the levels of multi- and single-unit spontaneous activity before and immediately following brief exposure (2 min) to tones at levels of either 109 or 85 dB SPL. Exposure frequency was selected to either correspond to the units' best frequency (BF) or fall within the borders of its inhibitory side band. The results demonstrate that these exposure conditions caused significant alterations in spontaneous activity and responses to BF tones. The induced changes have a fast onset (minutes) and are persistent for durations of at least 20 min. The directions of the change were found to depend on the freq...
Source: Hearing Research - October 31, 2016 Category: Audiology Authors: Gao Y, Manzoor N, Kaltenbach JA Tags: Hear Res Source Type: research

Quality of life at 6 months in the Idiopathic Intracranial Hypertension Treatment Trial
Conclusions: The marked reductions in baseline QOL seen among patients with mild visual loss from IIH are improved by treatment with acetazolamide. When combined with acetazolamide-associated improvements in visual field and other aspects of IIH, our findings with respect to QOL provide further support from the IIHTT in favor of acetazolamide to augment a dietary intervention in the treatment of IIH with mild visual loss (clinicaltrials.gov: NCT01003639). (Source: Neurology)
Source: Neurology - October 30, 2016 Category: Neurology Authors: Bruce, B. B., Digre, K. B., McDermott, M. P., Schron, E. B., Wall, M., On behalf of the NORDIC Idiopathic Intracranial Hypertension Study Group Tags: Idiopathic intracranial hypertension, Quality of life ARTICLE Source Type: research

Effects of long-term non-traumatic noise exposure on the adult central auditory system. Hearing problems without hearing loss.
Abstract It is known that hearing loss induces plastic changes in the brain, causing loudness recruitment and hyperacusis, increased spontaneous firing rates and neural synchrony, reorganizations of the cortical tonotopic maps, and tinnitus. Much less in known about the central effects of exposure to sounds that cause a temporary hearing loss, affect the ribbon synapses in the inner hair cells, and cause a loss of high-threshold auditory nerve fibers. In contrast there is a wealth of information about central effects of long-duration sound exposures at levels ≤ 80 dB SPL that do not even cause a temporary heari...
Source: Hearing Research - October 24, 2016 Category: Audiology Authors: Eggermont JJ Tags: Hear Res Source Type: research

Histopathology of Meniere ’s Disease
This study aims to perform an up-to-date review on Meniere’s Disease, focusing on histopathology, pathophysiology, genetics, and causative mechanisms. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - October 12, 2016 Category: ENT & OMF Authors: Sebahattin Cureoglu, Rafael da Costa Monsanto, Michael M. Paparella Source Type: research

Cochlear implantation in Meniere ’s disease
Meniere ’s disease (MD) is characterized by fluctuating hearing loss, episodic vertigo, tinnitus, and aural fullness. Whether secondary to intervention or to natural disease progression, a considerable subset of patients with MD has nonserviceable hearing in at least one ear. As such, cochlear implantatio n counseling and decision-making in the setting of MD must take into account the patient׳s surgical history. In patients who have undergone prior surgical labyrinthectomy, particular care must be taken in identifying the incus and facial nerve as the lateral semicircular canal has been removed. (Source: Operative T...
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - October 12, 2016 Category: ENT & OMF Authors: Jacob B. Hunter, Brendan P. O ׳Connell, David S. Haynes Source Type: research