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The Importance of Aging in Gray Matter Changes Within Tinnitus Patients Shown in Cortical Thickness, Surface Area and Volume.
This study explores the structural changes of gray matter using surface base methods and focuses more specifically on changes in cortical thickness in 127 tinnitus patients. The linear relationships between cortical thickness and behavioral measures including aging, tinnitus loudness, tinnitus duration, tinnitus distress, and hearing loss were analyzed. Three dimensional T1-weighted MR images were acquired and cortical gray matter volumes were segmented using FreeSurfer on Talairach space. The results showed that cortical thickness and volume are negatively correlated to age in widespread regions of frontal cortices, and p...
Source: Brain Topography - August 9, 2016 Category: Neuroscience Authors: Yoo HB, De Ridder D, Vanneste S Tags: Brain Topogr Source Type: research

Different infusion durations for preventing platinum-induced hearing loss in children with cancer.
CONCLUSIONS: Since only one eligible RCT evaluating the use of a continuous cisplatin infusion versus a one-hour bolus cisplatin infusion was found, and that had methodological limitations, no definitive conclusions can be made. It should be noted that 'no evidence of effect', as identified in this review, is not the same as 'evidence of no effect'. For other (combinations of) infusion durations and other platinum analogues no eligible studies were identified. More high quality research is needed. PMID: 27498707 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - August 7, 2016 Category: Journals (General) Authors: van As JW, van den Berg H, van Dalen EC Tags: Cochrane Database Syst Rev Source Type: research

The Role of Trace Elements in Tinnitus.
In this study, we aimed to investigate the role of three trace elements, namely, zinc, copper, and lead, in tinnitus by analyzing the serum level of copper and lead and both the serum and tissue level of zinc. Eighty patients, who applied to outpatient otolaryngology clinic with the complaints of having tinnitus, and 28 healthy volunteers were included. High-frequency audiometry was performed, and participants who had hearing loss according to the pure tone average were excluded; tinnitus frequency and loudness were determined and tinnitus reaction questionnaire scores were obtained from the patients. Of all the participan...
Source: Biological Trace Element Research - August 7, 2016 Category: Biology Authors: Yaşar M, Şahin Mİ, Karakükçü Ç, Güneri E, Doğan M, Sağıt M Tags: Biol Trace Elem Res Source Type: research

EP 50. High frequency stimulation of the rat dorsal cochlear nucleus inhibits tinnitus
Tinnitus can cause a serious burden on patients and remains often treatment-resistant. Up to date no standard effective treatment is available. Deep brain stimulation (DBS) has been widely applied for various neurological disorders, most often in patients with Parkinson ’s disease. There is growing evidence that deep brain stimulation might be able to interrupt the local altered neuronal activity found in tinnitus and hereby inhibit tinnitus perception. Multiple preclinical and clinical studies suggest that the dorsal cochlear nucleus (DCN) plays an important rol e in the development of tinnitus and could therefore b...
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: G. van Zwieten, J. Smit, A. Jahanshahi, R. Stokroos, Y. Temel Source Type: research

Tinnitus- related distress: evidence from fMRI of an emotional stroop task
Chronic tinnitus affects 5  % of the population, 17 % suffer under the condition. This distress seems mainly to be dependent on negative cognitive-emotional evaluation of the tinnitus and selective attention to... (Source: BMC Ear, Nose and Throat Disorders)
Source: BMC Ear, Nose and Throat Disorders - August 5, 2016 Category: ENT & OMF Authors: Dennis Golm, Carsten Schmidt-Samoa, Peter Dechent and Birgit Kr öner-Herwig Source Type: research

Demographic data, referral patterns and interventions used for children and adolescents with tinnitus and hyperacusis in Denmark
To investigate whether children and adolescents with tinnitus and/or hyperacusis are seen in Ear-Nose-Throat (ENT) clinics and to report the clinical data, treatment and referral patterns of these children. To describe the population of children and adolescents with tinnitus and/or hyperacusis found in Educational- Psychological Advisory services (EPAs) and Centres for special Education for Adults (CEAs) and to identify the referral patterns and interventions used for the children in each of these settings. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - August 4, 2016 Category: ENT & OMF Authors: Susanne Nemholt Rosing, Anestis Kapandais, Jesper Hvass Schmidt, David M. Baguley Source Type: research

Intratympanic corticosteroids injections: a systematic review of literature
The objective of the study was to determine the evidence of intratympanic steroids injections (ITSI) for efficacy in the management of the following inner ear diseases: M énière’s disease, tinnitus, noise-induced hearing loss (NIHL) and idiopathic sudden sensorineural hearing loss (ISSNHL). The data sources were literature review from 1946 to December 2014, PubMed and Medline. A systematic review of the existing literature was performed. Databases were searched f or all human prospective randomized clinical trials using ITSI in at least one treatment group. The authors identified 29 prospective randomiz...
Source: European Archives of Oto-Rhino-Laryngology - August 4, 2016 Category: ENT & OMF Source Type: research

A case series of a magnetic bone conduction hearing implant.
The objective of the study was to retrospectively review the postoperative outcomes of patients from a single centre who were implanted with a magnetic bone conduction hearing implant system. The medical and audiological case notes of all patients (n = 34) in a tertiary referral centre ENT department who had been implanted with a Baha® 4 Attract System between October 2013 and April 2015 were reviewed retrospectively. The main outcome measures were use of the aid and complications from implantation or use of the aid. Results indicated that 23 patients had no significant postoperative problems; 5 required an alteration ...
Source: Annals of the Royal College of Surgeons of England - August 3, 2016 Category: Surgery Authors: Reddy-Kolanu R, Gan R, Marshall AH Tags: Ann R Coll Surg Engl Source Type: research

Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer [Treatment-Related Complications]
Purpose Cisplatin is widely used but highly ototoxic. Effects of cumulative cisplatin dose on hearing loss have not been comprehensively evaluated in survivors of adult-onset cancer. Patients and Methods Comprehensive audiological measures were conducted on 488 North American male germ cell tumor (GCT) survivors in relation to cumulative cisplatin dose, including audiograms (0.25 to 12 kHz), tests of middle ear function, and tinnitus. American Speech-Language-Hearing Association criteria defined hearing loss severity. The geometric mean of hearing thresholds (0.25 to 12 kHz) summarized overall hearing status consistent wi...
Source: Journal of Clinical Oncology - August 2, 2016 Category: Cancer & Oncology Authors: Frisina, Wheeler, Fossa, Kerns, Fung, Sesso, Monahan, Feldman, Hamilton, Vaughn, Beard, Budnick, Johnson, Ardeshir-Rouhani-Fard, Einhorn, Lipshultz, Dolan, Travis Tags: Chemotherapy, Outcomes Research Treatment-Related Complications Source Type: research

Does stapes surgery improve tinnitus in patients with otosclerosis?
Conclusion Low pitch tinnitus is more likely to be resolved after stapedotomy for patients with otosclerosis. High pitch tinnitus may not resolve even after closure of the Air-Bone Gap at tinnitus frequencies. (Source: Brazilian Journal of Otorhinolaryngology)
Source: Brazilian Journal of Otorhinolaryngology - August 2, 2016 Category: ENT & OMF Source Type: research

Platinum-induced hearing loss after treatment for childhood cancer.
CONCLUSIONS: This systematic review shows that children treated with platinum analogues are at risk for developing hearing loss, but the exact prevalence and risk factors remain unclear. There were no data available for tinnitus. Based on the currently available evidence we can only advise that children treated with platinum analogues are screened for ototoxicity in order to make it possible to diagnose hearing loss early and to take appropriate measures. However, we are unable to give recommendations for specific follow-up protocols including frequency of testing. Counselling regarding the prevention of noise pollution ca...
Source: Cochrane Database of Systematic Reviews - August 2, 2016 Category: Journals (General) Authors: van As JW, van den Berg H, van Dalen EC Tags: Cochrane Database Syst Rev Source Type: research

Annie Award Recognizes Hearing Education Awareness for Rockers
Hearing Education Awareness for Rockers (HEAR), a nonprofit organization dedicated to “the prevention of hearing loss and tinnitus among musicians, other music professionals, and all music fans (especially teens and young adults) through education and grass-roots advocacy,” will receive ASHA’s 2016 Annie Glenn Award. (Source: The ASHA Leader Online)
Source: The ASHA Leader Online - August 1, 2016 Category: Speech Therapy Source Type: research

The Tinnitus-Traumatic Brain Injury Link: What is the role of the audiologist in patient care, treatment and coping strategies?
(Source: The ASHA Leader Online)
Source: The ASHA Leader Online - August 1, 2016 Category: Speech Therapy Source Type: research

Analysis of Outcome Domains in Adult Cochlear Implantation: A Systematic Review
Conclusions An analysis of randomized controlled trials studying cochlear implantation in adults yielded a wide spectrum of outcome domains. This is the first study to comprehensively describe the breadth of outcome domains in adult cochlear implantation. Validated instruments from these domains could be considered for potential inclusion as quality measures and registry use. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - July 31, 2016 Category: ENT & OMF Authors: Vila, P. M., Hullar, T. E., Buchman, C. A., Lieu, J. E. C. Tags: Review Articles Source Type: research

The Persistence of Tinnitus after Acoustic Neuroma Surgery
Objective Examine possible prognostic factors for the persistence of tinnitus after acoustic neuroma resection. Study Design Case series with chart review. Setting Tertiary academic medical center. Subjects and Methods The records of 166 patients who underwent acoustic neuroma resection from 2009 to 2014 were reviewed. Patients were asked to complete a survey, including the Tinnitus Handicap Inventory, 1 to 6 years postoperatively. Results Of the 53 patients who completed the survey, 17% reported that their tinnitus resolved; 9% reported improvement; 23% reported no change; 43% reported that their tinnitus worsened; an...
Source: Otolaryngology - Head and Neck Surgery - July 31, 2016 Category: ENT & OMF Authors: Bell, J. R., Anderson-Kim, S. J., Low, C., Leonetti, J. P. Tags: Otology and Neurotology Source Type: research

Evidence of activity-dependent plasticity in the dorsal cochlear nucleus, in  vivo, induced by brief sound exposure.
We examined the levels of multi- and single-unit spontaneous activity before and immediately following brief exposure (2 min) to tones at levels of either 109 or 85 dB SPL. Exposure frequency was selected to either correspond to the units' best frequency (BF) or fall within the borders of its inhibitory side band. The results demonstrate that these exposure conditions caused significant alterations in spontaneous activity and responses to BF tones. The induced changes have a fast onset (minutes) and are persistent for durations of at least 20 min. The directions of the change were found to depend on the freq...
Source: Hearing Research - July 31, 2016 Category: Audiology Authors: Gao Y, Manzoor N, Kaltenbach JA Tags: Hear Res Source Type: research

Effects on auditory function of chronic exposure to electromagnetic fields from mobile phones.
Abstract The widespread use of mobile phones has given rise to apprehension regarding the possible hazardous health effects of high-frequency electromagnetic fields (EMFs) on auditory function. We conducted a study to investigate the effects of long-term (>4 yr) exposure to EMFs emitted by mobile phones on auditory function. Our study population was made up of 40 healthy medical students-31 men and 9 women, aged 20 to 30 years (mean 22.7). Of this group, 31 subjects typically held their phone to the right ear and 9 to the left ear; the non-phone-using ear served as each subject's control ear. The phone-using su...
Source: Ear, Nose and Throat Journal - July 31, 2016 Category: ENT & OMF Authors: Bhagat S, Varshney S, Bist SS, Goel D, Mishra S, Jha VK Tags: Ear Nose Throat J Source Type: research

When alarm bells ring: emergency tinnitus.
CONCLUSIONS: Tinnitus, mainly linked to loss of hearing, is a frequent symptom among the population at large. About 7% of those affected by tinnitus turn to their doctor to solve their problem, while between 0.5 and 2% request urgent medical assistance. Their cry for help may be the result of an acute onset of tinnitus or the rapid impairment of an already chronic condition. Tinnitus is not considered an urgent ear, nose and throat (ENT) condition by the Associazione Otorinolaringologi Ospedalieri Italiani (AOOI) [Italian Association of Hospital ENT], even though there are many pathological conditions, sometimes serious, a...
Source: European Review for Medical and Pharmacological Sciences - July 29, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

O-032 Venous Blood Flow Visualization in Sigmoid Sinus Diverticulum Using MRI
ConclusionPT caused by SSD may be caused by a unique flow pattern in the SSD and sinuses as visualized on both MRV and CFD.Abstract O-032 Figure 1Townes projection CFD analysis of a patient with a left SSD and an upstream stenosis in the transverse sinus. The pretreatment analysis (A) shows a jet of flow from the stenosis into the SSD (arrow), vortex of flow in the SSD (double arrow), and a vortex component of flow in the sigmoid sinus down-stream from the SSD (arrow head). The post-treatment model (B) shows absence of the flow in the SSD as well as decreased vortex component of flow in down-stream sigmoid sinusDisclosures...
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Amans, M., Kao, E., Kefayati, S., Meisel, K., Faraji, F., Glastonbury, C., Ballweber, M., Halbach, V., Saloner, D. Tags: Oral abstracts Source Type: research

O-033 Jugular Vein Flow Patterns in Patients with Pulsatile Tinnitus Using Computational Fluid Dynamics
ConclusionThe geometry of the jugular vein significantly affects the position, size, and length of the vortex cores. Our results suggest a link between geometry, flow, and PT.Abstract O-033 Figure 1Visualization of streamlines (A, B) and vortex cores by swirling strength (C, D) in internal jugular veins of subjects without (A, C) and with (B, D) PT. White arrows (A, B) reperent the general re-direction of flow from the sigmoid sinus into the jagular vein as dictated by the shape of the junction with the jugular bulb (red lines). Subjects without PT have strong vortex cores in jugular bulb (C, red arrows), while those with ...
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Kao, E., Kefayati, S., Meisel, K., Ballweber, M., Faraji, F., Halbach, V., Saloner, D., Amans, M. Tags: Oral abstracts Source Type: research

P-024 Prominent Condylar Veins Causing Pulsatile Tinnitus: Dynamic Angiographic Confirmation
ConclusionProminent flow in condylar veins should be considered among the numerous causes of PT. This may be a frequent cause of these symptoms in patients who previously would have had no identifiable cause Further investigation is warranted with respect to this cause of PT and PT in general.DisclosuresM. Alexander: None. K. Meisel: None. V. Halbach: None. R. Darflinger: None. A. Nicholson: None. F. Settecase: None. D. Cooke: None. R. Higashida: None. C. Dowd: None. S. Hetts: None. M. Amans: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Alexander, M., Meisel, K., Halbach, V., Darflinger, R., Nicholson, A., Settecase, F., Cooke, D., Higashida, R., Dowd, C., Hetts, S., Amans, M. Tags: Oral poster abstracts Source Type: research

P-029 Turbulent Flow in the Venous Outflow Tract of Pulsatile Tinnitus Patients with Sigmoid Sinus Diverticulum
ConclusionThe unique flow patterns and the presence of turbulence introduced by the TSS and SSD may help explain PT in these patients. Treatment of TSS with PTA and stent implantation, or treatment of the SSD with coil embolization can potentially alter the TKE level and pattern.DisclosuresS. Kefayati: None. E. Kao: None. J. Liu: None. H. Haraldsson: None. F. Faraji: None. M. Ballweber: None. K. Meisel: None. V. Halbach: None. D. Saloner: None. M. Amans: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Kefayati, S., Kao, E., Liu, J., Haraldsson, H., Faraji, F., Ballweber, M., Meisel, K., Halbach, V., Saloner, D., Amans, M. Tags: Oral poster abstracts Source Type: research

E-008 Patient Outcomes Following Treatment of High Flow Vascular Lesions of the Anterior Cranial Fossa and Orbit
ConclusionsHFVL are uncommon lesions that are challenging to treat. Endovascular embolization alone or in combination with surgery results in HFVL obliteration in 50% of patients with an acceptable safety profile. Further studies should determine whether radiosurgery alone or in combination with endovascular embolization results in high rates of HFVL cure.Abstract E-008 Figure 1DisclosuresA. Moraff: None. R. Dodd: None. M. Marks: None. H. Do: None. G. Steinberg: None. S. Chang: None. J. Heit: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Moraff, A., Dodd, R., Marks, M., Do, H., Steinberg, G., Chang, S., Heit, J. Tags: Electronic poster abstracts Source Type: research

E-009 A Novel Transvenous Approach to Embolization of an Extensive Transverse and Sigmoid Sinus DAVM in a Patient with an Occluded Ipsilateral Internal Jugular Vein
We describe the case of a patient who presented with left-sided pulsatile tinnitus. Initial cerebral angiogram demonstrated an extensive DAVM of the left transverse and sigmoid sinuses being supplied primarily by branches of the left internal carotid, middle meningeal, and occipital arteries and the right occipital artery. We also observed cortical venous reflux compatible with venous hypertension. Given the extensive arterial supply, a transvenous approach to treatment was chosen. Upon attempted catheterization of the left internal jugular vein (IJ), we discovered that it was occluded up to the level of its junction with ...
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Adix, M., Choi, I., Kaminsky, I. Tags: Electronic poster abstracts Source Type: research

An electromyography guided botulinum toxin injection is effective treatment for objective tinnitus as an office procedure: A case report
We present a case of pulsatile tinnitus who was effectively treated with BTX injection under an electromyography guidance as an office procedure. (Source: Egyptian Journal of Ear, Nose, Throat and Allied Sciences)
Source: Egyptian Journal of Ear, Nose, Throat and Allied Sciences - July 27, 2016 Category: ENT & OMF Source Type: research

Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling
Publication date: Available online 26 July 2016 Source:Molecular and Cellular Neuroscience Author(s): Senthilvelan Manohar, Kimberly Dahar, Henry J. Adler, Ding Dalian, Richard Salvi Severe noise-induced damage to the inner ear leads to auditory nerve fiber degeneration thereby reducing the neural input to the cochlear nucleus (CN).Paradoxically, this leads to a significant increase in spontaneous activity in the CN which has been linked to tinnitus, hyperacusis and ear pain.The biological mechanisms that lead to an increased spontaneous activity are largely unknown, but could arise from changes in glutamatergic or ...
Source: Molecular and Cellular Neuroscience - July 25, 2016 Category: Neuroscience Source Type: research

Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases
Conclusion In our sample of patients with sudden SNHL, the prevalence of SAD was found relevant. The majority had tinnitus and dizziness concomitant hearing loss, unilateral involvement and had experienced profound hearing loss at the time of the installation. In spite of instituted treatment, most cases showed no improvement in audiometric thresholds. Apparently, patients with sudden SNHL and SAD have a more severe initial impairment, higher percentage of bilateral, lower response to treatment, and worse prognosis than patients with sudden SNHL of unknown etiology.[...]Thieme Publicações Ltda Rio de Jan...
Source: International Archives of Otorhinolaryngology - July 25, 2016 Category: ENT & OMF Authors: Rossini, Bruno Almeida Antunes Penido, Norma de Oliveira Munhoz, Mario Sergio Lei Bogaz, Eduardo Amaro Curi, Renata Souza Tags: Original Research Source Type: research

Reliability and validity of the Lithuanian Tinnitus Handicap Inventory
Conclusions The results suggest that the Lithuanian version of THI maintains its original validity and may serve as reliable and valid measure of general tinnitus related distress that can be used in a clinical setting to quantify the impact of tinnitus on daily living. (Source: Medicina)
Source: Medicina - July 22, 2016 Category: Journals (General) Source Type: research

The effect of intratympanic gentamicin for treatment of M énière’s disease on lower frequency hearing
Conclusion Our results indicate that intratympanic gentamicin especially affects the mean pure tone audiometry threshold in the low frequency range, which may have clinical implications. Though many of our results are (statistically) substantial the study was limited by the small cohort size. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - July 21, 2016 Category: Drugs & Pharmacology Source Type: research

Prevalence, Severity, Exposures, and Treatment Patterns of Tinnitus
This cross-sectional study quantifies the prevalence of tinnitus and describes the epidemiologic features of tinnitus in a nationally representative sample of US adults. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - July 21, 2016 Category: ENT & OMF Source Type: research

Growth rate of vestibular schwannoma
Publication date: Available online 20 July 2016 Source:Journal of Clinical Neuroscience Author(s): Iddo Paldor, Annie S. Chen, Andrew H. Kaye Vestibular schwannoma (VS) is the most common tumor in the extra-axial posterior fossa compartment in adults. Growth rate is paramount to decision making regarding treatment and follow up of these tumors. We conducted a comprehensive review of the literature to answer four questions: What percentage of newly diagnosed VS will grow on follow-up? What factors correlate to tumor growth? What is the “normal” growth rate for sporadic VS? What factors characterize VS with ...
Source: Journal of Clinical Neuroscience - July 20, 2016 Category: Neuroscience Source Type: research

Poszczepienne gru źlicze zapalenie ucha środkowego i jego powikłania – opis przypadku
Conclusion This case reminds us that correct diagnosis of tuberculosis remains a serious problem despite the long experience and the development of diagnostics and treatment methods. Nowadays we observe the unusual clinical manifestations of the disease (e.g. such as ear pain, tinnitus, rapid hearing loss) more frequently. (Source: Otolaryngologia Polska)
Source: Otolaryngologia Polska - July 20, 2016 Category: ENT & OMF Source Type: research

Tinnitus —More Than Ringing in the Ears
Publication date: May 2016 Source:Neuroimaging Clinics of North America, Volume 26, Issue 2 Author(s): Prashant Raghavan, Dheeraj Gandhi (Source: Neuroimaging Clinics of North America)
Source: Neuroimaging Clinics of North America - July 20, 2016 Category: Radiology Source Type: research

Botulinum Toxin Treatment of Objective Tinnitus Because of Essential Palatal Tremor: A Systematic Review
Conclusions: The included studies suffer from an extremely low evidence level with several sources of bias. When optimally injected, BT seems to be an effective treatment of objective tinnitus due to EPT, with few adverse effects and complications. We suggest BT injections as first choice in case of EPT and present a guideline regarding diagnostics, treatment, and follow-up. (Source: Otology and Neurotology)
Source: Otology and Neurotology - July 19, 2016 Category: ENT & OMF Tags: Review Articles Source Type: research

Focal Endolymphatic Hydrops as Seen in the Pars Inferior of the Human Inner Ear
Conclusions: Endolymphatic hydrops of the pars inferior in the human may have a focal distribution. This study suggests that the pathogenesis of endolymphatic hydrops is unlikely to be because of distal obstruction of longitudinal flow and was more consistent with the hypothesis that homeostasis of the endolymphatic and perilymphatic volumes occurs all along the cochlear duct. Other factors including variable distensibility of Reissner's membrane or disturbance of local solute homeostatic mechanisms may be responsible for wide variations in the degree of hydrops. A focal inflammatory process during life may be one cause of...
Source: Otology and Neurotology - July 19, 2016 Category: ENT & OMF Tags: Sensorineural Hearing Loss & Tinnitus Source Type: research

Tumor Necrosis Factor-induced Decrease of Cochlear Blood Flow Can Be Reversed by Etanercept or JTE-013
This study aimed to quantify the effects of tumor necrosis factor (TNF) inhibitor Etanercept and sphingosine-1-phosphate receptor 2 antagonist JTE-013 on cochlear blood flow in guinea pigs after TNF-induced decrease. Background: Sudden sensorineural hearing loss is a common cause for disability and reduced quality of life. Good understanding of the pathophysiology and strong evidence-based therapy concepts are still missing. In various inner ear disorders, inflammation and impairment of cochlear blood flow (CBF) have been considered factors in the pathophysiology. A central mediator of inflammation and microcirculation in...
Source: Otology and Neurotology - July 19, 2016 Category: ENT & OMF Tags: Sensorineural Hearing Loss & Tinnitus Source Type: research

Cochlear Implant Impedance Fluctuation in Ménière's Disease: A Case Study
Conclusion: Electrode impedances in the ear with MD showed a variation pattern similar to that found in the hearing fluctuation characteristic of the disease. These findings raise the possibility that the same physiological mechanisms of hearing fluctuation may be responsible for intracochlear electrode impedance changes. We hypothesize that impedance fluctuation is because of changes in the permeability of the blood–labyrinth barrier because of cyclic immune activity in the inner ear which alters the electrical resistance between scala tympani and blood. (Source: Otology and Neurotology)
Source: Otology and Neurotology - July 19, 2016 Category: ENT & OMF Tags: Cochlear Implants Source Type: research

Transient Hearing Loss and Objective Tinnitus Induced by Mouth Opening: A Rare Connection Between the Temporomandibular Joint and Middle Ear Space
Conclusions: Although an influence of temporomandibular disorder (TMD) on tinnitus perception has been debated, whether this association is causal or fortuitous has remained contentious. The present case showed a unique feature of tinnitus attributed to a connection between the mandibular fossa and middle ear space. (Source: Otology and Neurotology)
Source: Otology and Neurotology - July 19, 2016 Category: ENT & OMF Tags: Middle Ear and Mastoid Disease Source Type: research

Tinnitus Treatment Trends
Conclusion: Opinions regarding the treatment of tinnitus vary considerably. The AAO-HNS clinical practice guideline: tinnitus has not significantly altered the practices of otologists, but the guidelines provide meaningful, important information for other clinicians who deal infrequently with tinnitus. (Source: Otology and Neurotology)
Source: Otology and Neurotology - July 19, 2016 Category: ENT & OMF Tags: Medical Neurotology Source Type: research

Chapter 46 Vertigo and hearing loss
Publication date: 2016 Source:Handbook of Clinical Neurology, Volume 136 Author(s): David E. Newman-Toker, Charles C. Della Santina, Ari M. Blitz Symptoms referable to disorders affecting the inner ear and vestibulocochlear nerve (eighth cranial nerve) include dizziness, vertigo, tinnitus, and hearing loss, in various combinations. Similar symptoms may occur with involvement of the central nervous system, principally the brainstem and cerebellum, to which the vestibular and auditory systems are connected. Imaging choices should be tailored to patient symptoms and the clinical context. Computed tomography (CT) should b...
Source: Handbook of Clinical Neurology - July 16, 2016 Category: Neurology Source Type: research

Frequency-Dependent Neural Activity in Patients with Unilateral Vascular Pulsatile Tinnitus.
Abstract Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies have shown that neurological changes are important findings in vascular pulsatile tinnitus (PT) patients. Here, we utilized rs-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) in forty patients with unilateral PT and forty age-, gender-, and education-matched normal control subjects. Two different frequency bands (slow-4, 0.027-0.073 Hz, and slow-5, 0.010-0.027 Hz, which are more sensitive to subcortical and cortical neurological signal changes, resp.) were analyzed to examine the intrinsic brain...
Source: Neural Plasticity - July 16, 2016 Category: Neurology Authors: Lv H, Zhao P, Liu Z, Wang G, Zeng R, Yan F, Dong C, Zhang L, Li R, Wang P, Li T, Gong S, Wang Z Tags: Neural Plast Source Type: research

Cognitive Evaluation and Quality of Life Assessment in Patients with Subjective Tinnitus.
Authors: Dağ E, Bayar Muluk N, Karabiçak H, Kürşat Arikan O, Türkel Y PMID: 27411793 [PubMed - in process] (Source: Acta Neurologica Taiwanica)
Source: Acta Neurologica Taiwanica - July 16, 2016 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Electrical Stimulation of the Ear, Head, Cranial Nerve, or Cortex for the Treatment of Tinnitus: A Scoping Review.
Abstract Tinnitus is defined as the perception of sound in the absence of an external source. It is often associated with hearing loss and is thought to result from abnormal neural activity at some point or points in the auditory pathway, which is incorrectly interpreted by the brain as an actual sound. Neurostimulation therapies therefore, which interfere on some level with that abnormal activity, are a logical approach to treatment. For tinnitus, where the pathological neuronal activity might be associated with auditory and other areas of the brain, interventions using electromagnetic, electrical, or acoustic st...
Source: Neural Plasticity - July 14, 2016 Category: Neurology Authors: Hoare DJ, Adjamian P, Sereda M Tags: Neural Plast Source Type: research

Stent-Assisted Coil Embolization of a Transverse-Sigmoid Sinus Diverticulum Presenting with Pulsatile Tinnitus.
We present a case of persistent and troublesome pulsatile tinnitus caused by a transverse-sigmoid sinus diverticulum that was endovascularly treated with stent-assisted coiling. A 39-yearold woman presented with a 4-year history of progressive pulsatile tinnitus involving the right ear. Slight pulsatile bruit was heard on the right mastoid bone by auscultation. Cerebral angiography demonstrated a diverticulum of the transverse-sigmoid sinus. The procedure was performed with an 8F guiding catheter (Cordis, USA) catheterized into the right sigmoid sinus. The diverticulum was completely coiled following deployment of a 5.5 mm...
Source: Turkish Neurosurgery - July 12, 2016 Category: Neurosurgery Authors: Li B, Lv X, Wu Z, Cao X, Wang J, Ge A, Liu X, Li S Tags: Turk Neurosurg Source Type: research

Concentration‐Response Relationship of Hearing Impairment Caused by Quinine and Salicylate: Pharmacological Similarities but different molecular mechanisms
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - July 10, 2016 Category: Drugs & Pharmacology Authors: Gunnar Alvan, Erik Berninger, Lars L. Gustafsson, Kjell K. Karlsson, Gilles Paintaud, Monique Wakelkamp Tags: Mini ‐Review Source Type: research

Concentration ‐Response Relationship of Hearing Impairment Caused by Quinine and Salicylate: Pharmacological Similarities but different molecular mechanisms
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - July 10, 2016 Category: Drugs & Pharmacology Authors: Gunnar Alvan, Erik Berninger, Lars L. Gustafsson, Kjell K. Karlsson, Gilles Paintaud, Monique Wakelkamp Tags: Mini ‐Review Source Type: research

Possible Familial Presentation in Two Siblings with Carotid Fibromuscular Dysplasia.
Authors: Topal H, Lemmens R, Fourneau I Abstract Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory vascular disease which can affect the cervical, renal and visceral arteries. Here we report on two sisters diagnosed with carotid FMD at the same age, presenting with similar symptoms of pulsating tinnitus. The familial presentation of this rare disorder attracted our attention and was suggestive of a genetic etiology. Conservative treatment with aspirin was initiated. Carotid FMD is a rare disorder of which the exact pathophysiology is not known. A review of the literature on the clinical present...
Source: Acta Chirurgica Belgica - July 10, 2016 Category: Surgery Tags: Acta Chir Belg Source Type: research

Diazepam reduces excitability of amygdala and further influences auditory cortex following sodium salicylate treatment in rats.
CONCLUSION: Diazepam can reduce the excitability of lateral amygdala and eventually suppress the excitability of the auditory cortex in rats following salicylate treatment, indicating the regulating effect of lateral amygdala to the auditory cortex in the tinnitus procedure. OBJECTIVE: To study the spontaneous firing rates (SFR) of the auditory cortex and lateral amygdala regulated by diazepam in the tinnitus rat model induced by sodium salicylate. MATERIALS AND METHODS: This study first created a tinnitus rat modal induced by sodium salicylate, and recorded SFR of both auditory cortex and lateral amygdala. Then ...
Source: Acta Oto-Laryngologica - July 7, 2016 Category: ENT & OMF Authors: Song Y, Liu J, Ma F, Mao L Tags: Acta Otolaryngol Source Type: research

Anxiety and depression, personality traits relevant to tinnitus: A scoping review
10.1080/14992027.2016.1198966Mithila Durai (Source: International Journal of Audiology)
Source: International Journal of Audiology - July 6, 2016 Category: Audiology Authors: Mithila DuraiGrant Searchfield Source Type: research

Contemporary Neuroradiographic Assessment of the Cochleo-Carotid Partition
Purpose: The cochleo-carotid partition (CCP) describes the intimate anatomic relationship between the petrous carotid artery and the cochlear basal turn. This partition bears significant surgical and unique clinical relevance. The purpose of this paper is to radiographically assess the CCP and discuss its clinical implications. Methods: A total of 155 consecutive fine-cut temporal bone CT scans were retrospectively reviewed, and study scans were digitally analyzed in both axial and coronal views. The shortest distance between the petrous carotid canal and the cochlear basal turn was measured. Results: In all, 310 temporal ...
Source: ORL - July 6, 2016 Category: ENT & OMF Source Type: research