What do you call fluid collection around the heart?
Pericardial effusion is collection of fluid within the layers covering the heart. Pericardium is the covering of the heart. It has an inner layer and an outer layer. Fluid collects in between these layers in certain disease conditions and compresses the heart. If the amount of fluid is large or there is a rapid increase in the rate of fluid collection, the compression of the heart prevents its proper filling. An unfilled heart is not able to pump out blood well and the blood pressure falls. This serious condition is known as cardiac tamponade.
Cardiac tamponade needs urgent removal of fluid from the pericardial cavity by n...
Source: Cardiophile MD - April 25, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Questions grow about the validity and usefulness of direct-to-consumer blood tests for Alzheimer ’s Disease
For the first time, people worried about their risk of Alzheimer’s disease can go online, order a blood test, and receive results in the privacy of their homes.
This might seem appealing on the surface, but the development has Alzheimer’s researchers and clinicians up in arms.
The Quest Diagnostics blood test, AD-Detect, measures elevated levels of amyloid-beta proteins, a signature characteristic of Alzheimer’s. Introduced in late July, the test is targeted primarily at people 50 and older who suspect their memory and thinking might be impaired and people with a family history of Alzheimer’s or genetic risks for t...
Source: SharpBrains - October 19, 2023 Category: Neuroscience Authors: Judith Graham at Kaiser Health News Tags: Brain/ Mental Health AD-Detect Alzheimer’s Alzheimer’s biomarker amyloid-beta proteins brain health brain pathology cognitive cognitive-symptoms mini-strokes neurology neuropsychologist Quest Diagnostics sleep apnea Source Type: blogs
AI ’s role in Healthcare: Exclusive Interview with Catherine Estrampes, President & CEO at GE Healthcare
AI is increasingly being used in healthcare to reduce clinician workloads and improve patient outcomes. AI-driven technologies are helping to automate mundane tasks, freeing up clinicians to focus on more complex clinical decisions. AI-powered tools can also help identify patterns in medical data that can lead to faster diagnoses and better patient outcomes.
From the perspective of low hanging fruit, AI can be used to automate tedious administrative tasks such as scheduling appointments, updating medical records, or processing paperwork, saving clinicians time allow them to devote more of their efforts to direct p...
Source: Medgadget - May 3, 2023 Category: Medical Devices Authors: Alice Ferng Tags: Exclusive Informatics AI medicine GEHealthCare Source Type: blogs
So Much to Do, So Little Selenium Needed
You may know that antioxidants can help protect your cells from oxidative damage, but do you know about selenium—an element often found in special proteins called antioxidant enzymes? Selenium is essential to your body, which means you must get it from the food you eat. But it’s a trace element so you only need a small amount to benefit from its effects. In addition to its antioxidant properties, it’s also important for reproduction, DNA synthesis, and hormone metabolism.
In our bodies, selenium works in antioxidant enzymes to help protect us from oxidative damage. The element is also found in antidandruf...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 21, 2022 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Molecular Structures Cellular Processes Proteins Source Type: blogs
Stop calling it the good cancer
“You have the good cancer.” These are the most common words that spill out of providers’ mouths to patients just being diagnosed with papillary thyroid cancer. However, this statement does not make this diagnosis any easier to comprehend and digest the life-altering news that has been received by the patient. The survivability rate for this
Read more…
Stop calling it the good cancer originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 28, 2022 Category: General Medicine Authors: Tresia Rouse, RN Tags: Conditions Oncology/Hematology Source Type: blogs
Mining Ultrasound Data to Improve Liver Diagnostics: Interview with Beth Rogozinski, CEO at Oncoustics
Oncoustics, a medtech company based in Ontario, Canada, developed the OnX Liver Assessment Solution, an AI-powered ultrasound-based diagnostic system for liver disease. At present, detecting liver disease is a challenge, potentially involving high-end imaging systems, specialists, and invasive biopsies. These challenges, and the related expense, can limit patient access to such testing for those with strong indications of liver disease.
Consequently, in many cases, liver disease may not be detected until it is already quite advanced, limiting the potential for early detection and treatment. There is a clear need for a n...
Source: Medgadget - August 23, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Oncology Radiology liver disease oncoustics Source Type: blogs
Oncoustics Closes New Funding to Advance its AI Innovations in Ultrasound and Address Huge Unmet Clinical Needs in Liver Disease
Oncoustics’ SaMD Works on Any Ultrasound System Making AI-Driven Diagnostics, Surveillance and Treatment Monitoring Available and Accessible at Point of Care
Oncoustics (http://www.oncoustics.com), the leader in ultrasound-based tissue characterization solutions announces the initial close of a $5 million+ seed round of funding to advance its SaMD (software as a medical device) technology for the low-cost assessment of structural diseases at point of care. Oncoustics’ first products will focus on liver disease, one of the fastest-growing causes of morbidity and mortality in the world. The round is co-led by Cre...
Source: EMR and HIPAA - July 29, 2022 Category: Information Technology Authors: Healthcare IT News Tags: AI/Machine Learning Ambulatory Health IT Company Healthcare IT Hospital - Health System Beth Rogozinski Creative Ventures Dr. Chen Fong Fraser Kearney Capital Corp. Health IT Funding Health IT Fundings Health IT Investment James Wa Source Type: blogs
What Has A.I. In Medicine Ever Done For Us? At Least 50 Things!
Remember Monty Python’s brilliant Life of Brian movie scene where the Judean Jewish insurgent commando, planning the abduction of Pilate’s wife in return for all the horrors they had to endure from the Roman Empire, asks the rhetorical question: what have the Romans ever done for us? With the hype and overmarketing, not to speak about the fears around A.I, we asked the same question. What has A.I. in medicine ever done for us? Well, we found at least 50 things.
I have 50 responses to the pressing question on everyone’s mind who is interested in healthcare but tired of the hype or the doomsday scenarios around A.I....
Source: The Medical Futurist - March 1, 2022 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Future of Medicine AI cancer diagnostics digital health Healthcare Innovation medical Radiology technology medical imaging treatment administration digital health technology Source Type: blogs
Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice.
Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2021: Progress Towards the Treatment of Aging as a Medical Condition
Well, here we are again, at the end of another pandemic year, a year older and - hopefully - a year wiser and more knowledgeable. I said all that really needs to be said on the topic of COVID-19 as an age-related condition at the end of last year. We might hope that, given widespread vaccination, the pandemic will become a topic of diminishing importance as the year ahead progresses, even given the present round of variants, fears, and reintroduction of restrictions.
Advocacy for Aging Research
Have we finally made significant progress in convincing the world that aging is the cause of age-related disease, th...
Source: Fight Aging! - December 31, 2021 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Adult Disruption of Growth Hormone Receptor in Mice Produces Improved Health and Longevity
Genetic engineering of mouse lineages to produce life-long disruption of growth hormone metabolism, either growth hormone itself or growth hormone receptor, extends life. Animals are smaller, more challenged in maintaining body temperature, have more fat tissue, yet enhanced insulin sensitivity, and exhibit as much as a 70% longer life span. The present record for engineered mouse longevity has been held since 2003 by growth hormone receptor knockout (GHRKO) mice. That this record still stands in 2021 might be taken as a sign that the research and development community are not yet trying hard enough to produce therapies ca...
Source: Fight Aging! - December 2, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 13th 2021
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - September 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
AI and Multispectral Photoacoustic Imaging to Diagnose Thyroid Cancer
This study is significant in that it is the first to acquire photoacoustic images of thyroid nodules and classify malignant nodules using machine learning,” said Chulhong Kim, a researcher involved in the study, in a Pohang press release. “In addition to minimizing unnecessary biopsies in thyroid cancer patients, this technique can also be applied to a variety of other cancers, including breast cancer.”
“The ultrasonic device based on photoacoustic imaging will be helpful in effectively diagnosing thyroid cancer commonly found during health checkups and in reducing the number of biopsies,” ...
Source: Medgadget - July 13, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Oncology Radiology Source Type: blogs
