Patterns in the Reporting of Aggressive Histologic Subtypes in Papillary Thyroid Cancer
CONCLUSIONS: Aggressive subtypes of PTC are associated with worse outcomes. Academic and other facilities in the Middle Atlantic were more likely to report aPTC. This suggests the need for further evaluation of environmental or geographic factors versus a need for increased awareness and more accurate diagnosis of these subtypes.PMID:38657351 | DOI:10.1016/j.jss.2024.03.023 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Yeon J Lee Caitlin E Egan Jacques A Greenberg Teagan Marshall Abhinay Tumati Brendan M Finnerty Toni Beninato Rasa Zarnegar Thomas J Fahey Minerva A Romero Arenas Source Type: research
Extra-nuclear tert counteracts oxidative stress and promotes progression in papillary thyroid carcinoma
The reactivation of TERT is associated with poor outcome in papillary thyroid cancer (PTC). Extra-telomeric functions of TERT were reported, with a protective role against oxidative stress (OS). The aim of the present study was to explore the extra-nuclear TERT localization in PTC and its role in cancer progression.TERT nuclear export under OS were analyzed in K1 PTC cell line. We investigated the role of different TERT localizations using specific TERT constructs that limit its localization to the nucleus or to the mitochondria. (Source: Translational Research)
Source: Translational Research - April 24, 2024 Category: Research Authors: Marina Muzza, Gabriele Pogliaghi, Carla Colombo, Elisa Stellaria Grassi, Erika Carbone, Sonia Palazzo, Francesco Frattini, Giacomo Gazzano, Luca Persani, Laura Fugazzola Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
PD-1 inhibition with retifanlimab and/or arginase inhibition with INCB001158 in Japanese patients with solid tumors: A phase I study
CONCLUSION: Retifanlimab, INCB001158, and their combination had acceptable safety profiles. Promising retifanlimab antitumor activity warrants further investigation in Japanese patients.PMID:38651187 | DOI:10.1002/cam4.6980 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Yasutoshi Kuboki Takafumi Koyama Nobuaki Matsubara Yoichi Naito Shunsuke Kondo Kenichi Harano Kan Yonemori Kiyotaka Yoh Yuan Gu Tetsuya Mita Xuejun Chen Eiji Ueda Noboru Yamamoto Toshihiko Doi Toshio Shimizu Source Type: research
Predictors of treatment response in lymphogenic metastasized papillary thyroid cancer: a histopathological study
CONCLUSIONS: Detailed re-examination of lymph nodes revealed that only the presence of more than 5 lymph node metastases was an independent predictor of failure to achieve a complete response to treatment. No predictive value was found for other histopathological features, including the diameter of the lymph node metastases. These findings have the potential to improve risk stratification in patients with PTC and clinically evident lymph node metastases.PMID:38652802 | DOI:10.1093/ejendo/lvae048 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 23, 2024 Category: Endocrinology Authors: Caroline M J van Kinschot Lindsey Oudijk Charlotte van Noord Tim I M Korevaar Francien H van Nederveen Robin P Peeters Folkert J van Kemenade W Edward Visser Source Type: research
Medullary Thyroid Cancer: Single Institute Experience over Three Decades and Risk Factors for Recurrence
CONCLUSION: One of 4 patients undergoing surgery for MTC will recur. Risk factors associated with recurrence are male gender, lateral LN metastasis and high/highest MTC risk level mutations, but not necessarily surgery type. Preoperative calcitonin>2,175 pg/mL is suggestive of advanced disease and should prompt further evaluation.PMID:38651609 | DOI:10.1210/clinem/dgae279 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Sara Abou Azar Joseph Tobias Megan Applewhite Peter Angelos Xavier M Keutgen Source Type: research
Identification of 10 differentially expressed and cuproptosis-related genes in immune infiltration and prognosis of thyroid carcinoma
We presented the expression profiles of dysregulated genes in thyroid carcinoma. The findings of our study highlighted the potential of cuproptosis-related genes as prognostic biomarkers for thyroid carcinoma.PMID:38650151 | DOI:10.14715/cmb/2024.70.3.13 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Weixuan Yu Haiping Liu Yunda Zhang Ming Liu Weicong Li Libin Wang Dongwei Li Source Type: research
Identification of 10 differentially expressed and cuproptosis-related genes in immune infiltration and prognosis of thyroid carcinoma
We presented the expression profiles of dysregulated genes in thyroid carcinoma. The findings of our study highlighted the potential of cuproptosis-related genes as prognostic biomarkers for thyroid carcinoma.PMID:38650151 | DOI:10.14715/cmb/2024.70.3.13 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Weixuan Yu Haiping Liu Yunda Zhang Ming Liu Weicong Li Libin Wang Dongwei Li Source Type: research
PD ‐1 inhibition with retifanlimab and/or arginase inhibition with INCB001158 in Japanese patients with solid tumors: A phase I study
ConclusionRetifanlimab, INCB001158, and their combination had acceptable safety profiles. Promising retifanlimab antitumor activity warrants further investigation in Japanese patients. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Yasutoshi Kuboki,
Takafumi Koyama,
Nobuaki Matsubara,
Yoichi Naito,
Shunsuke Kondo,
Kenichi Harano,
Kan Yonemori,
Kiyotaka Yoh,
Yuan Gu,
Tetsuya Mita,
Xuejun Chen,
Eiji Ueda,
Noboru Yamamoto,
Toshihiko Doi,
Toshio Shimizu Tags: RESEARCH ARTICLE Source Type: research
CircPHGDH downregulation decreases papillary thyroid cancer progression through miR-122-5p/PKM2 axis
Although papillary thyroid carcinoma (PTC) has a favorable prognosis, it could affect patient life quality and become a serious threat because of invasion and metastasis. Many investigations have suggested tha... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Jiying Shen, Zhirong Ma, Jin Yang, Tianzhen Qu, Yu Xia, Yingjie Xu, Ming Zhou and Weiwei Liu Tags: Research Source Type: research
Intraluminal extension of papillary thyroid carcinoma into the Internal Jugular Vein; a case report
Papillary thyroid carcinoma (PTC), being the most common thyroid malignancy, is a slow-growing tumor and is usually limited to the thyroid. Extra thyroid extension is uncommon; besides, invasion to the vascula... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - April 23, 2024 Category: Endocrinology Authors: Firouze Jafari, Ali Taheri Akerdi, Hossein Abdolrahimzadeh Fard, Mehrdad karajizadeh and Shahram Paydar Tags: Case Report Source Type: research
Obesity and thyroid cancer: unraveling the connection through a systematic review and meta-analysis of cohort studies
ConclusionThe synthesis of 27 studies with diverse designs and populations underscores a robust positive association between adiposity and TC risk, providing compelling evidence for the potential role of increased adiposity in TC development. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 23, 2024 Category: Endocrinology Source Type: research
Superior Parathyroid Masquerading as Retropharyngeal Lymph Node
We report a case of incidentally discovered parathyroid gland located in the retropharyngeal space at the level of the oropharynx.Case PresentationThe patient in this report was a 60-year-old female with squamous cell carcinoma of the tonsil T2N0M0 with MRI showing a hyperintense ovoid structure, medial to the carotids at the level of the oropharynx, corresponding to the location of the lateral group of retropharyngeal lymph nodes. Patient underwent transoral ultrasonic radical tonsillectomy along with a retropharyngeal lymph node dissection by the transcervical route. Postoperative histopathology revealed the retropharyng...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 23, 2024 Category: ENT & OMF Source Type: research
