Cancer testis antigen subfamilies: Attractive targets for therapeutic vaccine (Review)
Int J Oncol. 2023 Jun;62(6):71. doi: 10.3892/ijo.2023.5519. Epub 2023 May 5.ABSTRACTCancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis and treatment. Most CTAs are located on the X chromosome and aggregate into large gene families, such as the melanoma antigen, synovial sarcoma X and G antigen families. Members of the CTA subfamily are usually co‑expressed in tumor tissues and share similar structural characteristics and biological functions. As cancer vaccines are recommended to induce specific antitumor responses, CTAs, particularly CTA subfamilies, are widely used in the des...
Source: International Journal of Oncology - May 5, 2023 Category: Cancer & Oncology Authors: Shengnan Ren Zhanyi Zhang Mengyuan Li Daren Wang Ruijie Guo Xuedong Fang Fangfang Chen Source Type: research
Cancer testis antigen subfamilies: Attractive targets for therapeutic vaccine (Review)
Int J Oncol. 2023 Jun;62(6):71. doi: 10.3892/ijo.2023.5519. Epub 2023 May 5.ABSTRACTCancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis and treatment. Most CTAs are located on the X chromosome and aggregate into large gene families, such as the melanoma antigen, synovial sarcoma X and G antigen families. Members of the CTA subfamily are usually co‑expressed in tumor tissues and share similar structural characteristics and biological functions. As cancer vaccines are recommended to induce specific antitumor responses, CTAs, particularly CTA subfamilies, are widely used in the des...
Source: International Journal of Oncology - May 5, 2023 Category: Cancer & Oncology Authors: Shengnan Ren Zhanyi Zhang Mengyuan Li Daren Wang Ruijie Guo Xuedong Fang Fangfang Chen Source Type: research
Cancer testis antigen subfamilies: Attractive targets for therapeutic vaccine (Review)
Int J Oncol. 2023 Jun;62(6):71. doi: 10.3892/ijo.2023.5519. Epub 2023 May 5.ABSTRACTCancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis and treatment. Most CTAs are located on the X chromosome and aggregate into large gene families, such as the melanoma antigen, synovial sarcoma X and G antigen families. Members of the CTA subfamily are usually co‑expressed in tumor tissues and share similar structural characteristics and biological functions. As cancer vaccines are recommended to induce specific antitumor responses, CTAs, particularly CTA subfamilies, are widely used in the des...
Source: International Journal of Oncology - May 5, 2023 Category: Cancer & Oncology Authors: Shengnan Ren Zhanyi Zhang Mengyuan Li Daren Wang Ruijie Guo Xuedong Fang Fangfang Chen Source Type: research
Treatment patterns and outcomes in patients with metastatic synovial sarcoma in France, Germany, Italy, Spain and the United Kingdom
Future Oncology, Ahead of Print. (Source: Future Oncology)
Source: Future Oncology - May 4, 2023 Category: Cancer & Oncology Authors: Nashita Patel Shibani Pokras Jane Ferma Vicky Casey Fil Manuguid Ken Culver Sebastian Bauer Source Type: research
Primary Synovial Sarcoma of the Nasopharynx in a Case-Case Report
We present a young man with recurrent left-sided nasal congestion with nosebleeds, confirmed by immunohistochemistry and cytogenetic examination as SS. SS is easily misdiagnosed, and the tumor should be considered in the differential diagnosis, with surgery combined with radiotherapy as the primary treatment option.PMID:37129185 | DOI:10.1177/01455613231173452 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - May 2, 2023 Category: ENT & OMF Authors: Xuejing Xiang Yuanyuan Luo Haibo Du Xiaojie Ma Source Type: research
Primary Synovial Sarcoma of the Nasopharynx in a Case-Case Report
We present a young man with recurrent left-sided nasal congestion with nosebleeds, confirmed by immunohistochemistry and cytogenetic examination as SS. SS is easily misdiagnosed, and the tumor should be considered in the differential diagnosis, with surgery combined with radiotherapy as the primary treatment option.PMID:37129185 | DOI:10.1177/01455613231173452 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - May 2, 2023 Category: ENT & OMF Authors: Xuejing Xiang Yuanyuan Luo Haibo Du Xiaojie Ma Source Type: research
Quantitative proteomic studies addressing unmet clinical needs in sarcoma
Sarcoma is a rare and complex disease comprising over 80 malignant subtypes that is frequently characterized by poor prognosis. Challenges in clinical management include uncertainties in diagnosis and disease classification, limited prognostic and predictive biomarkers, incompletely understood disease heterogeneity among and within subtypes, lack of effective treatment options, and limited progress in identifying new drug targets and novel therapeutics. Proteomics refers to the study of the entire complement of proteins expressed in specific cells or tissues. Advances in proteomics have included the development of quantita...
Source: Frontiers in Oncology - May 1, 2023 Category: Cancer & Oncology Source Type: research
Cardiac synovial sarcoma masquerading as effusive constrictive pericarditis
We describe an unusual case of a 22-year-old female who presented with complaints of dyspnoea on exertion, palpitations, and chest pain. Trans-thoracic echocardiography was suggestive of a cystic pericardial mass with pericardial effusion anterior and lateral to the right ventricle. Computed tomography scan (CT scan) revealed thick-walled predominantly cystic lesion over the left ventricle with gross pericardial effusion with internal septations. These findings were suggestive of an infected pericardial cyst. Upon surgery, an adherent mass in the pericardial cavity was found which was not separable from the right heart str...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - April 27, 2023 Category: Cardiovascular & Thoracic Surgery Source Type: research
Whole ‐exome sequencing in primary pulmonary synovial sarcoma misdiagnosed as mesothelioma: A case report and literature review
In this study, we report the case of a 38-year-old woman who was misdiagnosed with pleural mesothelioma and finally endured surgery to remove the tumor. The tumor showed SYT-SSX fusion transcripts and was diagnosed as PPSS by combining histopathological and immunohistochemical analyses. The patient was treated with anlotinib after surgery and had a good response, but subsequently, drug resistance developed, and the disease progressed. Finally, we determined some biomarkers through whole-exome sequencing (WES) to improve the diagnosis and treatment strategies. AbstractSynovial sarcoma is a highly malignant tumor that accoun...
Source: Thoracic Cancer - April 24, 2023 Category: Cancer & Oncology Authors: Di Wu,
Hongbing Zhang,
Xin Li,
Jinghao Liu,
Minghui Liu,
Hongyu Liu,
Ming Dong,
Jun Chen Tags: CASE REPORT Source Type: research
Real-world outcomes of pazopanib in metastatic soft tissue sarcoma: a retrospective Turkish oncology group (TOG) study
CONCLUSION: Pazopanib is effective and well-tolerated in treatment of non-adipocytic metastatic STS. Its earlier use (at second-line), good performance status may result in better outcomes. Worldwide scientific collaborations are important to gain knowledge on rarer STS subtypes by conducting studies in larger patient populations.PMID:37067546 | DOI:10.1007/s00432-023-04766-3 (Source: Cancer Control)
Source: Cancer Control - April 17, 2023 Category: Cancer & Oncology Authors: Ahmet Bilici Sinan Koca Mustafa Karaagac Sabin Goktas Aydin Emrah Eraslan Muhammed Ali Kaplan Birol Ocak Sema Sezgin Goksu Semra Paydas Fahri Akgul Sumeyye Derin Yakup Ergun Emre Yekeduz Cihan Erol Deniz Tataroglu Ozyukseler Atike Gokcen Demiray Mustafa K Source Type: research
Cancers, Vol. 15, Pages 2287: Current Landscape of Immunotherapy for Advanced Sarcoma
a Ángeles Vaz
There is substantial heterogeneity between different subtypes of sarcoma regarding their biological behavior and microenvironment, which impacts their responsiveness to immunotherapy. Alveolar soft-part sarcoma, synovial sarcoma and undifferentiated pleomorphic sarcoma show higher immunogenicity and better responses to checkpoint inhibitors. Combination strategies adding immunotherapy to chemotherapy and/or tyrosine–kinase inhibitors globally seem superior to single-agent schemes. Therapeutic vaccines and different forms of adoptive cell therapy, mainly engineered TCRs, CAR-T cells and TIL...
Source: Cancers - April 13, 2023 Category: Cancer & Oncology Authors: V íctor Albarrán Mar ía Luisa Villamayor Javier Pozas Jes ús Chamorro Diana Isabel Rosero Mar ía San Román Patricia Guerrero Patricia P érez de Aguado Juan Carlos Calvo Coral Garc ía de Quevedo Carlos Gonz ález Mar ía Ángeles Vaz Tags: Review Source Type: research
Ameloblastoma Transforming into Monophasic Synovial Sarcoma: A Case Report
(Source: Journal of Maxillofacial and Oral Surgery)
Source: Journal of Maxillofacial and Oral Surgery - April 12, 2023 Category: ENT & OMF Source Type: research
Synovial sarcoma in the buttocks: an exceptional location - case report according to SCARE guidelines
CONCLUSION: Our case enriches the poor literature on intergluteal synovial sarcoma, where less than 10 similar reports are available. We hope through our presentation to highlight this exceptional etiology of gluteal tumor and to recall that there is no relationship between the name of this tumor and the synovium as an anatomical entity.PMID:37008169 | PMC:PMC10060098 | DOI:10.1097/MS9.0000000000000232 (Source: Annals of Medicine)
Source: Annals of Medicine - April 3, 2023 Category: Internal Medicine Authors: Siham Elmir Mohammed Arghal Samia Malki Amal Bennani Imane Skiker Najib Abdeljaouad Hicham Yacoubi Abdelkrim Daoudi Mohammed Bouziane Ahmed A El Oumri Source Type: research
A case report of an unusual temporomandibular joint mass: Nodular fasciitis
This report presents a case of NF in the TMJ, focusing on various imaging features, along with a literature review aiming to determine the hallmark features of NF in the TMJ and highlight the diagnostic challenges.PMID:37006787 | PMC:PMC10060757 | DOI:10.5624/isd.20220175 (Source: Imaging Science in Dentistry)
Source: Imaging Science in Dentistry - April 3, 2023 Category: Dentistry Authors: Han-Sol Lee Kyu-Young Oh Ju-Hee Kang Jo-Eun Kim Kyung-Hoe Huh Won-Jin Yi Min-Suk Heo Sam-Sun Lee Source Type: research
Synovial sarcoma in the buttocks: an exceptional location - case report according to SCARE guidelines
CONCLUSION: Our case enriches the poor literature on intergluteal synovial sarcoma, where less than 10 similar reports are available. We hope through our presentation to highlight this exceptional etiology of gluteal tumor and to recall that there is no relationship between the name of this tumor and the synovium as an anatomical entity.PMID:37008169 | PMC:PMC10060098 | DOI:10.1097/MS9.0000000000000232 (Source: Annals of Medicine)
Source: Annals of Medicine - April 3, 2023 Category: Internal Medicine Authors: Siham Elmir Mohammed Arghal Samia Malki Amal Bennani Imane Skiker Najib Abdeljaouad Hicham Yacoubi Abdelkrim Daoudi Mohammed Bouziane Ahmed A El Oumri Source Type: research
