Ras family signaling pathway in immunopathogenesis of inflammatory rheumatic diseases
The Ras (rat sarcoma virus) is a GTP-binding protein that is considered one of the important members of the Ras-GTPase superfamily. The Ras involves several pathways in the cell that include proliferation, migration, survival, differentiation, and fibrosis. Abnormalities in the expression level and activation of the Ras family signaling pathway and its downstream kinases such as Raf/MEK/ERK1-2 contribute to the pathogenic mechanisms of rheumatic diseases including immune system dysregulation, inflammation, and fibrosis in systemic sclerosis (SSc); destruction and inflammation of synovial tissue in rheumatoid arthritis (RA)...
Source: Frontiers in Immunology - May 15, 2023 Category: Allergy & Immunology Source Type: research
Monophasic pericardial synovial sarcoma in a turkish female patient: a very rare case with cyto-histopathological findings
The aim was to present a 35-year-old female patient with diagnosis of monophasic primary pericardial synovial sarcoma (PSS) with cytopathological findings. (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - May 11, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Busra Yaprak Bayrak, Cigdem Vural, Huseyin Fatih Sezer, Aykut Eli çora and Yaprak Busra Tags: Case Report Source Type: research
Coil Embolization of a Pulmonary Varix via a Transseptal Approach Using Intracardiac Echocardiography
A 38-year-old man with a history of synovial sarcoma metastatic to the lungs on systemic chemotherapy presented to the emergency department with shortness of breath and hemoptysis. Contrast-enhanced computed tomography angiography of the chest was performed, revealing a new right lower lobe pulmonary venous aneurysm (varix) (Fig 1a, b). Catheter pulmonary arteriography opacified the pulmonary venous aneurysm on delayed images only, without arterial communication. After multidisciplinary discussion, a transseptal coil embolization procedure was performed jointly with the cardiac electrophysiology team, with the anesthesiolo...
Source: Journal of Vascular and Interventional Radiology : JVIR - May 8, 2023 Category: Radiology Authors: Sydney Cooper, Myles Mowery, Michael Brunner, Jarrod MacFarlane Tags: Letter to the Editor Source Type: research
Small Round Blue Cell Tumours of the Sinonasal Area: Our 5 year Experience in a Tertiary Care Centre in India
Conclusion: Sinonasal small round blue cell tumors are extremely rare tumours. Histopathological diagnosis with immunohistochemistry is characteristic of various tumors and is conclusive for diagnosis. Knowledge of these tumor entity is essential as early diagnosis helps in further management in preventing spread to vital structures and improving outcome. Most of the tumors have a multimodality treatment approach which includes surgical excision, radiotherapy and chemotherapy. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - May 6, 2023 Category: ENT & OMF Source Type: research
Cancer testis antigen subfamilies: Attractive targets for therapeutic vaccine (Review)
Int J Oncol. 2023 Jun;62(6):71. doi: 10.3892/ijo.2023.5519. Epub 2023 May 5.ABSTRACTCancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis and treatment. Most CTAs are located on the X chromosome and aggregate into large gene families, such as the melanoma antigen, synovial sarcoma X and G antigen families. Members of the CTA subfamily are usually co‑expressed in tumor tissues and share similar structural characteristics and biological functions. As cancer vaccines are recommended to induce specific antitumor responses, CTAs, particularly CTA subfamilies, are widely used in the des...
Source: International Journal of Oncology - May 5, 2023 Category: Cancer & Oncology Authors: Shengnan Ren Zhanyi Zhang Mengyuan Li Daren Wang Ruijie Guo Xuedong Fang Fangfang Chen Source Type: research
Cancer testis antigen subfamilies: Attractive targets for therapeutic vaccine (Review)
Int J Oncol. 2023 Jun;62(6):71. doi: 10.3892/ijo.2023.5519. Epub 2023 May 5.ABSTRACTCancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis and treatment. Most CTAs are located on the X chromosome and aggregate into large gene families, such as the melanoma antigen, synovial sarcoma X and G antigen families. Members of the CTA subfamily are usually co‑expressed in tumor tissues and share similar structural characteristics and biological functions. As cancer vaccines are recommended to induce specific antitumor responses, CTAs, particularly CTA subfamilies, are widely used in the des...
Source: International Journal of Oncology - May 5, 2023 Category: Cancer & Oncology Authors: Shengnan Ren Zhanyi Zhang Mengyuan Li Daren Wang Ruijie Guo Xuedong Fang Fangfang Chen Source Type: research
Cancer testis antigen subfamilies: Attractive targets for therapeutic vaccine (Review)
Int J Oncol. 2023 Jun;62(6):71. doi: 10.3892/ijo.2023.5519. Epub 2023 May 5.ABSTRACTCancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis and treatment. Most CTAs are located on the X chromosome and aggregate into large gene families, such as the melanoma antigen, synovial sarcoma X and G antigen families. Members of the CTA subfamily are usually co‑expressed in tumor tissues and share similar structural characteristics and biological functions. As cancer vaccines are recommended to induce specific antitumor responses, CTAs, particularly CTA subfamilies, are widely used in the des...
Source: International Journal of Oncology - May 5, 2023 Category: Cancer & Oncology Authors: Shengnan Ren Zhanyi Zhang Mengyuan Li Daren Wang Ruijie Guo Xuedong Fang Fangfang Chen Source Type: research
Cancer testis antigen subfamilies: Attractive targets for therapeutic vaccine (Review)
Int J Oncol. 2023 Jun;62(6):71. doi: 10.3892/ijo.2023.5519. Epub 2023 May 5.ABSTRACTCancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis and treatment. Most CTAs are located on the X chromosome and aggregate into large gene families, such as the melanoma antigen, synovial sarcoma X and G antigen families. Members of the CTA subfamily are usually co‑expressed in tumor tissues and share similar structural characteristics and biological functions. As cancer vaccines are recommended to induce specific antitumor responses, CTAs, particularly CTA subfamilies, are widely used in the des...
Source: International Journal of Oncology - May 5, 2023 Category: Cancer & Oncology Authors: Shengnan Ren Zhanyi Zhang Mengyuan Li Daren Wang Ruijie Guo Xuedong Fang Fangfang Chen Source Type: research
Cancer testis antigen subfamilies: Attractive targets for therapeutic vaccine (Review)
Int J Oncol. 2023 Jun;62(6):71. doi: 10.3892/ijo.2023.5519. Epub 2023 May 5.ABSTRACTCancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis and treatment. Most CTAs are located on the X chromosome and aggregate into large gene families, such as the melanoma antigen, synovial sarcoma X and G antigen families. Members of the CTA subfamily are usually co‑expressed in tumor tissues and share similar structural characteristics and biological functions. As cancer vaccines are recommended to induce specific antitumor responses, CTAs, particularly CTA subfamilies, are widely used in the des...
Source: International Journal of Oncology - May 5, 2023 Category: Cancer & Oncology Authors: Shengnan Ren Zhanyi Zhang Mengyuan Li Daren Wang Ruijie Guo Xuedong Fang Fangfang Chen Source Type: research
