Primary renal synovial sarcoma: A case report
Rationale: Synovial sarcoma (SS) is a malignant neoplasm that arises from soft tissues proximal to the joints. It occurs primarily at the major joints of the extremities, but may also occur in the deep soft tissues around the joints. While primary renal synovial sarcoma (PRSS) is extremely rare, it is important to have a better understanding of their imaging and clinical features to establish an effective treatment plan. Correct identification of PRSS is also useful for treating renal neoplasms. Patient's concerns: A 56-year-old Chinese man was admitted to our hospital due to moderate, paroxysmal left-sided loin pain....
Source: Medicine - October 16, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

[ 18 F]FDG PET/CT for evaluating early response to neoadjuvant chemotherapy in pediatric patients with sarcoma: a prospective single-center trial
AbstractIntroductionThis is a prospective, single-center trial in pediatric patients with sarcoma aiming to evaluate [18F]FDG PET/CT as a tool for early response assessment to neoadjuvant chemotherapy (neo-CTX).MethodsBone or soft tissue sarcoma patients with (1) baseline [18F]FDG PET/CT within 4  weeks prior to the start of neo-CTX (PET1), (2) early interim [18F]FDG PET/CT (6  weeks after the start of neo-CTX (PET2), (3) evaluation of neo-CTX response by histology or MRI, and (4) definitive therapy after neo-CTX (surgery or radiation) were included. Semiquantitative PET parameters (SUVmax, SUVmean, SUVpeak, MTV ...
Source: EJNMMI Research - October 15, 2020 Category: Radiology Source Type: research

Synovial Sarcoma of the Female Genital Tract: A Protean Mimic of Müllerian Neoplasia
Synovial sarcoma most commonly occurs in the extremities but has rarely been described in the female genital tract. In this series, we describe the clinical, morphologic, immunohistochemical, and molecular features of 7 cases of vulvovaginal synovial sarcoma (vulva, n=6; vagina, n=1). We emphasize their wide morphologic spectrum, which can overlap significantly with other more common tumors at these sites, as highlighted by 2 cases initially diagnosed as other entities (endometrioid carcinoma and malignant peripheral nerve sheath tumor). The average patient age was 41 (range: 23 to 62) years and tumor size ranged from 0.8 ...
Source: The American Journal of Surgical Pathology - October 14, 2020 Category: Pathology Tags: Original Articles Source Type: research

The value of re-staging chest CT at first local recurrence of extremity and trunk soft tissue sarcoma
ConclusionRe-staging chest CT at the time of first LR of STS identified a prevalence of 23.9% pulmonary metastases, which supports the need for chest CT at the time of LR in line with the UK guidelines for the management of bone and soft tissue sarcoma.Key Points• Pulmonary metastases were diagnosed in 1.3% of soft tissue sarcomas at presentation.• Pulmonary metastases were identified in ~ 24% of patients at first local recurrence of soft tissue sarcoma, most commonly with pleomorphic sarcoma and Trojani grade tumours.• No patient with a low-grade recurrence had pulmonary metastases. (Source: European Radiology)
Source: European Radiology - October 10, 2020 Category: Radiology Source Type: research

Reinnervation of the Diaphragm After Bilateral Phrenic Nerve Resection and Immediate Reconstruction Using a Contralateral Phrenic Nerve Autograft
A patient affected by a voluminous synovial sarcoma of mediastinum received radical surgery, resulting in injury of both phrenic nerves. Because of the cancer location, reconstruction of the left phrenic nerve was not possible, so to prevent the patient's ventilator dependence, the right phrenic nerve was reconstructed via an autograft from the residual proximal stump of the contralateral one. In 3 months, the right hemidiaphragm function showed a full recovery, documented by ultrasonographic and radiographic assessment of diaphragmatic excursion, and the patient was weaned from mechanical ventilation. When a nerve autogra...
Source: Annals of Plastic Surgery - October 9, 2020 Category: Cosmetic Surgery Tags: Peripheral Nerve Surgery and Research Source Type: research

Synovial sarcoma of the spine: A case report and review of the literature.
Conclusion: Due to the limited number of reported cases in the literature, it is difficult to predict the outcomes of spinal SS. Further, different treatment modalities have been used to treat spinal SS. However, most of the reported cases had poor outcomes. Therefore, prospective multi-center studies are needed to further investigate the treatment strategies and outcomes for patients with spinal SS. PMID: 33024595 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - October 9, 2020 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Synovial Sarcoma: A Complex Disease with Multifaceted Signaling and Epigenetic Landscapes
ABSTRACTPurpose of ReviewAside from a characteristicSS18 –SSX translocation identified in almost all cases, no genetic anomalies have been reliably isolated yet to drive the pathogenesis of synovial sarcoma. In the following review, we explore the structural units of wild-type SS18 and SSX, particularly as they relate to the transcriptional alterations and cellular pathway changes imposed by SS18 –SSX.Recent FindingsNative SS18 and SSX contribute recognizable domains to the SS18 –SSX chimeric proteins, which inflict transcriptional and epigenetic changes through selective protein interactions involving th...
Source: Current Oncology Reports - October 5, 2020 Category: Cancer & Oncology Source Type: research

Calcifying synovial sarcoma of the tongue with SS18 rearrangement: a rare variant in a rare location
We report a synovial sarcoma of the tongue in a 14-year-old female patient with unusual histology. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 23, 2020 Category: ENT & OMF Authors: Lama Alabdulaaly, Zahra AlDawood, Salim Afshar, Reza Rahbar, Alyaa Al-Ibraheemi, Sook-Bin Woo Source Type: research

Soft-tissue Sarcoma of the Hand: Patient Characteristics, Treatment, and Oncologic Outcomes.
CONCLUSION: Hand STSs are aggressive tumors with a high metastatic potential. Even with adequate oncologic treatment, long-term clinical follow-up (10 years) in these tumors is advised. The treating surgical oncologist should not be deceived by their smaller size. PMID: 32932303 [PubMed - as supplied by publisher] (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - September 17, 2020 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Primary Renal Synovial Sarcoma - A rare histology
Publication date: November 2020Source: Urology Case Reports, Volume 33Author(s): Premkumar Krishnappa (Source: Urology Case Reports)
Source: Urology Case Reports - September 16, 2020 Category: Urology & Nephrology Source Type: research

Identification of Metastasis-Associated Biomarkers in Synovial Sarcoma Using Bioinformatics Analysis
Synovial sarcoma (SS) is a highly aggressive soft tissue tumor with high risk of local recurrence and metastasis. However, the mechanisms underlying SS metastasis are still largely unclear. The purpose of this study is to screen metastasis-associated biomarkers in SS by integrated bioinformatics analysis. Two mRNA datasets (GSE40018 and GSE40021) were selected to analyze the differentially expressed genes (DEGs). Using the Database for Annotation, Visualization and Integrated Discovery (DAVID) and gene set enrichment analysis (GSEA), functional and pathway enrichment analyses were performed for DEGs. Then, the protein-prot...
Source: Frontiers in Genetics - September 10, 2020 Category: Genetics & Stem Cells Source Type: research

Sinonasal synovial sarcoma: evaluation of the role of radiological and clinicopathological features in diagnosis
To explore the value of radiological and clinicopathological features in the diagnosis of sinonasal synovial sarcomas (SS). (Source: Clinical Radiology)
Source: Clinical Radiology - September 4, 2020 Category: Radiology Authors: N. Lin, X. Liu, F. Zhang, Y. Pan, M. Qi, Y. Sha Source Type: research

The Efficacy and Safety of Apatinib in Advanced Synovial Sarcoma: A Case Series of Twenty-One Patients in One Single Institution [Corrigendum]
(Source: Cancer Management and Research)
Source: Cancer Management and Research - September 3, 2020 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

The survival and prognosis analysis of synovial sarcoma subtypes: a Surveillance, Epidemiology, and End Results population-based analysis
AbstractPurposeBy comparing epidemiologic and prognostic data of synovial sarcoma subtypes, this study aims to clarify the difference in prognosis and risk factors among different synovial sarcoma subtypes.MethodsIn total, 1692 patients with synovial sarcoma in the USA who were diagnosed during 1975 through 2016 and retrieved from the Surveillance, Epidemiology, and End Results (SEER) program were studied.ResultsThere were statistically significant differences in the distribution of age and race among three synovial sarcoma subtypes, while no major differences in the distribution of sex, tumor stage, and tumour size were f...
Source: International Orthopaedics - September 2, 2020 Category: Orthopaedics Source Type: research

Systematic literature review of clinical outcomes in adults with metastatic or advanced synovial sarcoma
Future Oncology, Ahead of Print. (Source: Future Oncology)
Source: Future Oncology - August 26, 2020 Category: Cancer & Oncology Authors: Kentaro Kogushi Michael LoPresti Shunya Ikeda Source Type: research

Calcifying Synovial Sarcoma of the Tongue with SS18 Rearrangement: A rare variant in a rare location.
Publication date: Available online 20 August 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Lama Alabdulaaly, Zahra AlDawood, Salim Afshar, Reza Rahbar, Alyaa Al-Ibraheemi, Sook-Bin Woo (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - August 21, 2020 Category: ENT & OMF Source Type: research

HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and its Association with Clinical Outcome.
CONCLUSIONS: Targeted gene panels like MSK-IMPACT may accurately report HLA type and identify loss of somatic HLA alleles. In a multivariable model, HLA-A*02-eligibility was not significantly associated with OS in patients with metastatic SS. PMID: 32816945 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - August 13, 2020 Category: Cancer & Oncology Authors: Rosenbaum E, Seier K, Bandlamudi C, Dickson MA, Gounder MM, Keohan ML, Chi P, Kelly C, Movva S, Nacev B, Simeone N, Donoghue MTA, Slotkin EK, Qin LX, Antonescu CR, Tap WD, D'Angelo SP Tags: Clin Cancer Res Source Type: research

Pediatric sarcomas display a variable EpCAM expression in a histology-dependent manner.
Abstract EpCAM is a transmembrane glycoprotein typically overexpressed in cancer of epithelial origin and mainly involved in the epithelial-to-mesenchymal transition (EMT) of tumor cells that spread and disseminate. Strategies for the targeting and capture of EpCAM-expressing tumor cells are showing promise in cancers prone to metastatize, both as diagnostic tools and potential therapies. Sarcomas are among the most aggressive tumors in children, with a common mesenchymal origin that comprises both soft tissue sarcomas (STS) and bone sarcomas. The aim of this study was to assess EpCAM expression in pediatric sarco...
Source: Translational Oncology - August 13, 2020 Category: Cancer & Oncology Authors: Tombolan L, Rossi E, Zin A, Santoro L, Bonvini P, Zamarchi R, Bisogno G Tags: Transl Oncol Source Type: research

CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas
Cyclin-Dependent Kinases (CDKs) are well-known reliable targets for cancer treatment being often deregulated. Among them, since the transcription-associated CDK9 represents the sentry of cell transcriptional homeostasis, it can be a valuable target for managing cancers in which the transcriptional machinery is dysregulated by tumor-driver oncogenes. Here we give an overview of some natural compounds identified as CDK inhibitors with reported activity also against CDK9, that were taken as a model for the development of highly active synthetic anti-CDK9 agents. After, we summarize the data on CDK9 inhibition in a group of ra...
Source: Frontiers in Pharmacology - August 12, 2020 Category: Drugs & Pharmacology Source Type: research

GSE139053 A bifunctional nucleosome binding protein mediates specialized mSWI/SNF complex targeting and activity (ChIP-seq dataset)
Contributors : Matthew McBride ; Andrew R D'Avno ; Cigall KadochSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHere we identify and characterize a minimal domain within the SS18-SSX fusion oncoprotein hallmark to synovial sarcoma, that exhibits a high-affinity interaction with the nucleosome acidic patch. We find that this region is necessary and sufficient for nucleosome binding, mSWI/SNF (BAF) chromatin remodeling complex targeting, catalytic activity, and activation of cancer-specific gene expression. Moreover, we identify PRC1-mediated H2AUb119 as a further rheostat...
Source: GEO: Gene Expression Omnibus - August 4, 2020 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE139054 A bifunctional nucleosome binding protein mediates specialized mSWI/SNF complex targeting and activity (RNA-seq dataset)
Contributors : Matthew McBride ; Andrew R D'Avno ; Cigall KadochSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we identify and characterize a minimal domain within the SS18-SSX fusion oncoprotein hallmark to synovial sarcoma, that exhibits a high-affinity interaction with the nucleosome acidic patch. We find that this region is necessary and sufficient for nucleosome binding, mSWI/SNF (BAF) chromatin remodeling complex targeting, catalytic activity, and activation of cancer-specific gene expression. Moreover, we identify PRC1-mediated H2AUb119 as a further rheostat governing fur...
Source: GEO: Gene Expression Omnibus - August 4, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Synovial sarcoma of the stomach: case report and systematic review of the literature.
We report a case of primary gastric synovial sarcoma in a 48-year-old female. Differential diagnosis of synovial sarcoma from other spindle cell, mesenchymal and cytokeratin-positive tumors is critical for the treatment and prognosis. Immunohistochemistry studies and molecular analysis are required to settle a proper diagnosis. PMID: 32729309 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - August 1, 2020 Category: Pathology Tags: Pol J Pathol Source Type: research

Atypical optic neuritis as the presenting feature of testicular malignancy: Rare case report with review of literature
Anju Meena, Harinder S Sethi, Mukesh Joshi, Mayuresh NaikIndian Journal of Ophthalmology 2020 68(8):1696-1698 A 23-year-old male presented with unilateral acute onset, painless, progressive diminution of vision. Initial clinical and radiological findings were consistent with optic neuritis. The patient was started on pulse steroids leading to visual recovery. However, the patient relapsed within one week. Repeat imaging revealed metastatic lesions near the orbital apex. Orbit is an unusual site of metastasis from testicular tumors and only 3 cases of testicular synovial sarcoma with orbital metastasis have been reported. ...
Source: Indian Journal of Ophthalmology - July 23, 2020 Category: Opthalmology Authors: Anju Meena Harinder S Sethi Mukesh Joshi Mayuresh Naik Source Type: research

Signatures of circulating microRNA in four sarcoma subtypes
Background: Sarcomas are rare malignant tumors of mesenchymal origin. The discovery of circulating biomarkers with high diagnostic value could supplement diagnosis of this heterogenous group of tumors. The aim of this study was to identify the profiles of circulating miRNA (c-miRNAs) in four groups of common bone and soft tissue sarcomas.Methods: At the time of diagnosis, blood samples were collected from 86 patients: 36 with locally advanced/unresectable/metastatic gastrointestinal stromal tumor (GIST) who received first-line treatment with imatinib; 16 with locally advanced osteosarcoma (OS); 26 with locally advanced syn...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Hanna Kosela-Paterczyk, Agnieszka Paziewska, Maria Kulecka, Aneta Balabas, Anna Kluska, Michalina Dabrowska, Magdalena Piatkowska, Natalia Zeber-Lubecka, Filip Ambrozkiewicz, Jakub Karczmarski, Michal Mikula, Piotr Rutkowski, Jerzy Ostrowski Tags: Research Paper Source Type: research

Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma.
In this study, we investigated whether S phase kinase-associated protein (Skp2) plays an oncogenic role in tumor initiation, progression, and metastasis of SS. Our study revealed that Skp2 is frequently overexpressed in SS specimens and SS18-SSX transgenic mouse tumors, as well as correlated with clinical stages. Next, we identified that genetic depletion of Skp2 reduced mesenchymal and stemness markers, and inhibited the invasive and proliferative capacities of SS cell lines. Furthermore, Skp2 depletion markedly suppressed the growth of SS xenografts tumors. Treatment of SS cell lines with the skp2 inhibitor flavokawain A...
Source: Translational Oncology - July 1, 2020 Category: Cancer & Oncology Authors: Wang J, Sato K, O'Donnell E, Singla A, Yaguare S, Aldahamsheh O, Batko B, Borjihan H, Tingling J, Zhang J, Weiser DA, Loeb DM, Gorlick R, Schwartz EL, Yang R, Zi X, Zhao H, Geller DS, Hoang BH Tags: Transl Oncol Source Type: research

The Efficacy and Safety of Apatinib in Advanced Synovial Sarcoma: A Case Series of Twenty-One Patients in One Single Institution
(Source: Cancer Management and Research)
Source: Cancer Management and Research - June 30, 2020 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

Real-World Outcomes of Pazopanib Treatment in Korean Patients with Advanced Soft Tissue Sarcoma: A Multicenter Retrospective Cohort Study
ConclusionsThis real-world data analysis showed acceptable efficacy and tolerability of pazopanib in patients pretreated with cytotoxic chemotherapy for advanced STS, with favorable treatment outcomes for ASPS and SFT. (Source: Targeted Oncology)
Source: Targeted Oncology - June 29, 2020 Category: Cancer & Oncology Source Type: research

Facts and hopes in immunotherapy of soft tissue sarcomas.
ne BA Abstract Sarcomas are mesenchymal tumors, encompassing more than 175 subtypes, each one with their own genetic complexities. As a result, immunotherapy approaches have not been universally successful across the wide rage of diverse subtypes. The actual state of science and the current clinical data utilizing immunotherapy within the soft tissue sarcomas (STS) will be detailed in this review. More precisely, the review will focus on: a) the role of the immune microenvironment in the development and activity of new therapeutic approaches; b) the recent identification of the sarcoma immune class (SIC) groups, e...
Source: Clinical Cancer Research - June 28, 2020 Category: Cancer & Oncology Authors: Martín-Broto J, Moura DS, Van Tine BA Tags: Clin Cancer Res Source Type: research

Radiotherapy is Associated With Improved Survival in Patients With Synovial Sarcoma Undergoing Surgery: A National Cancer Database Analysis
In this study, we sought to further analyze this association using a hospital-based data set where data on chemotherapy administration and surgical margin status are available. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - June 26, 2020 Category: Surgery Authors: Alicia A. Gingrich, Angelica S. Marrufo, Yu Liu, Chin-Shang Li, Morgan A. Darrow, Arta M. Monjazeb, Steven W. Thorpe, Robert J. Canter Tags: Oncology Source Type: research

MDM2 amplification and fusion gene ss18-ssx in a poorly differentiated synovial sarcoma: A rare but puzzling conjunction.
Abstract The detection of specific alterations by genetic analyses has been included in the diagnostic criterions of the World Health Organization's classification of soft tissues tumors since 2013. The presence of a SS18 rearrangement is pathognomonic of synovial sarcoma (SS). MDM2 amplification is strongly correlated to well-differentiated or dedifferentiated liposarcoma (DDLPS) in the context of sarcoma. We identified one case of poorly differentiated sarcoma harboring both SS18-SSX2 fusion and MDM2 amplification. The review of the literature showed high discrepancies, concerning the incidence of MDM2 amplifica...
Source: Neoplasia - June 15, 2020 Category: Cancer & Oncology Authors: Di Mauro I, Mescam-Mancini L, Chetaille B, Lae M, Pierron G, Dadone-Montaudie B, Bazin A, Bouvier C, Michiels JF, Pedeutour F Tags: Neoplasia Source Type: research

A Novel SS18-SSX Fusion-specific Antibody for the Diagnosis of Synovial Sarcoma
Synovial sarcoma (SS), an aggressive soft tissue sarcoma with a predilection for the extremities of young adults, harbors the pathognomonic t(X;18)(p11;q11) translocation, resulting in SS18-SSX rearrangements. SS includes monophasic, biphasic, and poorly differentiated variants, which show considerable histologic overlap with a range of other tumor types, making the diagnosis challenging on limited biopsies. Immunohistochemistry (IHC) is routinely used in the differential diagnosis; however, presently available markers lack specificity. Thus, cytogenetic or molecular genetic techniques are often employed to confirm the dia...
Source: The American Journal of Surgical Pathology - June 12, 2020 Category: Pathology Tags: Original Articles Source Type: research

Treatment of limb synovial sarcoma with metastasis at presentation
Limb synovial sarcoma (LSS) patients with metastasis at presentation usually have a very poor prognosis. Little is known about survival prediction and risk factors in these patients owing to the condition's rarity. Thus, this study examined the survival and prognostic variables of metastatic LSS. Clinical data for LSS patients with metastasis at presentation from 1975 to 2016 were obtained from the surveillance, epidemiology, and end results database. The Kaplan–Meier method was used to determine the survival curves. Univariate and multivariate Cox regression analysis were conducted to identify the prognostic predic...
Source: Medicine - June 5, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Unusual Mimicker of the Carotid Body Tumor: Synovial Sarcoma of the Carotid Space
Synovial cell sarcomas are malignant tumors originating from pluripotent mesenchymal stem cells, unlike its name. It is a common tumor in the periarticular area, accounting for 8% of all soft tissue sarcomas. Head and neck are among the rarest areas of this tumor. Synovial sarcomas of the head and neck are more aggressive than those seen in other regions and are associated with remarkable mortality and morbidity. Treatment of synovial sarcomas of the head and neck is usually extensive local excision and additional radiation and/or chemotherapy may be performed. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - June 1, 2020 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Exploring Two Protocols of FISH Using Cytocell SYT-SSX Probe on Formalin Fixed Paraffin Embedded Tissue Sections.
CONCLUSION: Optimised Dako FISH protocol was noted to be more suited for detecting SYT-SSX FISH signals on paraffin embedded tissues in comparison to Cytocell FISH protocol. PMID: 32458628 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - May 28, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Laryngeal Synovial Sarcoma: a Rare Clinical Entity
We present a case report here for its rarity along with a brief review of literature. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 20, 2020 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 12, Pages 1258: Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma
This study revealed for the first time the therapeutic potential of TNIK inhibition in synovial sarcoma. (Source: Cancers)
Source: Cancers - May 15, 2020 Category: Cancer & Oncology Authors: Tetsuya Sekita Tesshi Yamada Eisuke Kobayashi Akihiko Yoshida Toru Hirozane Akira Kawai Yuko Uno Hideki Moriyama Masaaki Sawa Yuichi Nagakawa Akihiko Tsuchida Morio Matsumoto Masaya Nakamura Robert Nakayama Mari Masuda Tags: Article Source Type: research

Synovial sarcoma presenting as an intra-articular mass in a pediatric patient: a case report
Synovial sarcoma (SS) is one of the reported sarcomas in the pediatric and adult populations. Delay in diagnosis and treatment is common in SS cases. SS may be excised before the correct diagnosis is made. (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - May 7, 2020 Category: Orthopaedics Authors: Omar A. Al-Mohrej, Saeed A. Al-Jarallah, Hamad H. Al-Dakhil Allah, Rajeev Pant and Zayed S. Al-Zayed Tags: Case report Source Type: research

Clinical outcomes of patients with advanced synovial sarcoma or myxoid/round cell liposarcoma treated at major cancer centers in the United States
ConclusionsTo the best of our knowledge, this is the largest retrospective study of patients with SS and MRCL. It provides an analysis of real ‐world clinical outcomes among patients treated at major sarcoma cancer centers and could inform treatment decisions and design of clinical trials. In general, the survival outcomes for this selected population appear more favorable than in published literature. (Source: Cancer Medicine)
Source: Cancer Medicine - May 5, 2020 Category: Cancer & Oncology Authors: Seth M. Pollack, Neeta Somaiah, Dejka M. Araujo, Mihaela Druta, Brian A. Van Tine, Melissa A. Burgess, Sant P. Chawla, Mahesh Seetharam, Scott H. Okuno, Chet Bohac, Michael Chen, Sergey Yurasov, Steven Attia Tags: ORIGINAL RESEARCH Source Type: research

Diagnostic Value of TLE1 in Synovial Sarcoma: A Systematic Review and Meta-Analysis.
Conclusion: TLE1 is a sensitive and specific marker for synovial sarcoma that can aid in its diagnosis. Due to its involvement in several relevant signaling pathways, TLE1 might have direct relevance to the pathophysiology of the disease. PMID: 32322158 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 25, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Importance of muldisciplinary management of giant mediastinal sarcoma: A case report with phrenic nerve reconstruction
Primary synovial sarcoma is a soft tissue tumor which originates from synovial ‐like undeveloped mesenchymal structures. Here, we report the case of a giant mediastinal sarcoma in a 41‐year‐old female patient. After diagnosis, she underwent neoadjuvant chemotherapy. Due to its low efficacy, we collegially decided to undergo cytoreductive debulking surgery. The mass invad ed the phrenic nerve bilaterally and its excision caused a severe lesion of the left nerve and a partial impairment of the right one. Thus, plastic surgeons decided to reconstruct the right phrenic nerve employing the contralateral remaining fibers.T...
Source: Thoracic Cancer - April 22, 2020 Category: Cancer & Oncology Authors: Luca Frasca, Filippo Longo, Giovanni Tacchi, Francesco Stilo, Anna Zito, Beniamino Brunetti, Massimiliano Depalma, Pierfilippo Crucitti Tags: CASE REPORT Source Type: research

Primary Subcutaneous Spindle Cell Synovial Sarcoma: First Reported Case
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - April 21, 2020 Category: Pathology Tags: Letters to the Editor Source Type: research

Gastric synovial sarcoma: a case report and literature review.
Authors: Wong HK, Law S, Collins R PMID: 32300075 [PubMed - in process] (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 19, 2020 Category: General Medicine Tags: Hong Kong Med J Source Type: research

Complications of muscle hematomas in hemophilia.
Authors: Rodriguez-Merchan EC Abstract Prevention is essential for avoiding the complications of muscle hematomas (compartment syndrome, pseudotumous and peripheral nerve lesions) in hemophilic patients. This is achieved through early diagnosis of muscle hematomas and proper long-term hematological treatment until they have resolved (confirmed by image studies). Ultrasound-guided percutaneous drainage could be beneficial in terms of achieving better and faster symptom relief. Acute compartment syndrome (ACS) requires emergency surgical treatment (decompression fasciotomy). As for pseudotumor, biopsy will help us co...
Source: Cardiovascular and Hematological Disorders Drug Targets - April 17, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Hydra: A mixture modeling framework for subtyping pediatric cancer cohorts using multimodal gene expression signatures
by Jacob Pfeil, Lauren M. Sanders, Ioannis Anastopoulos, A. Geoffrey Lyle, Alana S. Weinstein, Yuanqing Xue, Andrew Blair, Holly C. Beale, Alex Lee, Stanley G. Leung, Phuong T. Dinh, Avanthi Tayi Shah, Marcus R. Breese, W. Patrick Devine, Isabel Bjork, Sofie R. Salama, E. Alejandro Sweet-Cordero, David Haussler, Olena Morozova Vaske Precision oncology has primarily relied on coding mutations as biomarkers of response to therapies. While transcriptome analysis can provide valuable information, incorporation into workflows has been difficult. For example, the relative rather than absolute gene expression level needs to be c...
Source: PLoS Computational Biology - April 9, 2020 Category: Biology Authors: Jacob Pfeil Source Type: research

Establishment and characterization of NCC-SS3-C1: a novel patient-derived cell line of synovial sarcoma
We examined a range of proliferation-inhibiting effects of small molecule anti-cancer compounds, including FDA-approved anti-cancer drugs, using NCC-SS3-C1 cells, and identified anti-cancer drugs which inhibited the proliferation of NCC-SS3-C1 cells at the low concentration. We concluded that NCC-SS3-C1 would be a useful tool for basic and pre-clinical synovial sarcoma research. (Source: Human Cell)
Source: Human Cell - April 8, 2020 Category: Cytology Source Type: research

STAT6 Expression in Solitary Fibrous Tumor and Histologic Mimics: a Single Institution Experience
This study aims to validate the use of STAT6 rabbit monoclonal antibody in differentiating SFT from its histologic mimics. Forty-five cases of SFT and 110 cases from 9 other spindle cell tumors were collected for STAT6 immunostaining. Positive nuclear STAT6 staining was present in all 45 SFT cases (100% sensitivity). No nuclear staining was identified in other spindle cell neoplasms (0/13, dedifferentiated liposarcoma; 0/17, synovial sarcoma; 0/16, malignant peripheral nerve sheath tumors; 0/25, undifferentiated pleomorphic sarcoma; 0/10, dermatofibrosarcoma protuberans; 0/9, low-grade fibromyxoid sarcoma; 0/6, angiofibrom...
Source: Applied Immunohistochemistry and Molecular Morphology - April 1, 2020 Category: Chemistry Tags: Research Articles Source Type: research

BRAF V600E mutation is a potential therapeutic target for a small subset of synovial sarcoma
Modern Pathology, Published online: 01 April 2020; doi:10.1038/s41379-020-0530-3BRAF V600E mutation is a potential therapeutic target for a small subset of synovial sarcoma (Source: Modern Pathology)
Source: Modern Pathology - March 31, 2020 Category: Pathology Authors: Sho Watanabe Akihiko Shimomura Takashi Kubo Masaya Sekimizu Takuji Seo Shun-Ichi Watanabe Akira Kawai Noboru Yamamoto Kenji Tamura Takashi Kohno Hitoshi Ichikawa Akihiko Yoshida Source Type: research

GSE141251 A novel mouse model for human synovial sarcoma expressing SS18-SSX1
Contributors : Miwa Tanaka ; Takuro NakamuraSeries Type : Expression profiling by arrayOrganism : Mus musculusSS18-SSX fusion proteins play a central role in synovial sarcoma development, however, genetic network and mechanisms of synovial sarcomagenesis remain largely unknown. To clarify such unknown mechanisms, we have established a new ex vivo mouse model for synovial sarcoma, using retrovirus-mediated gene transfer of SS18-SSX1 to mouse embryonic mesenchymal cells followed by subcutaneous transplantation into nude mice. This approach successfully induced subcutaneous tumors in 100% of recipients, showing invasive proli...
Source: GEO: Gene Expression Omnibus - March 30, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

The Value of H3K27me3 Immunohistochemistry in Differentiating Malignant Peripheral Nerve Sheath Tumour with Its Histologic Mimickers.
Authors: Mustapar N, Zawawi MSF, Tuan Sharif SE Abstract BACKGROUND: Diagnosis of malignant peripheral nerve sheath tumor (MPNST) is rather challenging due to its divergent morphologic heterogeneity and lack of specific ancillary test. The emergence of H3K27 trimethylation (H3K27me3) as a new immunohistochemistry (IHC) marker for MPNST have recently available to assist pathologists in differentiating MPNST from other histologic mimics. We aim to study the expression pattern of H3K27me3 in MPNST and its histologic mimickers and their association with the clinicopathological data. METHODOLOGY: A total of 59 benig...
Source: Asian Pacific Journal of Cancer Prevention - March 28, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research