Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
In this study, we report systemic changes in the molecular regulation of biological processes under multiple lifespan-extending interventions, by jointly leveraging systems-level analyses on two mouse liver proteomic datasets, which were generated in the NIA Longevity Consortium, and a previously published mouse liver transcriptomic dataset. Differential Rank Conservation (DIRAC) analyses of mouse liver proteomics and transcriptomics data show that mechanistically distinct lifespan-extending interventions (acarbose, 17α-estradiol, rapamycin, and calorie restriction) generally tighten the regulation of biological modules. ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Study Warns That Even Light Drinking Can Raise Blood Pressure
Conclusion
In sum, the international research study underscores the significant impact of alcohol consumption on blood pressure, with effects noticed even at low levels. Contrary to common assumptions, it highlights no beneficial effects in low-level drinkers compared to non-drinkers.
The findings serve as a crucial reminder of the importance of moderation, or ideally, avoidance of alcohol for effective blood pressure management and optimal cardiovascular health. The global scale and comprehensive approach of the study lend weight to its findings, making them a key resource for individuals worldwide.
In the face o...
Source: The EMT Spot - August 1, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Beta-Blockers For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In conclusion, beta-blockers serve as an indispensable tool in the realm of modern medical treatment, particularly in managing a broad range of cardiovascular conditions.
Their unique mechanism of action, which includes decreasing heart rate and blood pressure, confers a significant cardio-protective effect.
This, combined with their versatility and the extensive clinical experience with their use, has cemented beta-blockers as a first-line treatment for various conditions, from hypertension and heart failure to anxiety and migraines.
Although beta-blockers present unique benefits, it’s crucial...
Source: The EMT Spot - July 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Consciously Exploring Your Relationship with Drugs
Humanity has a complex, long-term relationship with a wide variety of drugs. In this article let’s delve into your personal relationship with drugs, how you frame them, and how you might upgrade these relationships to be more conscious and aligned with your path of self-development. Let’s include common drug sources like coffee, tea, and chocolate too, so this will be very inclusive.
My purpose here isn’t to encourage or discourage you from using any particular substances but rather to invite you to take a more conscious and honest look at your current frames, attitudes, biases, and behaviors, and dete...
Source: Steve Pavlina's Personal Development Blog - July 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Emotions Health Lifestyle Relationships Values Source Type: blogs
Eggs And High Blood Pressure: Decoding The Dietary Dilemma
Conclusion
In navigating the winding road of managing high blood pressure, several key points emerge. Eggs, while a source of ongoing debate, can form part of a balanced diet for most people. It’s essential, though, to consider your entire dietary pattern, emphasizing heart-healthy choices like those found in the DASH and Mediterranean diets.
Avoiding processed meats and sugary breakfast options, while incorporating nutrient-dense foods, can significantly impact your blood pressure management. But remember, it’s not all about diet. A comprehensive approach, involving regular physical activity, stress mana...
Source: The EMT Spot - July 21, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Alpha-Beta-Blockers For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In conclusion, the advent of alpha-beta-blockers has marked a significant advancement in cardiovascular treatment.
These medications, combining the properties of both alpha and beta blockers, have demonstrated superiority in managing various cardiovascular conditions.
They offer the potential for enhanced blood pressure control, cardiovascular protection, and versatility in the management of several cardiovascular conditions.
The choice of using alpha-beta-blockers, however, must be tailored to the individual patient. Considerations such as past medical records, present health conditions, concurrent ...
Source: The EMT Spot - July 20, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
SENS Research Foundation 2023 Annual Report
The SENS Research Foundation has released its 2023 annual report. This is one of the few non-profit organizations focused on advancing the state of research and development of rejuvenation therapies. It exists in the same family tree as the Methuselah Foundation and LEV Foundation, and all three now have somewhat different areas of focus within the same broad outline. In comparison to the SENS Research Foundation, the Methuselah Foundation gives more attention to tissue engineering, while LEV Foundation is presently investigating combinations of potential rejuvenation therapies in animal models, a sorely neglected area of ...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Banana Bread (with Chocolate Bits)
I’m generally not a fan of bananas eaten anything other than in vivo, ie., peeled and popped into the mouth, fresh but not too ripe. I don’t like them in ice cream, oatmeal, cereal, cakes or even in fruit salads. Certain foods, in my opinion, just need to be enjoyed one-on-one, you know?
But last week, in my mother-in-law’s kitchen, a few over-ripe bananas were calling out not to be wasted, so my daughter and I decided to make banana bread. I figured that since others were there with us that evening, I would be under no obligation to eat the thing I was making, and my daughter and I would have a littl...
Source: The Blog That Ate Manhattan - July 10, 2023 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Bread Breakfast Desserts Banana bread Chocolate chips Source Type: blogs
Data Democracy! ‘Dr. Google’ (2023) Vs. ‘Every Man His Own Physician’ (1767)
BY MICHAEL MILLENSON
In the 18th-century, a pre-Google guide offered democratization of medical information
In 1767, as American colonists’ protestations against “taxation without representation” intensified, a Boston publisher reprinted a book by a British doctor seemingly tailor-made for the growing spirit of independence.
Talk about “democratization of health care information,” “participatory medicine” and “health citizens”! Every Man His Own Physician, by Dr. John Theobald, bore an impressive subtitle: Being a complete collection of efficacious and approved remedies for every disease...
Source: The Health Care Blog - July 7, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Democritization of Care Healthcare Michael Millenson Participatory medicine Source Type: blogs
Processed Foods Linked To Increased Blood Pressure, Study Finds
Conclusions
This groundbreaking study highlights the link between high consumption of processed foods and increased blood pressure variability, particularly at night.
The findings emphasize the crucial role of diet and lifestyle in cardiovascular health.
Interestingly, researchers noted an unexpected association: higher consumption of ultra-processed foods was linked to less variation in night-time blood pressure.
This puzzling finding suggests a need for further investigation into the effects of ultra-processed foods on our health.
In conclusion, the study underscores the importance of prioritizing unproc...
Source: The EMT Spot - July 4, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
8 Risk Factors Of Low Blood Pressure
Conclusion
In a nutshell, understanding the risk factors associated with low blood pressure is essential for maintaining good health.
Individuals with certain risk factors, such as age, medication usage, underlying medical conditions, dehydration, prolonged bed rest, nutritional deficiencies, pregnancy, and inherited factors, should be particularly aware of the potential for low blood pressure.
Regular monitoring of blood pressure, communication with healthcare providers, and appropriate management strategies are important for individuals with these risk factors to ensure their well-being.
Furthermore, diet pla...
Source: The EMT Spot - June 23, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Can You Drink A Juice Cleanse With Hypertension?
Conclusion
Navigating the crossroads of popular health trends and chronic conditions can be challenging. So, can you drink a juice cleanse with hypertension? Yes, but with an asterisk. The nature of the cleanse, your individual health, and the involvement of healthcare professionals all play a pivotal role.
The answer lies in striking the right balance – not too much sodium or sugar, an eye on potassium levels, and regular monitoring of blood pressure. As the experiences of Mark, Sarah, and John demonstrated, the journey is unique for everyone.
In the words of Dr. Naomi Fisher at Harvard Medical School:
...
Source: The EMT Spot - June 23, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
10 Steps To Live With Low Blood Pressure
Conclusion
To sum things up living with low blood pressure requires careful attention and management to ensure optimal health and well-being.
While often overshadowed by high blood pressure, low blood pressure should not be underestimated.
Insufficient blood flow to vital organs can lead to symptoms that significantly impact daily life and increase the risk of falls and injuries, especially in older adults.
By adopting strategies such as mindful breathing, staying cool, consuming small and frequent meals, using compression stockings, and maintaining adequate salt intake, individuals can effectively manage low b...
Source: The EMT Spot - June 22, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
