Effectiveness of spironolactone for women with acne vulgaris (SAFA) trial: a critically appraised research paper
Br J Dermatol. 2023 Jul 28:ljad270. doi: 10.1093/bjd/ljad270. Online ahead of print.NO ABSTRACTPMID:37503674 | DOI:10.1093/bjd/ljad270 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 28, 2023 Category: Dermatology Authors: Ali Shields John S Barbieri Source Type: research
Effectiveness of spironolactone for women with acne vulgaris (SAFA) trial: a critically appraised research paper
Br J Dermatol. 2023 Jul 28:ljad270. doi: 10.1093/bjd/ljad270. Online ahead of print.NO ABSTRACTPMID:37503674 | DOI:10.1093/bjd/ljad270 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 28, 2023 Category: Dermatology Authors: Ali Shields John S Barbieri Source Type: research
Preclinical efficacy of LP-184, a tumor site activated synthetic lethal therapeutic, in glioblastoma
CONCLUSIONS: These results establish LP-184 as a promising chemotherapeutic for GBM with enhanced efficacy in intrinsic or spironolactone-induced TC-NER deficient tumors.PMID:37494541 | DOI:10.1158/1078-0432.CCR-23-0673 (Source: Cell Research)
Source: Cell Research - July 26, 2023 Category: Cytology Authors: Bachchu Lal Aditya Kulkarni Joseph McDermott Rana Rais Jesse Alt Ying Wu Hernando Lopez-Bertoni Sophie Sall Umesh Kathad Jianli Zhou Barbara S Slusher Kishor Bhatia John Laterra Source Type: research
Preclinical efficacy of LP-184, a tumor site activated synthetic lethal therapeutic, in glioblastoma
CONCLUSIONS: These results establish LP-184 as a promising chemotherapeutic for GBM with enhanced efficacy in intrinsic or spironolactone-induced TC-NER deficient tumors.PMID:37494541 | DOI:10.1158/1078-0432.CCR-23-0673 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - July 26, 2023 Category: Cancer & Oncology Authors: Bachchu Lal Aditya Kulkarni Joseph McDermott Rana Rais Jesse Alt Ying Wu Hernando Lopez-Bertoni Sophie Sall Umesh Kathad Jianli Zhou Barbara S Slusher Kishor Bhatia John Laterra Source Type: research
Every second counts: giant ECG abnormality after every second beat
Clinical introduction The patient had recently been diagnosed with heart failure and dilated cardiomyopathy (left ventricular ejection fraction: 20%). Medication included furosemide, spironolactone, bisoprolol, perindopril, indapamide. The patient was found with a cardiac arrest. After successful basic life support and stabilized circulation, the following ECG was recorded (see figure 1). Question What is the possible explanation for these ECG features? Giant TU waves due to proarrhythmic effect of propafenone (Class 1/c antiarrhythmic drug) the patient was given as paroxysmal atrial fibrillation rhythm control. Hypokalaem...
Source: Emergency Medicine Journal - July 24, 2023 Category: Emergency Medicine Authors: Tomcsanyi, J., Aranyi, P. Tags: EMJ Image Challenge Source Type: research
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone-target gene expression
In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone (one with concomitant RAAS activation) and in a model of secondary hyperaldosteronism induced by cirrhosis. The expression of a subset of these genes was also tested in distal colon biopsies from control subjects or cirrhotic patients with varying levels of disease progression and treated or not with mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion ...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - July 18, 2023 Category: Physiology Authors: Natalia Serrano-Morillas Carlos Gonz ález-Alayón Arianna Vastola-Mascolo Ana E Rodr íguez-Rodríguez Guadalberto Hernandez Esteban Porrini Manuel Hern ández-Guerra Diego Alvarez de la Rosa Source Type: research
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone-target gene expression
In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone (one with concomitant RAAS activation) and in a model of secondary hyperaldosteronism induced by cirrhosis. The expression of a subset of these genes was also tested in distal colon biopsies from control subjects or cirrhotic patients with varying levels of disease progression and treated or not with mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion ...
Source: Am J Physiol Gastroi... - July 18, 2023 Category: Gastroenterology Authors: Natalia Serrano-Morillas Carlos Gonz ález-Alayón Arianna Vastola-Mascolo Ana E Rodr íguez-Rodríguez Guadalberto Hernandez Esteban Porrini Manuel Hern ández-Guerra Diego Alvarez de la Rosa Source Type: research
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone-target gene expression
In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone (one with concomitant RAAS activation) and in a model of secondary hyperaldosteronism induced by cirrhosis. The expression of a subset of these genes was also tested in distal colon biopsies from control subjects or cirrhotic patients with varying levels of disease progression and treated or not with mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion ...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - July 18, 2023 Category: Physiology Authors: Natalia Serrano-Morillas Carlos Gonz ález-Alayón Arianna Vastola-Mascolo Ana E Rodr íguez-Rodríguez Guadalberto Hernandez Esteban Porrini Manuel Hern ández-Guerra Diego Alvarez de la Rosa Source Type: research
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone-target gene expression
In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone (one with concomitant RAAS activation) and in a model of secondary hyperaldosteronism induced by cirrhosis. The expression of a subset of these genes was also tested in distal colon biopsies from control subjects or cirrhotic patients with varying levels of disease progression and treated or not with mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion ...
Source: Am J Physiol Gastroi... - July 18, 2023 Category: Gastroenterology Authors: Natalia Serrano-Morillas Carlos Gonz ález-Alayón Arianna Vastola-Mascolo Ana E Rodr íguez-Rodríguez Guadalberto Hernandez Esteban Porrini Manuel Hern ández-Guerra Diego Alvarez de la Rosa Source Type: research
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone-target gene expression
In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone (one with concomitant RAAS activation) and in a model of secondary hyperaldosteronism induced by cirrhosis. The expression of a subset of these genes was also tested in distal colon biopsies from control subjects or cirrhotic patients with varying levels of disease progression and treated or not with mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion ...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - July 18, 2023 Category: Physiology Authors: Natalia Serrano-Morillas Carlos Gonz ález-Alayón Arianna Vastola-Mascolo Ana E Rodr íguez-Rodríguez Guadalberto Hernandez Esteban Porrini Manuel Hern ández-Guerra Diego Alvarez de la Rosa Source Type: research
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone-target gene expression
In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone (one with concomitant RAAS activation) and in a model of secondary hyperaldosteronism induced by cirrhosis. The expression of a subset of these genes was also tested in distal colon biopsies from control subjects or cirrhotic patients with varying levels of disease progression and treated or not with mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion ...
Source: Am J Physiol Gastroi... - July 18, 2023 Category: Gastroenterology Authors: Natalia Serrano-Morillas Carlos Gonz ález-Alayón Arianna Vastola-Mascolo Ana E Rodr íguez-Rodríguez Guadalberto Hernandez Esteban Porrini Manuel Hern ández-Guerra Diego Alvarez de la Rosa Source Type: research
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone-target gene expression
In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone (one with concomitant RAAS activation) and in a model of secondary hyperaldosteronism induced by cirrhosis. The expression of a subset of these genes was also tested in distal colon biopsies from control subjects or cirrhotic patients with varying levels of disease progression and treated or not with mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion ...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - July 18, 2023 Category: Physiology Authors: Natalia Serrano-Morillas Carlos Gonz ález-Alayón Arianna Vastola-Mascolo Ana E Rodr íguez-Rodríguez Guadalberto Hernandez Esteban Porrini Manuel Hern ández-Guerra Diego Alvarez de la Rosa Source Type: research
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone-target gene expression
In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone (one with concomitant RAAS activation) and in a model of secondary hyperaldosteronism induced by cirrhosis. The expression of a subset of these genes was also tested in distal colon biopsies from control subjects or cirrhotic patients with varying levels of disease progression and treated or not with mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion ...
Source: Am J Physiol Gastroi... - July 18, 2023 Category: Gastroenterology Authors: Natalia Serrano-Morillas Carlos Gonz ález-Alayón Arianna Vastola-Mascolo Ana E Rodr íguez-Rodríguez Guadalberto Hernandez Esteban Porrini Manuel Hern ández-Guerra Diego Alvarez de la Rosa Source Type: research
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone-target gene expression
In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone (one with concomitant RAAS activation) and in a model of secondary hyperaldosteronism induced by cirrhosis. The expression of a subset of these genes was also tested in distal colon biopsies from control subjects or cirrhotic patients with varying levels of disease progression and treated or not with mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion ...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - July 18, 2023 Category: Physiology Authors: Natalia Serrano-Morillas Carlos Gonz ález-Alayón Arianna Vastola-Mascolo Ana E Rodr íguez-Rodríguez Guadalberto Hernandez Esteban Porrini Manuel Hern ández-Guerra Diego Alvarez de la Rosa Source Type: research
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone-target gene expression
In this study, we compared the transcriptional response of aldosterone target genes in the rat distal colon under two models of increased circulating aldosterone (one with concomitant RAAS activation) and in a model of secondary hyperaldosteronism induced by cirrhosis. The expression of a subset of these genes was also tested in distal colon biopsies from control subjects or cirrhotic patients with varying levels of disease progression and treated or not with mineralocorticoid receptor inhibitor spironolactone. We examined known aldosterone-regulated transcripts involved in corticosteroid signaling and transepithelial ion ...
Source: Am J Physiol Gastroi... - July 18, 2023 Category: Gastroenterology Authors: Natalia Serrano-Morillas Carlos Gonz ález-Alayón Arianna Vastola-Mascolo Ana E Rodr íguez-Rodríguez Guadalberto Hernandez Esteban Porrini Manuel Hern ández-Guerra Diego Alvarez de la Rosa Source Type: research
