Optimal Medical Treatment of Difficult-to-treat Hypertension
Conditions: Hypertension Interventions: Drug: Phase C: Eplerenone; Drug: Phase C: Spironolactone; Drug: Phase C: Torasemide; Drug: Phase B: Triplixam / Elestar HCT; Diagnostic Test: Phase A: Confirmation of uncontrolled hypertension Sponsors: National Institute of Cardiology, Warsaw, Poland Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials
A Study to Learn How the Body Processes Spironolactone and Hydrochlorothiazide Film Coated Tablets Manufactured at Two Sites: Viatris and Neolpharma
Conditions: Healthy Participants Interventions: Drug: Spironolactone/Hydrochlorothiazide (25 mg/25 mg) film coated tablets from Viatris; Drug: Spironolactone/Hydrochlorothiazide (25 mg/25 mg) film coated tablets from Neolpharma. Sponsors: Pfizer Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 15, 2024 Category: Research Source Type: clinical trials
SPironolactONe for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation
Conditions: Atrial Fibrillation Recurrent Interventions: Drug: Spironolactone Sponsors: University Hospital, Caen Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 12, 2024 Category: Research Source Type: clinical trials
Efficacy and Safety of Finerenone vs. Spironolactone in Patients With Primary Aldosteronism
Conditions: Primary Aldosteronism Interventions: Drug: Finerenone; Drug: Spironolactone Sponsors: Shanghai Jiao Tong University School of Medicine Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 11, 2023 Category: Research Source Type: clinical trials
Factors that influence women ’s enrolment and ongoing participation in a partially decentralised randomised controlled dermatology trial: a qualitative interview study with participants in the SAFA (Spironolactone for Adult Female Acne) trial
ConclusionsThe study has shown that decentralised methods used by responsive and approachable staff were widely accepted in the SAFA trial. Interviewees found the methods adopted in the SAFA trial helped the trial to fit with their needs and promoted a sense of feeling valued that encouraged ongoing trial engagement. Decentralised methods should be considered favourably when designing a dermatology trial as they can potentially enhance both recruitment and retention.Trial registration numberISRCTN 12892056. Registered on October 15, 2018. (Source: Trials)
Source: Trials - October 12, 2023 Category: Research Source Type: clinical trials
SPIOMET4HEALTH —efficacy, tolerability and safety of lifestyle intervention plus a fixed dose combination of spironolactone, pioglitazone and metformin (SPIOMET) for adolescent girls and young women with polycystic ovary syndrome: study protocol for a multicentre, randomised, double-blind, placebo-controlled, fo ur-arm, parallel-group, phase II clinical trial
DiscussionThe present study will be the first to evaluate —in a randomised, double-blind, placebo-controlled way—the efficacy, tolerability and safety of SPIOMET treatment for early PCOS, on top of a lifestyle intervention.Trial registrationEudraCT 2021 –003177-58. Registered on 22 December 2021.https://www.clinicaltrialsregister.eu/ctr-search/search?query=%092021-003177-58. (Source: Trials)
Source: Trials - September 15, 2023 Category: Research Source Type: clinical trials
Determination of Drug Levels for Pharmacotherapy of Heart Failure
Conditions: Cardiovascular Diseases; Heart Failure With Reduced Ejection Fraction Interventions: Drug: Nebivolol; Drug: Valsartan and Sacubitril; Drug: Carvedilol; Drug: Bisoprolol; Drug: Metoprolol; Drug: Spironolactone Sponsor: University Hospital Ostrava Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 13, 2023 Category: Research Source Type: clinical trials
