Effect of Spironolactone on Kidney Function in Kidney Transplant Recipients: A Randomized Placebo-Controlled Clinical Trial
CONCLUSION: Spironolactone added to standard therapy for three years in kidney transplant patients did not improve kidney function, long-term proteinuria or interstitial fibrosis.PMID:38416033 | DOI:10.2215/CJN.0000000000000439 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - February 28, 2024 Category: Urology & Nephrology Authors: Line A Mortensen Bente Jespersen Anne Sophie L Helligsoe Birgitte Tougaard Donata Cibulskyte-Ninkovic Martin Egfjord Lene Boesby Niels Marcussen Kirsten Madsen Boye L Jensen Inge Petersen Claus Bistrup Helle C Thiesson Source Type: research
No increased risk of breast or gynecologic malignancies in women exposed to spironolactone for dermatological conditions: a retrospective cohort study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 27, 2024 Category: Dermatology Authors: Rachel C. Hill, Yu Wang, Bilal Shaikh, Shari R. Lipner Source Type: research
Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study
Acta Derm Venereol. 2024 Feb 21;104:adv26002. doi: 10.2340/actadv.v104.26002.ABSTRACTAcne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne. This multicentre, controlled, randomized, double-blind prospective and parallel study assessed the efficacy of spironolactone compared with doxycycline in adult female acne. A total of 133 women with moderate acne were randomized to receive treatment with: (i) doxycycline and benzoyl peroxide for 3 months followed by a 3-month...
Source: Acta Dermato-Venereologica - February 21, 2024 Category: Dermatology Authors: Brigitte Dr éno Jean-Michel Nguyen Ewa Hainaut Laurent Machet Marie-Th érèse Leccia Nathalie Beneton Jean-Paul Claudel Philippe C élérier Marie Le Moigne Sarah Le Naour Florence Vrignaud Alexandra Poinas C écile Dert Aur élie Boisrobert Laurent Fle Source Type: research
Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study
Acta Derm Venereol. 2024 Feb 21;104:adv26002. doi: 10.2340/actadv.v104.26002.ABSTRACTAcne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne. This multicentre, controlled, randomized, double-blind prospective and parallel study assessed the efficacy of spironolactone compared with doxycycline in adult female acne. A total of 133 women with moderate acne were randomized to receive treatment with: (i) doxycycline and benzoyl peroxide for 3 months followed by a 3-month...
Source: Acta Derm Venereol A... - February 21, 2024 Category: Dermatology Authors: Brigitte Dr éno Jean-Michel Nguyen Ewa Hainaut Laurent Machet Marie-Th érèse Leccia Nathalie Beneton Jean-Paul Claudel Philippe C élérier Marie Le Moigne Sarah Le Naour Florence Vrignaud Alexandra Poinas C écile Dert Aur élie Boisrobert Laurent Fle Source Type: research
Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study
Acta Derm Venereol. 2024 Feb 21;104:adv26002. doi: 10.2340/actadv.v104.26002.ABSTRACTAcne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne. This multicentre, controlled, randomized, double-blind prospective and parallel study assessed the efficacy of spironolactone compared with doxycycline in adult female acne. A total of 133 women with moderate acne were randomized to receive treatment with: (i) doxycycline and benzoyl peroxide for 3 months followed by a 3-month...
Source: Acta Dermato-Venereologica - February 21, 2024 Category: Dermatology Authors: Brigitte Dr éno Jean-Michel Nguyen Ewa Hainaut Laurent Machet Marie-Th érèse Leccia Nathalie Beneton Jean-Paul Claudel Philippe C élérier Marie Le Moigne Sarah Le Naour Florence Vrignaud Alexandra Poinas C écile Dert Aur élie Boisrobert Laurent Fle Source Type: research
Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study
Acta Derm Venereol. 2024 Feb 21;104:adv26002. doi: 10.2340/actadv.v104.26002.ABSTRACTAcne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne. This multicentre, controlled, randomized, double-blind prospective and parallel study assessed the efficacy of spironolactone compared with doxycycline in adult female acne. A total of 133 women with moderate acne were randomized to receive treatment with: (i) doxycycline and benzoyl peroxide for 3 months followed by a 3-month...
Source: Acta Derm Venereol A... - February 21, 2024 Category: Dermatology Authors: Brigitte Dr éno Jean-Michel Nguyen Ewa Hainaut Laurent Machet Marie-Th érèse Leccia Nathalie Beneton Jean-Paul Claudel Philippe C élérier Marie Le Moigne Sarah Le Naour Florence Vrignaud Alexandra Poinas C écile Dert Aur élie Boisrobert Laurent Fle Source Type: research
Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study
Acta Derm Venereol. 2024 Feb 21;104:adv26002. doi: 10.2340/actadv.v104.26002.ABSTRACTAcne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne. This multicentre, controlled, randomized, double-blind prospective and parallel study assessed the efficacy of spironolactone compared with doxycycline in adult female acne. A total of 133 women with moderate acne were randomized to receive treatment with: (i) doxycycline and benzoyl peroxide for 3 months followed by a 3-month...
Source: Acta Dermato-Venereologica - February 21, 2024 Category: Dermatology Authors: Brigitte Dr éno Jean-Michel Nguyen Ewa Hainaut Laurent Machet Marie-Th érèse Leccia Nathalie Beneton Jean-Paul Claudel Philippe C élérier Marie Le Moigne Sarah Le Naour Florence Vrignaud Alexandra Poinas C écile Dert Aur élie Boisrobert Laurent Fle Source Type: research
Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study
Acta Derm Venereol. 2024 Feb 21;104:adv26002. doi: 10.2340/actadv.v104.26002.ABSTRACTAcne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne. This multicentre, controlled, randomized, double-blind prospective and parallel study assessed the efficacy of spironolactone compared with doxycycline in adult female acne. A total of 133 women with moderate acne were randomized to receive treatment with: (i) doxycycline and benzoyl peroxide for 3 months followed by a 3-month...
Source: Acta Derm Venereol A... - February 21, 2024 Category: Dermatology Authors: Brigitte Dr éno Jean-Michel Nguyen Ewa Hainaut Laurent Machet Marie-Th érèse Leccia Nathalie Beneton Jean-Paul Claudel Philippe C élérier Marie Le Moigne Sarah Le Naour Florence Vrignaud Alexandra Poinas C écile Dert Aur élie Boisrobert Laurent Fle Source Type: research
Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study
Acta Derm Venereol. 2024 Feb 21;104:adv26002. doi: 10.2340/actadv.v104.26002.ABSTRACTAcne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne. This multicentre, controlled, randomized, double-blind prospective and parallel study assessed the efficacy of spironolactone compared with doxycycline in adult female acne. A total of 133 women with moderate acne were randomized to receive treatment with: (i) doxycycline and benzoyl peroxide for 3 months followed by a 3-month...
Source: Acta Derm Venereol A... - February 21, 2024 Category: Dermatology Authors: Brigitte Dr éno Jean-Michel Nguyen Ewa Hainaut Laurent Machet Marie-Th érèse Leccia Nathalie Beneton Jean-Paul Claudel Philippe C élérier Marie Le Moigne Sarah Le Naour Florence Vrignaud Alexandra Poinas C écile Dert Aur élie Boisrobert Laurent Fle Source Type: research
Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study
Acta Derm Venereol. 2024 Feb 21;104:adv26002. doi: 10.2340/actadv.v104.26002.ABSTRACTAcne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne. This multicentre, controlled, randomized, double-blind prospective and parallel study assessed the efficacy of spironolactone compared with doxycycline in adult female acne. A total of 133 women with moderate acne were randomized to receive treatment with: (i) doxycycline and benzoyl peroxide for 3 months followed by a 3-month...
Source: Acta Dermato-Venereologica - February 21, 2024 Category: Dermatology Authors: Brigitte Dr éno Jean-Michel Nguyen Ewa Hainaut Laurent Machet Marie-Th érèse Leccia Nathalie Beneton Jean-Paul Claudel Philippe C élérier Marie Le Moigne Sarah Le Naour Florence Vrignaud Alexandra Poinas C écile Dert Aur élie Boisrobert Laurent Fle Source Type: research
Synergistic effect of albuminuria on atherosclerosis in patients with primary aldosteronism
CONCLUSION: Concomitant albuminuria in PA was associated with greater arterial stiffness and more substantial improvement after targeted treatment. Both the baseline and the improved extent of PWV increased in correlation with rising urine albumin-creatinine ratio levels, reaching a plateau when the urine albumin-creatinine ratio surpassed 100 mg/g.PMID:38362007 | PMC:PMC10867404 | DOI:10.1177/20406223231210114 (Source: Atherosclerosis)
Source: Atherosclerosis - February 16, 2024 Category: Cardiology Authors: Ting-Wei Kao Che-Wei Liao Cheng-Hsuan Tsai Yi-Yao Chang Chien-Ting Pan Chin-Chen Chang Bo-Ching Lee Wei-Chieh Huang Kuo-How Huang Ching-Chu Lu Tai-Shuan Lai Chieh-Kai Chan Jeff S Chueh Vin-Cent Wu Chi-Sheng Hung Zheng-Wei Chen Yen-Hung Lin Source Type: research
Synergistic effect of albuminuria on atherosclerosis in patients with primary aldosteronism
CONCLUSION: Concomitant albuminuria in PA was associated with greater arterial stiffness and more substantial improvement after targeted treatment. Both the baseline and the improved extent of PWV increased in correlation with rising urine albumin-creatinine ratio levels, reaching a plateau when the urine albumin-creatinine ratio surpassed 100 mg/g.PMID:38362007 | PMC:PMC10867404 | DOI:10.1177/20406223231210114 (Source: Atherosclerosis)
Source: Atherosclerosis - February 16, 2024 Category: Cardiology Authors: Ting-Wei Kao Che-Wei Liao Cheng-Hsuan Tsai Yi-Yao Chang Chien-Ting Pan Chin-Chen Chang Bo-Ching Lee Wei-Chieh Huang Kuo-How Huang Ching-Chu Lu Tai-Shuan Lai Chieh-Kai Chan Jeff S Chueh Vin-Cent Wu Chi-Sheng Hung Zheng-Wei Chen Yen-Hung Lin Source Type: research
GSE254742 Sildenafil as a candidate drug for Alzheimer ’s disease: Real-world patient data observation and mechanistic observations from patient-induced pluripotent stem cell-derived neurons.
Contributors : Dhruv Gohel ; Amit K Gupta ; Feixiong ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlzheimer ’s disease (AD) is a chronic neurodegenerative disease needing effective therapeutics urgently. Sildenafil, one of the approved phosphodiesterase-5 inhibitors, has been implicated as having potential beneficial effect in AD. We showed that sildenafil usage is associated with reduced likelihood of AD across four new drug compactor cohorts, including bumetanide, furosemide, spironolactone, and nifedipine. For instance, sildenafil usage is associated with a 54% reduced ...
Source: GEO: Gene Expression Omnibus - February 5, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Finerenone: A Novel Drug Discovery for the Treatment of Chronic Kidney Disease
CONCLUSION: The present review covers the complete picture of ADME properties, bioanalytical techniques, clinical trials, toxicity, and possible avenues in this arena. Finerenone is effective compared to other mineralocorticoid receptor-like spironolactone and eplerenone, for the treatment of chronic kidney disease.PMID:38288821 | DOI:10.2174/0115701638283354240103115420 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - January 30, 2024 Category: Drugs & Pharmacology Authors: Akshita Rana Jagdish K Sahu Source Type: research
Healthcare Challenges in the Management of Primary Aldosteronism in Southeast Asia
CONCLUSION: Large populations currently do not have access to the healthcare resources required for the optimal management of PA. Greater efforts are required to improve healthcare access and affordability. Future guideline revisions for PA may need to consider these limitations.PMID:38261997 | DOI:10.1210/clinem/dgae039 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 23, 2024 Category: Endocrinology Authors: Norlela Sukor Sarat Sunthornyothin Tran Viet Thang Tri Juli Tarigan Leilani B Mercado-Asis Satha Sum Moe Wint Aung Alice M L Yong Tania Tedjo Michael Villa Nang Ei Ei Khaing Elena Aisha Azizan Waye Hann Kang Vivien Lim Ada E D Teo Meifen Zhang Hieu Tran T Source Type: research
