Epidemiology of acutely decompensated systolic heart failure over the 2003 –2013 decade in Douala General Hospital, Cameroon
This study explores the epidemiology and prognostic factors of ADHF in Cameroonian patients.Methods and resultsThis was a retrospective study conducted between January 2003 and December 2013 from the medical files of patients followed at the intensive care and cardiovascular units of Douala General Hospital in Cameroon. Clinical, electrocardiographic, echocardiographic, and biological data were collected from 142 patients (58.5% men; mean age 58  ± 14 years) hospitalized for ADHF with reduced ejection fraction (HFrEF), whose left ventricular ejection fraction was70  mg/L (84.9%,n = 121)...
Source: ESC Heart Failure - November 22, 2020 Category: Cardiology Authors: Daniel Lemogoum, F élicité Kamdem, Hamadou Ba, William Ngatchou, Guillaume Hye Ndindjock, Anasthase Dzudie, Yves Monkam, Sidick Mouliom, Michel P. Hermans, Elysée Claude Bika Lele, Philippe Borne Tags: Original Research Article Source Type: research

Congenital chloride diarrhea in patient with SLC26A2 mutation - analysis of the clinical phenotype and differential diagnosis.
CONCLUSIONS: Persistent diarrhea and electrolyte disorder in pediatrics are easy to misdiagnose as CLD. Furthermore, it is difficult to identify Batter syndrome, Gitelman syndrome, renal tubular acidosis and CLD. Blood and stool electrolyte detection and SLC26A3 genetic tests are helpful for diagnosis, and sodium chloride and potassium chloride replacement therapy are critical for the patient prognosis. PMID: 33191723 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 16, 2020 Category: Endocrinology Authors: Sun M, Tao N, Liu X, Yang Y, Su Y, Xu F Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Clinical phenotypes, aetiologies, management, and mortality in acute heart failure: a single ‐institution study in Latin‐America
This study sought to assess the prevalence of, and identify differences among, in ‐hospital outcomes in patients hospitalized for AHF who were stratified by clinical phenotype at a hospital in Latin America.Methods and resultsThis is a retrospective cohort study of patients with AHF who were hospitalized in the coronary care unit of a Latin American teaching hospital from January 2006 to December 2018. Cox regression analysis was used to identify predictors of mortality. Of 21  042 patients admitted, 7759 (36.6%) had AHF. Their median age was 62 years, and 35% were women.De novo heart failure was seen in 39.4% ...
Source: ESC Heart Failure - November 11, 2020 Category: Cardiology Authors: H éctor González‐Pacheco, Amada Álvarez‐Sangabriel, Carlos Martínez‐Sánchez, José L. Briseño‐Cruz, Alfredo Altamirano‐Castillo, Salvador Mendoza‐García, Daniel Manzur‐Sandoval, Luis M. Amezcua‐Guerra, Julio Sandoval, Rafae Tags: Original Research Article Source Type: research

Aldosterone enhances high phosphate-induced vascular calcification through inhibition of AMPK-mediated autophagy.
Abstract It remains unclear whether the necessity of calcified mellitus induced by high inorganic phosphate (Pi) is required and the roles of autophagy plays in aldosterone (Aldo)-enhanced vascular calcification (VC) and vascular smooth muscle cell (VSMC) osteogenic differentiation. In the present study, we found that Aldo enhanced VC both in vivo and in vitro only in the presence of high Pi, alongside with increased expression of VSMC osteogenic proteins (BMP2, Runx2 and OCN) and decreased expression of VSMC contractile proteins (α-SMA, SM22α and smoothelin). However, these effects were blocked by min...
Source: J Cell Mol Med - November 4, 2020 Category: Molecular Biology Authors: Gao JW, He WB, Xie CM, Gao M, Feng LY, Liu ZY, Wang JF, Huang H, Liu PM Tags: J Cell Mol Med Source Type: research

Spironolactone discontinuation in patients with heart failure: complex interactions with loop diuretics. Letter regarding the article ‘Spironolactone dose in heart failure with preserved ejection fraction: findings from TOPCAT’
European Journal of Heart Failure, EarlyView. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - November 3, 2020 Category: Cardiology Authors: Viktor Čulić, Ivan Velat Tags: Letter to the Editor Source Type: research

Hyperkalemia and Acute Kidney Injury with Spironolactone Use Among Patients with Heart Failure
To quantify the risk of hyperkalemia and acute kidney injury (AKI) when spironolactone use is added on to loop diuretic use among patients with heart failure, and to evaluate whether the risk is modified by level of kidney function. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - November 1, 2020 Category: Internal Medicine Authors: Alex M. Secora, Jung-Im Shin, Yao Qiao, G. Caleb Alexander, Alex R. Chang, Leslie A. Inker, Josef Coresh, Morgan E. Grams Tags: Original article Source Type: research

Relationship between Galectin-3 and mineralocorticoid receptor in pulmonary hypertension
Background: Galectin-3 (Gal-3), a macrophage receptor, promotes experimental pulmonary arterial hypertension (PAH); however it has not been studied in human PAH. Mineralocorticoid receptor (MR) activates macrophages and has been implicated in PAH.Objectives: Investigate the relationship between Gal-3 and MR in human and experimental PAH.Methods: Tufts PAH registry included 109 idiopathic and connective tissue disease-PAH patients (IPAH, CTD-PAH), and 39 controls. Mice with selective MR deletion in myeloid cells were exposed to sugen/hypoxia PH vs. normoxia and compared with controls. A group of PH mice was treated with spi...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Tanba, C., Qi, G., Warburton, R., Penumatsa, K., Toksoz, D., Wilson, J., Farber, H., Hill, N., Preston, I. Tags: Pulmonary hypertension Source Type: research

A UK survey of the management of infants with bronchopulmonary dysplasia (BPD)
Introduction: BPD is the commonest adverse outcome of premature birth, hence appropriate management is essential.Methods: We undertook a survey of UK neonatal units to determine their management of infants with BPD.Results: Fifty-two neonatal units responded: 37% were level 3 NICUs, 49% level 2 and 14% level 1 units. Sixty percent of units had a BPD management guideline. Thirty-six units used patient triggered ventilation and 14 high frequency oscillatory ventilation. The majority (69%) used volume targeting. Nitric oxide was used by 29.9% of units with no consensus over dosage, range 5-20ppm. Diuretics were used by the ma...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Russell-Jones, E., Jeffreys, E., Williams, E., Sturrock, S., Greenough, A. Tags: Neonatology and paediatric intensive care Source Type: research

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease.
CONCLUSIONS: The effects of aldosterone antagonists when added to ACEi or ARB (or both) on the risks of death, major cardiovascular events, and kidney failure in people with proteinuric CKD are uncertain. Aldosterone antagonists may reduce proteinuria, eGFR, and systolic blood pressure in adults who have mild to moderate CKD but may increase the risk of hyperkalaemia, acute kidney injury and gynaecomastia when added to ACEi and/or ARB. PMID: 33107592 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 27, 2020 Category: General Medicine Authors: Chung EY, Ruospo M, Natale P, Bolignano D, Navaneethan SD, Palmer SC, Strippoli GF Tags: Cochrane Database Syst Rev Source Type: research

Efficacy and safety of spironolactone for the treatment of patients with acute heart failure: A protocol for systematic review
Conclusion: This study will seek to assess the efficacy and safety of spironolactone for treating AHF. Systematic review registration: INPLASY202070053. (Source: Medicine)
Source: Medicine - October 23, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Dietary sodium restriction sex-specifically impairs endothelial function via mineralocorticoid receptor-dependent reduction in NO bioavailability in Balb/C mice.
le EJ Abstract Recent findings from our group demonstrated that females exhibit higher endothelial mineralocorticoid receptor (MR) expression than males which predisposes them to aldosterone-mediated endothelial dysfunction in the context of metabolic disorders. However, whether the endothelium of female mice presents a higher propensity to MR-mediated dysfunction than that of males in the absence of comorbidities remains unknown. We therefore sought to investigate whether increasing aldosterone production endogenously with sodium restriction impairs endothelial function in otherwise healthy female mice. We fed ma...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 23, 2020 Category: Physiology Authors: Faulkner JL, Harwood DA, Kennard S, Antonova GN, Clere N, Belin de Chantemèle EJ Tags: Am J Physiol Heart Circ Physiol Source Type: research

Coronavirus-19: Possible Therapeutic Implications of Spironolactone and Dry Extract of Glycyrrhiza glabra L. (Licorice)
https://clinicaltrials.gov/ (NCT044241349, NCT043465887, NCT04487964) (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - October 22, 2020 Category: Drugs & Pharmacology Source Type: research

Impact of Mineralocorticoid Receptor And Angiotensin Ii Type 1 Receptor Antagonism on Blood Pressure Regulation in Obese Zucker Rats: Role of Sex Differences.
CONCLUSIONS: These results suggest that there are important sex differences in BP responses to chronic AT1R blockade but no major involvement of MR activation in BP regulation in OZR. PMID: 33075125 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 19, 2020 Category: Cardiology Authors: do Carmo JM, da Silva AA, Hall JE Tags: Am J Hypertens Source Type: research

Endocrine treatment of transgender individuals: current guidelines and strategies.
Authors: Prince JCJ, Safer JD Abstract INTRODUCTION: This review summarizes gender affirming medical and surgical care available to transgender individuals, along with proposals to improve medically and culturally appropriate care. AREAS COVERED: Transgender individuals are those whose gender identity differs from that recorded at birth (usually based on visualization of external sexual anatomy). In order to align the body with the patient's gender identity, clinicians can provide hormone therapy (HT) to bring sex hormone levels to the range associated with the patient's gender identity. At steady state, monito...
Source: Expert Review of Endocrinology and Metabolism - October 1, 2020 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Congestive Heart Failure Readmission and Guideline Based Therapy Rates Improvement At Safety Net Hospital Heart Health Center
The 2017 HFSA co-sponsored guidelines on heart failure (HF) focus on developing strategies to lower readmission rates and increase adherence to guideline directed medical therapy (GDMT), specifically beta blockers (BB), ACE inhibitors and Angiotensin II receptor blockers (ACEi/ARB), spironolactone, Bidil or combined hydralazine/isosorbide dinitrate (Hydral/ISDN), and ARB with neprilysin inhibitor (ARNI). Patients with HF at a disproportionately elevated risk for readmission are those in median-low income, often minority populations, at public safety net hospitals. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 30, 2020 Category: Cardiology Authors: Noah Silverstein, Perry Wengrofsky, Evan Botti, Filip Oleszak, Inna Bukharovich Tags: 338 Source Type: research

Comparing the Effect of Systolic Dysfunction on Outcomes By Sex In Patients with Heart Failure with Preserved Ejection Fraction
Because there may be signals of sex-based differences in response to HFpEF therapy according to left ventricular ejection fraction, we hypothesize that there will be a prognostic difference in clinical outcomes by sex according to global longitudinal strain (GLS) in HFpEF and this may be associated with treatment heterogeneity with spironolactone. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 30, 2020 Category: Cardiology Authors: Hasan Ali, Lin Zhong, Nicholas Hendren, W. H. Wilson Tang, Ambarish Pandey, Mark H. Drazner, Justin L. Grodin Tags: 319 Source Type: research

Spironolactone in Dermatology: Uses in Acne, Hidradenitis Suppurativa, Female Pattern Hair Loss, and Hirsutism
Publication date: Available online 18 September 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): P. Vargas-Mora, D. Morgado-Carrasco (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - September 29, 2020 Category: Dermatology Source Type: research

Gut microbiota in adolescent girls with polycystic ovary syndrome: Effects of randomized treatments
SummaryBackgroundGirls with obesity and polycystic ovary syndrome (PCOS) and women with PCOS have altered gut microbiota.ObjectiveTo study the gut microbiota composition of girls with PCOS without obesity (age, 15.8  years; body mass index [BMI] 25 kg/m2) and the effects of randomized treatments with an oral contraceptive (OC, N = 15) or with spironolactone ‐pioglitazone‐metformin (SPIOMET, N = 15) for 1 year. Thirty‐one age‐matched girls served as controls.Methods16S ribosomal subunit gene amplicon sequencing was performed in stool samples from all subjects; samples from 23 out of 30 girls with PCOS (OC, N ...
Source: Pediatric Obesity - September 28, 2020 Category: Eating Disorders & Weight Management Authors: Cristina Garcia ‐Beltran, Rita Malpique, Belen Carbonetto, Pedro González‐Torres, Desirée Henares, Pedro Brotons, Carmen Muñoz‐Almagro, Abel López‐Bermejo, Francis Zegher, Lourdes Ibáñez Tags: ORIGINAL RESEARCH Source Type: research

Central amygdala mineralocorticoid receptors modulate alcohol self-administration.
This study examined if reductions in self-administration following MR antagonist treatment were related to dysregulation of MR-mediated corticosterone negative feedback. Female rats treated with spironolactone (50 mg/kg; IP) showed increased plasma corticosterone following self-administration which correlated with reduced alcohol self-administration. Next, local microinjection of the MR-selective antagonist eplerenone was used to identify the brain-regional locus of MR action on alcohol self-administration. Eplerenone infusion produced dose-dependent reductions in alcohol self-administration in the CeA, but had no effect...
Source: Neuropharmacology - September 28, 2020 Category: Drugs & Pharmacology Authors: Makhijani VH, Irukulapati P, Van Voorhies K, Fortino B, Besheer J Tags: Neuropharmacology Source Type: research

Prognostic value of serum hyponatremia for outcomes in patients with heart failure with preserved ejection fraction: An observational cohort study.
Authors: Su Y, Ma M, Zhang H, Pan X, Zhang X, Zhang F, Lv Y, Yan C Abstract Hyponatremia is a risk factor associated with poor prognosis in patients with heart failure (HF) with reduced ejection fraction. However, whether hyponatremia has a similar role in patients with HF with preserved ejection fraction (HFpEF) has remained controversial. Therefore, the present study aimed to investigate the clinical characteristics and 24-month prognostic profile of a cohort of patients with HFpEF in China. From a registered observational cohort study on 1,027 subjects with HF, 496 patients with HFpEF were included. The associat...
Source: Experimental and Therapeutic Medicine - September 27, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

The initiation period of a combination therapy (spironolactone, lisinopril and atenolol) after myocardial infarction plays a major role on the kinetics of heart failure in rats
Publication date: October 2020Source: Archives of Cardiovascular Diseases Supplements, Volume 12, Issues 2–4Author(s): G. Bourdier, V. Delgado, S. Robelet (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - September 26, 2020 Category: Cardiology Source Type: research

Spironolactone as a therapeutic alternative for the bullous variant of central serous chorioretinopathy
Conclusion: We suggest the use of mineralocorticoid receptor antagonists, such as spironolactone, as a therapeutic alternative to more aggressive available treatments for the bullous variant of central serous chorioretinopathy. (Source: Retinal Cases and Brief Reports)
Source: Retinal Cases and Brief Reports - September 22, 2020 Category: Opthalmology Tags: Case Report Source Type: research

Spironolactone in Dermatology: Uses in Acne, Hidradenitis Suppurativa, Female Pattern Baldness, and Hirsutism
Publication date: Available online 18 September 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): P. Vargas-Mora, D. Morgado-Carrasco (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - September 19, 2020 Category: Dermatology Source Type: research

Prevention of anthracycline-induced cardiotoxicity: a systematic review and network meta-analysis
Conclusions The amount of left ventricular ejection fraction used by cardiac agents in anthracycline-based chemotherapy was reduced to a lesser extent. The effective and ineffective drugs were spironolactone and metoprolol, respectively. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Source Type: research

Resistant Hypertension in Chronic Kidney Disease (CKD): Prevalence, Treatment Particularities, and Research Agenda
AbstractPurpose of ReviewTo explore the prevalence, treatment particularities, and research agenda in the management of resistant hypertension among patients with chronic kidney disease (CKD).Recent FindingsThe prevalence of resistant hypertension is reported to be 2 –3 times higher in patients with CKD than in the general hypertensive population. Based in part on the results of the PATHWAY-2 trial showing add-on spironolactone to be superior to placebo or active treatment with an α- or β-blocker in reducing BP, international guidelines recommend the use of spironolactone as fourth-line agent in pharmacoth...
Source: Current Hypertension Reports - September 2, 2020 Category: Primary Care Source Type: research

80: Spironolactone Exposure Is Associated with Reduced Incidence of Prostate Cancer: A Population-Based Pharmacoepidemiologic Study
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - September 1, 2020 Category: Radiology Authors: Bryan Janzen, Brett Hiebert, Rohan Sanjanwala, Aldrich Ong, Julian Kim, Ross Feldman Source Type: research

[Hyperandrogenism, adrenal dysfunction, and hirsutism].
Authors: Makrantonaki E, Zouboulis CC Abstract Hyperandrogenism or hyperandrogenemia are medical conditions characterized by excessive levels of androgens in the periphery or systemically. Clinical manifestations of hyperandrogenism include hirsutism, seborrhea, acne, androgenetic alopecia, and virilization. Hirsutism, defined as excessive growth of terminal hair in women in a male-like pattern, is the most commonly used clinical diagnostic criterion of hyperandrogenism and is determined by using a standardized scoring system of hair growth. Acne and alopecia are further common androgenic skin changes and...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - August 30, 2020 Category: Dermatology Tags: Hautarzt Source Type: research

Spironolactone ameliorates lipopolysaccharide-induced cholestasis in rats by improving Mrp2 function: Role of transcriptional and post-transcriptional mechanisms
Publication date: Available online 27 August 2020Source: Life SciencesAuthor(s): María Valeria Razori, Pamela L. Martín, Paula M. Maidagan, Ismael R. Barosso, Nadia Ciriaci, Romina B. Andermatten, Enrique J. Sánchez Pozzi, Cecilia L. Basiglio, María Laura Ruiz, Marcelo G. Roma (Source: Life Sciences)
Source: Life Sciences - August 27, 2020 Category: Biology Source Type: research

Management of posaconazole-induced pseudohyperaldosteronism
ConclusionsWe report our experience with PIPH management, for which there is no universally effective strategy. We utilized a stepwise approach for management, starting with posaconazole dose reduction and repeat assessment of clinical and laboratory parameters. If resolution of PIPH is not achieved, an alternative triazole antifungal or the addition of an aldosterone antagonist are additional potential interventions. It is possible for PIPH to persist after therapeutic modification despite these interventions. Thus, early diagnosis and continuous monitoring is warranted. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - August 24, 2020 Category: Microbiology Source Type: research

Clinical efficacy and safety of spironolactone in patients with resistant hypertension: A systematic review and meta-analysis
Background: We conducted a meta-analysis to summarize all available evidence from randomized controlled trial studies regarding the clinical efficacy and safety of spironolactone in patients with resistant hypertension (RH) and provided a quantitative assessment. Methods: A systematic search of PubMed, Web of Science, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) databases through December 8, 2019, was performed. Randomized controlled trials randomized controlled trials meeting inclusion criteria were included to assess the effect of the addition of spironolactone on office blood pressur...
Source: Medicine - August 21, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Spironolactone: Diuretic or Disease ‐modifying Drug in Heart Failure with Preserved Ejection Fraction?
European Journal of Heart Failure, Accepted Article. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - August 18, 2020 Category: Cardiology Authors: Frederik H. Verbrugge, Kevin Damman Tags: Editorial Comment Source Type: research

Protective effects of morphine in a rat model of post-traumatic stress disorder: Role of hypothalamic-pituitary-adrenal axis and beta- adrenergic system.
Abstract Post-traumatic stress disorder (PTSD) arises after tremendous traumatic experiences. Recently, we have reported that morphine has time-dependent protective effects against behavioral and morphological deficits in the single prolonged stress (SPS) as an experimental model of PTSD in adult male rats. To find the mechanisms underlying the protective effects of morphine against SPS-induced PTSD-like symptoms, the present study investigated the interaction between morphine and hypothalamic-pituitary-adrenal (HPA) axis and beta - adrenergic system, which crucially involved in the stress response, on PTSD-like s...
Source: Behavioural Brain Research - August 18, 2020 Category: Neurology Authors: Abdullahi PR, Abdullahi ER, Sameni H, Vafaei AA, Ghanbari A, Rashidy-Pour A Tags: Behav Brain Res Source Type: research

Spironolactone: Diuretic or Disease ‐modifying Drug in Heart Failure with Preserved Ejection Fraction?
European Journal of Heart Failure, Accepted Article. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - August 18, 2020 Category: Cardiology Authors: Frederik H. Verbrugge, Kevin Damman Tags: Editorial Comment Source Type: research

Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone
This study ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - August 15, 2020 Category: Complementary Medicine Authors: Tun-Pin Hsueh and Tung-Hu Tsai Tags: Research article Source Type: research

The role of aldosterone inhibitors on cardiac ischemia/reperfusion injury.
THE ROLE OF ALDOSTERONE INHIBITORS ON CARDIAC ISCHEMIA/REPERFUSION INJURY. Can J Physiol Pharmacol. 2020 Aug 15;: Authors: Dragasevic N, Jakovljevic V, Zivkovic VI, Draginic ND, Andjic M, Bolevich S, Jovic S Abstract Myocardial ischaemia-reperfusion (I/R) injury is well known term for paradoxal exacerbation of cellular destruction and dysfunction, after the restoration of blood flow to previously ischaemic heart. A vast number of studies that has demonstrated the role of mineralocorticoids in cardiovascular diseases is based on the use of pharmacological mineralocorticoid receptor antagonists (MRA) su...
Source: Canadian Journal of Physiology and Pharmacology - August 14, 2020 Category: Drugs & Pharmacology Authors: Dragasevic N, Jakovljevic V, Zivkovic VI, Draginic ND, Andjic M, Bolevich S, Jovic S Tags: Can J Physiol Pharmacol Source Type: research

Furosemide and spironolactone doses and hyponatremia in patients with heart failure.
Authors: Velat I, Bušić Ž, Jurić Paić M, Čulić V Abstract BACKGROUND: Hyponatremia, a marker of disease severity and prognosis, has been associated with various clinical factors and drug use, especially diuretics. METHODS: This observational prospective cohort study enrolled patients hospitalized at the University Hospital Center Split because of heart failure (HF). We investigated the association of clinical variables and cardiovascular drugs, including furosemide, hydrochlorothiazide, spironolactone, and their doses, with the presence of hyponatremia at admission. RESULTS: Of the 565 included...
Source: BMC Pharmacology and Toxicology - August 13, 2020 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Clinical Characteristics of Resistant vs. Refractory Hypertension in a Population of Hypertensive Afrodescendants
Conclusion Africandescendant people with RH had a high cardiovascular risk, a high prevalence of RfH, a higher frequency of dyslipidemia and stroke, compatible with a high incidence of injury to target organs. (Arq Bras Cardiol.2020; 115(1):31-39) (Source: Arquivos Brasileiros de Cardiologia)
Source: Arquivos Brasileiros de Cardiologia - August 13, 2020 Category: Cardiology Source Type: research

Short Editorial: Clinical Characteristics of Resistant vs. Refractory Hypertension in a Population of Hypertensive Afro-descendants
Conclusion Africandescendant people with RH had a high cardiovascular risk, a high prevalence of RfH, a higher frequency of dyslipidemia and stroke, compatible with a high incidence of injury to target organs. (Arq Bras Cardiol.2020; 115(1):31-39) (Source: Arquivos Brasileiros de Cardiologia)
Source: Arquivos Brasileiros de Cardiologia - August 13, 2020 Category: Cardiology Source Type: research

Impact of SLCO4C1 Genotypes, Creatinine, and Spironolactone on Digoxin Population Pharmacokinetic Variables in Patients With Cardiac Insufficiency.
This study aimed to utilize a population pharmacokinetic method to obtain information about the influence of covariates on the in vivo behavior of digoxin in patients with cardiac insufficiency. METHODS: A total of 228 therapeutic drug monitoring concentrations were retrospectively collected from 176 inpatients. The patients were randomly divided into a modeling group (n = 126) and a validation group (n = 50). The first-order absorption one-compartment model was used to develop a population pharmacokinetic model from a nonlinear mixed effects modeling approach. Sixteen single nucleotide polymo...
Source: Clinical Therapeutics - August 11, 2020 Category: Drugs & Pharmacology Authors: Du P, Wang A, Ma Y, Jia A, Li Y, Li X Tags: Clin Ther Source Type: research

Furosemide and spironolactone doses and hyponatremia in patients with heart failure
Hyponatremia, a marker of disease severity and prognosis, has been associated with various clinical factors and drug use, especially diuretics. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Ivan Velat, Željko Bušić, Marina Jurić Paić and Viktor Čulić Tags: Research article Source Type: research

Spironolactone and Breast Cancer: Fear Not!
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - July 27, 2020 Category: Dermatology Authors: Warren R. Heymann Source Type: research

From Bartter's syndrome to renal tubular acidosis in a patient with Hashimoto's thyroiditis: A case report 
.
We report an HT patient who initially developed hypokalemic metabolic alkalosis and then developed metabolic acidosis within a few years. To our knowledge, this is the first report of two completely opposite acid-base disturbances associated with renal tubular diseases occurring consecutively in the same patient with HT. Our case may provide a valuable clue for exploring the mechanism of renal involvement in autoimmune diseases. PMID: 32691728 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 20, 2020 Category: Urology & Nephrology Authors: Wang S, Dong B, Wang C, Lu J, Shao L Tags: Clin Nephrol Source Type: research

Therapeutic potential of spironolactone in ankylosing spondylitis patients: Relation to disease activity and functional status
Publication date: Available online 14 July 2020Source: The Egyptian RheumatologistAuthor(s): Inderjeet Verma, Pawan Krishan, Ashit Syngle (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - July 15, 2020 Category: Rheumatology Source Type: research

Evolution of Patiromer Use: a Review
AbstractPurpose of ReviewThe purpose of this review is to present data from clinical trials that resulted in the key data supporting the use of patiromer as a potassium binder in clinical practice today.Recent FindingsIn addition to trials that support the current Food and Drug Administration label and published over the past 3  years, the recently published Spironolactone With Patiromer in the Treatment of Resistant Hypertension in Chronic Kidney Disease (AMBER) trial provides clear benefits of patiromer use in a group of resistant hypertension patients. The AMBER was a phase 2, multicenter, randomized, double-blind,...
Source: Current Cardiology Reports - July 8, 2020 Category: Cardiology Source Type: research

Secrets of Spironolactone: Continuing Insights from TOPCAT Americas
European Journal of Heart Failure, Accepted Article. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - July 5, 2020 Category: Cardiology Authors: Andreas P. Kalogeropoulos, Panagiotis Simitsis, Hal A. Skopicki Tags: Editorial Comment Source Type: research

Small Bowel Pseudomelanosis
A 78-year-old woman with a history of type 2 diabetes mellitus, chronic kidney disease stage 4, hypertension, atrial fibrillation, grade 1 follicular lymphoma, gastroesophageal reflux disease, and iron deficiency anemia presented with several months of transfusion-dependent anemia. Medications included oral ferrous sulfate, insulin, spironolactone, clonidine, metoprolol, simvastatin, omeprazole, and apixaban. In the past several months, she had been receiving weekly darbepoetin alfa injections and requiring 4 blood transfusions a month. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - June 30, 2020 Category: Internal Medicine Authors: Hyun Ji, Zongming E. Chen, Sunanda V. Kane Tags: Medical image Source Type: research

Primary hypokalemic periodic paralysis: Long-term management and complications in a child
Indar K Sharawat, Renu Suthar, Naveen Sankhyan, Pratibha SinghiJournal of Pediatric Neurosciences 2020 15(2):132-134Hypokalemic periodic paralysis (HPP) is a rare genetically determined neuromuscular disorder caused by mutation in skeletal muscles calcium and sodium channels. It presents with recurrent episodes of flaccid paralysis. A 9-year-old girl presented with recurrent episodic flaccid quadriparesis with complete recovery in-between the episodes. Investigations during the acute episode revealed marked hypokalemia with electrocardiogram changes. Next-generation sequencing showed pathogenic missense mutation in CACNA1S...
Source: Journal of Pediatric Neurosciences - June 29, 2020 Category: Neuroscience Authors: Indar K Sharawat Renu Suthar Naveen Sankhyan Pratibha Singhi Source Type: research