Glucocorticoid receptor activation stimulates the Na-Cl co-transporter and influences the diurnal rhythm of its phosphorylation.
This study has implications for circadian BP homeostasis, particularly in individuals with abnormal glucocorticoid signaling as is found in chronic stress and corticosteroid therapy. PMID: 31588796 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - October 7, 2019 Category: Physiology Authors: Ivy JR, Jones NK, Costello HM, Mansley MK, Peltz TS, Flatman PW, Bailey MA Tags: Am J Physiol Renal Physiol Source Type: research

Gitelman syndrome combined with growth hormone deficiency: Three cases report
Rationale: Gitelman syndrome (GS) is a rare autosomal recessive hereditary salt-losing tubulopathy caused by loss-of-function mutations in the SLC12A3 gene. It is usually characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria. There are only a few reports on GS combined with growth hormone deficiency (GHD). Patient concerns: Three patients presented with weakness, spasm, and growth retardation, respectively. Diagnoses: GS was diagnosed based on the clinical symptoms, laboratory test results, and genetic analysis. GH stimulation tests were performed when the magnesium level returned to ...
Source: Medicine - October 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Aldosterone promotes renal interstitial fibrosis via the AIF ‑1/AKT/mTOR signaling pathway.
Aldosterone promotes renal interstitial fibrosis via the AIF‑1/AKT/mTOR signaling pathway. Mol Med Rep. 2019 Sep 13;: Authors: Yuan X, Wang X, Li Y, Li X, Zhang S, Hao L Abstract A number of studies have shown that aldosterone serves an important role in promoting renal interstitial fibrosis, although the specific mechanism remains to be elucidated. A previous study revealed that the fibrotic effect of aldosterone was associated with the expression of allograft inflammatory factor 1 (AIF‑1) in RAW264.7 macrophage cells, in a time‑ and concentration‑dependent manner. However, the exact mech...
Source: Molecular Medicine Reports - September 24, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Klotho deficiency induces arteriolar hyalinosis in a trade-off with vascular calcification.
Abstract Hyalinosis is a vascular lesion affecting the renal vasculature and contributing to ageing-related renal function decline. We assessed whether arteriolar hyalinosis is caused by Klotho deficiency - a state known to induce both renal and vascular phenotypes associated with ageing. Histochemistry was used to assess hyalinosis in Klotho-/- kidneys, compared to Klotho+/- and wild-type littermates. Immunohistochemistry was used to investigate vascular lesion composition and the different layers of the vascular wall. Finally, spironolactone was used to inhibit calcification in kl/kl mice and vascular lesions we...
Source: The American Journal of Pathology - September 17, 2019 Category: Pathology Authors: Mencke R, Umbach AT, Wiggenhauser LM, Voelkl J, Olauson H, Harms G, Bulthuis M, Krenning G, Quintanilla-Martinez L, van Goor H, Lang F, Hillebrands JL Tags: Am J Pathol Source Type: research

Patiromer versus placebo to enable spironolactone use in patients with resistant hypertension and chronic kidney disease (AMBER): a phase 2, randomised, double-blind, placebo-controlled trial
Publication date: Available online 15 September 2019Source: The LancetAuthor(s): Rajiv Agarwal, Patrick Rossignol, Alain Romero, Dahlia Garza, Martha R Mayo, Suzette Warren, Jia Ma, William B White, Bryan WilliamsSummaryBackgroundSpironolactone is effective at reducing blood pressure in patients with uncontrolled resistant hypertension. However, the use of spironolactone in patients with chronic kidney disease can be restricted by hyperkalaemia. We evaluated use of the potassium binder patiromer to allow more persistent use of spironolactone in patients with chronic kidney disease and resistant hypertension.MethodsIn this ...
Source: The Lancet - September 16, 2019 Category: General Medicine Source Type: research

Prognosis Analysis of Heart Failure Based on Recurrent Attention Model
ConclusionExperiments show that the prognostic effect of the recurrent attention model is significantly higher than that of other traditional machine learning models. Because the model increases the attention mechanism, the important features affecting the prognostic results are obtained, which enables doctors to prescribe drugs according to the symptoms, take timely precautions and help patients to treat in time.Graphical abstract (Source: IRBM)
Source: IRBM - September 14, 2019 Category: Biomedical Engineering Source Type: research

New Molecules for Treating Resistant Hypertension: a Clinical Perspective
AbstractPurpose of ReviewTo review the findings of trials evaluating pharmacological treatment approaches for hypertension in general, and resistant hypertension (RH) in particular, and propose future research and clinical directions.Recent FindingsRH is defined as blood pressure (BP) that remains above target levels despite adherence to at least three antihypertensive medications, including a diuretic. Thus far, clinical trials of pharmacological approaches in RH have focused on older molecules, with spironolactone being demonstrated as the most efficacious fourth-line agent. However, the use of spironolactone in clinical...
Source: Current Hypertension Reports - September 10, 2019 Category: Primary Care Source Type: research

Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist [Medical Sciences]
The mineralocorticoid receptor (MR) is highly conserved across vertebrate evolution. In terrestrial vertebrates, the MR mediates sodium homeostasis by aldosterone and also acts as a receptor for cortisol. Although the MR is present in fish, they lack aldosterone. The MR binds progesterone and spironolactone as antagonists in human MR but... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 10, 2019 Category: Science Authors: Peter J. Fuller, Yi–Zhou Yao, Ruitao Jin, Sitong He, Beatriz Martin–Fernandez, Morag J. Young, Brian J. Smith Tags: Biological Sciences Source Type: research

The Safe Management of Acne Vulgaris in Lupus Erythematosus: A Systematic Review with Evidence-Based Treatment Recommendations
ConclusionWhile no definitive recommendations for the treatment of acne in LE can be made based on the existing quality and quantity of studies available, this article aims to provide a comprehensive overview and analysis of oral acne medication safety in patients with LE, while emphasizing the immense need for higher quality studies and distinct acne treatment guidelines for this vulnerable patient population. (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - September 7, 2019 Category: Dermatology Source Type: research

Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model
Spironolactone can improve endothelial dysfunction in the setting of heart failure and diabetes models. However, its beneficial effect in the cardiovascular system is not clear in the setting of non-diabetic r... (Source: BMC Nephrology)
Source: BMC Nephrology - September 6, 2019 Category: Urology & Nephrology Authors: Chun-Cheng Wang, An-Sheng Lee, Shu-Hui Liu, Kuan-Cheng Chang, Ming-Yi Shen and Chiz-Tzung Chang Tags: Research article Source Type: research

Chronic kidney disease progression in patients with resistant hypertension subject to 2 therapeutic strategies: Intensification with loop diuretics vs aldosterone antagonists.
Authors: Verdalles U, Goicoechea M, García de Vinuesa S, Torres E, Hernández A, Verde E, Pérez de José A, Luño J Abstract INTRODUCTION: Actualy, there are few data about glomerular filtration rate (eGFR) drop in patients with resistant hypertension and how diferent therapies can modify chronic kidney disease progression (CKD). OBJECTIVE: To evaluate CKD progression in patients with resistant hypertension undergoing 2diferent therapies: treatment with spironolactone or furosemide. METHODS: We included 30 patients (21M, 9W) with a mean age of 66.3±9.1 years, eGFR 55.8...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - August 30, 2019 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

[Spironolactone in resistant essential hypertension].
Abstract Resistant hypertension is defined as uncontrolled blood pressure (BP) despite three antihypertensive agents including a diuretic (thiazide diuretic if renal function is normal or loop diuretic in case of chronic kidney disease with eGFR
Source: Presse Medicale - August 28, 2019 Category: General Medicine Authors: Lorthioir A, Belmihoub I, Fouassier D, Azizi M, Amar L Tags: Presse Med Source Type: research

Successful ejaculatory sperm cryopreservation after cessation of long-term estrogen therapy in a transgender female
A 26 year old healthy transgender female with gender dysphoria presented for consideration of gender-affirming vaginoplasty with simultaneous orchiectomy. She had been living as a female for 19 months and started hormone treatment with estrogen injections and oral spironolactone 16 months prior to presentation. After discussion of gender-affirming surgery (GAS) including bilateral orchiectomy, the patient endorsed interest in sperm cryopreservation. Approximately 2 months prior to surgery, she stopped her estrogen and spironolactone. (Source: Urology)
Source: Urology - August 26, 2019 Category: Urology & Nephrology Authors: Ashley V Alford, Katherine Theisen, Nicholas Kim, Joshua Bodie, Joseph Pariser Source Type: research

Intestinal angioedema from angiotensin converting enzyme inhibitor
A 41-year-old Congolese woman born in 1977 presented in February 2018 to our emergency department with severe abdominal pain. Her medical history was notable for idiopathic collapsing glomerulopathy for which she was being initially treated with corticosteroids, later switched to tacrolimus. Additionally she was on candesartan 16 mg/d, then later switched in 2014 to enalapril 20 mg/d. During 2017, she was poorly compliant with her medications. In February 2018, her medications included tacrolimus, furosemide, spironolactone, lercanidipine, and enalapril. (Source: Kidney International)
Source: Kidney International - August 21, 2019 Category: Urology & Nephrology Authors: Valentine Gillion, Cristina Anca Dragean, G éraldine Dahlqvist, Michel Jadoul Tags: Nephrology Image Source Type: research

8059 —Safety of 5α-reductase inhibitors and spironolactone in breast cancer patients receiving endocrine therapies
Introduction: Endocrine therapies (ETs) are associated with alopecia (EIA) in 15-25% of patients. There are no approved therapies for EIA. The purpose of this review is to provide dermatologists and oncologists with a foundation for the practical understanding of 5 α-reductase inhibitors and spironolactone for breast cancer patients and survivors with alopecia attributed to ETs, including the effect of these treatments on sex hormone levels, any reported drug interactions, and any risk of malignancy. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Captopril and Spironolactone Can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting microRNA-192 and microRNA-29a/b/c
DNA and Cell Biology, Ahead of Print. (Source: DNA and Cell Biology)
Source: DNA and Cell Biology - August 21, 2019 Category: Cytology Authors: Zahra Ebadi Nariman Moradi Toktam Kazemi Fard Tourandokht Balochnejadmojarrad Elham Chamani Reza Fadaei Soudabeh Fallah Source Type: research

Effect of spironolactone on the progression of coronary calcification in peritoneal dialysis patients: a pilot study.
CONCLUSION: In peritoneal dialysis patients, spironolactone did not attenuate the progression of CC. However, large-scale studies are needed to confirm this observation. Disorders of mineral metabolism and dyslipidemia are involved in the progression of CC. PMID: 31419271 [PubMed - as supplied by publisher] (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - August 17, 2019 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Breast cancer and spironolactone: an observational postmarketing study
ConclusionThis study did not find evidence for breast cancer associated with spironolactone. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - August 15, 2019 Category: Drugs & Pharmacology Source Type: research

Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling via G Protein-Coupled Receptor Kinase 2
Hyperaldosteronism alters cardiac function, inducing adverse left ventricle (LV) remodeling either via increased fibrosis deposition, mitochondrial dysfunction, or both. These harmful effects are due, at least in part, to the activation of the G protein-coupled receptor kinase 2 (GRK2). In this context, we have previously reported that this kinase dysregulates both β-adrenergic receptor (βAR) and insulin (Ins) signaling. Yet whether aldosterone modulates cardiac Ins sensitivity and βAR function remains untested. Nor is it clear whether GRK2 has a role in this modulation, downstream of aldosterone. Here, we s...
Source: Frontiers in Pharmacology - August 9, 2019 Category: Drugs & Pharmacology Source Type: research

High-dose spironolactone for acne in patients with polycystic ovarian syndrome: a single institution retrospective study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 7, 2019 Category: Dermatology Authors: Pallavi Basu, Scott A. Elman, Boya Abudu, Ashley Beckles, Prerna Salian, Daniel A. Yanes, Martina L. Porter, Rachel V. Reynolds Source Type: research

Caring for individuals with hypertension in CKD, especially those with low education
Hypertension remains prevalent worldwide. In this commentary, the need for more effective treatment of this cardiovascular and renal risk factor is discussed. We can treat hypertension more effectively by getting the blood pressure measurement right, understanding the link between albuminuria and hypertension, enabling the use of spironolactone to treat resistant hypertension through the use of drugs that bind potassium in the gut, and addressing the structural determinants of health. (Source: Kidney International)
Source: Kidney International - August 2, 2019 Category: Urology & Nephrology Authors: Rajiv Agarwal Tags: Commentary Source Type: research

PKC-delta mediates mineralocorticoid receptor activation by angiotensin II to modulate smooth muscle cell function.
Abstract Angiotensin II (AngII) and the mineralocorticoid receptor(MR) ligand aldosterone, both contribute to cardiovascular disorders, including hypertension and adverse vascular remodeling.We previously demonstrated that AngII activates MR-mediated gene transcription in human vascular smooth muscle cells(SMC) yet the mechanism and the impact on SMC function are unknown.Using a MR responsive element-driven transcriptional reporter assay, we confirm that AngII induces MR transcriptional activity in multiple vascular SMC and endothelial cells, but not in Cos1 nor HEK293 cells.AngII activation of MR was blocked by t...
Source: Endocrinology - August 2, 2019 Category: Endocrinology Authors: Lu Q, Davel AP, McGraw AP, Rao SP, Newfell BG, Jaffe IZ Tags: Endocrinology Source Type: research

Hirsutism in Women.
Abstract Hirsutism is the excessive growth of terminal hair in a typical male pattern in a female. It is often a sign of excessive androgen levels. Although many conditions can lead to hirsutism, polycystic ovary syndrome and idiopathic hyperandrogenism account for more than 85% of cases. Less common causes include idiopathic hirsutism, nonclassic congenital adrenal hyperplasia, androgen-secreting tumors, medications, hyperprolactinemia, thyroid disorders, and Cushing syndrome. Women with an abnormal hirsutism score based on the Ferriman-Gallwey scoring system should be evaluated for elevated androgen levels. Wome...
Source: American Family Physician - August 1, 2019 Category: Primary Care Authors: Matheson E, Bain J Tags: Am Fam Physician Source Type: research

Metformin/spironolactone
(Source: Reactions Weekly)
Source: Reactions Weekly - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Influence of Age on the Efficacy and Safety of Spironolactone in Heart Failure with Preserved Ejection Fraction
We examined efficacy and safety of spironolactone by age in the Americas region (N=1767) of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2019 Category: Cardiology Authors: Orly Vardeny, Muthiah Vaduganathan, Brian Claggett, Akshay S. Desai, Inder S. Anand, Sanjiv J. Shah, Eileen O'Meara, Eldrin F. Lewis, Jean Rouleau, Bertram Pitt, Marc A. Pfeffer, Scott D. Solomon Tags: 027 Source Type: research

Relative Efficacy of Spironolactone, Eplerenone, and cAnRenone in patients with Chronic Heart failure (RESEARCH): a systematic review and network meta-analysis of randomized controlled trials
This study aims to assess the comparative benefit and risk profile of treatment with mineralocorticoid receptor antagonists (MRAs) with regard to all-cause mortality (primary endpoint), cardiovascular mortality, or heart failure (HF) –related hospitalization (secondary endpoints) and the safety endpoints hyperkalemia, acute renal failure, and gynecomastia in patients with chronic HF. We conducted a systematic review and network meta-analysis following PRISMA-P and PRISMA-NMA guidelines. From 16 different sources, 14 randomized controlled trials totaling 12,213 patients testing an active treatment of either spironolac...
Source: Heart Failure Reviews - July 30, 2019 Category: Cardiology Source Type: research

The human adrenal gland as a drug metabolizer: First in-vivo evidence for the conversion of steroidal drugs
Publication date: Available online 27 July 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Michaela F. Hartmann, Martin Reincke, Stefan A. Wudy, Rita BernhardtAbstractThe metabolism of drugs in mammals is attributed mainly to the liver and its cytochromes P450 localized in the endoplasmic reticulum. Here, we demonstrate for the first time in humans that there is no strict subdivision between P450 s involved in exogenous and endogenous metabolism. We determined the widely used mineralocorticoid receptor antagonist spironolactone, its active metabolite canrenone and their metabolites in...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 28, 2019 Category: Biochemistry Source Type: research

Spiral steroids as potential markers for pre-eclampsia: a pilot study
Publication date: Available online 26 July 2019Source: SteroidsAuthor(s): Fred Chasalow, Constance M. John, Ron BochnerAbstractPre-eclampsia is a condition that complicates 3-6% of pregnancies. At present, there is no FDA approved diagnostic method to evaluate risk or progression. We would like to report our observation of elevated levels of the spiral steroid phosphoester precursor in patients with pre-eclampsia.Samples from 20 normotensive pregnant women and from 20 women with pre-eclampsia were purchased from Global Alliance for the Prevention of Prematurity and Stillbirth (GAPPS). After addition of miltefosine (hexadec...
Source: Steroids - July 27, 2019 Category: Drugs & Pharmacology Source Type: research

Assessment of adherence to antihypertensive drugs in patients with resistant hypertension receiving optimal treatment
ConclusionsIn our study, more than two out of three patients with apparent resistant hypertension optimally treated and without white coat effect, were partially or completely non-adherent to treatment. Assessment of treatment adherence in these high cardiovascular risk patients should be systematically implemented and if possible by more objective methods. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - July 24, 2019 Category: Cardiology Source Type: research

Fluid balance in pediatric patients in prone position: a pragmatic study
SUMMARY OBJECTIVE: To verify the association between prone position, increased diuresis, and decreased cumulative fluid balance in critically ill pediatric patients who underwent mechanical ventilation (MV) for pulmonary causes and describe adverse events related to the use of the position. METHODS: This is a retrospective observational study. Patients aged between 1 month and 12 years who underwent MV for pulmonary causes, between January 2013 and December 2015, were selected and divided between those who were put on prone position (PG) and those who were not (CG) during the hospitalization at the Pediatric Intensive Care...
Source: Revista da Associacao Medica Brasileira - July 23, 2019 Category: General Medicine Source Type: research

Stability-indicating analytical method of quantifying spironolactone and canrenone in dermatological formulations and iontophoretic skin permeation experiments.
Abstract A simple, stability-indicating, chromatographic method of quantifying spironolactone (SPI) and its metabolite, canrenone (CAN), in the presence of excipients typical in dermatological formulations and skin matrices in studies of passive and iontophoretic permeation was proposed and validated here. SPI and CAN were separated using a reversed-phase column with a mobile phase of methanol:water (60:40, v/v) at a flow rate of 1.0 mL/min. Data were collected with a UV detector at 238 nm and 280 nm, with retention times of 6.2 and 7.9 min for SPI and CAN, respectively. The method was precise, accurate, and linea...
Source: Biomedical Chromatography : BMC - July 19, 2019 Category: Biomedical Science Authors: Ferreira-Nunes R, Ferreira LA, Gratieri T, Cunha-Filho M, Gelfuso GM Tags: Biomed Chromatogr Source Type: research

Resistant Hypertension Management: Comparison of the 2017 American and 2018 European High Blood Pressure Guidelines
AbstractPurpose of ReviewTo compare European and American guidelines for the diagnosis, evaluation, and management of resistant hypertension.Recent FindingsResistant hypertension is defined as high blood pressure that remains above goal with the use of 3 or more antihypertensive agents, commonly a renin-angiotensin blocker (either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker), a long-acting calcium channel blocker, and thiazide or thiazide-like diuretic. Resistant hypertension is common, with a recent analysis indicating that it affects approximately 17 –19% of adult Americans with hy...
Source: Current Hypertension Reports - July 18, 2019 Category: Primary Care Source Type: research

Licorice: From Pseudohyperaldosteronism to Therapeutic Uses
Licorice has been used as a medicinal plant from 2.500 years. It shows a wide range of biological and pharmacological activities, including anti-inflammatory and immune regulatory actions. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due to glycyrrhetinic acid, the main active component of the root. Glycyrrhetinic acid and metabolites block the 11 beta-hydroxysteroid dehydrogenase type 2 and also bind directly mineralocorticoid receptors as agonists. However, other interesting therapeutic uses of licorice are linked to its anti-androgen and e...
Source: Frontiers in Endocrinology - July 18, 2019 Category: Endocrinology Source Type: research

High-Dose Spironolactone When Patients With Acute Decompensated Heart Failure Are Resistant to Loop Diuretics: A Pilot Study.
PMID: 31307058 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - July 16, 2019 Category: Internal Medicine Authors: Bansal S, Munoz K, Brune S, Bailey S, Prasad A, Velagapudi C Tags: Ann Intern Med Source Type: research

Cell-free and Concentrated Ascites Reinfusion Therapy for Refractory Ascites in Cirrhosis in Post-marketing Surveillance and the Role of Tolvaptan.
The objective of this study was to confirm the safety and efficacy of CART, evaluate the actual situations with respect to the prescription of diuretics and determine the role of diuretics after the introduction of CART. Patients and Methods We recruited 34 cirrhotic patients who received CART with concomitant diuretics using furosemide (76.2%), spironolactone (48.5%), thiazide (4.0%) and tolvaptan (53.5%) from a post-marketing surveillance of CART. Results CART improved the tested clinical indices, i.e. body weight, abdominal circumference, performance status, dietary intake, total protein and albumin. The intervals of CA...
Source: Internal Medicine - July 13, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Heart failure from cancer therapy: can we prevent it?
ConclusionsSystematic evidence is needed to solidly found recommendations for cardioprotective prevention during chemotherapy. Likewise, trials on other neurohumoral drugs (spironolactone) and lipid ‐lowering approaches are required to improve protection for cardio‐oncology patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 11, 2019 Category: Cardiology Authors: Matthias Totzeck, Raluca I. Mincu, Gerd Heusch, Tienush Rassaf Tags: Original Research Article Source Type: research

Use of speckle tracking to assess heart failure with preserved ejection fraction.
Abstract Heart failure with preserved ejection fraction (HFpEF) currently represents approximately 50% of heart failure (HF) cases in the USA and is increasingly recognized as a leading cause of morbidity and mortality. Recent data suggest that the prevalence of HFpEF relative to HF with reduced ejection fraction (HFrEF) is increasing at a rate of 1% per year. With an aging population and increasing risk factors such as hypertension, obesity, and diabetes mellitus, HFpEF will soon be the most prevalent HF phenotype. Two-dimensional speckle-tracking echocardiography (STE) has been used to diagnose HFpEF specificall...
Source: Journal of Cardiology - July 11, 2019 Category: Cardiology Authors: Hiebert JB, Vacek J, Shah Z, Rahman F, Pierce JD Tags: J Cardiol Source Type: research

Very low dose spironolactone protects experimentally-induced polycystic ovarian syndrome from insulin-resistant metabolic disturbances by suppressing elevated circulating testosterone
In this study, we investigated the effects of SPL on IR and metabolic disturbances in letrozole-induced PCOS rats. Eighteen adults female Wistar rats were randomly divided into 3 groups and treated with vehicle, letrozole (LET; 1 mg/kg) and LET + SPL (SPL; 0.25 mg/kg), p.o. once daily for 21 consecutive days. Results showed that LET treatment induced PCOS characterised by elevated plasma testosterone and luteinizing hormone (LH) accompanied with increased body weight and visceral adiposity, IR, glucose intolerance, dyslipidemia and altered histomorphological ovaries. Treatment with SPL however attenuate...
Source: Chemico Biological Interactions - July 9, 2019 Category: Biochemistry Source Type: research

Very low dose spironolactone protects experimentally-induced polycystic ovarian syndrome from insulin-resistant metabolic disturbances by suppressing elevated circulating testosterone.
In this study, we investigated the effects of SPL on IR and metabolic disturbances in letrozole-induced PCOS rats. Eighteen adults female Wistar rats were randomly divided into 3 groups and treated with vehicle, letrozole (LET; 1 mg/kg) and LET + SPL (SPL; 0.25 mg/kg), p.o. once daily for 21 consecutive days. Results showed that LET treatment induced PCOS characterised by elevated plasma testosterone and luteinizing hormone (LH) accompanied with increased body weight and visceral adiposity, IR, glucose intolerance, dyslipidemia and altered histomorphological ovaries. Treatment with SPL however attenuate...
Source: Chemico-Biological Interactions - July 8, 2019 Category: Molecular Biology Authors: Adeyanju OA, Falodun TO, Fabunmi OA, Olatunji LA, Soladoye AO Tags: Chem Biol Interact Source Type: research

Position statement on the hormonal management of adult transgender and gender diverse individuals.
Authors: Cheung AS, Wynne K, Erasmus J, Murray S, Zajac JD Abstract INTRODUCTION: Rising demand for gender-affirming hormone therapy mandates a need for more formalised care of transgender and gender diverse (TGD) individuals in Australia. Estimates suggest that 0.1-2.0% of the population are TGD, yet medical education in transgender health is lacking. We aim to provide general practitioners, physicians and other medical professionals with specific Australian recommendations for the hormonal and related management of adult TGD individuals. MAIN RECOMMENDATIONS: Hormonal therapy is effective at aligning physical...
Source: Medical Journal of Australia - July 5, 2019 Category: General Medicine Tags: Med J Aust Source Type: research

A potential role of the renin-angiotensin-aldosterone system in epithelial-to-mesenchymal transition-induced renal abnormalities: Mechanisms and therapeutic implications
Publication date: August 2019Source: Pharmacological Research, Volume 146Author(s): Pitchai Balakumar, Ramanathan Sambathkumar, Nanjaian Mahadevan, Abdullatif Bin Muhsinah, Abdulrhman Alsayari, Nallasamy Venkateswaramurthy, Gowraganahalli JagadeeshAbstractEpithelial-to-mesenchymal transition (EMT) is an orchestrated event where epithelial cells progressively undergo biochemical changes and transition into mesenchymal-like cells by gradually losing their epithelial characteristics. EMT plays a crucial pathologic role in renal abnormalities, especially renal fibrosis. A number of bench studies suggest the potential involveme...
Source: Pharmacological Research - June 29, 2019 Category: Drugs & Pharmacology Source Type: research

Spironolactone reduces oxidative stress in living donor kidney transplantation: a randomized controlled trial.
In conclusion, spironolactone reduces the acute increase in urinary oxidative stress in living-donor KT recipients. PMID: 31241992 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - June 26, 2019 Category: Urology & Nephrology Authors: Morales-Buenrostro LE, Ortega Trejo JA, Pérez-Villalva R, Marino LA, Gonzalez Bobadilla Y, Juarez H, Zamora Mejia FM, Gonzalez N, Espinoza R, Barrera-Chimal J, Bobadilla NA Tags: Am J Physiol Renal Physiol Source Type: research

Unsupervised Machine Learning Identifies Treatment Response to Spironolactone in Patients with Heart Failure with Preserved Ejection Fraction: A TOPCAT Substudy
Background: Heart Failure with Preserved Ejection Fraction (HFpEF) is a heterogenous condition with several subgroups. Spironolactone has been postulated as beneficial therapy in certain patients, i.e. lower ejection fractions or lower natriuretic peptide levels. We aimed to determine whether machine learning (ML) methods could identify treatment responders. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - June 24, 2019 Category: Cardiology Authors: S. Nanayakkara, A. Beale, M. Inouye, D. Kaye Tags: 145 Source Type: research

The renin-angiotensin-aldosterone system and epithelial-to-mesenchymal transition-induced renal abnormalities: mechanisms and therapeutic implications
Publication date: Available online 20 June 2019Source: Pharmacological ResearchAuthor(s): Pitchai Balakumar, Ramanathan Sambathkumar, Nanjaian Mahadevan, Abdullatif Bin Muhsinah, Abdulrhman Alsayari, Nallasamy Venkateswaramurthy, Gowraganahalli JagadeeshAbstractEpithelial-to-mesenchymal transition (EMT) is an orchestrated event where epithelial cells progressively undergo biochemical changes and transition into mesenchymal-like cells by gradually losing their epithelial characteristics. EMT plays a crucial pathologic role in renal abnormalities, especially renal fibrosis. A number of bench studies suggest the potential inv...
Source: Pharmacological Research - June 22, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of Spironolactone on Atrial Fibrillation in Patients with Heart Failure with Preserved Ejection Fraction: Post-Hoc Analysis of the Randomized, Placebo-Controlled TOPCAT Trial
ConclusionSpironolactone does not reduce the risk of new-onset AF or AF recurrence in patients with HFpEF. This is in contrast to results in cohorts of patients with HF and a reduced ejection fraction.Clinical trial registrationClinicalTrials.gov identifier no. NCT00094302 (TOPCAT). (Source: American Journal of Cardiovascular Drugs)
Source: American Journal of Cardiovascular Drugs - June 19, 2019 Category: Cardiology Source Type: research

Effect of Spironolactone for One Year on Endothelial Function and Vascular Inflammation Biomarkers in Renal Transplant Recipients.
BL Abstract BACKGROUND: Kidney transplantation is associated with increased cardiovascular risk. Endothelial dysfunction and vascular inflammation contribute to negative outcome. In experimental models, mineralocorticoid receptor antagonists (MRA) improved endothelial function and reduced inflammation. The current study tested the hypothesis that the MRA spironolactone improves endothelial function and reduces vascular inflammation in renal transplant patients. METHODS: 80 renal transplant patients from an ongoing, double-blind randomized placebo-controlled trial were included. Paired plasma samples before a...
Source: American Journal of Physiology. Renal Physiology - June 5, 2019 Category: Physiology Authors: Mortensen LA, Bistrup C, Stubbe J, Carlström M, Checa A, Wheelock CE, Palarasah Y, Bladbjerg EM, Thiesson HC, Jensen BL Tags: Am J Physiol Renal Physiol Source Type: research

Both aldosterone and spironolactone can modulate the intracellular ACE/ANG II/AT1 and ACE2/ANG (1 ‐7)/MAS receptor axes in human mesangial cells
Aldosterone stimulation can modulate the intracellular RAAS of immortalized human mesangial cells by evaluating both the axes ACE/ANG II/AT ‐1 and ACE2/ANG‐ (1‐7)/Mas axes AbstractThe kidney is an important target of the renin ‐ANG‐aldosterone system (RAAS). To date, several studies have demonstrated the existence of a local RAAS in various tissues, including the renal tissue. The mineralocorticoid aldosterone is known to play a critical role in the classical RAAS; however, its effect on mesangial cells (MCs) remains to be elucidated. Based on this, our aim was to investigate whether aldosterone stimulation can m...
Source: Physiological Reports - June 4, 2019 Category: Physiology Authors: Danielle Stoll, Rodrigo Yokota, Danielle Sanches Arag ão, Dulce E. Casarini Tags: Original Research Source Type: research

Transcriptional activation of elephant shark mineralocorticoid receptor by corticosteroids, progesterone, and spironolactone.
Abstract The mineralocorticoid receptor (MR) is a nuclear receptor and part of a large and diverse family of transcription factors that also includes receptors for glucocorticoids, progesterone, androgens, and estrogens. The corticosteroid aldosterone is the physiological activator of the MR in humans and other terrestrial vertebrates; however, its activator is not known in cartilaginous fish, the oldest group of extant jawed vertebrates. Here, we analyzed the ability of corticosteroids and progesterone to activate the full-length MR from the elephant shark (Callorhinchus milii). On the basis of their measured act...
Source: Science Signaling - June 4, 2019 Category: Biomedical Science Authors: Katsu Y, Kohno S, Oka K, Lin X, Otake S, Pillai NE, Takagi W, Hyodo S, Venkatesh B, Baker ME Tags: Sci Signal Source Type: research

Both aldosterone and spironolactone can modulate the intracellular ACE/ANG II/AT1 and ACE2/ANG (1 ‐7)/MAS receptor axes in human mesangial cells
Aldosterone stimulation can modulate the intracellular RAAS of immortalized human mesangial cells by evaluating both the axes ACE/ANG II/AT ‐1 and ACE2/ANG‐ (1‐7)/Mas axes AbstractThe kidney is an important target of the renin ‐ANG‐aldosterone system (RAAS). To date, several studies have demonstrated the existence of a local RAAS in various tissues, including the renal tissue. The mineralocorticoid aldosterone is known to play a critical role in the classical RAAS; however, its effect on mesangial cells (MCs) remains to be elucidated. Based on this, our aim was to investigate whether aldosterone stimulation can m...
Source: Physiological Reports - June 4, 2019 Category: Physiology Authors: Danielle Stoll, Rodrigo Yokota, Danielle Sanches Arag ão, Dulce E. Casarini Tags: Original Research Source Type: research

Cortexolone 17 α-propionate (Clascoterone) Is a Novel Androgen Receptor Antagonist that Inhibits Production of Lipids and Inflammatory Cytokines from Sebocytes In Vitro
Cortexolone 17α-propionate (Clascoterone) Is a Novel Androgen Receptor Antagonist that Inhibits Production of Lipids and Inflammatory Cytokines from Sebocytes In Vitro J Drugs Dermatol. 2019 May 01;18(5):412-418 Authors: Rosette C, Agan FJ, Mazzetti A, Moro L, Gerloni M Abstract Cortexolone 17α-propionate (clascoterone) is a novel topical androgen antagonist that is being analyzed for its ability to treat acne. The pathogenesis of acne is attributed to multiple factors, including altered sebum production, inflammatory processes, dysregulation of the hormone microenvironment, and the prolife...
Source: Journal of Drugs in Dermatology - June 2, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research