Fight Aging! Newsletter, June 27th 2022
In conclusion, this study confirms that innate immune training can be induced in aging healthy individuals as well as critically ill sepsis patients. We found that innate immune training can be induced regardless of age and there was no substantive difference in the immune trained phenotype as a function of age. We employed β-glucan as our immune training stimulus. The ability of glucan to induce the trained phenotype suggests that it may be possible to pharmacologically induce the immune trained phenotype in aging human immunocytes.
Sitting Time Correlates with Mortality Risk
https://www.fightaging.org/archi...
Source: Fight Aging! - June 26, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Sabotaging the Link Between Hypertension and Cardiac Hypertrophy
The heart becomes larger and weaker in response to the raised blood pressure of hypertension, though inflammatory signaling clearly also plays an important role. Note the study that showed clearance of senescent cells, and thus removal of their pro-inflammatory signaling, reversed cardiac hypertrophy in mice. In the research noted here, scientists discuss the sensing mechanisms that link blood pressure with hypertrophy of the heart. Sabotaging that system is not as good as prevention of hypertension, as targeting deeper issues should always be better than preventing just a few of their consequences, but will no doubt give ...
Source: Fight Aging! - June 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Is there Intracellular edema in congestive heart failure ?
I am unable to answer this question confidently even after spending 25 years in the specialty of cardiology. I thought, the answer was yes. Reality is definitely different. Such is the complexity in the biology of the fluid and circulatory systems. The heart’s function doesn’t seem to end with just pumping 6 liters of blood every minute, ultimately, it has to handle a huge load of water as well with delicate coordination with the kidney. (ANP,& RASS feedback). It is fascinating to note, that the heart transforms into a powerful endocrine organ as and when it is necessary.
Read further, with a caution: (The...
Source: Dr.S.Venkatesan MD - May 31, 2022 Category: Cardiology Authors: dr s venkatesan Tags: cardiac failure edema in heart failure Source Type: blogs
Fight Aging! Newsletter, May 30th 2022
In conclusion, fisetin supplementation may be a novel strategy to target excess cellular senescence and thereby reduce mitochondrial ROS to improve NO-mediated endothelial function with aging.
Exercise Upregulates BDNF Expression to Promote Dopamine Release and Brain Function
https://www.fightaging.org/archives/2022/05/exercise-upregulates-bdnf-expression-to-promote-dopamine-release-and-brain-function/
Researchers have in the past shown that exercise results in greater amounts of BDNF, which in turn promotes neurogenesis. Here, this line of research is extended to show that exercise results in an increa...
Source: Fight Aging! - May 29, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Smart Pacifier Monitors Electrolyte Levels
At Washington State University a team developed a smart pacifier that can provide continuous monitoring of electrolyte levels in saliva. The measurements could help to avoid twice daily blood draws for premature infants. Blood draws are currently routine practice to monitor for signs of dehydration, which can be dangerous for infants born prematurely. The new pacifier uses microfluidic channels to draw saliva inside, and then sensors within the device measure sodium and potassium ion concentrations and transmit the data wirelessly to a caregiver through Bluetooth.
Premature infants are incredibly delicate and require a ...
Source: Medgadget - May 26, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Pediatrics WSU Source Type: blogs
Fisetin Reduces the Burden of Senescent Cells in the Vasculature of Mice
In conclusion, fisetin supplementation may be a novel strategy to target excess cellular senescence and thereby reduce mitochondrial ROS to improve NO-mediated endothelial function with aging.
Link: https://doi.org/10.1096/fasebj.2022.36.S1.R1931 (Source: Fight Aging!)
Source: Fight Aging! - May 24, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Another deadly and confusing ECG. Are you still one of the many people who will be fooled by this ECG, or do you recognize it instantly?
Submitted and written byDestiny Folk MD, peer reviewed by Meyers, Smith, Grauer, McLarenA man in his early 30s with no significant past medical history was brought to the ED by EMS after being found unresponsive by a friend. EMS arrived and found him awake and alert. He complained of generalized weakness and left lower extremity numbness. He reported that 12 hours prior to arrival he used fentanyl and cocaine. He reported difficulty walking and felt as if his left leg was “asleep.” He denied any chest pain or shortness of breath and stated he felt at his baseline yesterday prior to drug use. On arrival in the ED, he wa...
Source: Dr. Smith's ECG Blog - May 5, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Wireless Data Transfer for Implanted Devices Using Ionic Communication
Researchers at the Columbia University School of Engineering and Applied Science have developed a new method for implanted devices to communicate with the outside world that exploits the ions that are naturally present in our tissues. Ion-rich tissues store potential energy, and in this paradigm an implanted device would alter this stored energy with alternating electrical pulses. Electrodes placed on nearby skin can then measure these changes in energy and analyze them to obtain the clinical data. The method is rapid and requires low power.
Implantable devices need to communicate with the outside world. Current sol...
Source: Medgadget - April 25, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Diagnostics etc. Medicine Neurology Neurosurgery Pain Management Radiology columbia Source Type: blogs
What's new in midwifery - 21st April 2022
First, aCochrane review on repeat doses of prenatal corticosteroids for women at risk of preterm birth, for improving neonatal outcomes, And a trial of adding financial incentives tobest practices for smoking cessation among pregnant and newly postpartum women, an RCT carried out in Burlington, Vermont, USA.ASpectator article about an email sent from the NHS National Clinical Director for Maternity and Women ' s Health and the Chief Midwifery Officer, to NHS Trusts about the language used about birth in job adverts, that might suggest a bias to one mode of delivery. A government press release reporting resp...
Source: Browsing - April 21, 2022 Category: Databases & Libraries Tags: midwifery Source Type: blogs
An asymptomatic man in his 50s with heart rate in the 160s - what is the diagnosis? How will you manage this?
Written by Pendell MeyersA man in his late 50s with history of CAD with CABG, COPD, smoking, cirrhosis, and other comorbidities presented for an outpatient scheduled stress test which had been ordered for some exertional shortness of breath, palpitations, and presyncopal episodes over the past few months. When he presented to the office for the stress test, his screening vitals before any test or intervention were remarkable only for a heart rate of 160 bpm. He denied any symptoms whatsoever.A 12-lead ECG was performed in the office:What do you think?The ECG shows a wide complex regular monomorphic tachycardia. I mea...
Source: Dr. Smith's ECG Blog - April 2, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Painless Nasogastric Tube Placement
A 6-year-old boy presented with intermittent abdominal pain, nausea, and vomiting. Because his abdominal examination was unremarkable, the pain intermittent, and constipation a possibility, we provided an enema along with an abdominal pain workup but no radiographs. His pain improved, the abdominal labs were unremarkable, and the child tolerated an oral fluid challenge after treatment with ondansetron.The mother was advised at discharge to return if she became concerned about her child's condition. They did return a few hours later for increased vomiting and abdominal pain. A CT scan demonstrated multiple dilated loops ...
Source: M2E Too! Mellick's Multimedia EduBlog - March 1, 2022 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
The Potential Role Of Technology In Euthanasia And Assisted Death
In early 2021, Spanish lawmakers legalised euthanasia and assisted death for patients suffering from unbearable and/or incurable conditions, making Spain the sixth country in the world to do so. Prior to this move, the Netherlands expanded the eligibility to euthanasia to include advanced dementia patients, provided they made an earlier written request.
Following the new law in Spain, Health Minister Carolina Darias said that “we are heading towards a more humane and fair society”. She further praised this acknowledgement of the right to an assisted death as a crucial move “towards the recognition of human rights&...
Source: The Medical Futurist - January 18, 2022 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Forecast Lifestyle medicine Bioethics Biotechnology Healthcare Policy 3d printing euthanasia assisted dying Source Type: blogs
Acute respiratory distress: Correct interpretation of the initial and serial ECG findings, with aggressive management, might have saved his life.
Written by Pendell Meyers with edits by SmithA man in his 60s called EMS apparently for shortness of breath. EMS found him in distress and hypoxemic requiring 4 L nasal cannula to maintain oxygen saturation greater than 93%.Here is his triage ECG:What do you think?An old ECG was available on file, from 2 years ago:RBBB, otherwise normal.The triage ECG is diagnostic of life threatening hyperkalemia (sodium channel blockade would also produce this pattern, but the patient was not known to be on any sodium blocking medications). There is the very common brugada pattern STEMI mimic seen in V1 and partially in V3 and aVR....
Source: Dr. Smith's ECG Blog - January 16, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
The Tasty Food That Lowers Blood Pressure
The food that can reverse the damage done to blood vessels caused by a high-sodium diet. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - October 24, 2021 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Blood Pressure Source Type: blogs
It ’s Elementary: Celebrating National Chemistry Week
Happy National Chemistry Week! In honor of this celebration, we’re showcasing posts that focus on elements crucial for human health and scientific exploration. NIGMS-supported scientists are studying how each of these elements (and many others) can impact human health. Check out the list below to learn more, and let us know what your favorite element is in the comments section!
Credit: Adapted from Compound Interest. CC BY-NC-ND 4.0.
Helium: An Abundant History and a Shortage Threatening Scientific Tools
Scientists first discovered helium burning on the surface of the sun. Today, liquid helium plays an essential r...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 20, 2021 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Source Type: blogs
