How Does Fever Precipitate Arrhythmia in Brugada Syndrome?
In Brugada syndrome dysfunctional voltage gated sodium channels NaV1.5 have delayed activation and earlier inactivation. This leads to shortening of action potential duration. There is additional shortening of action potential duration at higher temperatures. This is the proposed mechanism of precipitation of arrhythmias in Brugada syndrome during febrile episodes. That is why prompt treatment of fever is an important preventive strategy to be deployed in those with Brugada syndrome.
Reference
Krahn AD, Behr ER, Hamilton R, Probst V, Laksman Z, Han HC. Brugada Syndrome. JACC Clin Electrophysiol. 2022 Mar;8(3):386-405. do...
Source: Cardiophile MD - October 17, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
What clinical scenario fits best?
Below are 4 ECGs from the same patient. Accompanying the ECGs is some clinical information. Look at the ECGs and consider the timeline and other information. At the bottom will be five alternative clinical scenarios to explain the findings.Which one do you think fits better with the ECGs and their timeline? The patient is a 60 something female. She was admitted to the hospital with clinical signs of infection. She was febrile and hypotensive at presentation. As part of her work up in the ED an ECG was recorded.What do you think?ECG#1 - day 1The above ECG shows sinus rhythm with a narrow QRS and normal axis. There is B...
Source: Dr. Smith's ECG Blog - October 12, 2023 Category: Cardiology Authors: Magnus Nossen Source Type: blogs
How I Bought and Estimated the Purity of Sodium Dichloroacetate
Trust, but verify. On second thought, just verify. (Source: Depth-First)
Source: Depth-First - October 10, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
WHO Report: Tackling Hypertension Could Avert 76M Deaths Globally
Conclusion
Hypertension, often referred to as the “silent killer,” isn’t just a mere health term; it’s a pressing global challenge with vast implications.
As the World Health Organization’s report underscores, controlling high blood pressure is more than a matter of personal health. It’s about potentially averting millions of deaths worldwide by 2050.
It’s heartening to see countries like Canada and South Korea lead the charge with effective treatment programs, offering hope and a pathway for others to follow.
Yet, the contrasting statistics on sodium intake and the p...
Source: The EMT Spot - September 26, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Battery Charged by Tears for Smart Contact Lenses
Researchers at Nanyang Technological University in Singapore have developed a tiny, flexible battery that is intended for use in smart contact lenses. The device is as thin as the human cornea and can be charged by a saline solution, which is particularly useful in the eye, as it is full of salty tears. When the battery-equipped smart lens is not in use, such as at night, then it can be stored in a saline solution, helping to further recharge the battery. The device avoids materials that could cause damage to the eye, such as metal electrodes, and works through a glucose oxidase coating that generates current when it react...
Source: Medgadget - September 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Ophthalmology NTUsg Source Type: blogs
Gene Therapy Targets Chronic Pain
Scientists at New York University have developed a gene therapy for chronic pain. The technology works by targeting the NaV1.7 sodium ion channel present on neurons, which is an important component of the pain response. The researchers encoded a version of a peptide that allows a modulatory protein, called CRMP2, to bind to NaV1.7 sodium ion channels and modulate their activity. Treating neurons so that they now express this peptide interfered with the ability of CRMP2 to affect the sodium channel, reducing the transmission of pain. As chronic pain affects a large number of patients, new treatments such as this could be se...
Source: Medgadget - August 25, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine Pain Management chronic pain nyu Source Type: blogs
Microneedle Patch for Antibiotic-Free Acne Treatment
Researchers at the University of Hong Kong have developed a microneedle patch for the drug-free treatment of skin infections, such as acne. Acne is often treated using antibiotics, but these have limited effectiveness over the long term and can result in drug-resistant bacteria. In an effort to develop a drug-free alternative, these researchers have created a microneedle patch that is ultrasound responsive. The patch contains zinc-based nanomaterials that produce a substantial amount of reactive oxygen species when stimulated using ultrasound. These reactive oxygen species are highly effective at killing acne-causing bacte...
Source: Medgadget - August 1, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Dermatology Materials Medicine acne HKUniversity Source Type: blogs
Vasodilators For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In summary, vasodilators play a pivotal role in managing cardiovascular conditions, including hypertension, which is rapidly becoming a global health concern.
By expanding the body’s blood vessels, these unique medications can improve blood flow and decrease the pressure exerted by the heart, thereby providing relief to numerous patients worldwide.
Their applications are diverse, extending beyond hypertension to conditions like angina, heart failure, and even erectile dysfunction.
However, these medications should be taken carefully and always under the supervision of a doctor due to the potent...
Source: The EMT Spot - July 27, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Handling Heat On Blood Pressure Medication: Your Summer Health Guide
Conclusion
Summing it up, individuals taking blood pressure medication must be cautious during the hot weather season. Heat exposure can significantly impact blood pressure and may amplify the effects of medication, leading to potentially harmful health conditions.
These risks, however, can be managed with the right precautions such as staying hydrated, dressing appropriately, and planning outdoor activities during cooler times of the day.
Importantly, each person’s response to heat and medication varies. Hence, a one-size-fits-all approach isn’t ideal. Your healthcare provider is an invaluable resourc...
Source: The EMT Spot - July 26, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Potassium: The Silent Ally In Your Battle With Hypertension
Conclusion: Balancing Potassium Intake As Part Of An Overall Healthy Lifestyle
While elevating your potassium intake can be instrumental in your battle against high blood pressure, it’s essential to remember that it’s part of a broader health strategy. There’s no magic bullet in managing blood pressure. A symphony of lifestyle adjustments working in harmony is what lays the groundwork for victory.
Eating an overall healthy diet, limiting your sodium intake, getting regular exercise, and quitting smoking if needed – all these factors dance hand in hand with your potassium intake. These habits f...
Source: The EMT Spot - July 26, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
A man in his 70s with weakness and syncope
DiscussionBrugada Type 1 ECG changes are associated with sudden cardiac death (SCD) and the occurrence of ventricular dysrhythmias. Patients that develop a Type 1 pattern without any precipitating or provoking factors have a risk of SCD of 0.5-0.8% per year. In patients that only have this pattern induced by a sodium channel blocking agent have a lower rate of SCD (0 - 0.35% per year)[1]. Drugs that have been associated with Brugada ECG patterns include tricyclic antidepressants, anesthetics, cocaine, methadone, antihistamines, electrolyte derangements, and even tramadol. [2]. Our patient had a Brugada Type ...
Source: Dr. Smith's ECG Blog - July 22, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
Eggs And High Blood Pressure: Decoding The Dietary Dilemma
Conclusion
In navigating the winding road of managing high blood pressure, several key points emerge. Eggs, while a source of ongoing debate, can form part of a balanced diet for most people. It’s essential, though, to consider your entire dietary pattern, emphasizing heart-healthy choices like those found in the DASH and Mediterranean diets.
Avoiding processed meats and sugary breakfast options, while incorporating nutrient-dense foods, can significantly impact your blood pressure management. But remember, it’s not all about diet. A comprehensive approach, involving regular physical activity, stress mana...
Source: The EMT Spot - July 21, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Blood Pressure Meds vs Blood Thinners: What ’ s The Difference?
Conclusion
In conclusion, while blood pressure medicines and blood thinners are both crucial to heart health, their roles and mechanisms of action are notably distinct. Blood pressure medication works primarily on the vascular system, aiding in reducing blood pressure by relaxing blood vessels or altering the heart’s function. On the other hand, blood thinners target the blood itself, working to prevent the formation of potentially dangerous blood clots.
Throughout this article, one thing becomes undeniably clear: the importance of regular consultations with your healthcare provider. When it comes to managing m...
Source: The EMT Spot - July 20, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Yoghurt: A Delicious Solution To High Blood Pressure?
Conclusion
In a nutshell, the humble pot of yoghurt could be a powerful tool in the fight against high blood pressure.
From its impressive mineral content to the potential blood-pressure-lowering action of its amino acids, yoghurt has proven to be more than just a tasty snack.
However, as we’ve learned from Dr. Lee, the type and quantity of yoghurt we consume matters.
The takeaway?
Dietary choices can significantly impact our health, making conscious consumption essential.
Now, you might view that bowl of yoghurt in a new light, not only for its delicious taste but also for its potential health-...
Source: The EMT Spot - July 16, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Can You Drink Licorice With Hypertension?
Conclusion
It’s clear that licorice, with its potent compound glycyrrhizin, can potentially raise blood pressure. This makes it a food item to approach with caution for those living with hypertension. But, remember, not all “licorice” you see on shelves contains real licorice root or extract. Checking labels can help identify those sneaky substitutes.
Moderation and informed choices are your allies. While occasional licorice consumption might be fine for some, it’s always best to consult your healthcare provider to ensure you’re not jeopardizing your well-being.
Delicious alternatives...
Source: The EMT Spot - June 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
