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Patient and Physician Decisional Factors Regarding Hypercalcemia of Malignancy Treatment: A Novel Mixed-Methods Study
CONCLUSION: Using mixed methods, CPG developers can obtain meaningful information regarding evidence to decision criteria. In the case of HCM CPGs, this approach has provided the required contextual information and supported the development of evidence-based recommendations.PMID:36545699 | DOI:10.1210/clinem/dgac630 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 22, 2022 Category: Endocrinology Authors: Aya Bassatne Mohammad H Murad Thomas Piggott Matthew T Drake Maya Rahme Ghada El-Hajj Fuleihan Source Type: research

Cinacalcet inhibition of neuronal action potentials preferentially targets the fast inactivated state of voltage-gated sodium channels
Voltage-gated sodium channel (VGSC) activation is essential for action potential generation in the brain. Allosteric calcium-sensing receptor (CaSR) agonist, cinacalcet, strongly and ubiquitously inhibits VGSC currents in neocortical neurons via an unidentified, G-protein-dependent inhibitory molecule. Here, using whole-cell patch VGSC clamp methods, we investigated the voltage-dependence of cinacalcet-mediated inhibition of VGSCs and the channel state preference of cinacalcet. The rate of inhibition of VGSC currents was accelerated at more depolarized holding potentials. Cinacalcet shifted the voltage-dependence of both f...
Source: Frontiers in Physiology - December 19, 2022 Category: Physiology Source Type: research

Predictive factors requiring high-dose evocalcet in hemodialysis patients with secondary hyperparathyroidism
by Masanori Tokumoto, Shin Tokunaga, Shinji Asada, Yuichi Endo, Noriaki Kurita, Masafumi Fukagawa, Tadao Akizawa The dosage of evocalcet required to control serum parathyroid hormone (PTH) levels varies among secondary hyperparathyroidism (SHPT) patients. This post hoc analysis evaluated the dose-dependent efficacy of evocalcet on serum intact PTH (iPTH) levels, corrected calcium (Ca) and phosphate (P) level s, and safety, in an evaluation period (week 28 to week 30) by stratifying the previous phase 3 data with the final evocalcet dosages (low 1–2 mg [131 patients], medium 3–4 mg [90 patients], high 5–8 mg [92 pati...
Source: PLoS One - December 13, 2022 Category: Biomedical Science Authors: Masanori Tokumoto Source Type: research

Etelcalcetide controls secondary hyperparathyroidism and raises sclerostin levels in hemodialysis patients previously uncontrolled with cinacalcet
CONCLUSION: Etelcalcetide improved sHPT control in this group of patients, previously under cinacalcet treatment, and significantly increased plasma sclerostin concentration. The impact of etelcalcetide treatment on sclerostin levels is a novel finding.PMID:36437202 | DOI:10.1016/j.nefroe.2022.11.014 (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - November 27, 2022 Category: Urology & Nephrology Authors: Luciano Artur Lopes Pereira Catarina Meng Manuel Augusto Gon çalves Amoedo Maria Teresa de Sousa Costa Pinto Ferreira Mendes Marco Alexandre Mateus Prazeres Marques Jo ão Miguel Machado Dória Frazão Andr é Luiz Loureiro Weigert Source Type: research

Complete resolution of calciphylaxis in a renal transplant patient with Calcifediol
Presentation: A 62-year-old woman with a Living Donor Kidney transplant in 2008 complicated with chronic kidney disease III, lupus nephritis, hypothyroidism (but no history of diabetes) presented with painful, bilateral, medial calf ischaemic ulcerations (figure 1), which on punch biopsy revealed calciphylaxis (figure 2). Her weight was 66.3 kg, height 1.6 m and body mass index of 25.9 kg/m2. She was on hydroxychloroquine, mycophenolate and prednisone for lupus/transplant and levothyroxine 125 mcg daily for hypothyroidism. Her baseline intact parathyroid harmone (iPTH), calcium, phosphorus and 25-hydroxy-vitamin D was 372 ...
Source: Postgraduate Medical Journal - November 22, 2022 Category: General Medicine Authors: Doraiswamy, M., Singh, P., Pesavento, T. E., Meng, S. Tags: Images Source Type: research

A systematic review and meta-analysis of efficacy and safety of Calcimimetic agents in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease
CONCLUSION: Calcimimetic agents can reduce the PTH level, Ca level, P level, calcium-phosphorus product level and do not increase the serious adverse events.PMID:36305135 | DOI:10.2174/1381612829666221027110656 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - October 28, 2022 Category: Drugs & Pharmacology Authors: Yiping Liu Qian Yang Guangyong Chen Tianbiao Zhou Source Type: research

< b > < i > APOL1 < /i > < /b > G3 Variant Is Associated with Cardiovascular Mortality and Sudden Cardiac Death in Patients Receiving Maintenance Hemodialysis of European Ancestry
Conclusions: G3 inAPOL1 variant was associated with cardiovascular events and cardiovascular mortality in the EA patients receiving dialysis. This suggests that variations in theAPOL1 gene that differ in populations of different ancestry may contribute to cardiovascular disease.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 28, 2022 Category: Urology & Nephrology Source Type: research

The efficacy and safety of medical and surgical therapy in patients with primary hyperparathyroidism: a systematic review and meta ‐analysis of randomized controlled trials
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - August 22, 2022 Category: Orthopaedics Authors: Zhikang Ye, Shonni J. Silverberg, Ashwini Sreekanta, Kyle Tong, Ying Wang, Yaping Chang, Mengmeng Zhang, Gordon Guyatt, Wimonchat Tangamornsuksun, Yi Zhang, Veena Manja, Layla Bakaa, Rachel J. Couban, Maria Luisa Brandi, Bart Clarke, Aliya Tags: Task Force Source Type: research