Cost-effectiveness analysis of cinacalcet vs. paricalcitol in the treatment of hyperparathyroidism secondary to chronic kidney disease
CONCLUSION: Cinacalcet was dominant to avoid parathyroidectomies, being cost-effective.PMID:37015047 | DOI:10.1590/2175-8239-JBN-2022-0126en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - April 4, 2023 Category: Urology & Nephrology Authors: Daniela Ponce Marilia Mastrocolla de Almeida Cardoso Juliana Rodrigues Machado R úgolo Silvana Andrea Molina Luis Gustavo Modelli de Andrade Daniel da Silva Pereira Curado Source Type: research
Recurrent parathyromatosis in a patient with concomitant MEN1 and CASR gene alterations: Clinical management of a case report and literature review
Conclusionsa rare case of parathyromatosis due to a combination of two genetic alterations never described. The main issues concern the diagnosis and the radical treatment. Somatostatin analogues may have a useful role in both diagnosis and therapy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 14, 2023 Category: Endocrinology Source Type: research
Impact of Cinacalcet and Etelcalcetide on Bone Mineral and Cardiovascular Disease in Dialysis Patients
AbstractPurposes of ReviewWith chronic kidney disease (CKD) progression, secondary hyperparathyroidism (sHPT) and mineral and bone metabolism disease (MBD) almost inevitably develop and result in renal osteodystrophy and cardiovascular disease (CVD). Together with active vitamin D, calcimimetics are the main therapy for sHPT in CKD. This review provides an overview of the therapeutic effects of oral cinacalcet and intravenous etelcalcetide on CKD-MBD and vascular disease, with a focus on pediatric dialysis patients.Recent FindingsRandomized controlled trials in adults and children demonstrate efficient lowering of parathyr...
Source: Current Osteoporosis Reports - February 27, 2023 Category: Orthopaedics Source Type: research
Validated BioAnalytical Method for Cinacalcet Concentrations in Rat Plasma by Reversed PhaseHigh Performance Liquid Chromatography Photodiode Array Detector Method
M. R. Nagasarapu* and I. B. Mahammad (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - February 24, 2023 Category: Drugs & Pharmacology Source Type: research
Long-term use of etelcalcetide for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis for end-stage renal failure: a real-life retrospective observational study
ConclusionFindings from this study demonstrate that the efficacy of etelcalcetide is maintained over the long term. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - February 15, 2023 Category: Urology & Nephrology Source Type: research
Rescue of High Glucose Impairment of Cultured Human Osteoblasts Using Cinacalcet and Parathyroid Hormone
AbstractPatients with type 2 diabetes mellitus (T2DM) experience a higher risk of fractures despite paradoxically exhibiting normal to high bone mineral density (BMD). This has drawn into question the applicability to T2DM of conventional fracture reduction treatments that aim to retain BMD. In a primary human osteoblast culture system, high glucose levels (25 mM) impaired cell proliferation and matrix mineralization compared to physiological glucose levels (5 mM). Treatment with parathyroid hormone (PTH, 10 nM), a bone anabolic agent, and cinacalcet (CN, 1 µM), a calcimimetic able to target the Ca2+-sensing receptor...
Source: Calcified Tissue International - February 8, 2023 Category: Orthopaedics Source Type: research
