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Management of lithium-associated hyperparathyroidism with cinacalcet hydrochloride
Br J Hosp Med (Lond). 2023 Jan 2;84(1):1-3. doi: 10.12968/hmed.2022.0330. Epub 2023 Jan 3.NO ABSTRACTPMID:36708345 | DOI:10.12968/hmed.2022.0330 (Source: British Journal of Hospital Medicine)
Source: British Journal of Hospital Medicine - January 28, 2023 Category: Internal Medicine Authors: Sarah Craus Emma L Mifsud Simon Mifsud Sandro Vella Source Type: research

Subtotal parathyroidectomy successfully controls calcium levels of patients with neonatal severe hyperparathyroidism carrying a novel CASR mutation
Conclusion: We report a novel heterozygous and homozygous missense variant (c.1817T>C; p.Leu606Pro) in CASR in two NSHPT patients. The mutation likely disrupts conformational changes of CASR and results in cinacalcet unresponsiveness. Intronic variants in CASR identified in the patient with heterozygous variant might have contributed to the clinical manifestations of the patient. Although total parathyroidectomy is wildly accepted as a standard treatment for NSHPT, we demonstrate that subtotal parathyroidectomy is also an effective procedure to normalize Ca levels and allow these patients to be in normocalcemia or mild hyp...
Source: Hormone Research in Paediatrics - January 10, 2023 Category: Endocrinology Source Type: research

Subtotal Parathyroidectomy Successfully Controls Calcium Levels of Patients with Neonatal Severe Hyperparathyroidism Carrying a Novel CASR Mutation
Conclusion: We report a novel heterozygous and homozygous missense variant (c.1817T#x3e;C; p.Leu606Pro) inCASR in two NSHPT patients. The mutation likely disrupts conformational changes of CASR and results in cinacalcet unresponsiveness. Intronic variants inCASR identified in the patient with heterozygous variant might have contributed to the clinical manifestations of the patient. Although total parathyroidectomy is widely accepted as a standard treatment for NSHPT, we demonstrate that subtotal parathyroidectomy is also an effective procedure to normalize Ca levels and allow these patients to be in normocalcemia or mild h...
Source: Hormone Research in Paediatrics - January 10, 2023 Category: Endocrinology Source Type: research

Sensitivity of Ca 2+ -sensing receptor-transient receptor potential-mediated Ca 2+ influx to extracellular acidity in bEND.3 endothelial cells
Chin J Physiol. 2022 Nov-Dec;65(6):277-281. doi: 10.4103/0304-4920.365460.ABSTRACTCa2+-sensing receptors (CaSRs) are G protein-coupled receptors activated by elevated concentrations of extracellular Ca2+. In our previous works, we showed protein and functional expression of CaSR in mouse cerebral endothelial cell (EC) (bEND.3); the CaSR response (high Ca2+-elicited cytosolic [Ca2+] elevation) was unaffected by suppression of phospholipase C but in part involved Ca2+ influx through transient receptor potential V1 (TRPV1) channels. In this work, we investigated if extracellular acidity affected CaSR-mediated Ca2+ influx trig...
Source: The Chinese Journal of Physiology - January 2, 2023 Category: Physiology Authors: Iat-Lon Leong Chung-Ming Yu Lian-Ru Shiao Paul Chan King-Chuen Wu Yuk-Man Leung Source Type: research