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Modular Bicyclophane-Based Molecular Platforms
Chemistry. 2023 Sep 18:e202302662. doi: 10.1002/chem.202302662. Online ahead of print.ABSTRACTThe modular synthesis of a series of nanoscale phenylene bicyclophanes with an intraaanular orthogonal pillar is described. The compounds are obtained by a Suzuki cross-coupling condensation and are characterized by mass spectrometry and NMR spectroscopy as well as in situ scanning tunneling microscopy at the solid/liquid interface of highly ordered pyrolytic graphite. In addition, their structures and conformations are supported by quantum chemical calculations, also after adsorption to the substrate. A set of two alkyl chain sub...
Source: Chemistry - September 18, 2023 Category: Chemistry Authors: Daniel Kalle Joshua Bahr Tristan Johannes Keller Julius Kleine B üning Stefan Grimme Markus Bursch Stefan-Sven Jester Sigurd H öger Source Type: research
Digital Motor Biomarkers of Cerebellar Ataxia Using an RGB-Depth Camera-Based Motion Analysis System
This study aimed to identify quantitative biomarkers of motor function for cerebellar ataxia by evaluating gait and postural control using an RGB-depth camera-based motion analysis system. In 28 patients with degenerative cerebellar ataxia and 33 age- and sex-matched healthy controls, motor tasks (short-distance walk, closed feet stance, and stepping in place) were selected from a previously reported protocol, and scanned using Kinect V2 and customized software. The Clinical Assessment Scale for the Assessment and Rating of Ataxia (SARA) was also evaluated. Compared with the normal control group, the cerebellar ataxia grou...
Source: Cerebellum - September 18, 2023 Category: Neuroscience Authors: Masahide Suzuki Shigeki Hirano Karen Otte Tanja Schmitz-H übsch Michiko Izumi Mitsuyoshi Tamura Ryota Kuroiwa Atsuhiko Sugiyama Masahiro Mori Hanna M R öhling Alexander U Brandt Atsushi Murata Friedemann Paul Satoshi Kuwabara Source Type: research
Artificial intelligence in breast imaging: potentials and challenges
Phys Med Biol. 2023 Sep 18. doi: 10.1088/1361-6560/acfade. Online ahead of print.ABSTRACTBreast cancer, which is the most common type of malignant tumor among humans, is a leading cause of death in females. Standard treatment strategies, including neoadjuvant chemotherapy, surgery, postoperative chemotherapy, targeted therapy, endocrine therapy, and radiotherapy, are tailored for individual patients. Such personalized therapies have tremendously reduced the threat of breast cancer in females. Furthermore, early imaging screening plays an important role in reducing the treatment cycle and improving breast cancer prognosis. ...
Source: Physics in Medicine and Biology - September 18, 2023 Category: Physics Authors: Jiawei Li Danli Sheng Jiangang Chen Chao You Shuai Liu Huixiong Xu Cai Chang Source Type: research
Treatment with a tissue-selective oestrogen complex does not affect disease pathology but reduces pre-BI cells in lupus-prone mice
CONCLUSION: TSEC does not aggravate a mouse model of lupus, when given in doses that protect against postmenopausal lupus-associated bone loss. This indicates that further investigations into TSEC as a treatment for osteoporosis or vasomotor symptoms in postmenopausal women with SLE are warranted.PMID:37722827 | DOI:10.1080/03009742.2023.2251753
Source: Scandinavian Journal of Rheumatology - September 18, 2023 Category: Rheumatology Authors: C Drevinge J M Scheffler J Nordqvist C Engdahl H Carlsten U Islander Source Type: research
Synthesis of chitosan-based perylene dye material for photovoltaic solar-cell application
This study proposes a novel chitosan biopolymer-based perylene dye; the dye is modified by chitosan with perylene-3,4,9,10-tetracarboxylic anhydride using a one-pot acylation of nitrogen nucleophiles for DSSCs. The chitosan biopolymer-based perylene dyes were characterized using attenuated total reflection infrared spectroscopy, solid-state 13C CP-TOSS nuclear magnetic resonance spectroscopy, X-ray powder diffraction analysis, thermogravimetric analysis, X-ray photoelectron spectrometry, and high-resolution field-emission scanning electron microscopy. The ultraviolet-visible and fluorescence spectroscopy of chitosan biopol...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Santosh Kumar Ira Singh Nazrul Hsan Bhabani Sankar Swain Joonseok Koh Source Type: research
Bacterial cellulose/gum Arabic composite production by in-situ modification from lavender residue hydrolysate
In this study, bacterial cellulose/gum Arabic composite (BC/GA) was synthesized by in-situ modification from lavender residue hydrolysate for the first time. The in-situ modification with GA adding showed great beneficial effect for BC/GA synthesis. Both the product (BC or BC/GA) yield and the product (BC or BC/GA) production per sugars consumption increased greatly by the in-situ modification when compared with the fermentation without GA adding (2.90 g/L vs. 0.91 g/L, and 0.461 g/g vs. 0.138 g/g). It is hypothesized that the combination of BC and GA is the main mechanism for the beneficial effect of the in-situ modificat...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Huai-Peng Jia Xiao-Lin Wang Zhuo-Wei Liu Yi Wu Jing Gao Yong Hu Yun Chen Chao Huang Source Type: research
Pulmonary Invasive Fungal Disease: Ultrasound and Computed Tomography Scan Findings
CONCLUSION: Combining the characteristic findings of ultrasound and CT-scan provides a higher value in diagnosing pulmonary invasive fungal disease.PMID:37721491 | DOI:10.5152/ThoracResPract.2023.23013
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Seyed Ali Alamdaran Raha Bagheri Seyedeh Fatemeh Darvari Elham Bakhtiari Ali Ghasemi Source Type: research
Diseases of the Coronary Microcirculation: Diagnosis and Treatment
CONCLUSION: Approximately 25% of patients with CMD have symptoms that do not respond to intensive treatment with the currently available modalities. New treatments, including interventional therapies, are being studied. Their long-term benefit remains to be assessed and compared to that of the existing methods.PMID:37721132 | DOI:10.3238/arztebl.m2023.0205
Source: Deutsches Arzteblatt International - September 18, 2023 Category: General Medicine Authors: Helen Ullrich-Daub Steffen Daub Maximilian Olschewski Thomas M ünzel Tommaso Gori Source Type: research
Radiation-dependent demyelination in normal appearing white matter in glioma patients, determined using quantitative magnetic resonance imaging
CONCLUSION: In the long-term follow-up for glioma patients, qMRI is a powerful tool for detecting small changes, such as a decrease of myelin concentration, in NAWM after CRT.PMID:37720464 | PMC:PMC10500023 | DOI:10.1016/j.phro.2023.100451
Source: Health Physics - September 18, 2023 Category: Physics Authors: Anna Ljusberg Ida Blystad Peter Lundberg Emelie Adolfsson Anders Tisell Source Type: research
Comparing the effectiveness of novel high-end compression garment with common compression garment and kinesio tape in preventing edema and improving tissue perfusion in lower extremities
CONCLUSION: The novel bandage showed a statistically significant reduction in edema when compared intraindividually, but no statistically significant advantage was found when compared with the other compression garment B and kinesio tape.Despite the widespread use of kinesio tape, we did not find any improvement in the range of motion, edema prevention and circulation in the lower limb after application of kinesio tape.PMID:37718791 | DOI:10.3233/CH-238111
Source: Clinical Hemorheology and Microcirculation - September 18, 2023 Category: Hematology Authors: Sophia T Diesch Daniel Schiltz Julian Kammermeier Lukas Prantl Christian D Taeger Source Type: research
PNIPAM-stabilized cubosomes as fusogenic delivery nanovectors for anticancer applications
Colloids Surf B Biointerfaces. 2023 Sep 9;231:113532. doi: 10.1016/j.colsurfb.2023.113532. Online ahead of print.ABSTRACTIn recent years, lipid cubic nanoparticles have emerged as promising nanocarriers for drug delivery, due to the several advantages they exhibit with respect to other lipid systems. Here, we report on lipid cubic nanoparticles stabilized by PNIPAM-based amphiphilic block copolymers, specifically, poly(N, N-dimethylacrylamide)-block-poly(N-isopropylacrylamide) (PDMA-b-PNIPAM), as a new class of drug delivery systems (DDS). In vitro studies on the internalization efficiency of the DDS towards two types of h...
Source: Colloids and Surfaces - September 18, 2023 Category: Biotechnology Authors: Arianna Balestri Laure Gibot Heinz Amenitisch Lorenzo Cervelli Costanza Montis Barbara Lonetti Debora Berti Source Type: research
Comparing the effectiveness of novel high-end compression garment with common compression garment and kinesio tape in preventing edema and improving tissue perfusion in lower extremities
CONCLUSION: The novel bandage showed a statistically significant reduction in edema when compared intraindividually, but no statistically significant advantage was found when compared with the other compression garment B and kinesio tape.Despite the widespread use of kinesio tape, we did not find any improvement in the range of motion, edema prevention and circulation in the lower limb after application of kinesio tape.PMID:37718791 | DOI:10.3233/CH-238111
Source: Clinical Hemorheology and Microcirculation - September 18, 2023 Category: Hematology Authors: Sophia T Diesch Daniel Schiltz Julian Kammermeier Lukas Prantl Christian D Taeger Source Type: research
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
T-scans in implant procedures
Bioinformation. 2023 Jan 31;19(1):35-38. doi: 10.6026/97320630019035. eCollection 2023.ABSTRACTT scans are a breakthrough in technology which allows the user to accurately analyze the occlusion of a patient with minimal to zero errors. They are used during prosthodontic rehabilitation to map out the patient's occlusion to plan for replacements. Such a high advancement in technology has a backdraw. The cost of the equipment is a concern for simple dental practitioners. There are no large scale studies using T scans in determining the occlusion. Therefore, it is of interest to analyze the use of T scans in determining the pe...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Prabhav Kumar Iyer Suresh Venugopalan Thiyaneswaran N Sam Jebaraj Source Type: research
