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White matter hyperintensity load mediates the relationship between age and cognition
Neurobiol Aging. 2023 Aug 25;132:56-66. doi: 10.1016/j.neurobiolaging.2023.08.007. Online ahead of print.ABSTRACTTo elucidate the relationship between age and cognitive decline, it is important to consider structural brain changes such as white matter hyperintensities (WMHs), which are common in older age and may affect behavior. Therefore, we aimed to investigate if WMH load is a mediator of the relationship between age and cognitive decline. Healthy participants (N = 166, 20-80 years) completed the Montreal Cognitive Assessment (MoCA). WMHs were manually delineated on FLAIR scans. Mediation analysis was conducted to dete...
Source: Neurobiology of Aging - September 20, 2023 Category: Geriatrics Authors: Natalie Busby Sarah Wilson Janina Wilmskoetter Roger Newman-Norlund Sara Sayers Sarah Newman-Norlund Rebecca Roth Chris Rorden Julius Fridriksson Leonardo Bonilha Source Type: research
Structural and histochemical aspects of the Gymnotus carapo tegument (Teleostei: Gymnotiformes)
An Acad Bras Cienc. 2023 Sep 18;95(4):e20191259. doi: 10.1590/0001-3765202320191259. eCollection 2023.ABSTRACTThe present study aims to structurally and histochemically characterize the Gymnotus carapo tegument. 30 specimens were captured and slaughtered by spinal section with anesthesia. The observation was carried out with a stereoscopic microscope and the body surface was photographed. Fragments of the dorsal, ventral and lateral region were fixed in Bouin's solution for 12 hours and subsequently preserved in 70% alcohol. They were subsequently observed in the scanning electron microscope (SEM). The preparation for SEM ...
Source: An Acad Bras Cienc - September 20, 2023 Category: Science Authors: Tania Blanco Cohene Gabriela Olea Carolina Flores Quintana Source Type: research
Deposition of secondary organic aerosol in human lung model: Effect of photochemically aged aerosol on human respiratory system
This study is to estimate the fraction of aerosol deposition using a multiple-path-particle-dosimetry (MPPD) model. For relevancy of real life, the model employed measured concentrations of toluene-derived fresh and aged SOA produced within serially connected smog chamber and PAM-OFR (Potential Aerosol Mass-Oxidation Flow Reactor) under atmospheric environmental conditions (NOx and relative humidity). The number concentrations and chemical composition of fresh and aged aerosols produced within the chambers were measured using Scanning Mobility Particle Sizer (SMPS) and High-Resolution Time-of-Flight Aerosol Mass Spectromet...
Source: Ecotoxicology and Environmental Safety - September 20, 2023 Category: Environmental Health Authors: Hyeon-Ju Oh Yanfang Chen Hwajin Kim Source Type: research
Analysis of image data from the EuroNet PHL-C2 trial indicates a potential reduction in injected F-18 FDG activities in children: a proposal to update the EANM Paediatric Dosage Card
CONCLUSION: The results of this work allow for a conservative update of the EANM Paediatric Dosage Card for [18F]FDG-PET/CT scans performed with conventional PET/CT systems.PMID:37728668 | DOI:10.1007/s00259-023-06396-w
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Johannes Tran-Gia Uta Eberlein Michael Lassmann Christine Mauz-K örholz Dieter K örholz Pietro Zuccetta Zvi Bar-Sever Ute Rosner Thomas Walter Georgi Osama Sabri Regine Kluge Arnoldo Piccardo Lars Kurch Source Type: research
Development of gallic acid-loaded ethylcellulose fibers as a potential wound dressing material
In this study, novel fibers were designed based on ethylcellulose (EC), loaded with different concentrations of gallic acid (GA) using the electrospinning technique, in order to investigate the potential of these materials as wound dressings. The chemical structure and morphology, along with the antimicrobial and biocompatibility tests of the EC_GA fibers were investigated. To observe the chemical interactions between the components, fourier transform infrared spectroscopy (FTIR) was used. The morphological analyzes were performed using scanning electron microscope (SEM). The uniaxial tensile test machine was used to obtai...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Alexa-Maria Croitoru Musa Ayran Eray Altan Yasin Karacelebi Songul Ulag Ali Sahin Mehmet Mucahit Guncu Burak Aksu Oguzhan Gunduz Bianca-Maria Tih ăuan Denisa Ficai Anton Ficai Source Type: research
Synchronous rectal adenocarcinoma and intestinal mantle cell lymphoma: A case report
CONCLUSION: Synchronous rectal adenocarcinoma and intestinal MCL presenting as multiple lymphomatous polyposis are extremely rare. MCL is often discovered fortuitously when rectal cancer is diagnosed. The coexistence of these tumors poses treatment challenges.PMID:37727717 | PMC:PMC10506007 | DOI:10.12998/wjcc.v11.i24.5772
Source: Clinical Colorectal Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Kim-Van Vu Nguyen-Van Trong Nguyen-Thi Khuyen Do Huyen Nga Hoang Anh Nguyen Tien Trung Pham Trung Thong Nguyen Minh Duc Source Type: research
Synthesis of phytic acid-modified chitosan and the research of the corrosion inhibition and antibacterial properties
In this study, chitosan (CS) and phytic acid (PA) were employed as raw materials to synthesize a range of chitosan-phytic acid complexes (CP) with different ratios (CS:PA = 12:1, 9:1, 6:1, 3:1, 1:1). The structures and elemental compositions of the compounds were characterized using Fourier-Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy with Energy-Dispersive X-ray Spectroscopy (SEM-EDS). The thermal stability of the synthesized materials was analyzed using a Thermogravimetric Analyzer (TG). Electrochemical testing was conducted to explore the corrosion inhibition effect of the modified inhibitors...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Qing Yin Jiali Liu Zicheng Zhong Yueyuan Zhang Feiran Zhang Mingming Wang Source Type: research
Vaccination coverage in children under one year of age and associated socioeconomic factors: maps of spatial heterogeneity
CONCLUSIONS: the results are useful for designing interventions regarding the structuring of vaccination services and the implementation of actions to increase vaccination coverage in clusters with less propensity to vaccinate.PMID:37729269 | DOI:10.1590/0034-7167-2022-0734
Source: Revista Brasileira de Enfermagem - September 20, 2023 Category: Nursing Authors: Matheus Adriano Divino Pereira Luis Henrique Arroyo Maria Del Pilar Serrano Gallardo Ricardo Alexandre Arc êncio Josianne Dias Gusm ão Gabriela Gon çalves Amaral Val éria Conceição de Oliveira Eliete Albano de Azevedo Guimar ães Source Type: research
Implementation of an integrated community approach in deprived neighbourhoods: a theory-based process evaluation using the Consolidated Framework for Implementation Research (CFIR)
CONCLUSIONS: Engaging citizens and professionals at an early stage is an important facilitator for implementation. The use of a shared vision on health also worked as a facilitator since it created a shared language among professionals, which is important in Population Health Management initiatives where multiple professionals are expected to collaborate.TRIAL REGISTRATION: NTR 6543; registration date, 25 July 2017.PMID:37726916 | DOI:10.1177/14034948231199804
Source: Scandinavian Journal of Public Health - September 20, 2023 Category: International Medicine & Public Health Authors: Sanneke J M Grootjans M M N Stijnen I Hesdahl-DE Jong M E A L Kroese D Ruwaard M W J Jansen Source Type: research
Changes in smoking due to COVID-19 pandemic among persons of migrant origin compared with the general population: a population-based study
CONCLUSIONS: The findings of this study contribute to better identification of at-risk populations in future crises situations. This will allow for more efficient targeting and tailoring of health promotion services, including smoking cessation.PMID:37726894 | DOI:10.1177/14034948231199792
Source: Scandinavian Journal of Public Health - September 20, 2023 Category: International Medicine & Public Health Authors: Otto Ruokolainen Eero Lilja Hanna Ollila Anu E Castaneda P äivikki Koponen Natalia Skogberg Source Type: research
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
In this study, we found that SIRT1 is closely related to expression of GLP-1R in hippocampus of 3xTg mice. Therefore, we used semaglutide, a novel GLP-1R agonist currently undergoing two phase 3 clinical trials in AD patients, to observe the effect of SIRT1 after semaglutide treatment in 3XTg mice and HT22 cells, and to explore the mechanism of SIRT1 in the glucose metabolism disorders of AD. The mice were injected with semaglutide on alternate days for 30 days, followed by behavioral experiments including open field test, new object recognition test, and Y-maze. The content of glucose in the brain was also measured by usi...
Source: Neuropharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: Zhao-Jun Wang Xin-Ru Li Shi-Fan Chai Wei-Ran Li Shuo Li Meng Hou Jia-Lei Li Yu-Cai Ye Hong-Yan Cai Christian H ölscher Mei-Na Wu Source Type: research
Cancers, Vol. 15, Pages 4651: Is Insulin Receptor Substrate4 (IRS4) a Platform Involved in the Activation of Several Oncogenes?
Miguel A. Ortega
The IRS (insulin receptor substrate) family of scaffold proteins includes insulin receptor substrate-4 (IRS4), which is expressed only in a few cell lines, including human kidney, brain, liver, and thymus and some cell lines. Its N-terminus carries a phosphotyrosine-binding (PTB) domain and a pleckstrin homology domain (PH), which distinguishes it as a member of this family. In this paper, we collected data about the molecular mechanisms that explain the relevance of IRS4 in the development of cancer and identify IRS4 differences that distinguish it from IRS1 and IRS2. Search engines and different dat...
Source: Cancers - September 20, 2023 Category: Cancer & Oncology Authors: Luis G. Guijarro Francisco Javier Justo Bermejo Diego Liviu Boaru Patricia De Castro-Martinez Diego De Leon-Oliva Oscar Fraile-Mart ínez Cielo Garcia-Montero Melchor Alvarez-Mon Mar ía del Val Toledo-Lobo Miguel A. Ortega Tags: Review Source Type: research
Photo-induced Scandium-catalyzed biomimetic skeleton conversion of lathyrane to naturally rare eupholathone Euphorbia diterpenes
Chem. Commun., 2023, Accepted Manuscript DOI: 10.1039/D3CC03541G, CommunicationJin-Bu Xu, Peng Wen, Neng Wang, Xiao-Huan Li, Jia-Hong Li, Steven De Jonghe, Dominique Schols, FengZheng Chen, Feng Gao The naturally scarce eupholathone-type euphornin E (1) was efficiently prepared from abundant lathyrane-type Euphorbia factor L1 via visible-light-induced Sc(OTf)3-catalyzed tandem process. Eupholathones 2 and 3 were also smoothly obtained by... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 19, 2023 Category: Chemistry Authors: Jin-Bu Xu Source Type: research
Is duration of residence a proxy for acculturation? The case of health risk behaviors among international immigrants
CONCLUSIONS: Our findings suggest that duration of residence should not be used as a proxy for acculturation when studying health risk behaviors among immigrants. Researchers should consider additional time-dependent factors to explain behavioral changes by duration of residence.PMID:37723980 | DOI:10.1177/14034948231199534
Source: Scandinavian Journal of Public Health - September 19, 2023 Category: International Medicine & Public Health Authors: Sol P Ju Árez Helena Honkaniemi Nina-Katri Gustafsson Lisa Berg Source Type: research
Residential overcrowding in relation to children's health, environment and schooling - a qualitative study
CONCLUSIONS: Our qualitative evidence suggest that overcrowding has a negative impact on children's health, environment and schooling.PMID:37723969 | DOI:10.1177/14034948231198285
Source: Scandinavian Journal of Public Health - September 19, 2023 Category: International Medicine & Public Health Authors: Johnny C Lorentzen Antonios Georgellis Maria Albin Marina Jonsson Source Type: research
