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Drug: Estradiol
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Skeletal muscle function is altered in male mice on low dose androgen receptor antagonist or estrogen receptor agonist
We examined the effect of acute (2 week) exposures to 17α-ethinyl estradiol (EE2), an estrogen receptor (ER) agonist, or flutamide, an androgen receptor (AR) antagonist, on the contractile function of individual skeletal muscle fibers from slow-contracting soleus and fast-contracting extensor digitorum longus muscles from adult male mice. Single fiber specific tension (force divided by cross-sectional area) was decreased with flutamide treatment in all myosin heavy chain fiber types examined (MHC I, IIA and IIB); similar effects were observed with EE2-treatment but only in the fastest-contracting MHC IIB fibers. The decre...
Source: Endocrinology - August 26, 2023 Category: Endocrinology Authors: Brent A Momb Gillian K Szabo Joshua P Mogus Stuart R Chipkin Laura N Vandenberg Mark S Miller Source Type: research
A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
CONCLUSIONS: Research in PMD, MM, and CE commonly have overlapping study design and research methods, and similar effects of some interventions suggest the possibility of overlapping mechanisms contributing to their cyclical symptom presentation. Our scoping review is the first to summarize existing clinical trials in these three brain disorders, specifically focusing on hormonal treatment trials. We find that PMD has a stronger body of literature for ovulation-suppressing COC and GnRHa trials; the field of MM consists of extensive estrogen-based studies; and current consensus in CE focuses on progesterone supplementation ...
Source: Frontiers in Neuroendocrinology - August 24, 2023 Category: Endocrinology Authors: Jordan C Barone Mitchell P Butler Ashley Ross Anna Patterson Melissa Wagner-Schuman Tory A Eisenlohr-Moul Source Type: research
Fertility-enhancing effects of inositol & amp; vitamin C on cisplatin induced ovarian and uterine toxicity in rats via suppressing oxidative stress and apoptosis
This study aimed to explore the effects of Inositol and vitamin C on cisplatin-induced infertility. Forty-eight adult female Wistar rats were divided into eight groups (N = 6) and orally treated for 21 days. The treatments were as follows: negative control (saline), positive control (saline and cisplatin injected into the abdomen on day 15), T1-T3: rats given vitamin C (150 mg/kg), Inositol (420 mg/kg), and vitamin C + Inositol, respectively, along with cisplatin injected into the abdomen on day 15, T4-T6: rats given only vitamin C, Inositol, and vitamin C + Inositol, respectively. Vitamin C and Inositol enhanced cisplatin...
Source: Food and Chemical Toxicology - August 24, 2023 Category: Food Science Authors: Amir Hosein Moslehi Fatemeh Hoseinpour Amir Saber Maryam Akhavan Taheri Amir Hossein Hashemian Source Type: research
A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
CONCLUSIONS: Research in PMD, MM, and CE commonly have overlapping study design and research methods, and similar effects of some interventions suggest the possibility of overlapping mechanisms contributing to their cyclical symptom presentation. Our scoping review is the first to summarize existing clinical trials in these three brain disorders, specifically focusing on hormonal treatment trials. We find that PMD has a stronger body of literature for ovulation-suppressing COC and GnRHa trials; the field of MM consists of extensive estrogen-based studies; and current consensus in CE focuses on progesterone supplementation ...
Source: Frontiers in Neuroendocrinology - August 24, 2023 Category: Endocrinology Authors: Jordan C Barone Mitchell P Butler Ashley Ross Anna Patterson Melissa Wagner-Schuman Tory A Eisenlohr-Moul Source Type: research
Nuclear receptor superfamily structural diversity in pacific oyster: In silico identification of estradiol binding candidates
Chemosphere. 2023 Aug 22:139877. doi: 10.1016/j.chemosphere.2023.139877. Online ahead of print.ABSTRACTThe increasing presence of anthropogenic contaminants in aquatic environments poses challenges for species inhabiting contaminated sites. Due to their structural binding characteristics to ligands that inhibit or activate gene transcription, these xenobiotic compounds frequently target the nuclear receptor superfamily. The present work aims to understand the potential interaction between the hormone 17-β-estradiol, an environmental contaminant, and the nuclear receptors of Crassostrea gigas, the Pacific oyster. This filt...
Source: Chemosphere - August 24, 2023 Category: Chemistry Authors: T âmela Zamboni Madaloz Karin Dos Santos Fl ávia Lucena Zacchi Afonso Celso Dias Bainy Guilherme Razzera Source Type: research
A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
CONCLUSIONS: Research in PMD, MM, and CE commonly have overlapping study design and research methods, and similar effects of some interventions suggest the possibility of overlapping mechanisms contributing to their cyclical symptom presentation. Our scoping review is the first to summarize existing clinical trials in these three brain disorders, specifically focusing on hormonal treatment trials. We find that PMD has a stronger body of literature for ovulation-suppressing COC and GnRHa trials; the field of MM consists of extensive estrogen-based studies; and current consensus in CE focuses on progesterone supplementation ...
Source: Frontiers in Neuroendocrinology - August 24, 2023 Category: Endocrinology Authors: Jordan C Barone Mitchell P Butler Ashley Ross Anna Patterson Melissa Wagner-Schuman Tory A Eisenlohr-Moul Source Type: research
Nuclear receptor superfamily structural diversity in pacific oyster: In silico identification of estradiol binding candidates
Chemosphere. 2023 Aug 22:139877. doi: 10.1016/j.chemosphere.2023.139877. Online ahead of print.ABSTRACTThe increasing presence of anthropogenic contaminants in aquatic environments poses challenges for species inhabiting contaminated sites. Due to their structural binding characteristics to ligands that inhibit or activate gene transcription, these xenobiotic compounds frequently target the nuclear receptor superfamily. The present work aims to understand the potential interaction between the hormone 17-β-estradiol, an environmental contaminant, and the nuclear receptors of Crassostrea gigas, the Pacific oyster. This filt...
Source: Chemosphere - August 24, 2023 Category: Chemistry Authors: T âmela Zamboni Madaloz Karin Dos Santos Fl ávia Lucena Zacchi Afonso Celso Dias Bainy Guilherme Razzera Source Type: research
A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: Studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
CONCLUSIONS: Research in PMD, MM, and CE commonly have overlapping study design and research methods, and similar effects of some interventions suggest the possibility of overlapping mechanisms contributing to their cyclical symptom presentation. Our scoping review is the first to summarize existing clinical trials in these three brain disorders, specifically focusing on hormonal treatment trials. We find that PMD has a stronger body of literature for ovulation-suppressing COC and GnRHa trials; the field of MM consists of extensive estrogen-based studies; and current consensus in CE focuses on progesterone supplementation ...
Source: Frontiers in Neuroendocrinology - August 24, 2023 Category: Endocrinology Authors: Jordan C Barone Mitchell P Butler Ashley Ross Anna Patterson Melissa Wagner-Schuman Tory A Eisenlohr-Moul Source Type: research
Fertility-enhancing effects of inositol & amp; vitamin C on cisplatin induced ovarian and uterine toxicity in rats via suppressing oxidative stress and apoptosis
This study aimed to explore the effects of Inositol and vitamin C on cisplatin-induced infertility. Forty-eight adult female Wistar rats were divided into eight groups (N = 6) and orally treated for 21 days. The treatments were as follows: negative control (saline), positive control (saline and cisplatin injected into the abdomen on day 15), T1-T3: rats given vitamin C (150 mg/kg), Inositol (420 mg/kg), and vitamin C + Inositol, respectively, along with cisplatin injected into the abdomen on day 15, T4-T6: rats given only vitamin C, Inositol, and vitamin C + Inositol, respectively. Vitamin C and Inositol enhanced cisplatin...
Source: Food and Chemical Toxicology - August 24, 2023 Category: Food Science Authors: Amir Hosein Moslehi Fatemeh Hoseinpour Amir Saber Maryam Akhavan Taheri Amir Hossein Hashemian Source Type: research
Functional Hypothalamic Amenorrhea and Preclinical Cardiovascular Disease
CONCLUSIONS: These results demonstrate endothelial dysfunction in one out of three young women with FHA. FHA may be a contributor to preclinical CVD, and it is not explained by hypoestrogenemia alone.PMID:37610989 | DOI:10.1210/clinem/dgad498
Source: The Journal of Clinical Endocrinology and Metabolism - August 23, 2023 Category: Endocrinology Authors: Chrisandra L Shufelt Mariam Saadedine Galen Cook-Wiens Margareta D Pisarska JoAnn E Manson Sarah L Berga Moshe Arditi Prediman K Shah C Noel Bairey Merz Source Type: research
Accelerated bone loss in older men with severe abdominal aortic calcification - the prospective MINOS study
CONCLUSIONS: Severe AAC is associated with faster bone loss in older men and may contribute to the higher fracture risk observed in this population.PMID:37610245 | DOI:10.1210/clinem/dgad459
Source: The Journal of Clinical Endocrinology and Metabolism - August 23, 2023 Category: Endocrinology Authors: Pawel Szulc Joshua R Lewis Roland Chapurlat Source Type: research
FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer
CONCLUSIONS: Collectively, our data suggest that one mechanism by which obesity and weight gain promote breast cancer progression is through estrogen-independent ER activation and cancer cell metabolic reprogramming, partly driven by FGF/FGFR. The first-line treatment for many patients with ER-positive breast cancer is inhibition of estrogen synthesis using aromatase inhibitors. In women with obesity who are experiencing weight gain, locally produced FGF1 may activate ER to promote cancer cell metabolic reprogramming and tumor progression independently of estrogen.PMID:37608351 | DOI:10.1186/s13058-023-01699-0
Source: Cell Research - August 23, 2023 Category: Cytology Authors: Marisol Castillo-Castrejon Barbara Mensah Sankofi Stevi Johnson Murguia Abasi-Ama Udeme Hoaning Howard Cen Yi Han Xia Nisha S Thomas William L Berry Kenneth L Jones Vincent R Richard Rene P Zahedi Christoph H Borchers James D Johnson Elizabeth A Wellberg Source Type: research
