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Medicinal Chemistry-driven Approach to Novel 2-Substituted Benzoxazole - Estradiol Chimeras: Synthesis, Anticancer Activity and Early ADME Profile
ChemMedChem. 2023 Sep 20:e202300352. doi: 10.1002/cmdc.202300352. Online ahead of print.ABSTRACTThe efficient synthesis of novel estradiol-based A-ring-fused oxazole derivatives, which can be considered as benzoxazole-steroid domain-integrated hybrids containing a common benzene structural motif, is described. The target compounds were prepared from steroidal 2-aminophenol precursors by heterocycle formation or functional group interconversion (FGI) strategies. According to 2D projection-based t-distributed stochastic neighbor embedding (t-SNE), the novel molecules were proved to represent a new chemical space among steroi...
Source: ChemMedChem - September 20, 2023 Category: Chemistry Authors: Ferenc Kov ács Ildik ó Huliák H édi Árva M ónika Kiricsi D óra Erdős Marianna Kocsis Gergely Tak ács Gy örgy T Balogh Éva Frank Source Type: research
Expression of concern: Solar-driven photodegradation of 17- β-estradiol and ciprofloxacin from waste water and CO2 conversion using sustainable coal-char/polymeric-g-C3N4/RGO metal-free nano-hybrids
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Amit Kumar, Ajay Kumar, Gaurav Sharma, Mu. Naushad, Renato Cataluna Veses, Ayman A. Ghfar, Florian J. Stadler, Mohammad Rizwan Khan To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - September 19, 2023 Category: Chemistry Authors: Amit Kumar Source Type: research
Biomonitoring of manganese metal pollution in water and its impacts on biological activities of Biomphalaria alexandrina snail and larvicidal potencies
Environ Sci Pollut Res Int. 2023 Sep 18. doi: 10.1007/s11356-023-29786-x. Online ahead of print.ABSTRACTMetal pollution has many dangerous environmental and human health consequences due to the bioaccumulation in the tissues. The present study aims to measure the bioaccumulation factor of the manganese (Mn) heavy metal in Biomphalaria alexandrina snails' tissues and water samples. The current results showed the concentration of Mn heavy metal in water (87.5 mg/l) and its bioaccumulation factor in Helisoma duryi tissue was higher than that in tissues of Physa acuta and B. alexandrina snails. Results showed that 87.5 mg/l Mn...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Amina Mohamed Ibrahim Ahmed Abdel-Salam Abdel-Haleem Rania Gamal Taha Source Type: research
Structure-function of DHEA binding proteins
Vitam Horm. 2023;123:587-617. doi: 10.1016/bs.vh.2022.12.002. Epub 2022 Dec 16.ABSTRACTDehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated metabolite DHEA-S are the most abundant circulating steroids and are precursors for active sex steroid hormones, estradiol and testosterone. DHEA has a broad range of reported effects in the central nervous system (CNS), cardiovascular system, adipose tissue, kidney, liver, and in the reproductive system. The mechanisms by which DHEA and DHEA-S initiate their biological effects are diverse. DHEA and DHEA-S may directly bind to plasma membrane (PM) receptors, i...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Barbara J Clark Carolyn M Klinge Source Type: research
Membrane estrogen receptor and follicle-stimulating hormone receptor
Vitam Horm. 2023;123:555-585. doi: 10.1016/bs.vh.2022.12.005. Epub 2022 Dec 29.ABSTRACTFollicle-stimulating hormone (FSH) and estrogens are fundamental to support reproductive functions. Beside the well-known FSH membrane receptor (FSHR), a G protein-coupled estrogen receptor (GPER) has been found, over the last two decades, in several tissues. It may trigger rapid, non-genomic responses of estradiol, activating proliferative and survival stimuli. The two receptors were co-characterized in the ovary, where they modulate different intracellular signaling cascades, according to the expression level and developmental stage of...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Livio Casarini Manuela Simoni Source Type: research
Structure-function of DHEA binding proteins
Vitam Horm. 2023;123:587-617. doi: 10.1016/bs.vh.2022.12.002. Epub 2022 Dec 16.ABSTRACTDehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated metabolite DHEA-S are the most abundant circulating steroids and are precursors for active sex steroid hormones, estradiol and testosterone. DHEA has a broad range of reported effects in the central nervous system (CNS), cardiovascular system, adipose tissue, kidney, liver, and in the reproductive system. The mechanisms by which DHEA and DHEA-S initiate their biological effects are diverse. DHEA and DHEA-S may directly bind to plasma membrane (PM) receptors, i...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Barbara J Clark Carolyn M Klinge Source Type: research
Membrane estrogen receptor and follicle-stimulating hormone receptor
Vitam Horm. 2023;123:555-585. doi: 10.1016/bs.vh.2022.12.005. Epub 2022 Dec 29.ABSTRACTFollicle-stimulating hormone (FSH) and estrogens are fundamental to support reproductive functions. Beside the well-known FSH membrane receptor (FSHR), a G protein-coupled estrogen receptor (GPER) has been found, over the last two decades, in several tissues. It may trigger rapid, non-genomic responses of estradiol, activating proliferative and survival stimuli. The two receptors were co-characterized in the ovary, where they modulate different intracellular signaling cascades, according to the expression level and developmental stage of...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Livio Casarini Manuela Simoni Source Type: research
Structure-function of DHEA binding proteins
Vitam Horm. 2023;123:587-617. doi: 10.1016/bs.vh.2022.12.002. Epub 2022 Dec 16.ABSTRACTDehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated metabolite DHEA-S are the most abundant circulating steroids and are precursors for active sex steroid hormones, estradiol and testosterone. DHEA has a broad range of reported effects in the central nervous system (CNS), cardiovascular system, adipose tissue, kidney, liver, and in the reproductive system. The mechanisms by which DHEA and DHEA-S initiate their biological effects are diverse. DHEA and DHEA-S may directly bind to plasma membrane (PM) receptors, i...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Barbara J Clark Carolyn M Klinge Source Type: research
Membrane estrogen receptor and follicle-stimulating hormone receptor
Vitam Horm. 2023;123:555-585. doi: 10.1016/bs.vh.2022.12.005. Epub 2022 Dec 29.ABSTRACTFollicle-stimulating hormone (FSH) and estrogens are fundamental to support reproductive functions. Beside the well-known FSH membrane receptor (FSHR), a G protein-coupled estrogen receptor (GPER) has been found, over the last two decades, in several tissues. It may trigger rapid, non-genomic responses of estradiol, activating proliferative and survival stimuli. The two receptors were co-characterized in the ovary, where they modulate different intracellular signaling cascades, according to the expression level and developmental stage of...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Livio Casarini Manuela Simoni Source Type: research
Impairment of oocyte maturation as a mechanism of decreased fecundity in Japanese medaka (Oryzias latipes) exposed to the brominated flame retardant, 1,2,5,6-tetrabromocyclooctane (TBCO)
Aquat Toxicol. 2023 Sep 11;263:106695. doi: 10.1016/j.aquatox.2023.106695. Online ahead of print.ABSTRACTInhibition of oocyte maturation is an understudied mechanism by which chemical stressors can impair fecundity of female fishes. The primary objective of the present study was to develop an assay to assess oocyte maturation disruption by chemical stressors in Japanese medaka (Oryzias latipes). First, an in vitro assay to assess maturation inducing hormone (MIH)-stimulated oocyte maturation in zebrafish was validated for use with Japanese medaka. Next, using the brominated flame retardant, 1,2,5,6-tetrabromocyclooctane (T...
Source: Aquatic Toxicology - September 16, 2023 Category: Toxicology Authors: Yamin Raza Chloe Devoy Paul D Jones Jon A Doering Steve Wiseman Source Type: research
Effects of the menstrual cycle on EPOC and fat oxidation after low-volume high-intensity interval training
CONCLUSIONS: These results suggest that the menstrual cycle does not affect the increase in EPOC or fat oxidation after low-volume HIIT.PMID:37712928 | DOI:10.23736/S0022-4707.23.15209-1
Source: Health Physics - September 15, 2023 Category: Physics Authors: Akira Ishikawa Tomoka Matsuda Nodoka Ikegami Akiko Funaki Mizuki Yamada Kayoko Kamemoto Mikako Sakamaki-Sunaga Source Type: research
