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Therapy: Stem Cell Therapy

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Total 39 results found since Jan 2013.

Mesenchymal stem cells (MSCs) and MSC ‐derived exosomes in animal models of central nervous system diseases: Targeting the NLRP3 inflammasome
AbstractThe NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is a multimeric protein complex that is engaged in the innate immune system and plays a vital role in inflammatory reactions. Activation of the NLRP3 inflammasome and subsequent release of proinflammatory cytokines can be triggered by microbial infection or cellular injury. The NLRP3 inflammasome has been implicated in the pathogenesis of many disorders affecting the central nervous system (CNS), ranging from stroke, traumatic brain injury, and spinal cord injury to Alzheimer's disease, Parkinson's disease, epilepsy, multiple sclerosis, and ...
Source: IUBMB Life - June 7, 2023 Category: Research Authors: Shahrzad Nazari, Seyed Mahmoud Pourmand, Elahe Motevaseli, Gholamreza Hassanzadeh Tags: CRITICAL REVIEW Source Type: research

Prognostic Signature for Human Umbilical Cord Mesenchymal Stem Cell Treatment of Ischemic Cerebral Infarction by Integrated Bioinformatic Analysis
Biomed Res Int. 2022 Dec 13;2022:9973232. doi: 10.1155/2022/9973232. eCollection 2022.ABSTRACTIn recent studies, stem cell-based therapy is a potential new approach in the treatment of stroke. The mechanism of human umbilical cord mesenchymal stem cell (hUMSC) transplantation as one of the new approaches in the treatment of ischemic stroke is still unclear. The aim of this study was to determine the traits of immune responses during stroke progression after treatment with human umbilical cord blood MSCs by bioinformatics, to predict potential prognostic biomarkers that could lead to sex differences, and to reveal potential...
Source: Biomed Res - December 23, 2022 Category: Research Authors: Zhifeng Wen Fangxi Liu Xinyu Lin Shanshan Zhong Xiuchun Zhang Zhike Zhou Jukka Jolkkonen Chang Liu Chuansheng Zhao Source Type: research

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process
AbstractAngiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorders are frequently treated by regulating angiogenesis by utilizing a va...
Source: European Journal of Medical Research - November 4, 2022 Category: Research Source Type: research

Clinical Perspectives on the Microcirculation
AbstractAn opportunity exists to advance our understanding of the microcirculation and capabilities to therapeutically manipulate it by connecting clinicians with basic science researchers. This special topic issue emphasizes the impacts of the microcirculation on different aspects of clinical medicine and showcases how microvascular research might bridge knowledge gaps to improve patient outcomes. Co ‐authored by clinicians and basic science researchers, our collection of review articles focuses on the roles of microvascular function and dysfunction in the prognosis, diagnosis, and therapeutic management of various dise...
Source: Microcirculation - February 25, 2021 Category: Research Authors: Asher A. Mendelson, Fong Lam, Shayn M. Peirce, Walter L. Murfee Tags: REVIEW Source Type: research

A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review.
Authors: Park YJ, Farooq J, Cho J, Cozene B, Gonzales-Portillo B, Sadanandan N, Saft M, Lee JY, Borlongan CV Abstract Stem cell-based therapy stands as a robust experimental treatment for ischemic stroke. Stem cells derived from fetal, embryonic, and adult tissues serve as potential sources for transplantable cells in the setting of ischemic stroke. However, the search continues for finding an optimal cell line for clinical use. Muse cells, a distinct subset of mesenchymal stem cells found sporadically in the connective tissue of nearly every organ, may be a suitable candidate due to its safety and accessibility. T...
Source: Advances in Experimental Medicine and Biology - November 11, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

New-onset Post-transplant Diabetes and Therapy in Long-term Survivors After Allogeneic Hematopoietic Stem Cell Transplantation
Conclusion: After allo-HSCT, a significant number of patients developed PTDM and patients with acute graft-versus-host-disease were found to have a higher risk for PTDM. Long-term and continuous follow-up for diabetes and cardiovascular risk factors after HSCT is important in order to be able to provide timely and appropriate treatment.
Source: In Vivo - November 3, 2020 Category: Research Authors: DALLA VIA, V., HALTER, J. P., GERULL, S., ARRANTO, C., TICHELLI, A., HEIM, D., PASSWEG, J. R., MEDINGER, M., CESANA-NIGRO, N. Tags: Clinical Studies Source Type: research

Transplantation of neural progenitor cells generated from human urine epithelial cell-derived induced pluripotent stem cells improves neurological functions in rats with stroke.
In this study, we differentiated NPCs from a urine-derived iPSC line (UC-05) which was generated with optimized episomal vectors in a feeder-free culture system. UC-05 can be induced into NPCs efficiently in monolayer cultures using dual SMAD inhibitions, and have the ability to differentiate further into astrocytes and functional neurons in vitro. We then characterized UC-05-derived NPCs upon transplantation into the striatum of adult male rats subjected to transient middle cerebral artery occlusion (tMCAO) reperfusion. While NPCs were grafted into rats 7 days before the MCAO surgery, cells were found to migrate from the ...
Source: Discovery Medicine - July 1, 2020 Category: Research Tags: Discov Med Source Type: research

Exosomes Derived from Human Neural Stem Cells Stimulated by Interferon Gamma Improve Therapeutic Ability in Ischemic Stroke Model
Publication date: Available online 25 May 2020Source: Journal of Advanced ResearchAuthor(s): Guilong Zhang, Zhihan Zhu, Hong Wang, Yongbo Yu, Wanghao Chen, Ahmed Waqas, Yezhong Wang, Lukui Chen
Source: Journal of Advanced Research - May 26, 2020 Category: Research Source Type: research

Neural Stem Cells.
Authors: Tuazon JP, Castelli V, Lee JY, Desideri GB, Stuppia L, Cimini AM, Borlongan CV Abstract Neural stem cell (NSC) transplantation has provided the basis for the development of potentially powerful new therapeutic cell-based strategies for a broad spectrum of clinical diseases, including stroke, psychiatric illnesses such as fetal alcohol spectrum disorders, and cancer. Here, we discuss pertinent preclinical investigations involving NSCs, including how NSCs can ameliorate these diseases, the current barriers hindering NSC-based treatments, and future directions for NSC research. There are still many translatio...
Source: Advances in Experimental Medicine and Biology - January 5, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

The Effects of Electroacupuncture in a Rat Model of Cerebral Ischemia-Reperfusion Injury Following Middle Cerebral Artery Occlusion Involves MicroRNA-223 and the PTEN Signaling Pathway.
CONCLUSIONS In a rat model of CIRI following MCAO, EA activated the NOTCH pathway, promoted the expression of miR-223, increased the number of NSCs, and reduced the expression of PTEN. PMID: 31883264 [PubMed - in process]
Source: Medical Science Monitor - December 29, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Science Saturday: Researching stem cell therapy for hemorrhagic stroke
Stroke is the leading cause of permanent disability in the U.S., striking nearly 800,000 people each year, according to the Centers for Disease Control and Prevention. In the last decade, there has been preclinical research that led to a small number of early phase clinical trials using mesenchymal stem cells (MSCs) as a possible treatment to reverse [...]
Source: Mayo Clinic Research News - August 9, 2019 Category: Research Source Type: news

Modification of human MSC surface with oligopeptide-PEG-lipids for selective binding to activated endothelium.
This article is protected by copyright. All rights reserved. PMID: 30983125 [PubMed - as supplied by publisher]
Source: Biomed Res - April 13, 2019 Category: Research Authors: Noiri M, Asawa K, Okada N, Kodama T, Murayama Y, Inoue Y, Ishihara K, Ekdahl KN, Nilsson B, Teramura Y Tags: J Biomed Mater Res A Source Type: research