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Therapy: Stem Cell Therapy

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Total 283 results found since Jan 2013.

A new era of macrophage-based cell therapy
Experimental & Molecular Medicine, Published online: 01 September 2023; doi:10.1038/s12276-023-01068-zTreating disease with the white blood cells called macrophages, in some cases genetically modified, could become an effective clinical option for a range of diseases. Macrophages are cells of the innate (non-specific) immune system that can destroy diseased cells or damaging materials. They can also enhance tissue repair by releasing growth factors and anti-inflammatory molecules. Seung Hyeok Seok and colleagues at Seoul National University in South Korea review the laboratory research and clinical trials that are inve...
Source: Experimental and Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Yi Rang Na Sang Wha Kim Seung Hyeok Seok Source Type: research

Parkinson ’ s Patients Get More Mobility And Better Balance With Whole Body Vibration Therapy
I’ve always believed that with a little coaxing, your body can self-heal – and the same is true for your brain. Conventional doctors will never tell you this. For them, being a physician means managing symptoms with Big Pharma meds. But for years, I’ve been helping patients recover using dietary changes, lasers, stem cells, and hyperbaric oxygen (HBOT). These therapies help your body heal itself. No Big Pharma drug can do this. But I recently began researching another natural therapy – called Whole Body Vibration, or WBV – that can help Parkinson’s patients regain their mobility and balance. WBV isn’t new. It...
Source: Al Sears, MD Natural Remedies - August 28, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Natural Cures Source Type: news

Exosomes from circRNA-Ptpn4 can modify ADSC treatment and repair nerve damage caused by cerebral infarction by shifting microglial M1/M2 polarization
This study showed that exosomes from hypoxia pretreatment of ADSCs had significant effects in promoting functional recovery following in vivo MCAO, through suppressed inflammatory factor expression, and shifting the microglial from M1 to M2 polarization activation. The results showed that circRNA-Ptpn4 was highly expressed during hypoxia pretreatment of ADSCs exosomes. Exosomes from circ-Ptpn4-modified ADSCs had a greater ability to promote functional recovery. The circ-Ptpn4 delivered from ADSC exosomes induced microglia/macrophage polarization from M1 to M2 by suppressing miR-153-3p and enhancing Nrf2 expressions. Taken ...
Source: Molecular and Cellular Biochemistry - August 26, 2023 Category: Biochemistry Authors: Fei Wang Mei Jiang Yongbin Chi Gang Huang Mingming Jin Source Type: research

Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the Therapeutic of ischemic stroke
Curr Stem Cell Res Ther. 2023 May 5. doi: 10.2174/1574888X18666230505103407. Online ahead of print.ABSTRACTIschemic stroke is the leading cause of death and disability worldwide, with increasing incidence and mortality, imposing a significant social and economic burden on patients and their families. However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures. The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal protection and...
Source: Current Stem Cell Research and Therapy - May 8, 2023 Category: Stem Cells Authors: Yidong Liao Jiang Ming Wenxue Song Guangtang Chen Junshuan Cui Longcai He Zili Wang Xudong Wang Mingsong Xiong Hua Yang Kaya Xu Source Type: research

Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy
Biomed Pharmacother. 2023 May 2;163:114817. doi: 10.1016/j.biopha.2023.114817. Online ahead of print.ABSTRACTCardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem and have high morbidity and mortality worldwide, as well as substantial health and economic burdens, representing an urgent clinical need. In recent years, the focus of research has shifted from the use of mesenchymal stem cells (MSCs) for transplantation to the use of their secretory exosomes (MSC-exosomes) for the treatment of numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusio...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2023 Category: Drugs & Pharmacology Authors: Yanhong Pan Weipeng Wu Xiaoxin Jiang Yunhong Liu Source Type: research

Synergistic effects of electroacupuncture and bone marrow stromal cells transplantation therapy in ischemic stroke
CONCLUSIONS: Our results show that the combination treatment significantly improved restoration of neurological deficits in the animal stroke model. However, further studies are required to see if EA could promote the rapid differentiation of BMSC into neural stem cells in the short term.PMID:37140285 | DOI:10.26355/eurrev_202304_32106
Source: European Review for Medical and Pharmacological Sciences - May 4, 2023 Category: Drugs & Pharmacology Authors: Z Sun Y-Q Chen B-Y Ran Q Wu W Shen L-N Kan Source Type: research

Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy
Biomed Pharmacother. 2023 May 2;163:114817. doi: 10.1016/j.biopha.2023.114817. Online ahead of print.ABSTRACTCardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem and have high morbidity and mortality worldwide, as well as substantial health and economic burdens, representing an urgent clinical need. In recent years, the focus of research has shifted from the use of mesenchymal stem cells (MSCs) for transplantation to the use of their secretory exosomes (MSC-exosomes) for the treatment of numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusio...
Source: Atherosclerosis - May 4, 2023 Category: Cardiology Authors: Yanhong Pan Weipeng Wu Xiaoxin Jiang Yunhong Liu Source Type: research

Synergistic effects of electroacupuncture and bone marrow stromal cells transplantation therapy in ischemic stroke
CONCLUSIONS: Our results show that the combination treatment significantly improved restoration of neurological deficits in the animal stroke model. However, further studies are required to see if EA could promote the rapid differentiation of BMSC into neural stem cells in the short term.PMID:37140285 | DOI:10.26355/eurrev_202304_32106
Source: Pharmacological Reviews - May 4, 2023 Category: Drugs & Pharmacology Authors: Z Sun Y-Q Chen B-Y Ran Q Wu W Shen L-N Kan Source Type: research