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Therapy: Statin Therapy

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Total 55 results found since Jan 2013.

Effects of Statin Intensity and Adherence on the Long-Term Prognosis After Acute Ischemic Stroke Clinical Sciences
Conclusions—After acute ischemic stroke, high-intensity statin therapy with good adherence was significantly associated with a lower risk of adverse events.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Ji Hoe Heo Tags: Secondary Prevention, Compliance/Adherence, Ischemic Stroke Original Contributions Source Type: research

Combined renin-angiotensin-aldosterone system blockade and statin therapy effectively reduces the risk of cerebrovascular accident in autosomal dominant polycystic kidney disease: a nationwide population-based cohort study.
In conclusion, ADPKD was associated with an increased risk of CVA occurrence. Combined RAAS blockade and statin therapy effectively reduces the risk of CVA in ADPKD. PMID: 28711910 [PubMed - as supplied by publisher]
Source: Oncotarget - July 18, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Changes in the prevalence of statin use in Germany - findings from national health interview and examination surveys 1997-1999 and 2008-2011.
CONCLUSION: The increase in the prevalence of statin use in Germany between the two national health surveys (1997-1999 and 2008-2011) reflects the implementation of current guideline recommendations without evidence for inequalities according to gender, education, type of health insurance or region of residence. These population-based data add to information on statin prescription obtained from statutory health insurance data. Limitations of survey-based information derive from potential misclassification and selection bias as well as large time gaps between the survey periods. Further studies are needed to examine why the...
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - May 19, 2017 Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research

Effect of statin use on clinical outcomes in ischemic stroke patients with atrial fibrillation
The objective of this study was to clarify whether statin therapy can influence the prognosis in recent ischemic stroke patients with atrial fibrillation. We identified ischemic stroke patients with atrial fibrillation between 2001 and 2011 from Taiwan National Health Insurance Database. Patients not treated with statins during the first 90 days after the index stroke were matched to patients treated with statins in the first 90 days in a 2:1 ratio on the basis of age, sex, hypertension, diabetes mellitus, ischemic heart disease, heart failure, estimated National Institutes of Health Stroke Scale, use of anticoagulant, an...
Source: Medicine - February 1, 2017 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Patient ‐related characteristics associated with non‐persistence with statin therapy in elderly patients following an ischemic stroke
ConclusionsOur findings suggest that patients aged ≥75 years or those with the presence of diabetes mellitus, dementia, hypercholesterolemia or polypharmacy were likely to be persistent with statin therapy, whereas those with anxiety disorders may need greater assistance with persistence of statin therapy. Copyright © 2016 John Wiley & Sons, Ltd.
Source: Pharmacoepidemiology and Drug Safety - November 30, 2016 Category: Drugs & Pharmacology Authors: Martin Wawruch, Dusan Zatko, Gejza Wimmer, Jan Luha, Vasil Hricak, Jan Murin, Peter Kukumberg, Tomas Tesar, Adam Hloska, Rashmi Shah Tags: Original Report Source Type: research

Predictors of Cardiovascular Hospitalization in Giant Cell Arteritis: Effect of Statin Exposure. A French Population-based Study.
CONCLUSION: Patients with GCA present a high risk of cardiovascular hospitalization after diagnosis. In patients with incident GCA from the Midi-Pyrenees region, southern France, statin therapy was associated with reduced cardiovascular hospitalizations. PMID: 27585686 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - September 3, 2016 Category: Rheumatology Tags: J Rheumatol Source Type: research

Ezetimibe-Simvastatin Therapy Reduce Recurrent Ischemic Stroke Risks in Type 2 Diabetic Patients.
CONCLUSIONS: High potency lipid-lowering therapy effectively reduces the risk of recurrent IS in diabetic patients regardless of ATOR or EZ-SIM combination therapy. PMID: 27270238 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 5, 2016 Category: Endocrinology Authors: Liu CH, Chen TH, Lin MS, Hung MJ, Chung CM, Cherng WJ, Lee TH, Lin YS Tags: J Clin Endocrinol Metab Source Type: research

Statin use after intracerebral hemorrhage: a 10 ‐year nationwide cohort study
ConclusionHydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on recurrent ICH or other components of the composite outcome. Additional studies are required to clarify the biological mechanisms underlying these observations. Statin therapy has demonstrated benefits in ischemic stroke patients, but statin use and intracerebral hemorrhage (ICH) remain a concern. Hydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on rec...
Source: Brain and Behavior - May 12, 2016 Category: Neurology Authors: Shu ‐Yu Tai, Feng‐Cheng Lin, Chung‐Yin Lee, Chai‐Jan Chang, Ming‐Tsang Wu, Chen‐Yu Chien Tags: Original Research Source Type: research

Statin use after intracerebral hemorrhage: a 10‐year nationwide cohort study
ConclusionHydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on recurrent ICH or other components of the composite outcome. Additional studies are required to clarify the biological mechanisms underlying these observations. Statin therapy has demonstrated benefits in ischemic stroke patients, but statin use and intracerebral hemorrhage (ICH) remain a concern. Hydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on rec...
Source: Brain and Behavior - March 31, 2016 Category: Neurology Authors: Shu‐Yu Tai, Feng‐Cheng Lin, Chung‐Yin Lee, Chai‐Jan Chang, Ming‐Tsang Wu, Chen‐Yu Chien Tags: Original Research Source Type: research

Statin Adherence After Ischemic Stroke or Transient Ischemic Attack Is Associated With Clinical Outcome.
CONCLUSIONS: Good statin adherence was associated with better clinical outcome in patients with acute ischemic stroke or TIA. PMID: 26742588 [PubMed - as supplied by publisher]
Source: Circulation Journal - January 8, 2016 Category: Cardiology Authors: Chen PS, Cheng CL, Kao Yang YH, Li YH Tags: Circ J Source Type: research

Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study
In this study, 5857 patients received coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4. There were no differences in comorbidity or use of antihypertensive drugs between patients who received CYP3A4-metabolized statins and those who received non-CYP3A4-metabolized statins. Patients who received CYP3A4-metabolized statins had significantly higher risk of acute kidney injury (adjusted odds ratio [OR] = 2.12; 95% CI = 1.35–3.35), hyperkalemia (adjusted OR = 2.94; 95% CI = 1.36–6.35), acute myocardial infarction (adjusted OR = 1.55; 95% CI = 1.16–2.07), and acute ischemic ...
Source: Medicine - January 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Processes and outcomes of ischemic stroke care: the influence of hospital level of care
Conclusions Outcomes among patients with ischemic stroke can be improved by thrombolytic therapy, antithrombotic therapy, statin treatment and rehabilitation assessment. Among patients with ischemic stroke, admission to designated stroke center hospitals may be associated with lower mortality through better processes of care.
Source: International Journal for Quality in Health Care - July 31, 2015 Category: Global & Universal Authors: Tung, Y.-C., Jeng, J.-S., Chang, G.-M., Chung, K.-P. Tags: Papers Source Type: research

An Increased Risk of Reversible Dementia May Occur After Zolpidem Derivative Use in the Elderly Population: A Population-Based Case-Control Study
Abstract: We evaluate the effects of zolpidem use to develop dementia or Alzheimer disease from the Taiwan National Health Insurance Research Database (NHIRD). A retrospective population-based nested case–control study. Newly diagnosed dementia patients 65 years and older and controls were sampled. A total of 8406 dementia and 16,812 control subjects were enrolled from Taiwan NHIRD during 2006 to 2010. The relationships between zolpidem use and dementia were measured using odds and adjusted odds ratios. The relationship between the average cumulative doses for zolpidem and dementia was also analyzed. Zolpidem alone or wi...
Source: Medicine - May 1, 2015 Category: Internal Medicine Tags: Article: Observational Study Source Type: research

Risk of Intracranial Hemorrhage from Statin Use in Asians: A Nationwide Cohort Study.
CONCLUSIONS: -Generally, no association was observed between cumulative statin use and risk of ICH among subjects without a prior history of stroke. An increased risk was identified among the non-hypertensive cohort, but this finding should be interpreted with caution. PMID: 25858194 [PubMed - as supplied by publisher]
Source: Circulation - April 9, 2015 Category: Cardiology Authors: Chang CH, Lin CH, Caffrey JL, Lee YC, Liu YC, Lin JW, Lai MS Tags: Circulation Source Type: research

Effectiveness and safety of extracranial carotid stent placement: A nationwide self-controlled case-series study
Conclusion CAS reduced the long-term risk for ischemic stroke. Self-controlled case series analysis might be an appropriate design for evaluating device safety and effectiveness.
Source: Journal of the Formosan Medical Association - March 14, 2015 Category: Journals (General) Source Type: research