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Therapy: Hormonal Therapy

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Total 44 results found since Jan 2013.

Women's Health Initiative clinical trials: potential interactive effect of calcium and vitamin D supplementation with hormonal therapy on cardiovascular disease
Conclusions: CaD did not consistently modify the effect of CEE therapy or CEE + MPA therapy on CVD events. However, the increased risk of stroke due to CEE therapy appears to be mitigated by CaD supplementation. In contrast, CaD supplementation did not influence the risk of stroke due to CEE + MPA.
Source: Menopause - August 1, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Vaginal estrogen use and chronic disease risk in the Nurses’ Health Study
Conclusions: Vaginal estrogen use was not associated with a higher risk of cardiovascular disease or cancer. Our findings lend support to the safety of vaginal estrogen use, a highly effective treatment for genitourinary syndrome of menopause.
Source: Menopause - June 1, 2019 Category: OBGYN Tags: Original Articles Source Type: research

MHT in myocardial infarction and stroke survivors
30 years ago, it was believed that there is a clear cut protective effect of estrogen in women with coronary artery disease. This was based on studies that monitored the outcomes of postmenopausal hormone therapy (MHT) in women with various basal clinical scenarios, such as myocardial infarction, coronary angiography or coronary artery bypass. These studies were observational, and treatment usually comprised of conjugated equine estrogen alone or combined with medroxyprogesterone acetate. However, results of randomized, placebo-controlled trials (secondary prevention, but mainly primary prevention) pointed at neutrality or...
Source: Maturitas - May 14, 2019 Category: Primary Care Authors: Amos Pines Tags: INV25 Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

Cardiovascular health in transgender people
AbstractThis review examines the relationship between exogenous sex steroids and cardiovascular events and surrogate markers in trans (transgender) people. Data from trans populations is compared to data from postmenopausal women and hypogonadal men when appropriate. In an age-adjusted comparison with cisgender people, trans people appear to have an increased risk for myocardial infarction and death due to cardiovascular disease. It is uncertain whether hormone therapy in trans people affects their risk of stroke. In studies that followed trans people on hormone therapy, the rates of myocardial infarction and stroke were c...
Source: Reviews in Endocrine and Metabolic Disorders - August 3, 2018 Category: Endocrinology Source Type: research

Cardiovascular health in transgender people.
Abstract This review examines the relationship between exogenous sex steroids and cardiovascular events and surrogate markers in trans (transgender) people. Data from trans populations is compared to data from postmenopausal women and hypogonadal men when appropriate. In an age-adjusted comparison with cisgender people, trans people appear to have an increased risk for myocardial infarction and death due to cardiovascular disease. It is uncertain whether hormone therapy in trans people affects their risk of stroke. In studies that followed trans people on hormone therapy, the rates of myocardial infarction and str...
Source: ENDOCR REV - August 3, 2018 Category: Endocrinology Authors: Irwig MS Tags: Rev Endocr Metab Disord Source Type: research

Heart Risks Tied to Transwomen ' s Hormone Therapy
TUESDAY, July 10, 2018 -- Transwomen who undergo hormone therapy may face higher chances of blood clots, stroke and heart attack, a new study suggests. The term transwoman refers to a woman who is designated male at birth. Some undergo hormone...
Source: Drugs.com - Daily MedNews - July 10, 2018 Category: General Medicine Source Type: news

Cross-sex Hormones and Acute Cardiovascular Events in Transgender Persons: A Cohort Study.
Conclusion: The patterns of increases in VTE and ischemic stroke rates among transfeminine persons are not consistent with those observed in cisgender women. These results may indicate the need for long-term vigilance in identifying vascular side effects of cross-sex estrogen. Primary Funding Source: Patient-Centered Outcomes Research Institute and Eunice Kennedy Shriver National Institute of Child Health and Human Development. PMID: 29987313 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - July 10, 2018 Category: Internal Medicine Authors: Getahun D, Nash R, Flanders WD, Baird TC, Becerra-Culqui TA, Cromwell L, Hunkeler E, Lash TL, Millman A, Quinn VP, Robinson B, Roblin D, Silverberg MJ, Safer J, Slovis J, Tangpricha V, Goodman M Tags: Ann Intern Med Source Type: research

Androgens and cardiovascular risk: A series of case report in the French and Canadian pharmacovigilance databases.
CONCLUSION: Our study shows a very low report of cardiovascular effects under testosterone, all doubtful. Pending further studies, it seems reasonable to consider the cardiovascular risk of patients who are candidates for hormone therapy for age-related androgen deficiency. LEVEL OF EVIDENCE: 3. PMID: 29650456 [PubMed - as supplied by publisher]
Source: Progres en Urologie - April 15, 2018 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

Sex steroids and cardiovascular outcomes in transgender individuals: a systematic review and meta-analysis.
Conclusions: Low quality evidence suggests that sex steroid therapy may increase LDL-C and TG and decrease HDL-C levels in FTM, while oral estrogens may increase TGs in MTF. Data about patient important outcomes remain sparse. PMID: 28945852 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - September 13, 2017 Category: Endocrinology Authors: Maraka S, Singh Ospina N, Rodriguez-Gutierrez R, Davidge-Pitts CJ, Nippoldt TB, Prokop LJ, Murad MH Tags: J Clin Endocrinol Metab Source Type: research

In assessing risk of hormone therapy for menopause, dose — not form — matters
FINDINGSWhen it comes to assessing the risk of estrogen therapy for menopause, how the therapy is delivered — taking a pill versus wearing a patch on one’s skin — doesn’t affect risk or benefit, researchers at UCLA and elsewhere have found. But with the commonly used conjugated equine estrogen, plus progestogen, the dosage does. Higher doses, especially over time, are associated with greater risk of problems, including heart disease and some types of cancer, especially among obese women.BACKGROUNDThe Women ’s Health Initiative established the potential of estrogen therapy to increase or decrease the risk of strok...
Source: UCLA Newsroom: Health Sciences - July 27, 2017 Category: Universities & Medical Training Source Type: news

Cardiovascular Disease Among Transgender Adults Receiving Hormone Therapy: A Narrative Review.
Abstract Recent reports estimate that 0.6% of adults in the United States, or approximately 1.4 million persons, identify as transgender. Despite gains in rights and media attention, the reality is that transgender persons experience health disparities, and a dearth of research and evidence-based guidelines remains regarding their specific health needs. The lack of research to characterize cardiovascular disease (CVD) and CVD risk factors in transgender populations receiving cross-sex hormone therapy (CSHT) limits appropriate primary and specialty care. As with hormone therapy in cisgender persons (that is, those ...
Source: Annals of Internal Medicine - July 25, 2017 Category: Internal Medicine Authors: Streed CG, Harfouch O, Marvel F, Blumenthal RS, Martin SS, Mukherjee M Tags: Ann Intern Med Source Type: research

Women losing out over hormone therapy fears, some experts say
The risk of heart attack, stroke or breast cancer due to hormone replacement therapy has been overstated, and that has scared away some women who could benefit from it, the Society of Obstetricians and Gynaecologists of Canada said at its annual conference in Ottawa this week.
Source: CBC | Health - June 23, 2017 Category: Consumer Health News Tags: News/Health Source Type: news

Hormone therapy and clinical and surrogate cardiovascular endpoints in women with chronic kidney disease: a systematic review and meta-analysis
Conclusions: Studies examining the effect of postmenopausal HT on CV outcomes in women with CKD are lacking. Further prospective study of the role of postmenopausal HT in this high-risk group is required.
Source: Menopause - August 26, 2016 Category: OBGYN Tags: Review Articles Source Type: research

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