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Women losing out over hormone therapy fears, some experts say

The risk of heart attack, stroke or breast cancer due to hormone replacement therapy has been overstated, and that has scared away some women who could benefit from it, the Society of Obstetricians and Gynaecologists of Canada said at its annual conference in Ottawa this week.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news

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FINDINGSWhen it comes to assessing the risk of estrogen therapy for menopause, how the therapy is delivered — taking a pill versus wearing a patch on one’s skin — doesn’t affect risk or benefit, researchers at UCLA and elsewhere have found. But with the commonly used conjugated equine estrogen, plus progestogen, the dosage does. Higher doses, especially over time, are associated with greater risk of problems, including heart disease and some types of cancer, especially among obese women.BACKGROUNDThe Women ’s Health Initiative established the potential of estrogen therapy to increase or decrea...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
It’s no secret that alcohol affects our brains, and most moderate drinkers like the way it makes them feel — happier, less stressed, more sociable. Science has verified alcohol’s feel-good effect; PET scans have shown that alcohol releases endorphins (the “pleasure hormones”) which bind to opiate receptors in the brain. Although excessive drinking is linked to an increased risk of dementia, decades of observational studies have indicated that moderate drinking — defined as no more than one drink a day for women and two for men — has few ill effects. (A drink equals 1.5 ounces of 80...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Brain and cognitive health Healthy Eating Heart Health Memory Source Type: blogs
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation." In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
An excerpt from my new book Undoctored. This one little tale about hormonal health of human females, pregnant horses, and drug patents paints a microcosm of the bigger healthcare picture. It is an example of how when money becomes the primary goal, health may not be served. For years, physicians prescribed estrogen hormone replacement for women experiencing menopause, believing that drugs like Premarin, manufactured by harvesting estrogens from the urine of pregnant horses, prevented osteoporosis, improved cholesterol values, and reduced cardiovascular risk, since preliminary epidemiological studies, not real clinical stud...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Hormone Replacement Drugs Undoctored Source Type: blogs
Conclusions: The occurrence of MI is very low in this cohort (4.4%), reassuring the clinicians that the older adults with comorbidities may not be at a higher risk of MI with adjuvant endocrine therapy. However, the confidence interval for the hazard ratio of AIs vs Tamoxifen is very wide, indicating that a larger sample may be needed for the power of the study to be conclusive.Citation Format: Kamaraju S, Smith E, Shi Y, Laud P, Neuner J. Are aromatase inhibitors associated with higher myocardial infarction risk in breast cancer patients? A Medicare population study [abstract]. In: Proceedings of the Thirty-Ninth Annual C...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Discussion Abstracts Source Type: research
Patients with breast cancer (BC) and those at high risk for BC are often reluctant to initiate Tamoxifen (Tam) due to potential adverse events (AEs) such as deep vein thrombosis (DVT), pulmonary embolus (PE), acute ischemic stroke (AIS), myocardial infarction (MI) and endometrial cancer (EC). Some decline this life saving therapy due to fear of AEs. AE rates from RCTs are low, but AE rates in the general population are not well documented.Methods: The MarketScanR database (2010-2013) was searched for patients aged 30-64 with a prescription of Tam active for more than 120 days. Patients with prior DVT, PE, AIS, MI or EC wer...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
Abstract PURPOSE: We performed a systematic review of patient-centered outcomes after the concomitant use of proton pump inhibitors (PPIs) and other drugs. METHODS: We searched 4 databases in July 2016 to find studies that reported mortality and morbidity after the concomitant use of PPIs and other drugs. We conducted direct meta-analyses using a random-effects model and graded the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation working group approach. FINDINGS: We included data from 17 systematic reviews and meta-analyses, 16 randomized controlled t...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Ther Source Type: research
STUDY QUESTION Can the diagnosis of common diseases before menopause influence age at natural menopause (ANM) onset? SUMMARY ANSWER Polycystic ovary syndrome (PCOS) and depression were observed to delay menopause. WHAT IS KNOWN ALREADY It has been observed that women who undergo early menopause experience a higher burden of health problems related to metabolic syndromes, heart disease and depression, but whether ANM can be influenced by common adult diseases has not been studied extensively. STUDY DESIGN, SIZE, DURATION All women attending mammography screening or clinical mammography at four hospitals in Sweden were in...
Source: Human Reproduction - Category: Reproduction Medicine Authors: Tags: Reproductive Epidemiology Source Type: research
Purpose of review: The recent relevant evidence of the effects of the Mediterranean diet (MedDiet) and lifestyle on health (2015 and first months of 2016). Recent findings: Large observational prospective epidemiological studies with adequate control of confounding and two large randomized trials support the benefits of the Mediterranean dietary pattern to increase life expectancy, reduce the risk of major chronic disease, and improve quality of life and well-being. Recently, 19 new studies from large prospective studies showed – with nearly perfect consistency – strong benefits of the MedDiet to reduce the ri...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: NUTRITION AND PHYSIOLOGICAL FUNCTION: Edited by Annemie M.W.J. Schols and Labros S. Sidossis Source Type: research
"Experts have linked eight more cancers to being overweight or obese, nearly tripling the list from five to 13," the Daily Mail reports. This is the latest finding of the International Agency for Research on Cancer (IARC), a group of cancer experts from around the world that look at risk factors for cancer.  What is the basis for these reports? The headlines are based on a report published in the peer-reviewed New England Journal of Medicine. The report is not exactly new research, but a review of previously published studies that looked at the link between weight and cancers. It is the result of...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Obesity Lifestyle/exercise Source Type: news
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