In assessing risk of hormone therapy for menopause, dose — not form — matters

FINDINGSWhen it comes to assessing the risk of estrogen therapy for menopause, how the therapy is delivered — taking a pill versus wearing a patch on one’s skin — doesn’t affect risk or benefit, researchers at UCLA and elsewhere have found. But with the commonly used conjugated equine estrogen, plus progestogen, the dosage does. Higher doses, especially over time, are associated with greater risk of problems, including heart disease and some types of cancer, especially among obese women.BACKGROUNDThe Women ’s Health Initiative established the potential of estrogen therapy to increase or decrease the risk of stroke, breast cancer and heart attack, but research had never compared the risks and benefits of various formulations of estrogen treatments or delivery methods.METHODThe researchers used data from about half the participants in the Women ’s Health Initiative Observational Study, which enlisted more than 93,000 postmenopausal women between the ages of 50 to 79 and tracked their health over an average of eight years.In this new study, the team examined data from 45,112 participants in the WHIOS to gauge how various types of estrogen pills, different delivery methods (patch versus pill) and different doses of oral conjugated equine estrogen affected women ’s health. With an average follow-up of 5 1/2 years per patient the researchers measured rates of adverse effects such as coronary heart disease, breast cancer, stroke, pulmonary e...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Abstract In this work, the as-prepared V2O5 nanobelts can sensitively quench the fluorescence of nitrogen-doped carbon dots (N-CDs) based on the inner filter effect (IFE). In the presence of ascorbic acid (AA), the fluorescence of N-CDs can recover through the redox reaction between V2O5 nanobelts and AA. Meanwhile, in the presence of both alkaline phosphatase (ALP) and ascorbyl-2-phosphate (AAP), the fluorescence of N-CDs can also restore since AAP can be hydrolyzed into AA by ALP. Under optimum conditions, the linear range for AA is from 0.01 to 2.5 μM with a detection limit of 3 nM and that for ALP is fr...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC07253E, CommunicationXuehan Yin, Ting Hou, Bingzheng Huang, Limin Yang, Feng Li We developed an aptamer recognition-trigged label-free homogeneous electrochemical biosensing method for highly selective and ultrasensitive detection of cancer-derived exosomes. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
ConclusionsPhysical and psychological functioning, pain, fatigue and appetite loss had prognostic significance above and beyond clinical predictors in CRC. Routine monitoring of these PROs may allow earlier detection and amelioration of problems, which may improve quality of life and perhaps extend survival. More research is needed to determine prognostic value of PROs in early-stage CRC, and prognostic significance of changes in PRO scores.
Source: Quality of Life Research - Category: Health Management Source Type: research
This study aims to address this gap.MethodsThe study used data from the Nihon University Japanese Longitudinal Study of Aging (NUJLSOA) and incidence-based multistate life tables to estimate disabled and disability-free life expectancy based on the stroke status of Japanese residents aged 65 and older.ResultsJapanese stroke survivors aged 65 who experienced an initial disability-free state could expect to live approximately 3 fewer total years of life, 4 –5 fewer years in a disability-free state, and 1–2 more years in a disabled state compared to those without history of a stroke (p 
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionsThe experience of changes in taste was common yet highly variable in its presentation and resultant changes in food preferences. Taste changes did not always resolve soon after treatment completion. Future research should identify ways to manage this symptom in pediatric cancer patients.
Source: Quality of Life Research - Category: Health Management Source Type: research
Recent studies have expanded the window for the use of systemic and catheter-directed thrombolysis and mechanical thrombectomy for acute stroke management. The purpose of this review was to evaluate the impact that contemporary cerebral imaging has on the indications for emergent cervical carotid revascularization.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Intravenous thrombolysis for treatment of acute carotid-associated stroke can be combined with carotid endarterectomy (CEA) either simultaneously or in a staged procedure. The aim of this single-center retrospective study was to analyze the short-term and long-term results of sequential lysis with CEA.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Synchronous cancer in patients with abdominal aortic aneurysm (AAA) increases their morbidity and mortality after AAA repair. However, little is known about the history of cancer in AAA patients and its impact on mortality after AAA repair. We analyzed the incidence and type of cancer history in patients who underwent AAA repair and difference in short- and long-term mortality.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Synthetic marijuana use has been reported in the last years as a possible causative factor of different cardiovascular events, including myocardial infarction, ischemic stroke, intracranial bleeding, and cerebral vasospasm. One case of aortic thrombosis was also reported, but that was in a patient using cocaine and synthetic marijuana together. A case of lower limb thromboembolism and synthetic marijuana use has not been reported to date. Intoxication, material impurity, blood vessel reactivity, and chemical interaction with other drugs have been proposed as possible mechanisms of these events.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
The aim of this study was to assess the feasibility of aspiration mechanical thrombectomy of massive or submassive pulmonary embolism (PE) and deep venous thrombosis (DVT), in a single session, in patients with contraindications to thrombolysis.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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