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Specialty: Endocrinology
Therapy: Dialysis

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Total 18 results found since Jan 2013.

Ankle-Brachial Index Is Independently Associated With Cardiovascular Outcomes and Foot Ulcers in Asian Patients With Type 2 Diabetes Mellitus
ConclusionsLow ABI was associated with cardiovascular events and diabetic foot ulcer independently in patients with type 2 DM.
Source: Frontiers in Endocrinology - November 18, 2021 Category: Endocrinology Source Type: research

Valuing health states of people with type  2 diabetes: Analyses of the nationwide representative linked databases
ConclusionsMajor vascular complications, connective tissue disease and depression are associated with considerably worse health ‐related quality of life. These health utility estimates can facilitate health economic evaluations to determine cost‐effective strategies for diabetes management.
Source: Journal of Diabetes Investigation - March 3, 2021 Category: Endocrinology Authors: Shihchen Kuo, Chun ‐Ting Yang, Hsuan‐Ying Chen, Huang‐Tz Ou Tags: Original Article Source Type: research

Valuing health states of people with type 2 diabetes: Analyses of the nationwide representative linked databases
ConclusionsMajor vascular complications, connective tissue disease, and depression are associated with considerably worse HRQoL. These health utility estimates can facilitate health economic evaluations to determine cost ‐effective strategies for diabetes management.
Source: Journal of Diabetes Investigation - February 4, 2021 Category: Endocrinology Authors: Shihchen Kuo, Chun ‐Ting Yang, Hsuan‐Ying Chen, Huang‐Tz Ou Tags: ORIGINAL ARTICLE Source Type: research

Cost-Effectiveness of Canagliflozin Added to Standard of Care for Treating Diabetic Kidney Disease (DKD) in Patients with Type  2 Diabetes Mellitus (T2DM) in England: Estimates Using the CREDEM-DKD Model
ConclusionModel results suggest that adding canagliflozin 100  mg to SoC can improve patient outcomes while reducing overall net costs from the NHS perspective in England.Trial RegistrationClinicalTrials.gov identifier, NCT02065791.
Source: Diabetes Therapy - December 2, 2020 Category: Endocrinology Source Type: research

Examining the heterogeneity inexcess risks of coronary heart disease, stroke, dialysis, and lower extremity amputation associated with type 2 diabetes mellitus across demographic subgroups in an Asian population: a population-based matched cohort study
Type 2 diabetes mellitus (T2DM) is a major cause of disability and death worldwide, as it increases the risks of debilitating health conditions such as coronary heart disease (CHD) [1, 2], stroke [2], chronic kidney disease (CKD) [3] and lower extremity amputation (LEA) [4] (hereafter “unfavourable events”). These unfavourable events incur high cost of medical treatment and productivity loss [5-7]; prevention and early detection of these events among individuals with T2DM are now the focus of population health interventions.
Source: Diabetes Research and Clinical Practice - November 21, 2020 Category: Endocrinology Authors: Ka Keat Lim, Vivian Shu Yi Lee, Chuen Seng Tan, Yu Heng Kwan, Zoey Hui Xian Lim, Hwee Lin Wee, Truls Østbye, Lian Leng Low Source Type: research

Development and Internal Validation of a Discrete Event Simulation Model of Diabetic Kidney Disease Using CREDENCE Trial Data
ConclusionCREDEM-DKD is an important new tool in the evaluation of treatment interventions in the DKD population.Trial RegistrationClinicalTrials.gov identifier, NCT02065791.
Source: Diabetes Therapy - September 14, 2020 Category: Endocrinology Source Type: research

Clinical characteristics of Japanese diabetic patients with critical limb ischemia presenting Fontaine stage IV
In conclusion, the advanced stage of diabetes-related complications was prevalent in patients with CLI presenting Fontaine stage IV.
Source: Diabetology International - December 8, 2018 Category: Endocrinology Source Type: research

Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetic patients with diabetic nephropathy
ConclusionsRenal AS was associated with increasing risks for renal composite events and cardiovascular events in both normal ‐range BP and HT. The risks of renal composite events and cardiovascular events were the highest in both renal AS and HT.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - December 5, 2018 Category: Endocrinology Authors: Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Tomoaki Funamoto, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Toshinari Takamura, Kiyoki Kitagawa, Mitsuhiro Yoshimura, Shuichi Kaneko, Hitoshi Yokoyama, Takashi Wada, Kanazawa Tags: Original Article Source Type: research

Evaluation of health utility values for diabetic complications, treatment regimens, glycemic control and other subjective symptoms in diabetic patients using the EQ-5D-5L
ConclusionsThe utility decrement related to each diabetic complication varied with its severity and accompanying symptoms. Complex treatment regimens were independently associated with lower utility values. The utility decrement associated with diabetic complication and complex treatment regimens would be overestimated in the analysis without adjustment for glycemic control or other subjective symptoms.
Source: Acta Diabetologica - October 23, 2018 Category: Endocrinology Source Type: research

ANGPTL2 is associated with an increased risk of cardiovascular events and death in diabetic patients
Conclusions/interpretationIn patients with type 2 diabetes, serum ANGPTL2 concentrations were independently associated with death and MACE. Therefore, ANGPTL2 is a promising candidate biomarker for improving risk stratification in type 2 diabetes patients, and may prove to be a valuable therapeutic target.
Source: Diabetologia - September 30, 2016 Category: Endocrinology Source Type: research

Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trials
Publication date: Available online 29 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Cholesterol Treatment Trialists' (CTT) Collaboration Background Statin therapy is effective for the prevention of coronary heart disease and stroke in patients with mild-to-moderate chronic kidney disease, but its effects in individuals with more advanced disease, particularly those undergoing dialysis, are uncertain. Methods We did a meta-analysis of individual participant data from 28 trials (n=183 419), examining effects of statin-based therapy on major vascular events (major coronary event [non-fatal myoca...
Source: The Lancet Diabetes and Endocrinology - July 28, 2016 Category: Endocrinology Source Type: research

Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus.
Authors: Kautzky-Willer A, Harreiter J, Pacini G Abstract T2DM is more frequently diagnosed at lower age and body-mass-index in men, however the most prominent risk factor, which is obesity, is more common in women. Generally, large sex-ratio differences across countries are observed. Diversities in biology, culture, lifestyle, environment and socioeconomic status impact differences between males and females in predisposition, development and clinical presentation. Genetic effects and epigenetic mechanisms, nutritional factors and sedentary lifestyle affect risk and complications differently in both sexes. Furtherm...
Source: Endocrine Reviews - May 11, 2016 Category: Endocrinology Tags: Endocr Rev Source Type: research