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Total 557 results found since Jan 2013.

Cessation of Anticoagulation for Bleeding and Thrombosis Events with a Fully Magnetically Levitated Centrifugal Left Ventricular Assist Device
Anticoagulation therapy for patients supported by a left ventricular assist device (LVAD) has not been adequately evaluated in relevance to newer pumps, such as the fully magnetically levitated HeartMate 3 pump. Current anticoagulation guidelines target a goal INR of 2.0 –3.0 with vitamin K antagonists to mitigate the risk of pump thrombosis and ischemic stroke, but are based on historical trials with older devices. Long-term outcomes associated with newer devices, such as the centrifugal-flow HeartMate 3 (HM3), have demonstrated a marked decrease in the incidence of pump thrombosis compared to mechanical bearing axial-f...
Source: The Journal of Heart and Lung Transplantation - April 28, 2019 Category: Transplant Surgery Authors: Igor Gosev, Brian Ayers, Katherine Wood, Bryan Barrus, Sunil Prasad Tags: Case Anecdotes, Comments and Opinions Source Type: research

Cessation of anti-coagulation for bleeding and subsequent thrombosis events with a fully magnetically levitated centrifugal left ventricular assist device
Anti-coagulation therapy for patients supported by a left ventricular assist device (LVAD) has not been adequately evaluated in relevance to newer pumps, such as the fully magnetically levitated HeartMate 3 (HM3) pump. Current anti-coagulation guidelines target a goal international normalized ratio (INR) of 2.0 to 3.0, with vitamin K antagonists to mitigate the risk of pump thrombosis and ischemic stroke, but are based on historical trials with older devices. Long-term outcomes associated with newer devices, such as the centrifugal-flow HM3, have demonstrated a marked decrease in the incidence of pump thrombosis compared w...
Source: The Journal of Heart and Lung Transplantation - April 28, 2019 Category: Transplant Surgery Authors: Igor Gosev, Brian Ayers, Katherine Wood, Bryan Barrus, Sunil Prasad Tags: CASE ANECDOTES, COMMENTS AND OPINIONS Source Type: research

Yale Study Revives Cellular Activity in Pig Brains Hours After Death Yale Study Revives Cellular Activity in Pig Brains Hours After Death
Yale University scientists have succeeded in restoring basic cellular activity in pigs ' brains hours after their deaths in a finding that may one day lead to advances in treating human stroke and brain injuries, researchers reported on Wednesday.Reuters Health Information
Source: Medscape Transplantation Headlines - April 18, 2019 Category: Transplant Surgery Tags: Neurology & Neurosurgery News Source Type: news

Safety and efficacy of a simple cardiotomy suction system as a blood salvage procedure during off-pump coronary artery bypass surgery
AbstractThe ideal blood-salvaging strategies for off-pump coronary artery bypass graft procedures have not been determined. We developed a new blood-salvaging system that uses a cardiotomy suction. The purpose of this study was to examine the efficacy of this novel method. This was a retrospective study involving 50 consecutive patients undergoing off-pump coronary artery bypass grafting. In 25 patients, a simple cardiotomy suction system was used (cardiotomy suction group). These individuals were compared with 25 historical cohorts who were treating with the conventional cell saver system (cell saver group). There was no ...
Source: Journal of Artificial Organs - April 8, 2019 Category: Transplant Surgery Source Type: research

Usefulness of anti-platelet therapy testing in children supported with a ventricular assist device
Stroke is the most recognized complication associated with the Berlin Heart EXCOR pediatric ventricular assist device (VAD).1 –3 Thromboelastography with Platelet Mapping (TEG/PM) has become the most commonly used platelet function test utilized in U.S. children supported with the EXCOR4 after it was incorporated into the Edmonton Antithrombotic Guideline for the U.S. Food and Drug Administration Trial of the EXCOR (refe r to Supplementary Material available online at www.jhltonline.org/).1 Despite its use, stroke occurred in one third of children in the EXCOR trial.
Source: The Journal of Heart and Lung Transplantation - April 2, 2019 Category: Transplant Surgery Authors: Lindsay J. May, Xiaoxi Liu, Tiffany Tesoro, Jaden Yang, Clara Lo, Sharon Chen, Jenna Murray, David N. Rosenthal, Alan D. Michelson, Christopher S. Almond Tags: RESEARCH CORRESPONDENCE Source Type: research

Usefulness of antiplatelet therapy testing in children supported with a ventricular assist device
Stroke is the most recognized complication associated with the Berlin Heart EXCOR ® Pediatric ventricular assist device (VAD).1-3 Thromboelastography with Platelet Mapping® (TEG/PM) has become the most commonly used platelet function test in US children supported with the EXCOR®4 after it was incorporated into the Edmonton Antithrombotic Guideline for the FDA Trial of the EXCO R® (Supplementary File).1 Despite its use, stroke occurred in one-third of children in the EXCOR® trial.1-3 Thus, some clinicians have questioned its validity as a primary means to guide antiplatelet therapy dosing in EXCOR® recipients.
Source: The Journal of Heart and Lung Transplantation - April 2, 2019 Category: Transplant Surgery Authors: Lindsay J. May, Xiaoxi Liu, Tiffany Tesoro, Jaden Yang, Clara Lo, Sharon Chen, Jenna Murray, David N. Rosenthal, Alan D. Michelson, Christopher S. Almond Tags: Research Correspondence Source Type: research

Stroke and death risk in ventricular assist device patients varies by ISHLT infection category: An INTERMACS analysis
Ventricular assist device (VAD) patients often experience infections, which increase the risk of stroke and mortality. Using the definitions of the International Society for Heart and Lung Transplantation (ISHLT), we have characterized differences in clinical outcomes for categories of infection: VAD-specific (e.g., pump component related); VAD-related (e.g., bloodstream infection, BSI); and non-VAD infections (e.g., pneumonia).
Source: The Journal of Heart and Lung Transplantation - April 2, 2019 Category: Transplant Surgery Authors: Palak Shah, Sarah E. Birk, Lauren B. Cooper, Mitchell A. Psotka, James K. Kirklin, Scott D. Barnett, Shalika B. Katugaha, Sheila Phillips, Mary M. Looby, Francis D. Pagani, Jennifer A. Cowger Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Peak Left Atrial Appendage Emptying Velocity Remains Reduced in Atrial Fibrillation during Continuous Flow Left Ventricular Assist Device Support
Although regions of stasis such as the left atrial appendage (LAA) may be potential sites of thrombus formation during atrial fibrillation (AF), its thrombotic contribution during high flow mechanical unloading is unknown. Moreover, registry studies only show a mixed association of AF and stroke during continuous flow left ventricular assist device (CF LVAD) support. Since a lower peak Left Atrial Appendage Emptying Velocity (LAAEV) of less than 40 cm/s during AF, mechanistically contributes to thrombosis and stroke in non-CF LVAD populations, we sought to evaluate the LAAEV in CF LVAD patients with and without AF.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: A. Rahman, E. Tam, L. ZHeng, J. Fontes, S. Forest, S. Vukelic, D. Sims, J. Shin, S. Patel, D.J. Goldstein, U.P. Jorde, O. Saeed Tags: 88 Source Type: research

Anti-Coagulation Management in Pediatric Ventricular Assist Device: A Quality Improvement Target
This report describes baseline AC data from ACTION centers, including agents used and aggregate levels of performance, to inform development of specific interventions.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: C. VanderPluym, M. O'Connor, A. Lorts, M. Ploutz, D. Peng, S. Law, M. Zinn, R. Niebler, D. Rosenthal, J. Conway, S. Auerbach, D. Sutcliffe, M. Mehegan Tags: 29 Source Type: research

Increased Risk of Stroke and Death in Ventricular Assist Device Patients Varies by ISHLT Infection Category: An INTERMACS Analysis
Ventricular assist device (VAD) patients experience infections, which increase the risk of stroke and mortality. We aimed to characterize key differences in clinical outcomes for VAD patients based on the ISHLT categorization of infections: VAD-specific (e.g. pump component related), VAD-related (e.g. bloodstream infection, BSI) and non-VAD infections (e.g. pneumonia).
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: P. Shah, S.E. Birk, L.B. Cooper, M.A. Psotka, J.K. Kirklin, S.D. Barnett, S.B. Katugaha, S. Phillips, M.M. Looby, F.D. Pagani, J.A. Cowger Tags: 224 Source Type: research

A Comparison of Middle Cerebral Artery and Central Retinal Artery Hemodynamics in HM II Patients
In the normal, pulsatile circulation, the hemodynamic pattern of the middle cerebral artery (MCA) differs from the central retinal artery (CRA). Whether continuous flow from a left ventricular assist device (LVAD) alters this relationship is not known. Since serious adverse events in different end-organs, such as stroke and GI bleeding, are frequent in LVAD patients, comparing hemodynamics in different arterial beds may enhance our understanding of the specific pathophysiology of these complications.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: E.J. St öhr, R. Ji, K. Akiyama, F. Castagna, A. Pinsino, J.R. Cockcroft, M. Yuzefpolskaya, A.R. Garan, V.K. Topkara, R.T. Te-Frey, H. Takayama, K. Takeda, Y. Naka, P.C. Colombo, J.Z. Willey, B.J. McDonnell Tags: 200 Source Type: research

Occurrence and Clinical Patterns of Stroke Based on Arterial Cannulation Strategy during Veno-Arterial Extracorporeal Membrane Oxygenation Support
Stroke is a major complication with potentially devastating consequences for patients receiving veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Arterial cannulation sites for VA-ECMO include ascending aorta, axillary artery, and femoral artery. However, rates of stroke according to cannulation site are currently unknown. The purpose of this study was to investigate the association between occurrence and patterns of stroke with ECMO arterial cannulation sites.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M. Nishikawa, J. Willey, A.R. Garan, M. Cevasco, L. Witer, J. Sanchez, P. Kurlansky, A. Kirtane, D. Brodie, M. Yuzefpolskaya, P. Colombo, H. Takayama, Y. Naka, K. Takeda Tags: 148 Source Type: research

Presence of Left Atrial or Left Ventricular Thrombus at the Time of CF-LVAD Implantation is Associated with Increased Post-Operative Risk of Stroke or Death
Patients with advanced HF are at increased risk for intra-cardiac thrombus formation. The impact of pre-existing left atrial (LA) or left ventricular (LV) thrombi on post-operative outcomes in LVAD patients is unknown.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: J.A. Fried, H. Lumish, A.M. Zuver, A.R. Garan, V.K. Topkara, B. Cagliostro, G. Parkis, M. Cevasco, M.T. Pineda, G.M. Mondellini, K. Ross, L. Witer, H. Takayama, K. Takeda, Y. Naka, M. Yuzefpolskaya, R.T. Demmer, P.C. Colombo Tags: 147 Source Type: research

Impact of Stroke Onset Severity on 2-Year Survival in Destination Therapy Patients Supported by Centrifugal Flow versus Axial Flow Ventricular Assist Devices
The ENDURANCE Supplemental Trial (DT2) was designed to prospectively study whether improved blood pressure management would reduce the incidence of strokes in destination therapy patients receiving an HVAD. The trial not only demonstrated a significant reduction in hemorrhagic strokes, but also some reductions in stroke-related severity. This analysis seeks to study further the impact of stroke severity on 2-year survival in both the HVAD and control cohorts of DT2.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: P. Shah, C. Mahr, J. Rogers, M. Kiernan, S. Boyce, N.A. Mokadam, F. Pagani, T. Vassiliades, J. Teuteberg Tags: 145 Source Type: research

Understanding Risk Factors for Stroke Subtypes in the ENDURANCE Trials
Stroke is one of the most devastating morbidities associated with left ventricular assist device (LVAD) support. Improved blood pressure management in LVAD patients has been shown to significantly reduce strokes, in particular hemorrhagic strokes. However, little is known regarding clinical risk factors for stroke subtypes.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: S. Cho, R. Starling, J. Teuteberg, J. Rogers, F. Pagani, P. Shah, K. Uchino, T. Vassiliades Tags: 142 Source Type: research