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Specialty: Transplant Surgery

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Total 557 results found since Jan 2013.

Risk of Stroke in Patients with Left Ventricular Assist Device Who Had Myocardial Recovery
The risk factors and incidence rates of stroke after implantation of left ventricular assist devices (LVAD) are well established. Little is known about the factors associated with stroke after LVAD explantation in patients who have had a myocardial recovery.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: S. Sundaravel, M. Urban, J. Um, A. Albulushi Tags: 1003 Source Type: research

Bridge from Central Extracorporeal Life Support to Durable LVAD in Acute Heart Failure Elevates a Risk of Stroke Long-Term
This study aimed to review outcomes of this bridge strategy from central ECLS to durable LVAD, as compared to those of primary LVAD implantation.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: K. Tonai, S. Fukushima, N. Tadokoro, N. Fukushima, T. Fujita Tags: (994) Source Type: research

Impact of Mitral Valve Prosthesis on Stroke after Insertion of Veno-Arterial Membrane Oxygenation for Postcardiotomy Shock
This study focused on stroke after valve surgery requiring VA-ECMO.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: S. Ohira, D. Spielvogel, R. Malekan, J.B. Goldberg, P.J. Spencer, S.L. Lansman, M. Kai Tags: 1026 Source Type: research

HVAD Lavare Cycle Reduces Cerebrovascular Events and Improves Survival
The Lavare Cycle (LC) is a pre-programmed speed modulation algorithm in the HVAD device designed to automatically increase both ventricular and pump washing. The ReVOLVE trial suggested a reduction in adverse outcomes including stroke. We assessed the effect LC ON compared to LC OFF on HVAD implants.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: C.G. Gidea, A. Emmarco, A. Reyentovich, J. Pavone, A. Fargnoli, T. Saraon, S. Rao, R. Goldberg, B. Kadosh, Z. Kon, N. Moazami, D. Smith Tags: 1067 Source Type: research

Mean Arterial Pressure is Not Associated with Hemocompatibility-Related Outcomes in LVAD Patients
Elevated mean arterial pressure (MAP) is associated with stroke in patients with HeartMate II and Heartware HVAD left ventricular assist devices (LVADs). We assessed the relationship between mean arterial pressure (MAP) and hemocompatibility-related clinical adverse events (HRAE) in patients with LVADs.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: T. Miller, M. Belkin, U. Siddiqi, A. Kanelidis, D. Rodgers, N. Uriel, T. Song, T. Ota, S. Kalantari, N. Sarswat, A. Nguyen, B. Chung, G. Kim, B. Smith, V. Jeevanandam, S. Pinney, J. Grinstein Tags: 1092 Source Type: research

Effects of ACE Inhibitors, Angiotensin Receptor Blockers and Angiotensin Receptor-Neprilysin Inhibitors on Survival Free from Gastrointestinal Bleeding in HeartMate 3 Patients - A Marginal Structural Modeling Analysis
The HeartMate 3 (HM3) is superior to HMII in survival free from disabling stroke and pump exchange, however, rates of GIB remain high. Prior studies show a protective effect of digoxin and ACEi/ARB on risk for GIB, whereas phosphodiesterase 5 inhibitors (PDE5i) have opposite effect in HMII using Cox Proportional Hazard (PH) models with inverse probability weighting (IPW). Compared to this approach, marginal structural modeling (MSM) accounts for time-dependent confounding thereby producing results closer to true causal effect.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: G.M. Mondellini, J. Qi, L. Braghieri, A. Pinsino, A.J. Kim, T. Melie, V.R. Feldman, K. Takeda, Y. Naka, G.T. Sayer, N. Uriel, I. Diaz, M. Yuzefpolskaya, K.L. Hoffman, P.C. Colombo Tags: 1124 Source Type: research

Arterial Pulsatility in Patients with Continuous Flow Left Ventricular Assist Device Support: Comparing Velocity and Mean Arterial Pressure
An increasing number of end-stage heart failure patients are supported by continuous-flow Left Ventricular Assist Devices (cfLVADs) as a bridge to heart transplantation. Accurate assessment of arterial pulsatility remains a challenge because of diminished pulse pressure, which itself can be associated with adverse events such as gastrointestinal bleeding and stroke. Our study investigates the value of simultaneous arterial pressure and arterial blood velocity assessment in cfLVAD patients.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: S. Emmanuel, A. Adji, D. Robson, P. Jain, C. Hayward Tags: 1138 Source Type: research

Aortic and Renal Artery Thrombosis as the First Clinical Manifestation of COVID-19 in a Heart Transplant Recipient
The relation between coronavirus 2019 disease (COVID-19) and thrombotic events is well established, and both arterial and venous thrombotic events are described. Although arterial events occur in about 3.6 to 10.5% of critically ill patients, they are usually stroke or acute myocardial infarction. Arterial thrombosis of other sites is rare.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: D.S. Belfort, C.R. Cafezeiro, D.A. Furlan, M.S. Lira, R.C. Dantas, C.A. Arag ão, I.W. Campos, M.S. Ávila, S. Mangini, L.B. Seguro, F.G. Marcondes-Braga, F. Bacal Tags: 1185 Source Type: research

A Comparative Analysis of Long-Term Outcomes in the MOMENTUM 3 Pivotal Trial and Continued Access Protocol Post-Approval Study Phase: A Study of over 1500 HeartMate 3 Implants
The MOMENTUM 3 pivotal trial conducted from 2014 to 2018 evaluated safety and effectiveness of the HeartMate 3 (HM3) left ventricular assist system (LVAS) compared to the HeartMate II pump. The trial demonstrated superiority of the HM3 LVAS for the primary endpoint of survival free of disabling stroke or reoperation to replace a malfunctioning pump at 2-years. HM3 LVAS superiority was due to improved hemocompatibility with near-elimination of device thrombosis, halving of stroke rates, and a decrease in gastrointestinal bleeding rates compared to the control device.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: M.R. Mehra Tags: (4) Source Type: research

The ABC's of Stroke Prevention: Reduction in Stroke Frequency Following a Quality Improvement Intervention by the Action Learning Network
To assess the frequency of stroke among ventricular assist device patients following a quality improvement bundled intervention (the “ABCs of Stroke Prevention” [ABCs] which focused on Anticoagulation, Blood pressure, and Communication) within the Advanced Cardiac Therapies Improving Outcomes Network (ACTION). The bundle intervention comprised 3 interventions. These were: a document harmonizing how to implement and maintain b ivalirudin infusion, a blood pressure management protocol and a daily stroke prevention checklist.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: J. Murray, D. Rosenthal, F. Zafar, A. Lorts, C. Connelly, P. Krack, C. Vanderpluym, B. Hawkins, R. Niebler, M. Mehegan, R. Gajarski, D. Sutcliffe, C. Villa Tags: (168) Source Type: research

Simultaneous Multi-Vascular Bed Imaging in a Patient Supported by a Continuous-Flow LVAD
Patients supported with left ventricular assist devices (LVADs) are burdened by frequent hemocompatibility-related adverse events related to patient-pump interactions. These predominantly vascular events include stroke, gastrointestinal bleeding, and pump thrombosis. Our center performs routine, invasive hemodynamic ramp speed titrations in LVAD patients to determine the optimal rotational speed after implantation. We sought to interrogate changes in vascular hemodynamics during an exercise ramp study to understand the influence of pump speed and exercise on outflow graft and cerebrovascular flow.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: I. Bole, D. Rodgers, B. Smith, A. Nguyen, B. Chung, S. Kalantari, N. Sarswat, G. Kim, T. Song, T. Ota, V. Jeevanandam, E. Kruse, C. Kordeck, C. Kramer, S. Pinney, J. Grinstein Tags: (1347) Source Type: research

Systemic tPA Treatment for Thrombosis in a Patient with Dilated Cardiomyopathy on Berlin Heart
We present a case of thrombosis in a patient on Berlin Heart LVAD that was successfully treated with systemic alteplase.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: L.D. Glass, R. Murthy, P. Pastuszko Tags: (1357) Source Type: research

Left thoracotomy vs full sternotomy for centrifugal durable LVAD implantation: 1-year outcome comparison post-LVAD and post-heart transplantation
This study sought to compare the outcomes of FS and LT patients post-primary LVAD implantation and post-subsequent heart transplant (HT). This was a single-center retrospective study. 83 patients who underwent primary centrifugal durable LVAD implantation from January 2014 to June 2018 were included (FS,n = 41; LT,n = 42). 41 patients had a subsequent HT (FS,n = 19; LT,n = 22). Pre-operative patient demographics, intraoperative variables, post-operative 1-year survival, length of hospital stay, complications, and outcomes for LVAD implantation and following HT were analyzed. Intraoperative data showed that ...
Source: Journal of Artificial Organs - March 19, 2021 Category: Transplant Surgery Source Type: research

Stroke in pediatric ventricular assist device patients-a pedimacs registry analysis
Cerebral vascular accidents (CVA) are common complications of pediatric ventricular assist devices (VAD). We employed the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) to investigate rates, risk factors, and outcomes of CVA in pediatric patients supported on VAD.
Source: The Journal of Heart and Lung Transplantation - March 11, 2021 Category: Transplant Surgery Authors: Robert A Niebler, Shahnawaz Amdani, Betsy Blume, Ryan S. Cantor, Luqin Deng, James K Kirklin, Angela Lorts, David L Morales, David N Rosenthal, Nancy S Ghanayem Source Type: research

Stroke in pediatric ventricular assist device patients —a pedimacs registry analysis
Cerebralvascular accidents (CVA) are common complications of pediatric ventricular assist devices (VADs). We employed the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) to investigate rates, risk factors, and outcomes of CVA in pediatric patients supported on VAD.
Source: The Journal of Heart and Lung Transplantation - March 11, 2021 Category: Transplant Surgery Authors: Robert A Niebler, Shahnawaz Amdani, Betsy Blume, Ryan S. Cantor, Luqin Deng, James K Kirklin, Angela Lorts, David L Morales, David N Rosenthal, Nancy S Ghanayem Tags: Original clinical science Source Type: research