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Specialty: Cardiology
Nutrition: Calcium
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Total 323 results found since Jan 2013.
Drug-drug interactions associated with antiplatelet therapy.
Authors: Dunn SP, Macaulay TE
Abstract
Antiplatelet therapy is of paramount importance in the treatment and prevention of adverse cardiovascular events and stroke. Drug-drug interactions (DDIs) among antiplatelet therapies have been growing in both prevalence and clinical importance. Most DDIs with antiplatelet therapies are pharmacodynamic in nature. DDIs with thienopyridines and proton pump inhibitors have resulted in advisories from regulatory agencies although the full significance of this interaction is unknown. Other DDIs with thienopyridines may potentially exist with statins, calcium channel blockers, and w...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
Pulse Pressure Is Useful for Determining the Choice of Antihypertensive Drugs in Postmenopausal Women
Objective: To assess the efficacy of various classes of antihypertensive drugs in postmenopausal women with hypertension using pulse pressure (PP) as an index. Patients and Methods: Selected women were required to be naturally menopausal for at least 1 year but not more than 5 years past their menstrual period. Exclusion criteria were a history of preeclampsia or eclampsia, a severe illness such as myocardial infarction or stroke within 6 months, the use of estrogens or progestins within 3 months, proteinuric nephropathy, and surgically induced menopause. There were 114 women who participated in this study after having giv...
Source: Pulse - November 6, 2014 Category: Cardiology Source Type: research
Prognostic Value of Coronary Computed Tomography Angiography in Stroke Patients
The predictive value of coronary computed tomography angiography (CCTA) in stroke patients has not yet been established. We investigated the prognostic value of coronary artery disease (CAD) detection by CCTA, and determined the incremental risk stratification benefit of CCTA findings as compared to coronary artery calcium scores (CACS) in ischemic stroke patients without chest pain.
Source: Atherosclerosis - November 4, 2014 Category: Cardiology Authors: Jin Hur, Kye Ho Lee, Sae Rom Hong, Young Joo Suh, Yoo Jin Hong, Hye-Jeong Lee, Young Jin Kim, Hye Sun Lee, Hyuk-Jae Chang, Byoung Wook Choi Source Type: research
Elevated Parathyroid Hormone, But Not Vitamin D Deficiency, Is Associated With Increased Risk of Heart Failure in Older Men With and Without Cardiovascular Disease Original Articles
Conclusions—
Elevated PTH, but not 25-hydroxyvitamin D or other markers of mineral metabolism, is associated with increased risk of HF in both older men with and without myocardial infarction/stroke. This increased risk was not explained by its association with known risk factors for HF. Further studies are now needed to elucidate the mechanisms underlying this association.
Source: Circulation: Heart Failure - September 16, 2014 Category: Cardiology Authors: Wannamethee, S. G., Welsh, P., Papacosta, O., Lennon, L., Whincup, P. H., Sattar, N. Tags: Congestive, Epidemiology Original Articles Source Type: research
Hypoxia and ischemia-reperfusion: a BiK contribution?
Over the last decades, cardiovascular disease has become the primary cause of death in the Western world, and this trend is expanding throughout the world. In particular, atherosclerosis and the subsequent vessel obliterations are the primary cause of ischemic disease (stroke and coronary heart disease). Excess calcium influx into the cells is one of the major pathophysiological mechanisms important for ischemic injury in the brain and heart in humans. The large-conductance calcium-activated K+ channels (BK) are thus interesting candidates to protect against excess calcium influx and the events leading to ischemic injury. ...
Source: AJP: Heart and Circulatory Physiology - September 15, 2014 Category: Cardiology Authors: Tano, J.-Y., Gollasch, M. Tags: REVIEW Source Type: research
Coronary Artery Calcium and Risk of Atrial Fibrillation (From the Multi-Ethnic Study of Atherosclerosis)
Calcified coronary arteries are associated with the development of cardiovascular disease and stroke. It is currently unknown whether coronary artery calcium (CAC) is associated with an increased risk of atrial fibrillation (AF). We addressed this question in 6,641 participants (mean age 62 ± 10; 53% women; 62% non-whites) from the Multi-Ethnic Study of Atherosclerosis (MESA) who were free of baseline clinical cardiovascular disease and AF. CAC measurements were assessed by cardiac computed tomography (CT) at study baseline.
Source: The American Journal of Cardiology - September 14, 2014 Category: Cardiology Authors: Wesley T. O’Neal, Jimmy T. Efird, Farah Z. Dawood, Joseph Yeboah, Alvaro Alonso, Susan R. Heckbert, Elsayed Z. Soliman Source Type: research
Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial1
Conclusion:Despite no significant difference in cardiovascular events, the different safety profiles suggest that the combination of olmesartan and CCB may be preferable to that of olmesartan and diuretic.
Source: Journal of Hypertension - September 10, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Randomized controlled trial Source Type: research
Impact of Heme and Heme Degradation Products on Vascular Diameter in Mouse Visual Cortex Stroke
Conclusions
We identified individual components of the oxidative bilirubin degradation that led to vasoconstriction of cerebral arterioles. The vasoconstrictive effect of Z-BOX A and Z-BOX B was mediated by BKCa channel activity that might represent a signaling pathway in the occurrence of delayed cerebral vasospasm in subarachnoid hemorrhage patients.
Source: JAHA:Journal of the American Heart Association - August 28, 2014 Category: Cardiology Authors: Joerk, A., Seidel, R. A., Walter, S. G., Wiegand, A., Kahnes, M., Klopfleisch, M., Kirmse, K., Pohnert, G., Westerhausen, M., Witte, O. W., Holthoff, K. Tags: Stroke Source Type: research
The Relationship Between Nocturnal Blood Pressure and Hemorrhagic Stroke in Chinese Hypertensive Patients
To study the relationship between nocturnal blood pressure (BP) variation and spontaneous intracerebral hemorrhage (ICH) among Chinese hypertensive patients and its clinical significance, the authors retrospectively screened 371 patients with primary hypertension (189 patients with ICH, 182 patients without ICH) in Shanghai and analyzed their demographics, clinical information, nocturnal blood pressure variability and medication. Compared with the control group, the levels of blood glucose, triglycerides, and creatinine were significantly increased in the ICH group, along with a marked reduction in nocturnal BP drop (P<...
Source: The Journal of Clinical Hypertension - July 24, 2014 Category: Cardiology Authors: Jialan Sun, Wanlin Yang, Yang Zhu, Xiaohong Liu, Xin Wei, Baisong Wang, Jiuchang Zhong, Yi Fu Tags: Original Paper Source Type: research
Calcium Channel Blocker Compared With Angiotensin Receptor Blocker for Patients With Hypertension: A Meta‐Analysis of Randomized Controlled Trials
To explore the clinical effects of a calcium channel blocker compared with an angiotensin II receptor blocker in hypertensive patients, the authors collected data from randomized controlled trials. The pooled outcomes were all‐cause mortality, stroke, myocardial infarction, and heart failure. Eight head‐to‐head trials enrolling 25,084 patients were included. There was no significant mortality difference in the two arms (relative risk, 0.99; 95% confidence interval, 0.91–1.07). However, calcium channel blockers were more effective in reducing stroke (relative risk, 0.87; 95% confidence interval, 0.76–0.99) and myo...
Source: The Journal of Clinical Hypertension - July 1, 2014 Category: Cardiology Authors: Ling Wu, Song‐Bai Deng, Qiang She Tags: Review Paper Source Type: research
Headed in the Right Direction But at Risk for Miscalculation A Critical Appraisal of the 2013 ACC/AHA Risk Assessment Guidelines
The newly released 2013 ACC/AHA Guidelines for Assessing Cardiovascular Risk makes progress compared with previous cardiovascular risk assessment algorithms. For example, the new focus on total atherosclerotic cardiovascular diseases (ASCVD) is now inclusive of stroke in addition to hard coronary events, and there are now separate equations to facilitate estimation of risk in non-Hispanic white and black individuals and separate equations for women. Physicians may now estimate lifetime risk in addition to 10-year risk. Despite this progress, the new risk equations do not appear to lead to significantly better discriminati...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 23, 2014 Category: Cardiology Source Type: research
Mechano-electrical coupling as framework for understanding functional remodeling during LBBB and CRT
In conclusion, MEC may represent a useful framework for better understanding the long-term changes in cardiac electrophysiology and contraction following LBBB as well as CRT.
Source: AJP: Heart and Circulatory Physiology - June 15, 2014 Category: Cardiology Authors: Kuijpers, N. H. L., Hermeling, E., Lumens, J., ten Eikelder, H. M. M., Delhaas, T., Prinzen, F. W. Tags: CARDIAC EXCITATION AND CONTRACTION Source Type: research
Future of Polypill Use for the Prevention of Cardiovascular Disease and Strokes
In conclusion, a polypill treatment strategy may be effective in the prevention of CVD and stroke, but, to be cost-effective, it may be reasonable to target patients with a high CACS and FRS.
Source: The American Journal of Cardiology - June 9, 2014 Category: Cardiology Authors: Steven G. Chrysant, George S. Chrysant Tags: Review Source Type: research
Blood pressure control and cardiovascular outcomes in normal-weight, overweight, and obese hypertensive patients treated with three different antihypertensives in ALLHAT
Objective:Epidemiologically, there is a strong relationship between BMI and blood pressure (BP) levels. We prospectively examined randomization to first-step chlorthalidone, a thiazide-type diuretic; amlodipine, a calcium-channel blocker; and lisinopril, an angiotensin-converting enzyme inhibitor, on BP control and cardiovascular outcomes in a hypertensive cohort stratified by baseline BMI [kg/m2; normal weight (BMI 30)].
Methods:In a randomized, double-blind, practice-based Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, 33 357 hypertensive participants, aged at least 55 years, were followed...
Source: Journal of Hypertension - June 6, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Obesity Source Type: research
Prevalence of subclinical coronary artery disease in ischemic stroke patients.
CONCLUSIONS: Our results show that the prevalence of subclinical CAD in ischemic stroke patients was high, and that a quarter of them had high-risk CAD. Age, diabetes, stroke, and male sex were independent predictors of high-risk CAD.
PMID: 24861913 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - May 23, 2014 Category: Cardiology Authors: Iwasaki K, Haraoka K, Hamaguchi T, Imamura T, Kawada S, Ohno M, Kashihara K Tags: J Cardiol Source Type: research
