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Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack Stroke
Conclusions Participants with asymptomatic atherosclerosis did not exhibit an obvious change in gut microbiota and blood TMAO levels; however, stroke and transient ischemic attack patients showed significant dysbiosis of the gut microbiota, and their blood TMAO levels were decreased.
Source: JAHA:Journal of the American Heart Association - November 23, 2015 Category: Cardiology Authors: Yin, J., Liao, S.-X., He, Y., Wang, S., Xia, G.-H., Liu, F.-T., Zhu, J.-J., You, C., Chen, Q., Zhou, L., Pan, S.-Y., Zhou, H.-W. Tags: Stroke Source Type: research

TMAO as a Novel Predictor of Major Adverse Vascular Events and Recurrence in Patients with Large Artery Atherosclerotic Ischemic Stroke
CONCLUSION: Elevated plasma TMAO concentration was independently associated with LAA ischemic stroke. The risk of major vascular event recurrence increased by 2.128 times in the LAA stroke subjects with plasma TMAO level higher than 126.83 pg/mL. Plasma TMAO concentration might be a potential biomarker of major vascular event recurrence.PMID:35345908 | DOI:10.1177/10760296221090503
Source: Atherosclerosis - March 29, 2022 Category: Cardiology Authors: Yan-Yan Chen Zu-Sen Ye Nian-Ge Xia Yun Xu Source Type: research

Association of Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide with First Ischemic Stroke.
CONCLUSIONS: This study suggested a positive association between plasma TMAO and ischemic stroke. Further studies are required to explore the role of plasma TMAO concentrations in predicting stroke risk. PMID: 32641646 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - July 10, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Plasma Trimethylamine- < em > N < /em > -Oxide and Incident Ischemic Stroke: The Cardiovascular Health Study and the Multi-Ethnic Study of Atherosclerosis
Conclusions Plasma TMAO levels are associated with incident ischemic stroke in a diverse population. Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT00005133.PMID:37581385 | DOI:10.1161/JAHA.122.029230
Source: Atherosclerosis - August 15, 2023 Category: Cardiology Authors: Rozenn N Lemaitre Paul N Jensen Zeneng Wang Amanda M Fretts Colleen M Sitlani Ina Nemet Nona Sotoodehnia Marcia C de Oliveira Otto Weifei Zhu Matt Budoff W T Longstreth Bruce M Psaty David S Siscovick Stanley L Hazen Dariush Mozaffarian Source Type: research

Nontraditional Risk Factors for Residual Recurrence Risk in Patients with Ischemic Stroke of Different Etiologies
CONCLUSIONS: LAA and SAO subtypes own the specific nontraditional risk factors while inflammation is a common risk factor for residual recurrence risk of both.PMID:35390802 | DOI:10.1159/000523919
Source: Atherosclerosis - April 7, 2022 Category: Cardiology Authors: Jie Xu Jinglin Mo Xing Zhang Zimo Chen Yuesong Pan Hongyi Yan Xia Meng Yongjun Wang Source Type: research

Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke
CONCLUSIONS AND RELEVANCE: In this observational study, TMAO was associated with cerebral small vessel disease determined by WMHV and acute lacunar infarction. The association was independent of traditional vascular risk factors.PMID:37610752 | DOI:10.1001/jamanetworkopen.2023.30446
Source: Atherosclerosis - August 23, 2023 Category: Cardiology Authors: Naruchorn Kijpaisalratana Zsuzsanna Ament Matthew B Bevers Varun M Bhave Ana-Lucia Garcia Guarniz Catharine A Couch M Ryan Irvin W Taylor Kimberly Source Type: research

Gut Microbiota-Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes.
CONCLUSIONS: The present study demonstrates for the first time a graded relation between TMAO levels and the risk of subsequent cardiovascular events in patients with recent prior ischemic stroke. Our data support the notion that TMAO-related increase of proinflammatory monocytes may add to elevated cardiovascular risk of patients with increased TMAO levels. PMID: 29976769 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 5, 2018 Category: Cardiology Authors: Haghikia A, Li XS, Liman TG, Bledau N, Schmidt D, Zimmermann F, Kränkel N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Fraccarollo D, Heimesaat MM, Bauersachs J, Wang Z, Zhu W, Bavendiek U, Hazen SL, Endres M, Landmesser U Tags: Arterioscler Thromb Vasc Biol Source Type: research

Gut microbiota-dependent TMAO, aortic atherosclerosis and risk of cardiovascular events in patients with stroke
Aim: In experimental studies gut microbiota-dependent metabolites, in particular trimethylamine N-oxide (TMAO), have recently been reported to promote atherosclerosis. Here, we examined for the first time the relation of TMAO with the severity of aortic atherosclerosis and the risk of incident cardiovascular events (CVE) in patients with recent first-ever ischemic stroke.
Source: Atherosclerosis - August 1, 2018 Category: Cardiology Authors: A. Haghikia, X.S. Li, T. Liman, C. Widera, K. Sonnenschein, A. Haghikia, K. Weissenborn, J. Bauersachs, U. Bavendiek, S.L. Hazen, M. Endres, U. Landmesser Source Type: research

Unraveling the Effects of Trimethylamine N-Oxide on Stroke: "The lower, the better?"
Authors: Yamashita T, Yoshida N, Emoto T, Hirata KI PMID: 32999209 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - October 2, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Biomarkers (plasma trimethylamine-N-oxide) to predict atrial fibrillation: Are we there yet?
Atrial fibrillation (AF) is the most prevalent arrhythmia and is projected to rise from 2.7 –6.1 million in 2010 to 12.1 million by 2030 [1]. AF portends a 4–5 fold risk of ischemic stroke in non-anticoagulated patients, and is an independent risk factor for ischemic stroke severity, recurrence, and mortality [1]. Due to the alarming increase in global prevalence with the attached incr ease in morbidity, mortality, and cost there has been increased effort to identify risk factors in the hope that prevention would turn the tide of this disease [1,2].
Source: International Journal of Cardiology - May 30, 2018 Category: Cardiology Authors: Mihail G. Chelu, Na Li Tags: Editorial Source Type: research

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
Conclusion Elevated plasma levels of choline and betaine are each associated with incident MACE risk independent of traditional risk factors. However, high choline and betaine levels are only associated with higher risk of future MACE with concomitant increase in TMAO.
Source: European Heart Journal - April 7, 2014 Category: Cardiology Authors: Wang, Z., Tang, W. H. W., Buffa, J. A., Fu, X., Britt, E. B., Koeth, R. A., Levison, B. S., Fan, Y., Wu, Y., Hazen, S. L. Tags: BASIC SCIENCE Source Type: research

Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors
Conclusion</div>Plasma TMAO levels among patients presenting with chest pain predict both near- and long-term risks of incident cardiovascular events, and may thus provide clinical utility in risk stratification among subjects presenting with suspected ACS.</span>
Source: European Heart Journal - January 10, 2017 Category: Cardiology Source Type: research

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